The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins

Endocrinology

Volumn 144, Issue 3, 2003, Pages 922-928

  Ranzi, Valeria ^a   Meakin, Susan O ^b   Miranda, Claudia ^a   Mondellini, Piera ^a   Pierotti, Marco A ^a   Greco, Angela ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2; FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3; MUTANT PROTEIN; NEUROTROPHIC TYROSINE RECEPTOR KINASE TYPE 1; NEUROTROPHIC TYROSINE RECEPTOR KINASE TYPE 1 RECEPTOR; ONCOPROTEIN; PROTEIN TRK T1; PROTEIN TRK T3; PROTEIN TYROSINE KINASE; TYROSINE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CARCINOGENESIS; CONTROLLED STUDY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; THYROID CARCINOMA; THYROID TUMOR;

3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION; IMMUNOSORBENT TECHNIQUES; LIPOPROTEINS; MEMBRANE PROTEINS; MICE; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPROTEINS; RECEPTOR, TRKA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; THYROID GLAND; THYROID NEOPLASMS; TRANSFECTION;

EID: 0037372082     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-221002     Document Type: Article

References (21)

1. Pierotti MA, Bongarzone I, Borrello MG, Greco A, Pilotti S, Sozzi G 1996 Cytogenetics and molecular genetics of the carcinomas arising from the thyroid epithelial follicular cells. Genes Chromosomes Cancer 16:1-14
2. Greco A, Pierotti MA, Bongarzone I, Pagliardini S, Lanzi C, Della Porta G 1992 TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene 7:237-242
3. Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA 1995 The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. Mol Cell Biol 15:6118-6127
4. Greco A, Orlandi R, Mariani C, Miranda C, Borrello MG, Cattaneo A, Pagliardini S, Pierotti MA 1993 Expression of TRK-T1 oncogene induces differentiation of PC12 cells. Cell Growth Differ 4:539-546
5. Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti MG, Pelicci PG, Pierotti MA 1994 The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins. Oncogene 9:1661-1668
6. Rabin SJ, Cleghon V, Kaplan DR 1993 SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol Cell Biol 13:2203-2213
7. Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax, Schlessinger J 1997 A lipid-anchored Grb2-binding protein that links FGFreceptor activation to the Ras/MAPK signaling pathway. Cell 89:693-702
8. Meakin SO, MacDonald JIS, Gryz EA, Kubu CJ, Verdi JM 1999 The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J Biol Chem 274:9861-9870
9. Ong SH, Guy GR, Hadari YR, Laks S, Gotoh N, Schlessinger J, Lax I 2000 FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol 20:979-989
10. Hadari YR, Kouhara H, Lax I, Schlessinger J 1998 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol Cell Biol 18:3966-3973
11. McDougall K, Kubu C, Verdi JM, Meakin SO 2001 Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis. Mech Dev 103:145-148
12. Descamps S, Lebourhis X, Delehedde M, Boilly B, Hondermarck H 1998 Nerve growth factor is mitogenic for cancerous but not normal human breast epithelial cells. J Biol Chem 273:16659-16662
13. Miknyoczki SJ, Lang D, Huang L, Klein-Szanto AJ, Dionne CA, Ruggeri BA 1999 Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int J Cancer 81:417-427
14. Weeraratna AT, Dalrymple SL, Lamb JC, Denmeade SR, Miknyoczki SJ, Dionne CA, Isaacs JT 2001 Pan-trk inhibition decreases metastasis and enhances host survival in experimental models as a result of its selective induction of apoptosis of prostate cancer cells. Clin Cancer Res 7:2237-2245
15. Greco A, Villa R, Tubino B, Romano L, Penso D, Pierotti MA 1999 A novel NTRK1 mutation associated with congenital insensitivity to pain anhidrosis. Am J Hum Genet 64:1207-1210
16. Roccato E, Miranda C, Ranzi V, Gishizky ML, Pierotti MA, Greco A 2002 Biological activity of the thyroid TRK-T3 oncogene requires signaling through Shc. Br J Cancer 8:645-653
17. Byrd DA, Sweet DJ, Panté N, Konstantinov KN, Guan T, Shapire ACS, Mitchell PJ, Cooper CS, Aebi U, Gerace L 1994 Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. J Cell Biol 127:1515-1526
18. Peng X, Greene LA, Kaplan DR, Stephens RM 1995 Deletion of a conserved juxtamembrane sequence in trk abolishes NGF-promoted neuritogenesis. Neuron 15:395-406
19. Hashimoto T 1988 K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylatin of proteins in PC12h cells. J Cell Biol 107:1531-1539
20. Wang JK, Xu H, Li HC, Goldfarb M 1996 Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras. Oncogene 13:721-729
21. Rich BE, Steitz JA 1987 Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. Mol Cell Biol 7:4065-4074