메뉴 건너뛰기




Volumn 77, Issue 6, 2003, Pages 3516-3530

The stable 2.0-kilobase intron of the herpes simplex virus type 1 latency-associated transcript does not function as an antisense repressor of ICP0 in nonneuronal cells

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; GENE REPRESSION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; INTRON; LATENT PERIOD; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; VIRUS REPLICATION;

EID: 0037333380     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.6.3516-3530.2003     Document Type: Article
Times cited : (19)

References (56)
  • 1
    • 0036138853 scopus 로고    scopus 로고
    • Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo
    • Ahmed, M., M. Lock, C. G. Miller, and N. W. Fraser. 2002. Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo. J. Virol. 76:717-729.
    • (2002) J. Virol. , vol.76 , pp. 717-729
    • Ahmed, M.1    Lock, M.2    Miller, C.G.3    Fraser, N.W.4
  • 2
    • 0032958432 scopus 로고    scopus 로고
    • Genetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection
    • Alvira, M. R., W. F. Goins, J. B. Cohen, and J. C. Glorioso. 1999. Genetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection. J. Virol. 73:3866-3876.
    • (1999) J. Virol. , vol.73 , pp. 3866-3876
    • Alvira, M.R.1    Goins, W.F.2    Cohen, J.B.3    Glorioso, J.C.4
  • 3
    • 0027202553 scopus 로고
    • An HSV LAT null mutant reactivates slowly from latent infection and makes small plaques on CV-1 monolayers
    • Block, T. M., S. Deshmane, J. Masonis, J. Maggioncalda, T. Valyi Nagi, and N. W. Fraser. 1993. An HSV LAT null mutant reactivates slowly from latent infection and makes small plaques on CV-1 monolayers. Virology 192:618-630.
    • (1993) Virology , vol.192 , pp. 618-630
    • Block, T.M.1    Deshmane, S.2    Masonis, J.3    Maggioncalda, J.4    Valyi Nagi, T.5    Fraser, N.W.6
  • 4
    • 0029912982 scopus 로고    scopus 로고
    • A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation
    • Bloom, D. C., J. M. Hill, G. Devi Rao, E. K. Wagner, L. T. Feldman, and J. G. Stevens. 1996. A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation. J. Virol. 70:2449-2459.
    • (1996) J. Virol. , vol.70 , pp. 2449-2459
    • Bloom, D.C.1    Hill, J.M.2    Devi Rao, G.3    Wagner, E.K.4    Feldman, L.T.5    Stevens, J.G.6
  • 5
    • 0037271976 scopus 로고    scopus 로고
    • Use of the herpes simplex viral genome to construct gene therapy vectors
    • Burton, E. A., S. Huang, W. F. Goins, and J. C. Glorioso. 2003. Use of the herpes simplex viral genome to construct gene therapy vectors. Methods Mol. Med. 76:1-31.
    • (2003) Methods Mol. Med. , vol.76 , pp. 1-31
    • Burton, E.A.1    Huang, S.2    Goins, W.F.3    Glorioso, J.C.4
  • 6
    • 0026533363 scopus 로고
    • Herpes simplex virus type I ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells
    • Cai, W., and P. A. Schaffer. 1992. Herpes simplex virus type I ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells. J. Virol. 66:2904-2915.
    • (1992) J. Virol. , vol.66 , pp. 2904-2915
    • Cai, W.1    Schaffer, P.A.2
  • 7
    • 0030744358 scopus 로고    scopus 로고
    • A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus
    • Chen, S. H., M. F. Kramer, P. A. Schaffer, and D. M. Coen. 1997. A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus. J. Virol. 71:5878-5884.
    • (1997) J. Virol. , vol.71 , pp. 5878-5884
    • Chen, S.H.1    Kramer, M.F.2    Schaffer, P.A.3    Coen, D.M.4
  • 8
    • 0033779586 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 ICP0 protein does not accumulate in the nucleus of primary neurons in culture
    • Chen, X., J. Li, M. Mata, J. Goss, D. Wolfe, J. C. Glorioso, and D. J. Fink. 2000. Herpes simplex virus type 1 ICP0 protein does not accumulate in the nucleus of primary neurons in culture. J. Virol. 74:10132-10141.
