Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 25, Issue 2, 2003, Pages 97-110

  Das, Biswadeep ^a,c   Sarkar, C ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^b International Center for Health Sciences   (India)

^c SIKKIM MANIPAL INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

3 Pyridyl pinacidil; Anesthetized rabbit; Coronary occlusion; Free radicals; HMR 1883; Mitochondrial KATP channel; Myocardial ischemia; Nicorandil; Reperfusion arrhythmia; Sarcolemmal KATP channel

Indexed keywords

3 PYRIDYLPINACIDIL; 5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; ANTIARRHYTHMIC AGENT; CLAMIKALANT; GLUTATHIONE; MALONALDEHYDE; NICORANDIL; POTASSIUM CHANNEL; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; 3 PYRIDYL PINACIDIL; 3-PYRIDYL PINACIDIL; 5-HYDROXYDECANOIC ACID; ANTIOXIDANT; DECANOIC ACID DERIVATIVE; DRUG DERIVATIVE; HYDROXYACID; MEMBRANE PROTEIN; MITOCHONDRIAL K(ATP) CHANNEL; PINACIDIL; POTASSIUM CHANNEL BLOCKING AGENT; SULFONAMIDE; THIOUREA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; DOSE RESPONSE; DRUG EFFECT; HEART ARRHYTHMIA; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEMODYNAMICS; MALE; NONHUMAN; PERICARDIOTOMY; RABBIT; STATISTICAL ANALYSIS; THORAX; ANIMAL; BLOOD PRESSURE; CHANNEL GATING; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; ELECTROCARDIOGRAPHY; HEART RATE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; REPERFUSION INJURY; SARCOLEMMA; SURVIVAL RATE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTIOXIDANTS; ARRHYTHMIA; BLOOD PRESSURE; DECANOIC ACIDS; ELECTROCARDIOGRAPHY; HEART RATE; HYDROXY ACIDS; ION CHANNEL GATING; MALE; MEMBRANE PROTEINS; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NICORANDIL; OXIDATIVE STRESS; PINACIDIL; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RABBITS; SARCOLEMMA; SULFONAMIDES; SURVIVAL RATE; THIOUREA;

EID: 0037355279     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2003.25.2.723683     Document Type: Article

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