Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes

Journal of Molecular and Cellular Cardiology

Volumn 29, Issue 4, 1997, Pages 1123-1130

  Critz, Stuart D ^a   Liu, Guang Shung ^a   Chujo, Mitsuaki ^b   Downey, James M ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Ischemia; Nicorandil; Pinacidil; Rabbit

Indexed keywords

GLIBENCLAMIDE; NICORANDIL; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM ION;

ANIMAL CELL; ARTICLE; CELL VIABILITY; FEMALE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; MEMBRANE CURRENT; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0031128375     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1996.0335     Document Type: Article

References (42)

1. ARENA JP, KASS RS, 1989. Enhancement of potassium-sensitive current in heart cells by pinacidil. Circ Res 65: 436-445.
2. ARMSTRONG S, DOWNEY JM, GANOTE CE, 1994. Preconditioning of isolated rabbit cardiomyocytes, induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor. Cardiovasc Res 28: 72-77.
3. ARMSTRONG SC, LIU GS, DOWNEY JM, GANOTE CE, 1995. Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil. J Mol Cell Cardiol 27: 1765-1774.
4. ASHCROFT FM, 1988. Adenosine 5′-triphosphate-sensitive potassium channels. Neuroscience 11: 97-118.
5. AUCHAMPACH JA, MARAYAMA M, CAVERO J, GROSS GJ, 1991. The new K+ channel opener aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes. J Pharmacol Exp Ther 259: 961-967.
6. COHEN MV AND DOWNEY JM, 1996. Myocardial preconditioning promises to be a novel approach to the treatment of ischemic heart disease. Annu Rev Med 47: 21-29.
7. DOUPNIK CA, DAVIDSON N, LESTER HA, 1995. The inward rectifier potassium channel family. Curr Opin Neurobiol 5: 286-277.
8. ESCANDE D, THURINGER D, GUERN L, COURTIEX J, LAVILLE M, CAVERO I, 1989. Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes. Eur J Physiol 414: 669-675.
9. GROSS G, AUCHAMPACH J, MARUYAMA M, WALTIER D, PIEPER G, 1992. Cardioprotective effects of nicorandil. J Cardiovasc Pharm 20 (Suppl. 3): S22-S28.
10. GROSS GJ, AUCHAMPACH JA, 1992. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 70: 223-233.
11. GROVER GJ, SLEPH PG, PARHAM CS, 1990. Nicorandil improves postischemic contractile function independently of direct myocardial effects. J Cardiovasc Pharm 15: 698-705.
12. GROVER GJ, SLEPH PG, DZWONCZYK S, 1992. Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with adenosine A1-receptors. Circulation 86: 1310-1316.
13. GROVER GJ, 1993. An explanation for the reported observation that ATP dependent potassium channel openers fail to mimic preconditioning. Cardiovasc Res 27: 1564.
14. HAMMILL OP, MARTY A, NEHER E, SAKMANN B, SIGWORTH FJ, 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391: 85-100.
15. HEARSE DJ, 1995. Activation of ATP-sensitive potassium channels: a novel pharmacological approach to myocardial protection? Cardiovasc Res 30: 1-17.
16. HENRY P AND ESCANDE D, 1994. Do potassium channel openers compete with ATP to activate ATP-sensitive potassium channels? Cardiovasc Res 28: 754-759.
17. Hu K, DUAN D, LI G-R, NATTEL S, 1996. Protein kinase C activates ATP-sensitive K+ current in human and rabbit ventricular myocytes. Circ Res 78: 492-498.
18. IKONOMIDIS JS, SHIRAI T, WEISEL RD, DERYLO B, RAO V, WHITESIDE CI, MICKLE DAG, LI R-K, 1995. "Ischemic" or adenosine preconditioning of human ventricular cardiomyocytes is protein kinase C dependent (abstract). Circulation 92 (Suppl. I): 1-12.
19. JAHANGIR A, TERZIC A, KURACHI Y, 1994. Intracellular acidification and ADP enhance nicorandil induction of ATP sensitive potassium channel current in cardiomyocytes. Cardiovasc Res 28: 831-835.
