Etiopathogenesis of pediatric Crohn's disease. Biologic pathways based on interactions between genetic and environmental factors

Medical Hypotheses

Volumn 60, Issue 3, 2003, Pages 344-350

  Amre, Devendra K ^a   Seidman, Ernest G ^a,b  

^a UNIVERSITY OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYLATED HYDROXYANISOLE; BUTYLCRESOL; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DNA; FLAVORING AGENT; FOOD ADDITIVE; GLUTAMATE SODIUM; HETEROCYCLIC AMINE;

CHILD; CHILDHOOD DISEASE; CROHN DISEASE; DIETARY INTAKE; ENVIRONMENTAL FACTOR; ENZYME INDUCTION; GASTROINTESTINAL DISEASE; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 0037370817     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(02)00401-2     Document Type: Review

References (41)

1. Loftus E. V., Jr, Silverstein M. D., Sandbom W. J., Tremaine W. J., Harmsen W. S., Zinsmeister A. R. Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gastroenterology 1998; 114: 1161-1168.
2. Armitage E., Drummond H., Ghosh S., Ferguson A. Incidence of juvenile-onset Crohn's disease in Scotland. Lancet 1999; 353: 1496-1497.
3. Grand R. J., Ramakrishna J., Calenda K Inflammatory bowel disease in the pediatric patient. Gastroenterol Clin North Am 1995; 24: 613-632.
4. Scholmerich J. Inflammatory bowel disease at the end of its first century. Hepatogastroenterology 2000; 47: 2-4.
5. Shoda R., Matsueda K., Yamato S., Umeda N. Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n - 6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. Am J Clin Nutr 1996; 63: 741-745.
6. O'Morain C., Tobin A., Suzuki Y., O'Riordan T. Risk factors in inflammatory bowel disease. Scand J Gastroenterol 1989; 24(Suppl 170): 58-60.
7. Reif S., Lubin F., Farbstein M., Hallak A., Gilat T. Pre-illness dietary factors in inflammatory bowel disease. Gut 1997; 40: 754-760.
8. Kurata J. H. Dietary and other risk factors of ulcerative colitis. A case-control study in Japan. J Clin Gastroenterol 1994; 19: 166-171.
9. Persson P. G., Ahlbom A., Hellers G. Diet and inflammatory bowel disease: a case-control study. Epidemiology 1992; 3: 47-52.
10. Chuah S. Y., Jayanthi V., Lee C. N., McDonald B., Probert C. S., Mayberry J. F. Dietary fats and inflammatory bowel disease in Asians. Ital J Gastroenterol 1992; 24: 386-388.
11. Kasper H., Sommer H. Dietary fiber and nutrient intake in Crohn's disease. Am J Clin Nutr 1979; 32: 1898-1901.
12. Mayberry J. F., Rhodes J., Allan R., Newcombe R. G., Regan G. M., Chamberlain L. M., Wragg K. G. Diet in Crohn's disease. Two studies of current and previous habits in newly diagnosed patients. Dig Dis Sci 1981; 26: 444-448.
13. Tragnone A., Valpiani D., Miglio F. et al. Dietary habits as risk factors for inflammatory bowel disease. Eur Gastroenterol Hepatol 1995; 7: 47-51.
14. Thorton J. R., Emmett P. M., Heaton K. W. Diet and ulcerative colitis. BMJ 1980; 2: 293-294.
15. Nebert D. W., Ingelman-Sundberg M., Daly A. K. Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drag metabolizing enzyme genes, their functional importance, and nomenclature issues. Drug Metab Rev 1999; 31: 467-487.
16. McKinnon R. A., McManus M. E. Localization of cytochromes P-450 in human tissues: implications for chemical toxicity. Pathology 1996; 28: 148-155.
17. Hertervig E., Nilsson A., Seidegard J. The expression of glutathione transferase μ in patients with inflammatory bowel disease. Scand J Gastroenterol 1994; 29: 729-735.
18. Klotz U., Hoensch H., Tatjana S. et al. Expression of intestinal drug-metabolizing enzymes in patients with chronic inflammatory bowel disease. Curr Ther Res 1998; 59: 556-563.
19. Yang C. S., Brady J. F., Hong J. Y. Dietary effects on cytochome P450, xenobiotic metabolism, and toxicity. FASEB 1992; 6: 737-744.
