Genetic selection for modulators of a retinoic-acid-responsive reporter in human cells

Genetics

Volumn 163, Issue 3, 2003, Pages 1047-1060

  Richards, Burt ^a,b   Karpilow, Jon ^a   Dunn, Christine ^a,b   Peterson, Isaac ^a   Maxfield, Andrew ^a   Zharkikh, Ludmilla ^a   Abedi, Majid ^a   Hurlburt, Anthony ^a   Hardman, Joshua ^a   Hsu, Forrest ^a   Li, Wenhua ^a   Rebentisch, Matthew ^a   Sandrock, Robert ^a   Sandrock, Tanya ^a   Kamb, Alexander ^a   Teng, David H F ^a,c  

^a Deltagen Proteomics Incorporated   (United States)

^b Utah   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYCLOPHILIN B; DNA FRAGMENT; ISOMERASE; RETINOIC ACID;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CLONE; CONTROLLED STUDY; DNA ISOLATION; DNA MICROARRAY; EPISTASIS; GENE EXPRESSION; GENE FUSION; GENETIC SCREENING; GENETIC SELECTION; GENETIC STABILITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SUPPRESSOR GENE;

5' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; CYCLOPHILINS; DNA, COMPLEMENTARY; DNA, MITOCHONDRIAL; GENE LIBRARY; GENES, REPORTER; GENETIC SCREENING; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDYLPROLYL ISOMERASE; RECEPTORS, RETINOIC ACID; RESTRICTION MAPPING; SELECTION (GENETICS); TRANSFECTION;