    • (2000) J. Virol. , vol.74 , pp. 10132-10141
    • Chen, X.1    Li, J.2    Mata, M.3    Goss, J.4    Wolfe, D.5    Glorioso, J.C.6    Fink, D.J.7
  • 9
    • 0028857930 scopus 로고
    • Two herpes simplex virus type I latency-active promoters differ in their contributions to latency-associated transcript expression during lyric and latent infections
    • Chen, X., M. C. Schmidt, W. F. Goins, and J. C. Glorioso. 1995. Two herpes simplex virus type I latency-active promoters differ in their contributions to latency-associated transcript expression during lyric and latent infections. J. Virol. 69:7899-7908.
    • (1995) J. Virol. , vol.69 , pp. 7899-7908
    • Chen, X.1    Schmidt, M.C.2    Goins, W.F.3    Glorioso, J.C.4
  • 10
    • 0032437923 scopus 로고    scopus 로고
    • The herpes simplex virus 2 kb latency associated transcript (LAT) leader sequence allows efficient expression of downstream proteins which is enhanced in neuronal cells: Possible function of LAT ORFs
    • Coffin, R. S., S. K. Thomas, D. P. Thomas, and D. S. Latchman. 1998. The herpes simplex virus 2 kb latency associated transcript (LAT) leader sequence allows efficient expression of downstream proteins which is enhanced in neuronal cells: possible function of LAT ORFs. J. Gen. Virol. 79:3019-3026.
    • (1998) J. Gen. Virol. , vol.79 , pp. 3019-3026
    • Coffin, R.S.1    Thomas, S.K.2    Thomas, D.P.3    Latchman, D.S.4
  • 11
    • 0009602729 scopus 로고
    • RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice
    • Deatly, A. M., J. G. Spivack, E. Lavi, and N. W. Fraser. 1987. RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice. Proc. Natl. Acad. Sci. USA 84:3204-3208.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 3204-3208
    • Deatly, A.M.1    Spivack, J.G.2    Lavi, E.3    Fraser, N.W.4
  • 12
    • 0025866210 scopus 로고
    • Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts
    • Devi Rao, G. B., S. A. Goodart, L. M. Hecht, R. Rochford, M. K. Rice, and E. K. Wagner. 1991. Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts. J. Virol. 65:2179-2190.
    • (1991) J. Virol. , vol.65 , pp. 2179-2190
    • Devi Rao, G.B.1    Goodart, S.A.2    Hecht, L.M.3    Rochford, R.4    Rice, M.K.5    Wagner, E.K.6
  • 13
    • 0024311526 scopus 로고
    • Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus
    • Dobson, A. T., F. Sederati, G. Devi Rao, W. M. Flanagan, M. J. Farrell, J. G. Stevens, E. K. Wagner, and L. T. Feldman. 1989. Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J. Virol. 63:3844-3851.
    • (1989) J. Virol. , vol.63 , pp. 3844-3851
    • Dobson, A.T.1    Sederati, F.2    Devi Rao, G.3    Flanagan, W.M.4    Farrell, M.J.5    Stevens, J.G.6    Wagner, E.K.7    Feldman, L.T.8
  • 14
    • 0025912007 scopus 로고
    • An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1
    • Doerig, C., L. I. Pizer, and C. L. Wilcox. 1991. An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1. J. Virol. 65:2724-2727.
    • (1991) J. Virol. , vol.65 , pp. 2724-2727
    • Doerig, C.1    Pizer, L.I.2    Wilcox, C.L.3
  • 15
    • 0033524337 scopus 로고    scopus 로고
    • Expression of the first 811 nucleotides of the herpes simplex virus type 1 latency-associated transcript (LAT) partially restores wild-type spontaneous reactivation to a LAT-null mutant
    • Drolet, B. S., G. C. Perng, R. J. Villosis, S. M. Slanina, A. B. Nesburn, and S. L. Wechsler. 1999. Expression of the first 811 nucleotides of the herpes simplex virus type 1 latency-associated transcript (LAT) partially restores wild-type spontaneous reactivation to a LAT-null mutant. Virology 253:96-106.
    • (1999) Virology , vol.253 , pp. 96-106
    • Drolet, B.S.1    Perng, G.C.2    Villosis, R.J.3    Slanina, S.M.4    Nesburn, A.B.5    Wechsler, S.L.6
  • 16
    • 0028109676 scopus 로고
    • Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency
    • Fareed, M. U., and J. G. Spivack. 1994. Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency. J. Virol. 68:8071-8081.
