IFN-γ up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice

Journal of Neuroimmunology

Volumn 137, Issue 1-2, 2003, Pages 154-163

  Wu, Yadi ^a   Lin, Ying ^a   Hou, Wanqiu ^a   Wang, Yanping ^a   Sun, Bing ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

EAU; IFN ; IL 12 receptor beta 2

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 BETA 2 RECEPTOR; INTERLEUKIN RECEPTOR; STAT4 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; FEMALE; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL; UPREGULATION; UVEITIS;

EID: 0037377275     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(03)00071-7     Document Type: Article

References (34)

1. Billiau A., Heremans H., Vandekerckhove F., Dijkmans R., Sobis H., Meulepas E., Carton H. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. J. Immunol. 140:1988;1506-1510.
2. Bottazzo G.F., Pujol-Borrell R., Hanafusa T., Feldmann M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet. 2:1983;1115-1119.
3. Caspi R.R., Roberge F.G., Chan C.-C., Wiggert B., Chader G.J., Rozenszajn L.A., Lando Z., Nussenblatt R.B. A new model of autoimmune disease, Experiment autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol. 140:1988;1490-1495.
4. Caspi R.R., Chan C.C., Grubbs B.G., Silver P.B., Wiggert B., Bahmanyar C.F., Billiau S.A., Hermans H. Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice. J. Immunol. 152:1994;890-899.
5. Caspi R.R., Silver P.B., Chan C.C., Sun B., Agarwal R.K., Wells J., Oddo S., Fujino Y., Najafian F., Wilder R.L. Genetic susceptibility experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response. J. Immunol. 157:1996;2668-2675.
6. Chan C.C., Caspi R.R., Leake W.C., Wiggert B., Chader G.J., Nussenblatt R.B. Pathology of experimental autoimmune uveoretinitis in mice. J. Autoimmun. 3:1990;247-255.
7. Chang J.T., Shevach E.M., Segal B.M. Regulation of interleukin (IL)-12 receptor β2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J. Exp. Med. 189:1999;969-978.
8. Charteris D.G., Lightman S.L. Interferon-gamma production in vivo in experimental autoimmune uveoretinitis. Immunology. 75:1992;463-467.
9. Fallarino F., Grohmann U., Bianchi C., Vacca C., Fioretti F.C., Puccetti P. Th1 and Th2 clones to a poorly immunogenic tumor antigen initiate CD8+ T cell-dependent tumor eradication in vivo. J. Immunol. 165:2000;5495-5501.
10. Franchimont D., Galon J., Gadina M., Visconti R., Zhou Y., Aringer M., Frucht D.M., Chrousos G.P., O'Shea J.J. Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes. J. Immunol. 164:2000;1768-1774.
11. Gery I., Mochizuki M., Nussenblatt R.B. Retinal specific antigens and immunopathogenic processes they provoke. Prog. Retin. Res. 5:1986;75-79.
12. Grohmann U., Belladonna M.L., Vacca C., Bianchi R., Fallarino F., Orabona C., Fioretti M.C., Puccetti P. Positive regulatory role of IL-12 in macrophages and modulation by IFN-γ J. Immunol. 167:2001;221-227.
13. + T cells through IL-12 produced by Listeria-induced macrophages. Science. 260:1993;547-549.
14. Kaplan M.K., Sun Y.L., Hoey T., Grusby J. Impaired IL-12 responses and enhanced development of Th2 cells in STAT4-deficient mice. Nature. 382:1996;174-177.
15. Leslie S.J., Rizzo L.V., Agarwal R.K., Tarrant T.K., Chan C.C., Wiggert B., Caspi R.R. IFN-γ-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J. Immunol. 158:1997;5997-6005.
16. Pepperberg D.R., Okajima T.L., Ropps H., Chader G.J., Wiggert B. Functional properties of interphotoreceptor retinoid-binding protein. Photochem. Photobiol. 54:1991;1057-1060.
17. Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.Y., Gately M.K., Gubler U. A functional interleukin 12 receptor complex in composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U. S. A. 93:1996;14002-14007.
18. Robinson D.S., O'Garra A. Further checkpoints in Th1 development. Immunity. 16:2002;755-758.
19. Rogge L., Luisella B.M., Biffi M., Passini N., Presky D.H., Gubler U. Selective expression of Interleukin-12 receptor component by Human T helper 1 cells. J. Exp. Med. 185:1997;825-831.
20. Ryuta N., Rolf O.E., Warren S. T helper Type 2 cell differentiation occurs in the presence of interleukin 12 receptor β2 chain expression and signaling. J. Exp. Med. 191:2000;847-853.
21. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. U. S. A. 90:1993;10188-10192.
22. Smeltz R.B., Chen J., Ehrhardt R., Shevach E.M. Role of IFN-γ in Th1 differentiation: IFN-γ regulates IL-18Rα expression by preventing the negative effects of IL-4 and by Inducing/Maintaining IL-12 receptor β2 expression. J. Immunol. 168:2002;6165-6172.
23. Sun B., Well J., Goldmuntz E., Silver P., Remmers E.F., Wilder R.L., Caspi R.R. A simplified, competitive RT-PCR method for measuring rat IFN-g mRNA expression. J. Immunol. Methods. 195:1996;139-145.
24. Sun B., Rizzo L.V., Sun S.H., Chan C.C., Wiggert B. Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response. J. Immunol. 159:1997;1004-1011.
25. Sun B., Sun S.H., Chan C.C., Wiggert B., Caspi R.R. Autoimmunity to a pathogenic retinal antigen begins as a balanced cytokine response that polarizes towards type 1 in a disease-susceptible and towards type 2 in a disease-resistant genotype. Int. Immunol. 11:1999;1307-1312.
26. Sun B., Sun S.H., Chan C.C., Caspi R.R. Evaluation of in vivo cytokine expression in EAU-susceptible and resistant rats: a role for IL-10 in resistance? Exp. Eye Res. 70:2000;493-502.
27. Szabo S.J., Jacobson N.G., Dighe A.S., Gilber U., Murphy K.M. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 2:1995;665-675.
28. Szabo S.J., Dighe A.S., Gubler U., Murphy K.M. Regulation of interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:1997;817-824.
29. Szabo S.J., Kim S.T., Costa G., Zhang X., Fathman C.G., Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 100:2000;655-669.
30. Tarrant T.K., Silver P.B., Chan C.C., Wiggert B., Caspi R.R. Endogenous IL-12 is required for induction and expression of experiment autoimmune uveitis. J. Immunol. 161:1998;122-126.
31. Wahl S.M., Allen J.B., Ohura K., Chenoweth D.E., Hand A.R. IFN-gamma inhibits inflammatory cell recruitment and the evolution of bacterial cell wall-induced arthritis. J. Immunol. 146:1991;95-100.
32. Wenner C.A., Gubler M.L., Macatonia S.E., O'Garra A., Murphy K.M. Roles of IFN-γ and TFNα in IL-12-induced T helper cell-1 development. J. Immunol. 156:1996;1442-1447.
33. Yoshida A., Koide Y., Uchijima M., Yoshida T.O. IFN-γ induces IL-12 mRNA expression by a murine macrophage cell line, J774. Biochem. Biophys. Res. Commun. 198:1994;857-861.
34. Zhang Y., Apolasdo R., Coleman J., Paul W.E., Huang H. Interferon-g stabilizes the T helper cell type 1 phenotype. J. Exp. Med. 194:2001;165-172.