Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11P in human colorectal cancer

British Journal of Cancer

Volumn 76, Issue 9, 1997, Pages 1124-1130

  Hiltunen, M O ^a   Koistinaho, J ^a   Alhonen, L ^a   Myohanen S ^a   Marin, S ^b   Kosma, V M ^b   Paakkonen M ^b   Janne J ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Chromosome 11p; Colorectal cancer; DNA methylation; Gene expression; Genomic sequencing; Sp1

Indexed keywords

CALCITONIN;

ADENOMA; ARTICLE; CHROMOSOME 11P; COLON ADENOMA; COLON CARCINOMA; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; NEPHROBLASTOMA; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE;

EID: 0030775517     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.522     Document Type: Article

References (26)

1. Bustros A, Nelkin BD, Silverman A, Ehrlich G, Poiesz B and Baylin SB (1988) The short arm of chromosome 11 is a 'hot spot' for hypermethylation in human neoplasia. Proc Natl Acad Sci USA 85: 5693-5647
2. Cunningham C and Dunlop MG (1994) Genetics of colorectal cancer. Br Med Bul 50: 640-655
3. Feinberg AP, Gehrke CW, Kuo KC and Ehrlich M (1988) Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 48: 1159-1161
4. Fraizer GC, Wu, YJ, Hewitt SM, Maity T, Ton CCT, Huff V and Saunders GF (1994) Transcriptional regulation of the human Wilms' tumor gene (WTI). J Biol Chem 269: 8892-8900
5. Goelz SE, Vogelstein B, Hamilton SR and Feinberg AP (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228: 187-190
6. Hakkarainen M, Wahlfors J, Myöhänen S, Hiltunen MO, Eskelinen M, Johansson R and Jänne, J (1996) Hypermethylation of calcitonin gene regulator, sequences in human breast cancer as revealed by genomic sequencing. Int J Cancer (in press)
7. Hamilton SR (1992) Molecular genetics of colorectal cancer. Cancer Suppl 70: 1216-1221
8. Hewitt SM, Fraizer GC and Saunders GF (1995) Transcriptional silencer of the Wilms' tumor gene WT1 contains an Alu repeat. J Biol Chem 270: 17908-17912
9. Hiltunen MO, Alhonen L, Koistinaho J, Myöhänen, S, Pääkkönen, M, Marin S, Kosma V-M and Jänne J (1997) Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. Int J Cancer (in press)
10. Hofmann W, Royer HD, Drechsler M, Schneider S and Royer-Pokora B (1993) Characterization of the transcriptional regulatory region of the human WT1 gene. Oncogene 8: 3123-3132
11. Ichikawa T, Ichikawa Y, Dong J, Hawkings AL, Griffin CA, Isaacs WB, Oshimura M, Barrett JC and Isaacs JT (1992) Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. Cancer Res 52: 3486-3490
12. Issa J-PJ, Vertino PM, Wu J, Sazawal S, Celano P, Nelkin BD, Hamilton SR and Baylin SB (1993) Increased cytosine DNA-methyltransferase activity during colon cancer progression. J Natl Cancer Inst 85: 1235-1240
13. Issa J-PJ, Ottavino YL, Celano P, Hamilton SR, Davidson NE and Baylin SB (1994) Methylation of the oestrogen receptor gene CpG islands links ageing and neoplasia in human colon. Nature Genet 7: 536-540
14. Jones PA (1996) DNA methylation errors and cancer. Cancer Res 56: 2463-2467
15. Laird PW and Jaenisch R (1994) DNA methylation and cancer. Hum Molec Genet 3: 1487-1495
16. Lichy JH, Modi WS, Seuanez HN and Howley PM (1992) Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells. Cell Growth Differ 3: 541-548
17. Loh WE Jr, Serable HJ, Livanos E, Arboleda MJ, Cavenne WK, Oshimura M and Weissman BE (1992) Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma. Proc Natl Acad Sci USA 89: 1755-1759
18. MacLeod RA and Szyf M (1995) Expression of antisense to DNA methyltransferase mRNA induces DNA methylation and inhibits tumorigenesis. J Biol Chem 270: 8037-8043
19. Malik KT, Wallace JI, Ivins SM and Brown KW (1995) Identification of an antisense WT1 promoter in intron I: implications for WT1 gene regulation. Oncogene 11: 1589-1595
20. Myöhänen S, Wahlfors J and Jäunne J (1994) Automated fluorescent genomic sequencing as applied to the methylation analysis of the human ornithine decarboxylase gene. DNA Seq 5: 1-8
21. Rauscher FJ 3d, Morris JF, Tournay OE, Cook DM and Curran T (1990) Binding of the Wilms' tumor locus zinc linger protein to the EGR-1 consensus sequence Science 250: 1259-1262
22. Schalling M, Dagerlind A, Brene S, Hallman H, Djurfeldt M, Persson H, Terenius L, Goldstein M, Schlesinger D and Hökfelt T (1988) Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptine tyrosine in the rat and bovine adrenal gland: effects of reserpine. Proc Natl Acad Sci USA 85: 8306-8310
23. Sharrard RM, Royds JA, Rogers S and Shorthouse, AJ (1992) Patterns of methylation of the c-myc gene in human colorectal cancer progression. Br J Cancer 65: 667-672
24. Silverman AL, Park JG, Hamilton SR, Gazdar AF, Luk GD and Baylin SB (1989) Abnormal methylation of the calcitonin gene in human colonic neoplasms. Cancer Rev 49: 3468-3473
25. Strohmeyer T (1993) Nephroblastom (Wilms' tumor): Zytogenetische und molekularbiologische Grundlagen. Klin Pädiatr 205: 135-139
26. Tornaletti S and Pfeifer GP (1995) Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers. Oncogene 10: 1493-1499