    • (1994) J. Virol. , vol.68 , pp. 8071-8081
    • Fareed, M.U.1    Spivack, J.G.2
  • 17
    • 0026025927 scopus 로고
    • Herpes simplex virus latency-associated transcript is a stable intron
    • Farrell, M. J., A. T. Dobson, and L. T. Feldman. 1991. Herpes simplex virus latency-associated transcript is a stable intron. Proc. Natl. Acad. Sci. USA 88:790-794.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 790-794
    • Farrell, M.J.1    Dobson, A.T.2    Feldman, L.T.3
  • 18
    • 0028060352 scopus 로고
    • Effect of the transcription start region of the herpes simplex virus type 1 latency-associated transcript promoter on expression of productively infected neurons in vivo
    • Farrell, M. J., T. P. Margolis, W. A. Gomes, and L. T. Feldman. 1994. Effect of the transcription start region of the herpes simplex virus type 1 latency-associated transcript promoter on expression of productively infected neurons in vivo. J. Virol. 68:5337-5343.
    • (1994) J. Virol. , vol.68 , pp. 5337-5343
    • Farrell, M.J.1    Margolis, T.P.2    Gomes, W.A.3    Feldman, L.T.4
  • 19
    • 0030848169 scopus 로고    scopus 로고
    • A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1
    • Garber, D. A., P. A. Schaffer, and D. M. Knipe. 1997. A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1. J. Virol. 71:5885-5893.
    • (1997) J. Virol. , vol.71 , pp. 5885-5893
    • Garber, D.A.1    Schaffer, P.A.2    Knipe, D.M.3
  • 20
    • 0030945465 scopus 로고    scopus 로고
    • The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia
    • Goldenberg, D., N. Mador, M. J. Ball, A. Panet, and I. Steiner. 1997. The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia. J. Virol. 71:2897-2904.
    • (1997) J. Virol. , vol.71 , pp. 2897-2904
    • Goldenberg, D.1    Mador, N.2    Ball, M.J.3    Panet, A.4    Steiner, I.5
  • 21
    • 0025166428 scopus 로고
    • Herpes simplex virus latent phase transcription facilitates in vivo reactivation
    • Hill, J. M., F. Sedarati, R. T. Javier, E. K. Wagner, and J. G. Stevens. 1990. Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology 174:117-125.
    • (1990) Virology , vol.174 , pp. 117-125
    • Hill, J.M.1    Sedarati, F.2    Javier, R.T.3    Wagner, E.K.4    Stevens, J.G.5
  • 22
    • 0024363535 scopus 로고
    • Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse
    • Ho, D. Y., and E. S. Mocarski. 1989. Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse. Proc. Natl. Acad. Sci. USA 86:7596-7600.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7596-7600
    • Ho, D.Y.1    Mocarski, E.S.2
  • 23
    • 0035087392 scopus 로고    scopus 로고
    • Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture
    • Inman, M., G. C. Perng, G. Henderson, H. Ghiasi, A. B. Nesburn, S. L. Wechsler, and C. Jones. 2001. Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture. J. Virol. 75:3636-3646.
    • (2001) J. Virol. , vol.75 , pp. 3636-3646
    • Inman, M.1    Perng, G.C.2    Henderson, G.3    Ghiasi, H.4    Nesburn, A.B.5    Wechsler, S.L.6    Jones, C.7
  • 24
    • 0024077236 scopus 로고
    • A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state
    • Javier, R. T., J. G. Stevens, V. B. Dissette, and E. K. Wagner. 1988. A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state. Virology 166:254-257.
    • (1988) Virology , vol.166 , pp. 254-257
    • Javier, R.T.1    Stevens, J.G.2    Dissette, V.B.3    Wagner, E.K.4
  • 25
    • 0030741818 scopus 로고    scopus 로고
    • Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcript
    • Krummenacher, C., J. M. Zabolotny, and N. W. Fraser. 1997. Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcript. J. Virol. 71:5849-5860.
