Delivery of peptide drugs to the brain by adenovirus-mediated heterologous expression of human oligopeptide transporter at the blood-brain barrier

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 1, 2003, Pages 40-47

  Toyobuku, Hidekazu ^a   Sai, Yoshimichi ^a,c   Kagami, Toru ^a   Tamai, Ikumi ^a,b,c   Tsuji, Akira ^a,c  

^a KANAZAWA UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGOPEPTIDE;

ADENOVIRUS; ANIMAL CELL; ARTICLE; BIOAVAILABILITY; BLOOD BRAIN BARRIER; BRAIN PERFUSION; DRUG EFFECT; DRUG TARGETING; ENDOTHELIUM CELL; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PLAQUE FORMING CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VIRUS EXPRESSION;

ADENOVIRIDAE; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENETIC VECTORS; HUMANS; MEMBRANE TRANSPORT PROTEINS; PEPTIDES; POLYLYSINE; RATS; RECOMBINANT FUSION PROTEINS; TRANSDUCTION, GENETIC;

EID: 0037379894     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.046243     Document Type: Article

References (39)

1. Balimane PV, Tamai I, Guo A, Nakanishi T, Kitada H, Leibach FH, Tsuji A, and Sinko PJ (1998) Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir. Biochem Biophys Res Commun 250:246-251.
2. Banks WA and Kastin AJ (1994) Delivering peptides to the central nervous system: dilemmas and strategies. Pharm Res (NY) 11:1345-1350.
3. Berger UV and Hediger MA (1999) Distribution of peptide transporter PEPT2 mRNA in the rat nervous system. Anat Embryol (Berl) 199:439-449.
4. Board RJ (1996) Brain-derived peptides regulate the steady state levels and increase stability of the blood-brain barrier (BBB) GLUT1 glucose transporter reporter gene. Neurosci Lett 220:53-56.
5. Bockman DE, Ganapathy V, Oblak TG, and Leibach FH (1997) Localization of peptide transporter in nuclei and lysosomes of pancreas. Int J Pancreatology 22:221-225.
6. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
7. Covitz K-MY, Amidon GL, and Sadee W (1996) Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm Res (NY) 13:1631-1634.
8. Croyle MA, Roessler BJ, Hsu C-P, Sun R, and Amidon GL (1998) Beta cyclodextrins enhance adenoviral-mediated gene delivery to the intestine. Pharm Res (NY) 15:1348-1355.
9. Fei YJ, Kanai Y, Nussberger S, Ganapathy V, Leibach FH, Romeo MF, Singh SK, Boron WF, and Hediger MA (1994) Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature (Lond) 368:563-566.
10. Gonzalez DB, Covitz K-MY, Sadee W, and Mrsny RJ (1998) An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2. Cancer Res 58:519-525.
11. Guo A, Hu P, Balimane PV, Leibach FH, and Sinko PJ (1999) Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. J Pharmacol Exp Ther 289:448-454.
12. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, and Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95: 2509-2514.
13. Hu M and Amidon GL (1988) Intestinal absorption of captopril in rats. J Pharm Sci 77:1007-1011.
14. 3H]MIA binding and RT-PCR analysis. Brain Res Mol Brain Res 58:178-187.
15. Kerr DK, Li Z, Diemers NO, Senter PD, and Vrudhula VM (1998) Development and activities of a new melphalan prodrug designed for tumor-selective activation. Bioconjugate Chem 9:255-259.
16. Kido Y, Tamai I, Okamoto M, Suzuki F, and Tsuji A (2000) Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies. Pharm Res (NY) 17:55-62.
17. +/peptide co-transporter. Cloning, functional expression and chromosomal localization. J Biol Chem 270:6456-6463.
18. Miyamoto K, Shiraga T, Morita K, Yamamoto H, Haga H, Taketani Y, Tamai I, Sai Y, Tsuji A, and Takeda E (1996) Sequence, tissue distribution and developmental change in rat intestinal oligopeptide transporter. Biochim Biophys Acta 1305:34-38.
