Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product

Modern Pathology

Volumn 16, Issue 3, 2003, Pages 229-235

  Zhang, Paul J ^a   Goldblum, John R ^b   Pawel, Bruce R ^c   Fisher, Cyril ^d   Pasha, Teresa L ^a   Barr, Frederic G ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

Desmoplastic small round cell tumor; EWS WT1 fusion product; HER2 neu; Immunophenotype

Indexed keywords

ALKALINE PHOSPHATASE PLACENTA ISOENZYME; ANTIBODY; CALRETININ; CD99 ANTIGEN; CYTOKERATIN; DESMIN; GENE PRODUCT; MYOD PROTEIN; MYOGENIC FACTOR 5; MYOGENIN; MYOGLOBIN; NEU DIFFERENTIATION FACTOR; PROTEIN; RNA BINDING PROTEIN EWS; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG; WT1 PROTEIN;

ARTICLE; CARCINOMA; CLINICAL ARTICLE; DESMOPLASTIC SMALL ROUND CELL TUMOR; EWING SARCOMA; GENE FUSION; HISTOGENESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MESOTHELIOMA; MICROSCOPY; MORPHOLOGY; NEUROECTODERM TUMOR; PERITONEUM; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; TUMOR DIAGNOSIS;

ANTIGENS, NEOPLASM; CARCINOMA, SMALL CELL; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MESOTHELIOMA; NEUROECTODERMAL TUMORS, PRIMITIVE; ONCOGENE PROTEINS, FUSION; PERITONEAL NEOPLASMS; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, ERBB-2; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SARCOMA, EWING'S; TUMOR MARKERS, BIOLOGICAL;

EID: 0037342957     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.MP.0000056630.76035.F3     Document Type: Article

References (32)

