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Immunological, clinical and molecular aspects of sarcoidosis
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1 Agostini C, Semenzato G, James DG: Immunological, clinical and molecular aspects of sarcoidosis. Mol Aspects Med 1997, 18:91-165.
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Mol Aspects Med
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Agostini, C.1
Semenzato, G.2
James, D.G.3
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3
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0032997923
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The clinical management of sarcoidosis: A 50-year experience at the Johns Hopkins Hospital
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3 Jones CJ, Michele TM: The clinical management of sarcoidosis: a 50-year experience at the Johns Hopkins Hospital. Medicine (Baltimore) 1999; 78:65-111. The management issues outlined in this article are based on the authors' broad clinical experience at the Johns Hopkins Hospital and on data reported in several longitudinal studies. This review is critical to understanding past and recent progresses in clinical management of sarcoidosis.
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Medicine (Baltimore)
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Jones, C.J.1
Michele, T.M.2
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4
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0032881310
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Statement on sarcoidosis
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4 Hunninghake G, Costabel U, Ando M, Baughman RP, Cordier J, duBois R, Eklund A, Kitaichi M, Lynch J, Rizzato G, Rose C, Selroos O, Semenzato G, Sharma OP: Statement on sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1999, 16:149-173. This fundamental paper that reports guidelines for sarcoidosis is the result of three recent meetings of a Joint Commission formed by experts of the American Thoracic Society (ATS), European Respiratory Society (ERS) and World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG). Required reading.
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Sarcoidosis Vasc Diffuse Lung Dis
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Hunninghake, G.1
Costabel, U.2
Ando, M.3
Baughman, R.P.4
Cordier, J.5
DuBois, R.6
Eklund, A.7
Kitaichi, M.8
Lynch, J.9
Rizzato, G.10
Rose, C.11
Selroos, O.12
Semenzato, G.13
Sharma, O.P.14
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5
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0031571868
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Cytokine patterns in tuberculous and sarcoid granulomas
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5 Bergeron A, Bonay M, Kambouchner M, Lecossier D, Hance A, Tazi A: Cytokine patterns in tuberculous and sarcoid granulomas. J Immunol 1997, 159:3034-3043.
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J Immunol
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Bergeron, A.1
Bonay, M.2
Kambouchner, M.3
Lecossier, D.4
Hance, A.5
Tazi, A.6
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6
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0031808505
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Cells and molecules involved in the development of sarcoid granuloma
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6 Agostini C, Basso U, Semenzato G: Cells and molecules involved in the development of sarcoid granuloma. J Clin Immunol 1998, 18:184-192. Cells producing Th1 cytokines and chemokines are involved in the local recruitment and activation of immunocompetent cells that contribute to the development of the new granulomas.
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J Clin Immunol
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Agostini, C.1
Basso, U.2
Semenzato, G.3
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7
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Cells and cytokines involved in the pathogenesis of sarcoidosis
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7 Moller DR: Cells and cytokines involved in the pathogenesis of sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1999, 16:24-31. An excellent overview on the role of cytokines in the pathogenesis of sarcoidosis.
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Sarcoidosis Vasc Diffuse Lung Dis
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Moller, D.R.1
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8
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Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis
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8 Moller DR, Forman JD, Liu MC: Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunol 1996; 156:4952-4960.
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Moller, D.R.1
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Liu, M.C.3
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9
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Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo
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9 Rogge L, Papi A, Presky DH, Biffi M, Minetti LJ, Miotto D, Agostini C, Semenzato G, Fabbri LM, Sinigaglia F: Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo. J Immunol 1999, 162:3926-3932. This study clearly demonstrates that CD4 T cells isolated from the lower respiratory tract of patients with sarcoidosis express the β2 chain of the IL-12 receptor, a molecule that is expressed by Th1 but not Th2 cells.
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J Immunol
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Rogge, L.1
Papi, A.2
Presky, D.H.3
Biffi, M.4
Minetti, L.J.5
Miotto, D.6
Agostini, C.7
Semenzato, G.8
Fabbri, L.M.9
Sinigaglia, F.10
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11
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Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
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11 Car BD, Meloni F, Luisetti M, Semenzato G, Gialdroni-Grassi G, Walz A: Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Crit Care Med 1994, 149:655-659.
