Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump

Journal of Bacteriology

Volumn 178, Issue 13, 1996, Pages 3791-3795

  Liu, Jun ^a   Tariff, Howard E ^b   Nikaido, Hiroshi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Insituto Venez de Invest Cie   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CIPROFLOXACIN; ENOXACIN; NALIDIXIC ACID; NORFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ACTIVE TRANSPORT; ANTIBIOTIC RESISTANCE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG TRANSPORT; MICHAELIS MENTEN KINETICS; MOLECULAR CLONING; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PLASMID; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STEADY STATE;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM SMEGMATIS;

EID: 0030013072     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.178.13.3791-3795.1996     Document Type: Article

References (36)

1. Brennan, P. J., and H. Nikaido. 1995. The envelope of mycobacteria. Annu. Rev. Biochem. 64:29-63.
2. Bryan, L. E., and J. Bedard. 1991. Impermeability to quinolones in grampositive and gram-negative bacteria. Eur. J. Clin. Microbiol. Infect. Dis. 10:232-239.
3. Cambau, E., W. Sougakoff, M. Besson, C. Truffol-Perot, J. Grasset, and V. Jarlier. 1994. Selection of a gyrA mutant of Mycobacterim tuberculosis resistant to fluoroquinolones during treatment with ofloxacin. J. Infect. Dis. 170:479-483.
4. Chamberland, S, A. S. Bayer, T. Schollardt, S. A. Wong, and L. E. Bryan. 1989. Characterization of mechanisms of quinolone resistance in Pseudonwnas aeruginosa strains isolated in vitro and in vivo during experimental endocarditis. Antimicrob. Agents Chemother. 33:624-634.
5. Cohen, S. P., D. C. Hooper, J. S. Wolfson, K. S. Souza, L. M. McMurry, and S. B. Levy. 1988. Endogenous active efflux of norfloxacin in susceptible Escherichia coli. Antimicrob. Agents Chemother. 32:1182-1191.
6. Frieden, T. R., T. Sterling, A. Pablos-Mendez, J. O. Kilburn, G. M. Cauthen, and S. W. Dooley. 1993. The emergence of drug-resistant tuberculosis in New York City. N. Engl. J. Med. 328:521-526.
7. Goble, M., M. D. Iseman, L. A. Madsen, D. Waite, L. Ackerson, and C. R. Horsburgh. 1993. Treatment of 171 patients with pulmonary tuberculosis resistant to isoniazid and rifampin. N. Engl. J. Med. 328:527-532.
8. Grinius, L. L., and E. R. Goldberg. 1994. Bacterial multidrug resistance is due to a single membrane protein which functions as a drug pump. J. Biol. Chem. 269:29998-30004.
9. Hashmi, Z., and J. M. B. Smith. 1991. Outer membrane changes in quinolone resistant Pseudomonas aeruginosa. J. Antimicrob. Chemother. 28:465-470.
10. Hooper, D. C., J. S. Wolfson, K. S. Souza, C. Tang, G. L. McHugh, and M. N. Swartz. 1986. Genetic and biochemical characterization of norfloxacin resistance in Escherichia coli. Antimicrob. Agents Chemother. 29:639-644.
11. Ito, H., H. Yoshida, M. Bogaki-Shonai, T. Niga, H. Hattori, and S. Nakamura. 1994. Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aurcus. Antimicrob. Agents Chemother. 38: 2014-2023.
12. Jacobs, W. R., Jr., G. V. Kalpana, J. D. Cirillo, L. Pascopella, S. B. Snapper, R. A. Udani, W. Jones, R. G. Barletta, and B. R. Bloom. 1991. Genetic systems for mycobacteria. Methods Enzymol. 204:537-555.
13. Jarlier, V., and H. Nikaido. 1990. Permeability barrier to hydrophilic solutes in Mycobacterium chelonei. J. Bacteriol. 172:1418-1423.
14. Jarlier, V., and H. Nikaido. 1994. Mycobacterial cell wall: structure and role in natural resistance to antibiotics. FEMS Microbiol. Lett. 123:11-18.
15. Levy, S. B. 1992. Active efflux mechanisms for antimicrobial resistance. Antimicrob. Agents Chemother. 36:695-703.