19. Nakanishi T, Tamai I, Sai Y, Sasaki T, and Tsuji A (1997) Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080. Cancer Res 57:4118-4122.
20. Nakanishi T, Tamai I, Takaki A, and Tsuji A (2000) Cancer cell-targeted drug delivery utilizing oligopeptide transport activity. Int J Cancer 88:274-280.
21. Papuotsi M, Kurz H, Schachtele C, Marme D, Christ B, Prols F, and Wilting J (2000) Induction of the blood-brain barrier marker neurothelin/HT7 in endothelial cells by a variety of tumors in chick embryos. Histochem Cell Biol 113:105-113.
22. Pardridge WM (2002) Drug and gene targeting to the brain with molecular trojan horses. Nature (Lond) Review Drug Discovery 1:131-139.
23. Pardridge WM, Boado RJ, and Farrell CR (1990) Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization. J Biol Chem 265:18035-18040.
24. Sai Y, Tamai I, Sumikawa H, Hayashi K, Nakanishi T, Amano O, Numata M, Iseki S, and Tsuji A (1996) Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of β-lactam antibiotics. FEBS Lett 392:25-29.
25. Saito H and Inui K (1993) Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. Am J Physiol 265:G289-G294.
26. Saleh M, Jonas NK, Wiegmans A, and Stylli SS (2000) The treatment of established intracranial tumors by in situ retroviral INF-gamma transfer. Gene Therapy 7:1715-1724.
27. Schlapbach R and Fontana A (1997) Differential activity of bcl-2 and ICE enzyme family protease inhibitors on Fas and puromycin-induced apoptosis of glioma cells. Biochim Biophys Acta 1359:174-180.
28. Sun D, Landowski CP, Chu X, Wallsten R, Fleisher D, and Amidon GL (2001) Drug inhibition of GlySar uptake and hPEPT1 localization using hPEPT1-GFP fusion protein. AAPS Pharmsci 3.
29. Takasato Y, Rapoport SI, and Smith QR (1984) An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 247:H484-H493.
30. Tamai I, Nakanishi T, Hayashi K, Terao T, Sai Y, Shiraga T, Miyamoto K, Takeda E, Higashida H, and Tsuji A (1997) The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of β-lactam antibiotics in the rat small intestine. J Pharm Pharmacol 49:796-801.
31. Tamai I, Nakanishi T, Nakahara H, Sai Y, Ganapathy V, Leibach FH, and Tsuji A (1998) Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1. J Pharm Sci 87:1542-1546.
32. Teuscher NS, Keep RF, and Smith DE (2001) PEPT2-mediated uptake of neuropeptides in rat choroid plexus. Pharm Res (NY) 18:807-813.
33. Torok M, Huwyler J, Drewe J, Gutmann H, and Fricker G (1998) Transport of the beta-lactam antibiotic benzylpenicillin and the dipeptide glycylsarcosine by brain capillary endothelial cells in vitro. Drug Metab Dispos 26:1144-1148.
34. Toyobuku H, Sai Y, Tamai I, and Tsuji A (2002) Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of human oligopeptide transporter PEPT1. J Pharmacol Exp Ther 301:812-819.
35. Toyoda K, Ooboshi H, Chu Y, Fasbender A, Davidson BL, Welsh MJ, and Heistad DD (1998) Cationic polymer and lipids enhance adenovirus-mediated gene transfer to rabbit carotid artery. Stroke 29:2181-2188.
36. Tsuji A and Tamai I (1999) Carrier-mediated or specialized transport of drugs across the blood-brain barrier. Adv Drug Deliv Rev 36:277-290.
37. Tsuji A, Yoshikawa T, Nishide K, Minai H, Kimura M, Nakashima E, Terasaki T, Miyamoto E, Nightingale CH, and Yamaha T (1983) Physiologically based pharmacokinetic model for beta-lactam antibiotics. I. Tissue distribution and elimination in rat. J Pharm Sci 72:239-251.
38. Yamashita T, Shimada S, Guo W, Sato K, Kohmura E, Hayakawa T, Takagi T, and Tohyama M (1997) Cloning and functional expression of brain peptide/histidine transporter. J Biol Chem 272:10205-10211.
39. Zlokovic BV (1995) Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier. Pharm Res (NY) 12:1395-1406.