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Car, B.D.1
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Gialdroni-Grassi, G.5
Walz, A.6
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12
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Increased expression of proinflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis
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12 Ziegenhagen MW, Schrum S, Zissel G, Zipfel PF, Schlaak M, Muller-Quernheim J: Increased expression of proinflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis. J Invest Med 1998, 46:223-231. An exaggerated expression of IL-8 is characteristic for sarcoid patients who show disease progression.
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J Invest Med
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Ziegenhagen, M.W.1
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Schlaak, M.5
Muller-Quernheim, J.6
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13
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Involvement of the IP-10 chemokine in sarcoid granulomatous reactions
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13 Agostini C, Cassatella M, Zambello R, Trentin L, Gasperini S, Perin A, Piazza F, Siviero M, Facco M, Dziejman M, Chilosi M, Qin SX, Luster AD, Semenzato G: Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. J Immunol 1998, 161:6413-6420. This study emphasizes the role of the lymphotactic chemokine IP-10 in the organization of the T cell rim surrounding the central core of the sarcoid granuloma.
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J Immunol
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Agostini, C.1
Cassatella, M.2
Zambello, R.3
Trentin, L.4
Gasperini, S.5
Perin, A.6
Piazza, F.7
Siviero, M.8
Facco, M.9
Dziejman, M.10
Chilosi, M.11
Qin, S.X.12
Luster, A.D.13
Semenzato, G.14
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14
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0032036309
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Expression of RANTES by bronchoalveolar lavage cells in nonsmoking patients with interstitial lung diseases
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14 Kodama N, Yamaguchi E, Hizawa N, Furuya K, Kojima J, Oguri M, Takahashi T, Kawakami Y: Expression of RANTES by bronchoalveolar lavage cells in nonsmoking patients with interstitial lung diseases. Am J Respir Cell Mol Biol 1998, 18:526-531. The degree of lymphocytosis in the BAL is directly related to the levels of RANTES.
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Kodama, N.1
Yamaguchi, E.2
Hizawa, N.3
Furuya, K.4
Kojima, J.5
Oguri, M.6
Takahashi, T.7
Kawakami, Y.8
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15
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Chemotactic cytokines: From the molecular level to clinical use
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15 Semenzato G: Chemotactic cytokines: from the molecular level to clinical use. Sarcoidosis Vasc Diffuse Lung Dis 1998, 15:131-133. A brief review of the role of chemokines in interstitial lung diseases, including putative therapeutic approaches.
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Semenzato, G.1
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16
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6844240851
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Correlation of plasma monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1β (MIP-1β) levels with disease activity and clinical course of sarcoidosis
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16 Hashimoto S, Nakayama T, Gon Y, Hata N, Koura T, Maruoka S, Matsumoto K, Hayashi S, Abe Y, Horie T: Correlation of plasma monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1β (MIP-1β) levels with disease activity and clinical course of sarcoidosis. Clin Exp Immunol 1998, 111:604-610. MCP-1 and MIP-1β are involved in the pathogenesis of sarcoid inflammation and correlate with disease activity.
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Clin Exp Immunol
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Hashimoto, S.1
Nakayama, T.2
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Abe, Y.9
Horie, T.10
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0028298049
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Production of the RANTES chemokine in delayed-type hypersensitivity reactions: Involvement of macrophages and endothelial cells
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17 Devergne O, Marfaing Koka A, Schall, TT, Leger Ravet MB, Sadick M, Peuchmaur M, Crevon MC, Kim T, Galanaud P, Emilie D: Production of the RANTES chemokine in delayed-type hypersensitivity reactions: involvement of macrophages and endothelial cells. J Exp Med 1994, 179:1689-1694.
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18
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0033065336
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The role of the C-C chemokine receptor 2 gene polymorphism V64I (CCR2-64I) in sarcoidosis in a Japanese population
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18 Hizawa N, Yamaguchi E, Furuya K, Jinushi E, Ito A, Kawakami Y: The role of the C-C chemokine receptor 2 gene polymorphism V64I (CCR2-64I) in sarcoidosis in a Japanese population. Am J Respir Crit Care Med 1999, 159:2021-2023. These data suggest that genetic factors controling chemokines and their receptors might be important host determinants for disease susceptibility and severity in sarcoidosis.