20. Guengerich F. P. Influence of nutrients and other dietary materials on cytochrome P-450 enzymes. Am J Clin Nutr 1995; 61(Suppl): 651S-658S.
21. Hong J. Y., Pan J., Dong Z., Ning S. M., Yang C. S. Regulation of N-nitrodimethyamine demethylase in rat liver and kidney. Can Res 1987; 47: 5948-5953.
22. Wormhoudt L. W., Commandeur J. N. M., Vermeulen Nico P. E. Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. Crit Rev Toxicol 1999; 29: 59-124.
23. Oliw E. H. Oxygenation of polyunsaturated fatty acids by cytochrome P450 monooxygenases. Prog Lipid Res 1994; 33: 329-354.
24. Morimoto M., Reitz R. C., Morin R. J., Nguyen K., Ingelman-Sundberg M., French S. W. CYP-2E1 inhibitors partially ameliorate the changes in hepatic fatty acid composition induced in rats by chronic administration of ethanol and a high fat diet. J Nutr 1995; 125: 2953-2964.
25. Nair P., Mayberry J. F. Vegetarianism, dietary fibre and gastro-intestinal disease. Dig Dis 1994; 12: 177-185.
26. Zhang Z., Hamilton S. M., Stewart C., Strother A., Teel R. W. Inhibition of liver microsomal cytochromes P-450 activity and metabolism of the tobacco-specific nitrosamine NNK by capsaicin and ellagic acid. Anticancer Res 1993; 13: 2341-2346.
27. Nijhoff W. A., Grubben M. J., Nagengast F. M. et al. Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans. Carcinogenesis 1995; 16: 2125-2128.
28. Lampe J. W., King I. B., Li S. et al. Brassica vegetables increase and apiaceous vegetables decrease cytochrome P4501A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis 2000; 21: 1157-1162.
29. Sheen L. Y., Chen H. W., Kung Y. L., Liu C. T., Lii C. K. Effects of garlic oil and its organosulfur compounds on the activities of hepatic drug-metabolizing and antioxidant enzymes in rats fed high- and low-fat diets. Nutr Cancer 1999; 35: 160-166.
30. Wattenberg L. W. Inhibition of chemical carcinogens by minor dietary components. In: M. S. Arnott, J. van Eys, Y. M. Wang (eds). Molecular Interrelations of Nutrition and Cancer. New York: Raven Press, 1982: 43-56.
31. Conney A. H., Pantuck E. J., Hsiao K. C. et al. Enhanced phenacetin metabolism in human subjects fed charcol-broiled beef. Clin Pharmacol Ther 1976; 20: 633-642.
32. Bhaskar L., Ramakrishna B. S., Balasubramanian K. A. Colonic mucosal antioxidant enzymes and lipid peroxide levels in normal subjects and patients with ulcerative colitis. J Gastroenterol Hepatol 1995; 10: 140-143.
33. Duncan H., Swan C., Green J. et al. Susceptibility to ulcerative colitis and crohns disease: interactions between glutathione S-transferase GSTM1 and GSST1 genotypes. Clin Chim Acta 1995; 240: 53-61.
34. Miura S., Tsuzuki Y., Hokari R., Ishit H. Modulation of intestinal immune system by dietary fat intake: relevance to Crohn's disease. J Gastroenterol Hepatol 1998; 13: 1183-1190.
35. Alexander J. W. Immunonutrition: the role of ώ-3 fatty acids. Nutrition 1998; 14: 627-633.
36. Belluzzi A., Boschi S., Brignola C., Munarini A., Cariani G., Miglio F. Polyunsaturated fatty acids and inflammatory bowel disease. Am J Clin Nutr 2000; 71(Suppl): 339S-342S.
37. Palmblad J., Gyllenhammar H. Effect of dietary lipids on immunity and inflammation. APMIS 1988; 96: 571-583.
38. James M. J., Gibson R. A., Cleland L. G. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 2000; 71(Suppl): 343S-348S.
39. van Heel D. A., Satsangi J., Carey A. H., Jewell D. P. Inflammatory bowel disease: progress towards a gene. Can J Gastroenterol 2000; 14: 207-219.
40. Rioux J. D., Silverberg M. S., Daly M. J. et al. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet 2000; 66: 1863-1870.
41. Rioux J. D., Daly M. J., Silverberg M. S. et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn's disease. Nat Genet 2001; 29: 223-228.