    • (1997) J. Virol. , vol.71 , pp. 5849-5860
    • Krummenacher, C.1    Zabolotny, J.M.2    Fraser, N.W.3
  • 26
    • 0031737516 scopus 로고    scopus 로고
    • Antisense RNA: Function and fate of duplex RNA in cells of higher eukaryotes
    • Kumar, M., and G. G. Carmichael. 1998. Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes. Microbiol. Mol. Biol. Rev. 62:1415-1434.
    • (1998) Microbiol. Mol. Biol. Rev. , vol.62 , pp. 1415-1434
    • Kumar, M.1    Carmichael, G.G.2
  • 27
    • 0035394763 scopus 로고    scopus 로고
    • Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: Engineered tRNAs with an extended 3′ end can be exported efficiently and specifically to the cytoplasm in mammalian cells
    • Kuwabara, T., M. Warashina, S. Koseki, M. Sano, J. Ohkawa, K. Nakayama, and K. Taira. 2001. Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3′ end can be exported efficiently and specifically to the cytoplasm in mammalian cells. Nucleic Acids Res. 29:2780-2788.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 2780-2788
    • Kuwabara, T.1    Warashina, M.2    Koseki, S.3    Sano, M.4    Ohkawa, J.5    Nakayama, K.6    Taira, K.7
  • 28
    • 0035100883 scopus 로고    scopus 로고
    • Analysis of protein expression from within the region encoding the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1
    • Lock, M., C. Miller, and N. W. Fraser. 2001. Analysis of protein expression from within the region encoding the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1. J. Virol. 75:3413-3426.
    • (2001) J. Virol. , vol.75 , pp. 3413-3426
    • Lock, M.1    Miller, C.2    Fraser, N.W.3
  • 29
  • 30
    • 0031925976 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line
    • Mador, N., D. Goldenberg, O. Cohen, A. Panet, and I. Steiner. 1998. Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line. J. Virol. 72:5067-5075.
    • (1998) J. Virol. , vol.72 , pp. 5067-5075
    • Mador, N.1    Goldenberg, D.2    Cohen, O.3    Panet, A.4    Steiner, I.5
  • 31
    • 0028138560 scopus 로고
    • The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency
    • Perng, G. C., E. C. Dunkel, P. A. Geary, S. M. Slanina, H. Ghiasi, R. Kaiwar, A. B. Nesburn, and S. L. Wechsler. 1994. The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J. Virol. 68:8045-8055.
    • (1994) J. Virol. , vol.68 , pp. 8045-8055
    • Perng, G.C.1    Dunkel, E.C.2    Geary, P.A.3    Slanina, S.M.4    Ghiasi, H.5    Kaiwar, R.6    Nesburn, A.B.7    Wechsler, S.L.8
  • 32
    • 0030030341 scopus 로고    scopus 로고
    • The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript
    • Perng, G. C., H. Ghiasi, S. M. Slanina, A. B. Nesburn, and S. L. Wechsler. 1996. The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript. J. Virol. 70:976-984.
    • (1996) J. Virol. , vol.70 , pp. 976-984
    • Perng, G.C.1    Ghiasi, H.2    Slanina, S.M.3    Nesburn, A.B.4    Wechsler, S.L.5
  • 35
    • 0023502309 scopus 로고
    • Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1
    • Rock, D. L., A. B. Nesburn, H. Ghiasi, J. Ong, T. L. Lewis, J. R. Lokensgard, and S. L. Wechsler. 1987. Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. J. Virol. 61:3820-3826.
    • (1987) J. Virol. , vol.61 , pp. 3820-3826
    • Rock, D.L.1    Nesburn, A.B.2    Ghiasi, H.3    Ong, J.4    Lewis, T.L.5    Lokensgard, J.R.6    Wechsler, S.L.7
  • 36
    • 0031025114 scopus 로고    scopus 로고
    • Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: Evidence for a stable, nonlinear structure
    • Rodahl, E., and L. Haarr. 1997. Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure. J. Virol. 71:1703-1707.
    • (1997) J. Virol. , vol.71 , pp. 1703-1707
    • Rodahl, E.1    Haarr, L.2
  • 37
    • 0000595684 scopus 로고    scopus 로고
    • Herpes simplex viruses and their replication
    • B. N. Fields, D. M. Knipe, and P. M. Howley (ed.). Lippincott-Raven, Philadelphia, Pa
    • Roizman, B., and A. E. Sears. 1996. Herpes simplex viruses and their replication, p. 2231-2295. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed., vol. 2. Lippincott-Raven, Philadelphia, Pa.