EID: 0037357391     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. ABEDI, M. R., G. CAPONIGRO and A. KAMB, 1998 Green fluorescent protein as a scaffold for intracellular presentation of peptides. Nucleic Acids Res. 26: 623-630.
2. ALLAIN, F., S. DURIEUX, A. DENYS, M. CARPENTIER and G. SPIK, 1999 Cyclophilin B binding to platelets supports calcium-dependent adhesion to collagen. Blood 94: 976-983.
3. AXENOVICH, S. A., A. R. KAZAROV, A. D. BOIKO, G. ARMIN, I. B. RONINSON et al., 1998 Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response. Cancer Res. 58: 3423-3428.
4. BEGER, C., L. N. PIERCE, M. KRUGER, E. G. MARCUSSON, J. M. ROBBINS et al., 2001 Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. Proc. Natl. Acad. Sci. USA 98: 130-135.
5. BLUM, J. H., S. L. DOVE, A. HOCHSCHILD and J. J. MEKALANOS, 2000 Isolation of peptide aptamers that inhibit intracellular processes. Proc. Nad. Acad. Sci. USA 97: 2241-2246.
6. BUTZ, K., C. DENK, A. ULLMANN, M. SCHEFFNER and F. HOPPE-SEYLER, 2000 Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein. Proc. Natl. Acad. Sci. USA 97: 6693-6697.
7. CAPONIGRO, G., M. R. ABEDI, A. P. HURLBURT, A. MAXFIELD, W. JUDD et al., 1998 Transdominant genetic analysis of a growth control pathway. Proc. Natl. Acad. Sci. USA 95: 7508-7513.
8. CHAMBON, P., 1996 A decade of molecular biology of retinoic acid receptors. FASEB J. 10: 940-954.
9. COLAS, P., B. COHEN, T. JESSEN, I. GRISHINA, J. MCCOY et al., 1996 Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2. Nature 380: 548-550.
10. DE LUCA, L. M., 1991 Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J. 5: 2924-2933.
11. DRAGNEV, K. H., J. R. RIGAS and E. DMITROVSKY, 2000 The retinoids and cancer prevention mechanisms. Oncologist 5: 361-368.
12. FENAUX, P., C. CHOMIENNE and L. DEGOS, 2001 All-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia. Semin. Hematol. 38: 13-25.
13. FIERING, S., J. P. NORTHROP, G. P. NOLAN, P. S. MATTILA, G. R. CRABTREE et al., 1990 Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. Genes Dev. 4: 1823-1834.
14. FIRE, A., 1999 RNA-triggered gene silencing. Trends Genet. 15: 358-363.
15. FREEDMAN, L. P., 1999 Increasing the complexity of coactivation in nuclear receptor signaling. Cell 97: 5-8.
16. GAO, Y., and S. W. PIMPLIKAR, 2001 The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc. Natl. Acad. Sci. USA 98:14979-14984.
17. GEYER, C. R., A. COLMAN-LERNER and R. BRENT, 1999 "Mutagenesis" by peptide aptamers identifies genetic network members and pathway connections. Proc. Natl. Acad. Sci. USA 96: 8567-8572.
18. GUDKOV, A. V., A. R. KAZAROV, R. THIMMAPAYA, S. A. AXENOVICH, I. A. MAZO et al., 1994 Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc. Natl. Acad. Sci. USA 91: 3744-3748.
19. HANSEN, L. A., C. C. SIGMAN, F. ANDREOLA, S. A. ROSS, G. J. KELLOFF et al., 2000 Retinoids in chemoprevention and differentiation therapy. Carcinogenesis 21: 1271-1279.
20. HARLOW, E., and D. LANE, 1988 Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
21. HERMANN, T., and D. J. PATEL, 2000 Adaptive recognition by nucleic acid aptamers. Science 287: 820-825.
22. HERSKOWITZ, I., 1987 Functional inactivation of genes by dominant negative mutations. Nature 329: 219-222.
23. HOLZMAYER, T. A., D. G. PESTOV and I. B. RONINSON, 1992 Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments. Nucleic Acids Res. 20: 711-717.
24. ISOGAI, M., M. V. CHIANTORE, M. HAQUE, G. SCITA and L. M. DE LUCA, 1997 Expression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH-3T3 cell growth. Cancer Res. 57: 4460-4464.
25. JOHNSON, A., and R. A. CHANDRARATNA, 1999 Novel retinoids with receptor selectivity and functional selectivity. Br. J. Dermatol. 140 (Suppl. 54): 12-17.
26. KAMB, A., and D. H. TENG, 2000 Transdominant genetics, peptide inhibitors and drug targets. Curr. Opin. Mol. Ther. 2: 662-669.
27. KARTTUNEN, J., and N. SHASTRI, 1991 Measurement of ligand-induced activation in single viable T cells using the lacZ reporter gene. Proc. Natl. Acad. Sci. USA 88: 3972-3976.
28. KINSELLA, T. M., C. T. OHASHI, A. G. HARDER, G. C. YAM, W. LI et al., 2002 Retrovirally delivered random cyclic peptide libraries yield inhibitors of interleukin-4 signaling in human B cells. J. Biol. Chem. 277: 37512-37518.
29. KOLONIN, M. G., and R. L. FINLEY, JR., 1998 Targeting cyclin-dependent kinases in Drosophila with peptide aptamers. Proc. Natl. Acad. Sci. USA 95: 14266-14271.
30. LEVENSON, V. V., E. LAUSCH, D. J. KIRSCHLING, E. V. BROUDE, I. A. DAVIDOVICH et al., 1999 A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication. Somat. Cell Mol. Genet. 25: 9-26.
31. NORMAN, T. C., D. L. SMITH, P. K. & SORGER, B. L. DREES, S. M. O'ROURKE et al., 1999 Genetic selection of peptide inhibitors of biological pathways. Science 285: 591-595.
32. PRICE, E. R., L. D. ZYDOWSKY, M. J. JIN, C. H. BAKER, F. D. MCKEON et al., 1991 Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. Proc. Natl. Acad. Sci. USA 88: 1903-1907.
33. RICHARDS, B., J. KARPILOW, C. DUNN, L. ZHARKIKH, A. MAXFIELD et al., 1999 Creation of a stable human reporter cell line suitable for FACS-based, transdominant genetic selection. Somat. Cell Mol. Genet. 25: 191-205.
34. ROSSI, F. M., A. M. KRINGSTEIN, A. SPICHER, O. M. GUICHERIT and H. M. BLAU, 2000 Transcriptional control: rheostat converted to on/off switch. Mol. Cell 6: 723-728.
35. RYCYZYN, M. A., S. C. REILLY, K. O'MALLEY and C. V. CLEVENGER, 2000 Role of cyclophilin B in prolactin signal transduction and nuclear retrotranslocation. Mol. Endocrinol. 14: 1175-1186.
36. SANDROCK, T. M., B. RISLEY, B. T. RICHARDS, M. A. PORITZ, H. A. AUSTIN et al., 2001 Exogenous peptide and protein expression levels using retroviral vectors in human cells. Mol. Ther. 4: 398-406.
37. SAURAT, J. H., 1999 Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J. Am. Acad. Dermatol. 41: S2-S6.
38. SMITH, M. A., D. R. PARKINSON, B. D. CHESON and M. A. FRIEDMAN, 1992 Retinoids in cancer therapy. J. Clin. Oncol. 10: 839-864.
39. SWANSON, S. K., T. BORN, L. D. ZYDOWSKY, H. CHO, H. Y. CHANG et al., 1992 Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B. Proc. Natl. Acad. Sci. USA 89: 3741-3745.
40. TSAI, S., S. BARTELMEZ, R. HEYMAN, K. DAMM, R. EVANS et al., 1992 A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line. Genes Dev. 6: 2258-2269.
41. VARGHESE, L., A. JANCKILA and L. T. YAM, 1999 Acute promyelocytic leukemia: new methods in diagnosis and treatment. J. Ky. Med. Assoc. 97: 61-65.
42. WELCH, P. J., E. G. MARCUSSON, Q. X. LI, C. BEGER, M. KRUGER et al., 2000 Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes. Genomics 66: 274-283.
43. XU, L., C. K. GLASS and M. G. ROSENFELD, 1999 Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev. 9: 140-147.
44. ZHENG, P., J. EASTMAN, S. VANDE POL and S. W. PIMPLIKAR, 1998 PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl. Acad. Sci. USA 95: 14745-14750.