Broadening of the T cell receptor spectrum among rheumatoid arthritis synovial cell-lines in relation to disease duration

Clinical and Experimental Rheumatology

Volumn 18, Issue 2, 2000, Pages 201-207

  Elewaut, D ^a   De Keyser, F ^a   Van Den Bosch, F ^a   Verbruggen, G ^a   Veys, E M ^a  

^a NONE

Author keywords

Rheumatoid arthritis; Rheumatoid nodules; Rheumatoid synovium; T cell receptor

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ADULT; AGED; ARTICLE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE ADHERENCE; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RHEUMATOID NODULE; SYNOVIUM; T LYMPHOCYTE;

ADULT; AGED; ARTHRITIS, RHEUMATOID; CELL ADHESION; CELL LINE; FEMALE; FLOW CYTOMETRY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; RHEUMATOID FACTOR; RHEUMATOID NODULE; SYNOVIAL MEMBRANE; T-LYMPHOCYTES; TIME FACTORS;

EID: 0034127703     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. VAN BOXEL JJ, PAGET SA: Predominantly T cell infiltrate in rheumatoid synovial membranes. N Engl J Med 1975; 293: 517-21.
2. DUKE O, PANAYI GS, JANOSSY G, POULTIER LW: An immunohistological analysis of lymphocyte subpopulations and their microenvironment in the synovial membranes of patients wtih rheumatoid arthritis using monoclonal antibodies. Clin Exp Immunol 1982; 49:22-30.
3. FØRRE Ø, THOEN J, LEA T, et al.: In situ characterization of mononuclear cells in rheumatoid arthritis, using monclonal antibodies. Scand J Immunol 1982; 16: 315-9.
4. VAN EDEN W, HOLOSHITZ J, NEVO Z, FRENKEL A, KLAJMAN A, COHEN IR: Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans. Proc Natl Acad Sci USA 1985; 82: 5117-20.
5. PANAYI GS: The immunopathogenesis of rheumatoid arthritis. Br J Rheumatol 1993; 32 (Suppl. 1): 4-14.
6. THOMAS R, LIPSKY PE: Presentation of self peptides by dendritic cells: Possible implications for the pathogenesis of rheumatoid arthritis. Arthritis Rheum 1996; 39: 183-90.
7. ZIFF M: The rheumatoid nodule. Arthritis Rheum 1990; 33: 761-7.
8. MIYASAKA N, SATO K, YAMAMOTO K, GOTO M, NISHIOKA K: Immunological and immunohistochemical analysis of rheumatoid nodules. Ann Rheum Dis 1989; 48: 220-6.
9. VEYS EM, DE KEYSER F: Rheumatoid nodules: Differential diagnosis and immunohistological findings. Ann Rheum Dis 1993; 52: 625-6.
10. DE KEYSER F, VERBRUGGEN G, VEYS EM, et al.: T cell receptor V beta usage in rheumatoid nodules: Marked oligoclonality among IL-2 expanded lymphocytes. Clin Immunol Immunopathol 1993; 68: 29-34.
11. DE KEYSER F, ELEWAUT D, OVERMEERGRAUS JPM, VAN DEN BROEK P, RIJNDERS AWM, VEYS EM: Dominant T cell receptor rearrangements in IL-2 expanded lymphocytes from rheumatoid nodules suggest an antigen-driven T cell activation in situ. J Rheumatol 1997; 24: 1685-9
12. ARNETT FC, EDWORTHY SM, BLOCK DA et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
13. STAMPER HB, WOODRUFF JJ: Lymphocyte homing into lymph nodes: In vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules. J Exp Med 1976; 144: 828-33.
14. MCRAE BL, VANDERLUGT CL, DAL CANTO MC, MILLER SD: Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J Exp Med 1995; 182: 75-85.
15. MILLER SD, VANDERLUGT CL, LENSCHOW DJ et al.: Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murinc EAE. Immunity 1995; 3: 739-45.
16. VANDERLUGT CJ, MILLER SD: Epitope spreading. Curr Opin Immunol 1996; 8: 831-6.
17. MILLER SD, MCRAE BL, VANDERLUGT CL et al.: Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases. Immunol Rev 1995; 144: 225-44.
18. FISCHER DC, OPALKA B, HOFFMANN A, MAYR W, HAUBECK HD: Limited heterogeneity of rearranged T cell receptor V alpha and V beta transcripts in synovial fluid T cells in early stages of rheumatoid arthritis. Arthritis Rheum 1996; 39: 454-62.
19. BUCHT A, OKSENBERG JR, LINDBLAD S, GRONBERG A, STEINMAN L, KLARESKOG L: Characterization of T-cell receptor alpha beta repertoire in synovial tissue from different temporal phases of rheumatoid arthritis. Scand J Immunol 1992; 35: 159-65.
20. BROKER BM, KORTHAUER U, HEPPT P et al.: Biased T cell receptor V gene usage in rheumatoid arthritis. Oligoclonal expansion of T cells expressing V alpha 2 genes in synovial fluid but not in peripheral blood. Arthritis Rheum 1993; 36: 1234-43.
21. VAN DER BORGHT A, VAN DER AA A, GEUSENS P et al.: Identification of over-represented T cell receptor genes in blood and tissue biopsies by PCR-ELISA. J Immunol Meth 1999; 223: 47-61.
22. VAN DER BORGHT A, GEUSENS P, DE KEYSER F et al.: TCR expression in the joints of early RA patients before and after cyclosporin A microemulsion treatment. Scand J Immunol 1999; 49: 337 (abstract).
23. LIM A, TOUBERT A, PANNETIER C et al.: Spread of clonal T-cell expansions in rheumatoid arthritis patients. Hum Immunol 1996; 48 (1-2): 77-83.
24. CELIS L, VANDEVYVER C, GEUSENS P, DEQUEKER J, RAUS J, ZHANG JW: Clonal expansion of mycobacterial heat shock protein reactive T lymphocytes in the synovial fluid and blood of rheumatoid arthritis patients. Arthritis Rheum 1997; 40: 510-9.
25. ELEWAUT D, DE KEYSER F, DE WEVER N et al.: A comparative phenotypical analysis of rheumatoid nodules and rheumatoid synovium with special reference to adhesion molecules and activation markers. Ann Rheum Dis 1998; 57: 480-6.