Cryptosporidium parvum induces host cell actin accumulation at the host- parasite interface

Infection and Immunity

Volumn 68, Issue 4, 2000, Pages 2315-2322

  Elliott, David A ^a   Clark, Douglas P ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; ACTININ; BETA CATENIN; EZRIN; PLAKOGLOBIN; TALIN; VINCULIN; ZYXIN;

ARTICLE; CRYPTOSPORIDIUM PARVUM; CYTOSKELETON; DIARRHEA; HOST PARASITE INTERACTION; IMMUNOFLUORESCENCE; INTESTINE CELL; LASER MICROSCOPY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTOZOON;

ACTINS; ANIMALS; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; CYTOSKELETON; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GREEN FLUORESCENT PROTEINS; HOST-PARASITE RELATIONS; HUMANS; INDICATORS AND REAGENTS; LUMINESCENT PROTEINS; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MICROVILLI; PHALLOIDINE; PHOSPHORYLATION; PHOSPHOTYROSINE; TUMOR CELLS, CULTURED;

EID: 0034116189     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.4.2315-2322.2000     Document Type: Article

References (30)

1. Aberle, H., H. Schwartz, and R. Kemler. 1996. Cadherin-catenin complex: protein interactions and their implications for cadherin function. J. Cell Biochem. 61:514-523.
2. Beckerle, M. C. 1997. Zyxin: zinc fingers at sites of cell adhesion. Bioessays 19:949-957.
3. Brugge, J. S. 1998. Casting light on focal adhesions. Nat. Genet. 19:309-311.
4. Clark, D. P., and C. L. Sears. 1996. The pathogenesis of cryptosporidiosis. Parasitol. Today 12:221-225.
5. Clerc, P., and P. J. Sansonetti. 1987. Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulation. Infect. Immun. 55:2681-2688.
6. Cudmore, S., P. Cossart, G. Griffiths, and M. Way. 1995. Actin-based motility of vaccinia virus. Nature 378:636-638.
7. Current, W. L., and L. S. Garcia. 1991. Cryptosporidiosis. Clin. Microbiol. Rev. 4:325-358.
8. Dabiri, G. A., J. M. Sanger, D. A. Portnoy, and F. S. Southwick. 1990. Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly. Proc. Natl. Acad. Sci. USA 87:6068-6072.
9. Dobrowolski, J. M., and L. D. Sibley. 1996. Taxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell 34: 933-939.
10. Dubreuil, R. 1991. Structure and evolution of the actin crosslinking proteins. Bioessays 13:219-226.
11. Finlay, B. B., and P. Cossart, 1997. Exploitation of mammalian host cell functions by bacterial pathogens. Science 276:718-725.
12. Finlay, B. B., I. Rosenshine, M. S. Donnenberg, and J. B. Kaper. 1992. Cytoskeletal composition of attaching and effacing lesions associated with enteropathogenic Escherichia coli adherence to HeLa cells. Infect. Immun. 60:2541-2543.
13. Finlay, B. B., S. Ruschkowski, and S. Dedhar. 1991. Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells. J. Cell Sci. 99: 283-296.
14. Forney, J. R., D. B. DeWald, S. Yang, C. A. Speer, and M. C. Healey. 1999. A role for host phosphoinositide 3-kinase and cytoskeletal remodeling during Cryptosporidium parvum infection. Infect. Immun. 67:844-852.
15. Godwin, T. A. 1991. Crytosporidiosis in the acquired immunodeficiency syndrome: a study of 15 autopsy cases. Hum. Pathol. 22:1215-1224.
16. Griffiths, J. K., R. Balakrishnan, G. Widmer, and S. Tzipori. 1998. Paromomycin and geneticin inhibit intracellular Cryptosporidium parvum without trafficking through the host cell cytoplasm: implications for drug delivery. Infect. Immun. 66:3874-3883.
17. Jou, T.-S., D. Stewart, J. Stappert, W. Nelson, and J. A. Marrs. 1995. Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc. Natl. Acad. Sci. USA 92:5067-5071.
18. Lefkowitch, J. H., S. Krumholz, K.-C. Feng-Chen, P. Griffin, D. Despommier, and T. A. Brasitus. 1984. Cryptosporidiosis of the human small intestine: a light and electron microscopic study. Hum. Pathol. 15:746-752.
19. Lumadue, J. A., Y. C. Manabe, R. D. Moore, P. C. Belitsos, C. L. Sears, and D. P. Clark. 1998. A clinicopathologic analysis of AIDS-related cryptosporidiosis. AIDS 12:2459-2466.
20. Manjarrez-Hernandez, H. A., T. J. Baldwin, A. Aitken, S. Knutton, and P. H. Williams. 1992. Intestinal epithelial cell protein phosphorylation in entero-pathogenic Escherichia coli diarrhoea. Lancet 339:521-523.
21. Marcial, M. A., and J. L. Madara. 1986. Cryptosporidium: cellular localization, structural analysis of absorptive cell-parasite membrane-membrane interactions in guinea pigs, and suggestion of protozoan transport by M cells. Gastroenterology 90:583-594.
22. Morisaki, J. H., J. E. Heuser, and L. O. Sibley. 1995. Invasion of Toxoplasma gondii occurs by active penetration of the host cell. J. Cell Sci. 108:2457-2464.
23. Nieset, J. E., A. R. Tedfield, F. Jin, K. A. Knudsen, K. R. Johnson, and M. J. Wheelock. 1997. Characterization of the interactions of alpha-catenin with α-actinin and β-catenin/plakoglobin. J. Cell Sci. 110:1013-1022.
24. Ozawa, M., M. Ringwald, and R. Kemler. 1990. Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc. Natl. Acad. Sci. USA 87:4246-4250.
25. Robbins, J. R., A. I. Barth, H. Marquis, E. L. de Hostos, W. J. Nelson, and J. A. Theriot. 1999. Listeria monocytogenes exploits normal host cell processes to spread from cell to cell. J. Cell Biol. 146:1333-1350.
26. Rosenshine, I., M. S. Donnenberg, J. B. Kaper, and B. B. Finlay. 1992. Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake. EMBO J. 11:3551-3560.
27. Tilney, L. G., and D. A. Portnoy. 1989. Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite. Liberia monocytogenes. J. Cell Biol. 109:1597-1608.
28. Tzipori, S., and J. K. Griffiths. 1998. Natural history and biology of Cryptosporidium parvum. Adv. Parasitol. 40:6-36.
29. Vetterling, J. M., A. Takeuchi, and P. A. Madden. 1971. Ultrastructure of Cryptosporidium wrairi from the guinea pig. J. Protozool. 18:248-260.
30. Watarai, M., Y. Kamata, S. Kozaki, and C. Sasakawa. 1997. Rho, a small GTP-binding protein, is essential for Shigella invasion of epithelial cells. J. Exp. Med. 185:281-292.