16. Li, X.-Z., D. M. Livermore, and H. Nikaido. 1994. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa resistance to tetracycline, chloramphenicol, and norfloxacin. Antimicrob. Agents Chemother. 38:1732-1741.
17. Liu, J., and H. Nikaido. Unpublished results.
18. Liu, J., E. Y. Rosenberg, and H. Nikaido. 1995. Fluidity of the lipid domain of cell wall from Mycobacterium chelonei. Proc. Natl. Acad. Sci. USA 92: 11254-11258.
19. Masuda, N., E. Sakagawa, and S. Ohya. 1995. Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:645-649.
20. McMurry, L. M., R. E. Petrueel, Jr., and S. B. Levy. 1980. Active efflux of tetracycline encoded by four genetically different tctracyclinc resistance determinants in Escherichia coli. Proc. Natl. Acad. Sci. USA 77:3974-3977.
21. Mühlradt, P. F., J. Menzel, J. R. Golecki, and V. Speth. 1974. Lateral mobility and surface density of lipopolysaccharide in the outer membrane of Salmonella typhimurium. Eur. J. Biochem. 43:533-539.
22. Nakamura, S., M. Nakamura, T. Kojima, and H. Yoshida. 1989. gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli. Antimicrob. Agents Chemother. 33:254-255.
23. Neyfakh, A. A., C. M. Borsch, and G. W. Kaatz. 1993. Fluoroquinolonc resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter. Antimicrob. Agents Chemother. 37:128-129.
24. Ng, E.-Y., M. Trucksis, and D. C. Hooper. 1994. Quinolone resistance mediated by norA: physiological characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome. Antimicrob. Agents Chemother. 38:1345-1355.
25. Nikaido, H. 1994. Prevention of drug access to bacterial targets: role of permeability barriers and active efflux. Science 264:382-388.
26. Nikaido, H., and D. G. Thanassi. 1993. Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples. Antimicrob. Agents Chemother. 37:1393-1399.
27. Poole, K., K. Krebes, C. McNally, and S. Ncshat. 1993. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for an involvement of an efflux operon. J. Bacteriol. 175:7363-7372.
28. Robillard, N. J., and A. L. Scarpa. 1988. Genetic and physiological characterization of ciprofloxacin resistance in Pseudomonas aeruginosa PAO. Antimicrob. Agents Chemother. 32:535-539.
29. Rounch, D. A., D. S. Cram, D. DiBeraradino, T. G. Littlejohn, and R. A. Skurray. 1990. Efflux-mediated antiseptic resistance qacA gene from Staphylococcus aureus. common ancestry with tetracyclinc- and sugar-transport proteins. Mol. Microbiol. 4:2051-2062.
30. Shen, L. L., L. A. Mitsher, P. N. Sharma, T. J. O'Donnell, W. T. Chu, C. S. Cooper, T. Rosen, and A. G. Pernet. 1989. Mechanism of inhibition of DNA gyrase by quinolone antibacterial. A cooperative drug-DNA binding model. Biochemistry 28:3886-3894.
31. Sullivan, E. A., B. N. Kreiswirth, L. Palumbo, V. Kapur, J. M. Musser, A. Ebrahimzadeh, and T. R. Friden. 1995. Emergence of fluoroquinoloneresistant tuberculosis in New York City. Lancet 345:1148-1150.
32. Takiff, H. E., M. Cimino, M. C. Musso, T. Weisbrod, R. Martinez, M. B. Delgado, L. Salazar, B. R. Bloom, and W. R. Jacbos, Jr. 1996. Efflux pumps of the proton antiporter family confers low level fluoroquinolone resistance in M. smegmatis. Proc. Natl. Acad. Sci. USA 93:362-366.
33. Takiff, H. E., L. Salazar, C. Guerrero, W. Philip, W. Huang, B. Kreiswirth, S. T. Cole, W. R. Jacobs, Jr., and A. Telenti. 1994. Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations. Antimicrob. Agents Chemother. 38:773-780.
34. Thanassi, D. G., G. S. B. Suh, and H. Nikaido. 1995. Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli. J. Bacteriol. 177:998-1007.
35. Trias, J., and R. Benz. 1994. Permeability of the cell wall of Mycobacterium smegmatis. Mol. Microbiol. 14:283-290.
36. Yoshida, H., M. Bogaki, S. Nakamura, K. Vbukala, and M. Knnno. 1990. Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones. J. Bacteriol. 172:6942-6944.