Conjugation of an antisense oligodeoxynucleotide to ribonuclease H results in sequence-specific cleavage and intracellular inhibition of HCV gene expression

Bioconjugate Chemistry

Volumn 14, Issue 2, 2003, Pages 295-301

  Fukuma, Toshiko ^a   Walton, Cherie M ^a   Wu, Catherine H ^a   Wu, George Y ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROPHORESIS; ESCHERICHIA COLI; GENE EXPRESSION; RNA; SODIUM COMPOUNDS; SULFUR COMPOUNDS; VIRUSES;

ANTISENSE OLIGODEOXYNUCLEOTIDES; CELL LINES; GENES EXPRESSION; HEPATITIS C VIRUS; NON-CODING REGION; OLIGODEOXYNUCLEOTIDES; RECOMBINANT E COLI; RECOMBINANT E. COLI; SPECIFIC CLEAVAGES; SULPHATE-POLYACRYLAMIDE GEL ELECTROPHORESIS;

CELL CULTURE;

MESSENGER RNA; OLIGODEOXYNUCLEOTIDE DERIVATIVE; RIBONUCLEASE H ANTISENSE OLIGODEOXYNUCLEOTIDE CONJUGATE; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; CELL TRANSPORT; CONJUGATION; CONTROLLED STUDY; ENZYME BINDING; ENZYME PURIFICATION; GENE EXPRESSION REGULATION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; REPORTER GENE; RNA DEGRADATION; RNA TRANSPORT; VIRUS GENE;

CUCUMBER MOSAIC VIRUS; ESCHERICHIA COLI; HEPATITIS C VIRUS; RNA VIRUSES; VIBRIO PHAGE NT-1;

EID: 0037347125     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0256300     Document Type: Article

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