The herpes simplex virus 2 kb latency associated transcript (LAT) leader sequence allows efficient expression of downstream proteins which is enhanced in neuronal cells: Possible function of LAT ORFs

Journal of General Virology

Volumn 79, Issue 12, 1998, Pages 3019-3026

  Coffin, R S ^a   Thomas, S K ^a   Thomas, D P ^b   Latchman, D S ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SIGNAL PEPTIDE; VIRUS PROTEIN;

ARTICLE; HERPES SIMPLEX VIRUS 1; IMMEDIATE EARLY GENE; NERVE CELL; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SPLICING; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS TRANSCRIPTION;

DNA VIRUSES; HERPES; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2;

EID: 0032437923     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-79-12-3019     Document Type: Article

References (3)

1. Block, T. M., Deshmane, S., Masonis, J., Maggioncalda, J., Valyi-Nagi, T. & Fraser, N. W. (1993). An HSV LAT null mutant reactivates slowly from latent infection and makes small plaques on CV-1 monolayers. Virology 192, 618-630.
2. Bloom, D. C, Hill, J. M., Devi-Rao, G., Wagner, E. K., Feldman, L. T. & Stevens, J. G. (1996). A 348-base-pair region in the latency associated transcript facilitates herpes simplex virus type 1 reactivation. Journal of Virology 70, 2449-2459.
3. Chen, X., Schmidt, M. C, Coins, W. F. & Glorioso, J. C. (1995). Two herpes simplex virus type I latency active promoters differ in their contribution to latency associated transcript expression during lytic and latent infections. Journal of Virology 69, 7899-7908.