5-HT moduline: An endogenous inhibitor of 5-HT 1B/1D-mediated contraction in pulmonary arteries

British Journal of Pharmacology

Volumn 138, Issue 5, 2003, Pages 795-800

  Murdoch, R ^a   Morecroft, I ^a   MacLean, M R ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

5 HT moduline; 5 HT 1B 1D receptors; Contraction; Pulmonary artery

Indexed keywords

5 CARBAMOYLTRYPTAMINE; AMINOPEPTIDASE INHIBITOR; BESTATIN; ENZYME INHIBITOR; LEUCYLSERYLALANYLLEUCINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHLORIDE; SEROTONIN 1B AGONIST; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1D AGONIST; SEROTONIN 1D ANTAGONIST; SEROTONIN 1D RECEPTOR; TETRAPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; HYPOXIA; IC 50; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RABBIT; RAT; RAT STRAIN;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NEUROPEPTIDES; OLIGOPEPTIDES; PULMONARY ARTERY; RABBITS; RATS; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; VASOCONSTRICTION;

EID: 0037349209     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705123     Document Type: Article

References (24)

1. CHESTER, A.H., AMRANI, M., SPROSON, C.A. & YACOUB, M.H. (2000). Interaction between thromboxane A2 and 5-hydroxytryptamine in the radial artery compared to the internal thoracic artery. Gen. Pharmacol., 35, 89-93.
2. CLOEZ-TAYARANI, I., CARDONA, A., ROUSSELLE, J.C., MASSOT, O., EDELMAN, L. & FILLION, G. (1997). Autoradiographical characterization of [3H]-5-HT-moduline binding sites in rodent brain and their relationship to 5-HT1B receptors. Proc. Natl. Acad. Sci. U.S.A., 94, 9899-9904.
3. DE HOON, J.N., WILLIGERS, J.M., TROOST, J., STRUIJKER-BOUDIER, H.A. & VAN BORTEL, L.M. (2000). Vascular effects of 5-HT1B/1D-receptor agonists in patients with migraine headaches. Clin. Pharmacol. Ther., 68, 418-426.
4. FENIUK, W., HUMPHREY, P.P.A., PERREN, M.J. & WATTS, A.D. (1985). A comparison of 5-hydroxytryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists. Br. J. Pharmacol., 86, 697-704.
5. GRIMALDI, B. & FILLION, M.P. (2000). 5-HT-moduline controls serotonergic activity: implications in neuroimmune reciprocal regulation mechanisms. Prog. Neurobiol., 60, 1-12.
6. GRIMALDI, B., FILLION, M.P., BONNIN, A., ROUSELLE, J.C., MASSOT, O. & FILLION, G. (1997). Immunocytochemical localization of neurons expressing 5-HT-moduline in the mouse brain. Neuropharmacology, 36, 1079-1087.
7. HERGET, J., SUGGET, A.J., LEACH, E. & BARER, G.R. (1978). Resolution of pulmonary hypertension and other features induced by chronic hypoxia in rats during complete and intermittent normoxia. Thorax, 33, 468-473.
8. ISHIDA, T., KAWASHIMA, S., HIRATA, K. & YOKOYAMA, M. (1998). Nitric oxide is produced via the 5-HT1B and 5-HT2B receptor activation in human coronary artery endothelial cells. Kobe J. Med. Sci., 44, 51-63.
9. KEEGAN, A., MORECROFT, I., SMILLIE, D., HICKS, M.N. & MACLEAN, M.R. (2001). Contribution of the 5-HT1B receptor to chronic hypoxia-induced pulmonary hypertension: Converging evidence using 5-HT1B receptor knockout mice and the 5-HT1B/1D receptor antagonist GR127935. Circ. Res., 89, 1231-1239.
10. MACLEAN, M.R. (1999). Pulmonary hypertension, anorexigens and 5-hydroxytryptamine: Pharmacological Synergism in action? Trends Pharmacol. Sci., 20, 490-495.