1. Gerald WL, Miller HK, Battifora H, Miettinen M, Silva E, Rosai J. Intra-abdominal desmoplastic small round-cell tumor. Am J Surg Pathol 1991;15:499-513.
2. Gerald WL, Ladanyi M, de Alava E, Cuatrecasas M, Kushner BH, LaQuaglia MP, et al. Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(P13;q12); desmoplastic small round-cell tumor and its variants. J Clin Oncol 1998;16:3028-36.
3. Ordonez NG, Zirkin R, Bloom RE. Malignant small-cell epithelial tumor of the peritoneum coexpressing mesenchymal-type intermediate filaments. Am J Surg Pathol 1989;13:413-21.
4. Gonzalez-Crussi F, Crawford SE, Sun C-C. Intraabdominal desmoplastic small-cell tumors with divergent differentiation. Am J Surg Pathol 1990;14:633-42.
5. Ordonez NG, El-Naggar AK, Ro JY, Silva EG, Mackay B. Intra-abdominal desmoplastic small cell tumor: a light microscopic, immunohistochemical, ultrastructural, and flow cytometric study. Hum Pathol 1993;24:850-65.
6. Sawyer JR, Tryka FA, Lewis JM. A novel reciprocal chromosome translocation t(11;22) (p13;q12) in an intraabdominal desmoplastic small round-cell tumor. Am J Surg Pathol 1992;16:411-6.
7. De Alava E, Ladanyi M, Rosai J. Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by RT-PCR. Am J Pathol 1995;147:1584-91.
8. Biegel JA, Conrad K, Brooks JJ. Translocation (11:22)(p.13;q12); primary change in intraabdominal desmoplastic small round cell tumor. Genes Chromosomes Cancer 1993;7:119-21.
9. Barnoud R, Dellattre O, Peoch M, Pasquier D, Plantaz D, Leroux D, et al. Desmoplastic small round cell tumor: RT-PCR analysis and immunohistochemical detection of the Wilm's tumor gene WT1. Pathol Res Pract 1998;194:693-700.
10. Coussens L, Yang-Feng TL, Chen YLE, et al. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 1985;230:1132-9.
11. Yarden Y, Kuang WS, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, et al. Human proto-oncogene, c-kit, a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987;6:3341-51.
12. Matsuda R, Takahashi T, Nakamura S, Sekido Y, Nishida K, Seto M, et al. Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues. Am J Pathol 1993;142:339-46.
13. Lux ML, Rubin BP, Biase TL, Chen CJ, Maclure T, Demetri G, et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol 2000;156:791-5.
14. Ricotti E, Fagioli F, Garelli E, Linari C, Crescenzio N, Norenstein AL, et al. c-kit is expressed in soft tissue sarcoma of neuroectodermic origin and its ligand prevents apoptosis of neoplastic cells. Blood 1998;91:2397-405.
15. Wang WL, Healy ME, Sattler M, Verma S, Lin J, Maulik G, et al. Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosin kinase inhibitor STI 571. Oncology 2000;19:3521-8.
16. Joensuu H, Roberts PJ, Sarlomo-Rikala M, Anderson LC, Tervahartiala P, Tuveson D, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001;344:1052-6.
17. Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-Her2 monoclonal antibody in women who have Her2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999;17:2639-48.
18. Barnoud R, Sabourin JC, Pasquier D, Ranchere D, Bailly C, Terrier-Lacombe MJ, et al. Immunohistochemical expression of WT1 by desmoplastic small round cell tumor: a comparative study with other small round cell tumors. Am J Surg Pathol 2000;24:830-6.
19. Barr FG, Chatten J, D'Cruz CM, Wilson AE, Nauta LE, Nycum LM, et al. Molecular assays for chromosomal translocations in the diagnosis of pediatric soft tissue sarcomas. JAMA 1995;273:553-7.
20. Charles AK, Moore IE, Berry PJ. Immunohistochemical detection of the Wilm's tumour gene WT1 in desmoplastic small round cell tumour. Histopathology 1997;30:312-4.
21. Ordonez NG. Desmoplastic small round cell tumor. II. An ultrastructural and immunohistochemical study with emphasis on new immunohistochemical markers. Am J Surg Pathol 1998;22:1314-27.
22. Goldsmith JD, Pawel B, Goldblum JR, Pasha TL, Robert S, Khurana JS, et al. Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation. Am J Pathol 2002;26:1627-33.
23. Armstrong JF, Pritchard-Jones K, Bickmore WA, Hastie HD, Bard JB. The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech Dev 1993;40:85-97.
24. Little M, Wells C. A clinical overview of WT1 gene mutations. Hum Mutat 1997;9:209-25.
25. Parkash V, Gerald WL, Parma A, Miettinen M, Rosai J. Desmoplastic small round cell tumor of the pleura. Am J Surg Pathol 1995;19:659-65.
26. Choi JK, van Hoeven K, Brooks JJ, Gupta PK. Desmoplastic small round cell tumor presenting pleural fluid and accompanied by desmin-positive mesothelial cells. Acta Cytol 1995;39:377-8.
27. Wolf AN, Ladanyi M, Paull G, Blaugrund JE, Westra WH. The expanding clinical spectrum of desmoplastic small round-cell tumor: a report of two cases with molecular confirmation. Hum Pathol 1999;30:430-5.
28. Doglioni C, Tos AP, Laurino L, Iuzzolino P, Chiarelli C, Celio MR, et al. Calretinin: a novel immunocytochemical marker for mesothelioma. Am J Surg Pathol 1996;20:1037-46.
29. Rogers JH. Calretinin: a gene for a novel calcium-binding protein expressed principally in neurons. J Cell Biol 1987;105:1343-53.
30. Trupiano JK, Machen SK, Barr FG, Goldblum JR. Cytokeratin-negative desmoplastic small round cell tumor: a report of two cases emphasizing the utility of reverse transcriptase-polymerase chain reaction. Mod Pathol 1999;12:849-53.
31. Ordonez NG, Desmoplastic small round cell tumor. I. A histopathologic study of 39 cases with emphasis on unusual histological patterns. Am J Surg Pathol 1998;22:1303-13.
32. Smithey BE, Pappo AS, Hill DA. C-kit expression in pediatric solid tumors. Am J Surg Pathol 2002;26:486-92.