    • (1996) Fields Virology, 3rd Ed. , vol.2 , pp. 2231-2295
    • Roizman, B.1    Sears, A.E.2
  • 38
    • 0031947861 scopus 로고    scopus 로고
    • Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins
    • Samaniego, L. A., L. Neiderhiser, and N. A. DeLuca. 1998. Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins. J. Virol. 72:3307-3320.
    • (1998) J. Virol. , vol.72 , pp. 3307-3320
    • Samaniego, L.A.1    Neiderhiser, L.2    DeLuca, N.A.3
  • 40
    • 0026583838 scopus 로고
    • Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency
    • Sawtell, N. M., and R. L. Thompson. 1992. Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency. J. Virol. 66:2157-2169.
    • (1992) J. Virol. , vol.66 , pp. 2157-2169
    • Sawtell, N.M.1    Thompson, R.L.2
  • 41
    • 0024452761 scopus 로고
    • Herpes simplex virus type 1 latency-associated transcription plays no role in establishment or maintenance of a latent infection in murine sensory neurons
    • Sedarati, F., K. M. Izumi, E. K. Wagner, and J. G. Stevens. 1989. Herpes simplex virus type 1 latency-associated transcription plays no role in establishment or maintenance of a latent infection in murine sensory neurons. J. Virol. 63:4455-4458.
    • (1989) J. Virol. , vol.63 , pp. 4455-4458
    • Sedarati, F.1    Izumi, K.M.2    Wagner, E.K.3    Stevens, J.G.4
  • 42
    • 0023472243 scopus 로고
    • Detection of herpes simplex virus type 1 transcripts during latent infection in mice
    • Spivack, J. G., and N. W. Fraser. 1987. Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J. Virol. 61:3841-3847.
    • (1987) J. Virol. , vol.61 , pp. 3841-3847
    • Spivack, J.G.1    Fraser, N.W.2
  • 43
    • 0023875743 scopus 로고
    • Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection
    • Spivack, J. G., and N. W. Fraser. 1988. Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. J. Virol. 62:1479-1485.
    • (1988) J. Virol. , vol.62 , pp. 1479-1485
    • Spivack, J.G.1    Fraser, N.W.2
  • 44
    • 0025837281 scopus 로고
    • Identification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): Translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT
    • Spivack, J. G., G. M. Woods, and N. W. Fraser. 1991. Identification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT. J. Virol. 65:6800-6810.
    • (1991) J. Virol. , vol.65 , pp. 6800-6810
    • Spivack, J.G.1    Woods, G.M.2    Fraser, N.W.3
  • 45
    • 0024394162 scopus 로고
    • Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection
    • Steiner, I., J. G. Spivack, R. P. Lirette, S. M. Brown, A. R. MacLean, J. H. Subak Sharpe, and N. W. Fraser. 1989. Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection. EMBO J. 8:505-511.
    • (1989) EMBO J. , vol.8 , pp. 505-511
    • Steiner, I.1    Spivack, J.G.2    Lirette, R.P.3    Brown, S.M.4    MacLean, A.R.5    Subak Sharpe, J.H.6    Fraser, N.W.7
  • 46
    • 0023140228 scopus 로고
    • RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons
    • Stevens, J. G., E. K. Wagner, G. B. Devi Rao, M. L. Cook, and L. T. Feldman. 1987. RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science 235:1056-1059.
    • (1987) Science , vol.235 , pp. 1056-1059
    • Stevens, J.G.1    Wagner, E.K.2    Devi Rao, G.B.3    Cook, M.L.4    Feldman, L.T.5
  • 47
    • 0032809226 scopus 로고    scopus 로고
    • Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latency
    • Thomas, S. K., G. Gough, D. S. Latchman, and R. S. Coffin. 1999. Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latency. J. Virol. 73:6618-6625.
    • (1999) J. Virol. , vol.73 , pp. 6618-6625
    • Thomas, S.K.1    Gough, G.2    Latchman, D.S.3    Coffin, R.S.4
  • 48
    • 0036193751 scopus 로고    scopus 로고
    • A protein encoded by the herpes simplex virus (HSV) type 1 2-kilobase latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSV genome
    • Thomas, S. K., C. E. Lilley, D. S. Latchman, and R. S. Coffin. 2002. A protein encoded by the herpes simplex virus (HSV) type 1 2-kilobase latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSV genome. J. Virol. 76:4056-4067.
