Cytokine profile of the rheumatoid nodule suggests that it is a Th1 granuloma

Arthritis and Rheumatism

Volumn 48, Issue 2, 2003, Pages 334-338

  Hessian, Paul A ^a   Highton, John ^a,b   Kean, Annabel ^a   Sun, Cheuk Kwan ^a   Chin, Michael ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b Department of Medical Sciences ^*  (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LYMPHOKINE; MESSENGER RNA; METHOTREXATE; RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION; GRANULOMA; HUMAN; HUMAN TISSUE; INFLAMMATION; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RHEUMATOID NODULE; SUBCUTANEOUS TISSUE; SYNOVIUM; TH1 CELL; TH2 CELL;

AGED; ANTIRHEUMATIC AGENTS; CYTOKINES; FEMALE; GENE EXPRESSION; GRANULOMA; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-13; INTERLEUKIN-15; INTERLEUKIN-18; MALE; METHOTREXATE; MIDDLE AGED; RHEUMATOID NODULE; RNA, MESSENGER; TH1 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037332228     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10776     Document Type: Article

References (18)

1. Sokoloff L, McClusky T, Bunim JJ. Vascularity of the early subcutaneous nodule of rheumatoid arthritis. Arch Pathol Lab Med 1953;55:475-95.
2. Ziff M. The rheumatoid nodule. Arthritis Rheum 1990;33:761-7.
3. Palmer DG, Hogg N, Highton J, Hessian PA, Denholm I. Macrophage migration and maturation within rheumatoid nodules. Arthritis Rheum 1987;30:728-36.
4. Wikaningrum R, Highton J, Parker A, Coleman M, Hessian PA, Roberts-Thomson PJ, et al. Pathogenic mechanisms in the rheumatoid nodule: comparison of proinflammatory cytokine production and cell adhesion molecule expression in rheumatoid nodules and synovial membranes from the same patient. Arthritis Rheum 1998;41:1783-9.
5. Highton J, Palmer DG, Smith M, Hessian PA. Phenotypic markers of lymphocyte and mononuclear phagocyte activation within rheumatoid nodules. J Rheumatol 1990;17:1130-6.
6. Highton J, Kean A, Hessian PA, Thomson J, Rietveld J, Hart DN. Cells expressing dendritic cell markers are present in the rheumatoid nodule. J Rheumatol 2000;27:339-46.
7. Janossy G, Panayi G, Duke O, Bofill M, Poulter LW, Goldstein G. Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet 1981;2:839-42.
8. Saunders BM, Cooper AM. Restraining mycobacteria: role of granulomas in mycobacterial infections. Immunol Cell Biol 2000;78:334-41.
9. Agostini L, Adami F, Semenzato G. New pathogenic insights into the sarcoid granuloma. Curr Opin Rheumatol 2000;12:71-8.
10. Fallon PG. Immunopathology of schistosomiasis: a cautionary tale of mice and men. Immunol Today 2000;21:29-35.
11. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
12. Weyand CM. New insights into the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 2000;39 Suppl 1:3-8.
13. Miossec P. Are T cells in rheumatoid synovium aggressors or bystanders? Curr Opin Rheumatol 2000;12:181-5.
14. De Keyser F, Elewaut D, Overmeer-Graus JP, Van den Broek P, Rijnders AW, Veys EM. Dominant T cell receptor rearrangements in interleukin 2 expanded lymphocytes from rheumatoid nodules suggest antigen driven T cell activation in situ. J Rheumatol 1997;24:1685-9.
15. Elewaut D, De Keyser F, Van den Bosch, Verbruggen G, Veys EM. Broadening of the T cell receptor spectrum among rheumatoid arthritis synovial cell-lines in relation to disease duration. Clin Exp Rheumatol 2000;18:201-7.
16. McInnes IB, Gracie G, Leung BP, Wei X-Q, Liew FY. Interleukin 18: a pleiotropic participant in chronic inflammation. Immunol Today 2000;21:312-5.
17. McInnes IB, Gracie G, Liew FY. Interleukin-18: a novel cytokine in inflammatory rheumatic disease. Arthritis Rheum 2001;44:1481-3.
18. McInnes IB, Leung BP, Sturrock RD, Field M, Liew FY. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat Med 1997;3:185-95.