11. MACLEAN, M.R., CLAYTON, R.A., TEMPLETON, A.G.B. & MORECROFT, I. (1996a). Evidence for 5-HT1-like receptor mediated vasoconstriction in human pulmonary artery. Br. J. Pharmacol., 119, 277-282.
12. MACLEAN, M.R.,. HERVE, P., EDDAHIBI, S. & ADNOT, S. (2000). 5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension. Br. J. Pharmacol., 131, 161-382.
13. MACLEAN, M.R. & MORECROFT, I. (2001). Increased contractile response to 5-HT1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy. Br. J. Pharmacol., 134, 614-620.
14. MACLEAN, M.R., SWEENEY, G., BAIRD, M., MCCULLOCH, K.M., HOUSLAY, M. & MORECROFT, I. (1996b). 5-hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats. Br. J. Pharmacol., 119, 917-930.
15. MASSOT, O., ROUSSELLE, J.-C., FILLION, M.-P., GRIMALDI, B., CLOEZ-TAYARANI, I., FUGELLA, A., PRUDHOMME, N., SEGUIN, L., ROUSSEAU, B., PLANTEFOL, M., HEN, R. & FILLION, O. (1996). 5-HT-moduline, a new endogenous cerebral peptide, controls the serotinergic activity via its specific interaction with 5-HT1B/1D receptors. Mol. Pharmacol., 50, 752-762.
16. MCDUFFIE, J.E., COAXUM, S.D. & MALEQUE, M.A. (1999). 5-hydroxytryptamine evokes endothelial nitric oxide synthase activation in bovine aortic endothelial cell cultures. Proc. Soc. Exp. Biol, Med., 221, 386-390.
17. MORECROFT, I., HEELEY, R.P., PRENTICE, H.M., KIRK, A. & MACLEAN, M.R. (1999). 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Br. J. Pharmacol., 128, 730-734.
18. MORECROFT, I. & MACLEAN, M.R. (1998). 5-hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries. Br. J. Pharmacol., 125, 69-78.
19. NILSSON, T., LONGMORE, J., SHAW, D., OLESEN, I.J. & EDVINSSON, L. (1999). Contractile 5-HT1B receptors in human cerebral arteries: pharmacological characterization and localization with immunocytochemistry. Br. J. Pharmacol., 128, 1133-1140.
20. PLANTEFOL, M., ROUSSELLE, M.P., BENARDI, E., SCHOOFS, A.R., POURRIAS, B. & FILLION, G. (1999a). Endoproteolytic activity in mammalian brain membranes cleaves 5-hydroxytryptamine-moduline into dipeptides. Eur. J. Pharmacol., 376, 109-117.
21. PLANTEFOL, M., ROUSSELLE, J.C., MASSOT, O., BERNARDI, E., SCHOOFS, A.R., POURRIAS, B., OLLIVIER, R. & FILLION, G. (1999b). Structural requirements of 5-HT-moduline analogues to interact with the 5-HT1B receptor. J. Neurochem., 73, 2617-2620.
22. PRICE, G.W., BURTON, M.J., COLLIN, L.J., DUCKWORTH, M., GASTER, L., GOTHERT, M., JONES, B.J., ROBERTS, C., WATSON, J.M. & MIDDLEMASS, D.N. (1997). SB216641 and BRL15572-compounds to pharmacologically discriminate h5-HT1B and 5-HT1D receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 356, 312-360.
23. ROUSSELLE, J.C., MASSOT, O., FILLION, M.P., DELEPIERRE, M., ZIFA, E., ROUSSEAU, B. & FILLION, G. (1996). Isolation and characterisation of an endogenous peptide from rat brain interacting specifically with 5-HT1B receptors. J. Biol. Chem., 271, 726-735.
24. ROUSSELLE, J.-C., PLANTEFOL, M., FILLION, M.-P., MASSOT, O., PAUWELS, P.J. & FILLION, G. (1998). Specific interactions of 5-HT moduline with human 5-HT(1b) as well as 5-HT(1d) receptors expressed in transfected cultured cells. Naunyn-Schmiedeberg's Arch. Pharmacol., 358, 279-286.