    • (2002) J. Virol. , vol.76 , pp. 4056-4067
    • Thomas, S.K.1    Lilley, C.E.2    Latchman, D.S.3    Coffin, R.S.4
  • 49
    • 0034988860 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival
    • Thompson, R. L., and N. M. Sawtell. 2001. Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival. J. Virol. 75:6660-6675.
    • (2001) J. Virol. , vol.75 , pp. 6660-6675
    • Thompson, R.L.1    Sawtell, N.M.2
  • 50
    • 0030920240 scopus 로고    scopus 로고
    • The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency
    • Thompson, R. L., and N. M. Sawtell. 1997. The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency. J. Virol. 71:5432-5440.
    • (1997) J. Virol. , vol.71 , pp. 5432-5440
    • Thompson, R.L.1    Sawtell, N.M.2
  • 51
    • 0024205630 scopus 로고
    • The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection
    • Wagner, E. K., W. M. Flanagan, G. Devi Rao, Y. F. Zhang, J. M. Hill, K. P. Anderson, and J. G. Stevens. 1988. The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection. J. Virol. 62:4577-4585.
    • (1988) J. Virol. , vol.62 , pp. 4577-4585
    • Wagner, E.K.1    Flanagan, W.M.2    Devi Rao, G.3    Zhang, Y.F.4    Hill, J.M.5    Anderson, K.P.6    Stevens, J.G.7
  • 52
    • 0023774515 scopus 로고
    • Fine mapping of the latency-related gene of herpes simplex virus type 1: Alternative splicing produces distinct latency-related RNAs containing open reading frames
    • Wechsler, S. L., A. B. Nesburn, R. Watson, S. M. Slanina, and H. Ghiasi. 1988. Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames. J. Virol. 62:4051-4058.
    • (1988) J. Virol. , vol.62 , pp. 4051-4058
    • Wechsler, S.L.1    Nesburn, A.B.2    Watson, R.3    Slanina, S.M.4    Ghiasi, H.5
  • 53
    • 0032579849 scopus 로고    scopus 로고
    • Atypical splicing of the latency-associated transcripts of herpes simplex type 1
    • Wu, T. T., Y. H. Su, T. M. Block, and J. M. Taylor. 1998. Atypical splicing of the latency-associated transcripts of herpes simplex type 1. Virology 243:140-149.
    • (1998) Virology , vol.243 , pp. 140-149
    • Wu, T.T.1    Su, Y.H.2    Block, T.M.3    Taylor, J.M.4
  • 54
    • 0029838369 scopus 로고    scopus 로고
    • Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear
    • Wu, T. T., Y. H. Su, T. M. Block, and J. M. Taylor. 1996. Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear. J. Virol. 70:5962-5967.
    • (1996) J. Virol. , vol.70 , pp. 5962-5967
    • Wu, T.T.1    Su, Y.H.2    Block, T.M.3    Taylor, J.M.4
  • 55
    • 0030919832 scopus 로고    scopus 로고
    • The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine
    • Zabolotny, J. M., C. Krummenacher, and N. W. Fraser. 1997. The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine. J. Virol. 71:4199-4208.
    • (1997) J. Virol. , vol.71 , pp. 4199-4208
    • Zabolotny, J.M.1    Krummenacher, C.2    Fraser, N.W.3
  • 56
    • 0025048749 scopus 로고
    • Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: Evidence for neuron specificity and for a large LAT transcript
    • Zwaagstra, J. C., H. Ghlasi, S. M. Slanina, A. B. Nesburn, S. C. Wheatley, K. Lillycrop, J. Wood, D. S. Latchman, K. Patel, and S. L. Wechsler. 1990. Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J. Virol. 64:5019-5028.
    • (1990) J. Virol. , vol.64 , pp. 5019-5028
    • Zwaagstra, J.C.1    Ghlasi, H.2    Slanina, S.M.3    Nesburn, A.B.4    Wheatley, S.C.5    Lillycrop, K.6    Wood, J.7    Latchman, D.S.8    Patel, K.9    Wechsler, S.L.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.