20. KITZEN JM, MCCALLUM JD, HARVEY C, MORIN ME, OSHIRO GT, COLATSKY TJ, 1992. Potassium channel activators chromakalim and celikalim (WAY-120-491) fail to decrease myocardial infacrt size in the anesthitized canine. Pharmacology 45: 71-82.
21. LATHROP DA, NANASI PP, VARRO A, 1990. In vitro cardiac models of dog Purkinje fibre triggered and spontaneous electrical activity: effects of nicorandil. Br J Pharmacol 99: 123-199.
22. LIU Y, DOWNEY JM, 1992. Ischemic preconditioning protects against infarction in rat heart. Am J Physiol 263: H1107-H1112.
23. LIU Y, GAO WD, O'ROURKE B, MARBAN E, 1996. Synergistic modulation of ATP-sensitive K+ currents by protein kinase C and adenosine. Circ Res 78: 443-454.
24. MITCHELL MB, MENG X, AO L, BROWN JM, HARKEN AH, BANERJEE A, 1995. Preconditioning of isolated rat heart is mediated by protein kinase C. Circ Res 76: 73-81.
25. NOMA A, 1983. ATP-regulated potassium channels in cardiac muscle. Nature 305: 147-148.
26. PIEPER GM, GROSS GJ, 1989. Protective effect of nicorandil on postischemic function and tissue adenine nucleotides following a brief period of low-flow global ischemia in the isolated rat heart. Pharmacology 38: 205-213.
27. PRZYKLENK K, SUSSMAN MA, SIMKHOVICH BZ, KLONER RA, 1995. Does ischemic preconditioning trigger translocation of protein kinase C in the canine model? Circulation 92: 1546-1557.
28. RAVENS U, WANG X-L, WETTWER E, 1989. Alpha adrenergic stimulation reduces outward currents in rat ventricular myocytes. J Pharm Exp Ther 250: 364-370.
29. SATOH K, MORI T, YAMADA H, TAIRA N, 1993. Nicorandil as a nitrate, and cromakalim as a potassium channel opener, dilate isolated porcine large coronary arteries in an agonist-nonselective manner. Cardiovasc Drugs Ther 7: 691-699.
30. SCHULZ R, ROSE J, MARTIN C, HEUSCH G, 1994. Involvement of activation of ATP-dependent potassium channels in ischemic preconditioning in swine. Am J Physiol 267: 341-352.
31. + channel. Circ Res 69: 1152-1158.
32. SPEECHLY-DICK ME, MOCANU MM, YELLON DM, 1994. Protein kinase C: its role in ischemic preconditioning in the rat. Circ Res 75: 586-590.
33. + channel. Circ Res 77: 1030-1035.
34. THORNTON J, THORNTON CS, STERLING DL, DOWNEY JM, 1993. Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts. Circ Res 72: 44-49.
35. TOOMBS CF, MOORE TL, SHEBUSKI RJ, 1993. Limitation of infarct size in the rabbit by ischaemic preconditioning is reversible with glibenclamide. Cardiovasc Res 27: 617-622.
36. TSENG GN, HUFFMAN BF: Actions of pinacidil on membrane currents in canine ventricular myocytes and their modulation by intracellular ATP and cAMP. Eur J Physiol 415: 414-424.
37. VAHLHAUS C, SCHULZ R, POST H, ONALLAH R, HEUSCH G, 1996. No preservation of ischemic preconditioning by the protein kinase C inhibitor staurosporine in swine. Circ Res 79: 407-414.
38. VAN WINKLE DM, CHIEN GL, WOLEE RA, SOIFER BE, KUZUME K, DAVIS RF, 1994. Cardioprotection provided by adenosine receptor activation is abolished by blockade of the KATP channel. Am J Physiol 266: H829-H839.
39. VANDER HEIDE RS, RIM D, HOHL CM, GANOTE CE, 1990. An in vitro model of myocardial ischemia utilizing isolated adult rat myocytes. J MoL Cell Cardiol 22: 165-181.
40. VOGT A, BARANCIK M, WEIHRAUCH D, ARRAS M, PODZUWEIT T, SCHAPER W, 1994. Protein kinase C inhibitors reduce infarct size in pig hearts in vivo (abstract). Circulation 90 (Suppl. I): I-647.
41. ATP channel antagonist to attenuate preconditioning in rabbit myocardium. Cardiovasc Res 28: 1337-1341.
42. YTREHUS K, LIU Y, DOWNEY JM, 1994. Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am J Physiol 266: H1145-H1152.