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Am J Respir Crit Care Med
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Role of IL-15, IL-2 and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis
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19 Agostini C, Trentin L, Facco M, Sancetta R, Cerutti A, Tassinari C, Cimarosto L, Adami F, Cipriani A, Zambello R, Semenzato G: Role of IL-15, IL-2 and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis. J Immunol 1996, 157:910-918.
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Regulation of alveolar macrophage/T cell interactions during Th1-type sarcoid inflammatory process
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20 Agostini C, Trentin L, Perin A, Facco M, Siviero M, Piazza F, Basso U, Adami F, Zambello R, Semenzato G : Regulation of alveolar macrophage/T cell interactions during Th1-type sarcoid inflammatory process. Am J Physiol 1999, 277:L240-L250. IL-15 is involved in the regulation of Th1 response in organs involved by the sarcoid inflammatory process.
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Proliferation, macrophage colony-stimulating factor, and macrophage colony-stimulating factor-receptor expression of alveolar macrophages in active sarcoidosis
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21 Kreipe H, Radzun, HJ, Heidorn K, Barth J, Kiemle-Kallee J, Petermann W, Gerdes J, Parwaresch MR: Proliferation, macrophage colony-stimulating factor, and macrophage colony-stimulating factor-receptor expression of alveolar macrophages in active sarcoidosis. Lab Invest 1990, 62:697-703.
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T-cell receptor genes in sarcoidosis
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22 Moller DR. T-cell receptor genes in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1998, 15:158-164. The author provides a brief but complete overview on the T cell receptor repertoire in sarcoidosis.
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Selection of T lymphocytes bearing limited T-cell receptor Vβ regions in the lung of patients with hypersensitivity pneumonitis and sarcoidosis
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23 Trentin L, Zambello R, Facco M, Tassinari C, Sancetta R, Siviero M, Cerutti A, Cipriani A, Marcer G, Majori M, Pesci A, Agostini C, Semenzato G: Selection of T lymphocytes bearing limited T-cell receptor Vβ regions in the lung of patients with hypersensitivity pneumonitis and sarcoidosis. Am J Respir Critical Care Med 1997, 155:587-596.
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Limited heterogeneity of biased T-cell receptor Vβ gene usage in lung but not blood t cells in active pulmonary sarcoidosis
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24 Silver RF, Crystal RG, Moller DR: Limited heterogeneity of biased T-cell receptor Vβ gene usage in lung but not blood T cells in active pulmonary sarcoidosis. Immunology 1996, 88:516-523.
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T-cell receptor variable region gene usage by CD4+ and CD8+ T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients
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25 Grunewald J, Olerup O, Persson U, Ohrn MB, Wigzell H, Eklund A: T-cell receptor variable region gene usage by CD4+ and CD8+ T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients. Proc Natl Acad Sci USA 1994, 91:4965-4969.
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Selective activation and accumulation of oligoclonal Vβ-specific T cells in active pulmonary sarcoidosis
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26 Forman JD, Klein JT, Silver RF, Liu MC, Greenlee BM, Moller DR: Selective activation and accumulation of oligoclonal Vβ-specific T cells in active pulmonary sarcoidosis. J Clin Invest 1994, 94:1533-1542.
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Cell apoptosis and granulomatous lung diseases
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27 Agostini C, Perin A, Semenzato G: Cell apoptosis and granulomatous lung diseases. Curr Opin Pulmon Med 1998, 4:261-266. A brief review of the role of apoptosis in the pathophysiology of granuloma formation.
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Expression of tumor necrosis factorreceptor superfamily members by lung T lymphocytes in interstitial lung disease
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28 Agostini C, Zambello R, Sancetta R, Cerutti A, Milani A, Tassinari C, Facco M, Cipriani A, Trentin L, Semenzato G: Expression of tumor necrosis factorreceptor superfamily members by lung T lymphocytes in interstitial lung disease. Am J Respir Crit Care Med 1996, 153:1359-1367.
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Alternatives to corticosteroids in the treatment of sarcoidosis
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29 Baughman RP: Alternatives to corticosteroids in the treatment of sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1997, 14:121-130.
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30 Lewis SJ, Ainslie GM, Bateman ED: Efficacy of azathioprine as second-line treatment in pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1999, 16:87-92. The authors provide data on the immunosuppressive efficacy of azathioprine in the treatment of patients with sarcoidosis refractory to steroids.
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