IL-4 regulates IL-12 p40 expression post-transcriptionally as well as via a promoter-based mechanism

European Journal of Immunology

Volumn 33, Issue 2, 2003, Pages 428-433

  Seegmüller, Irene ^a   Häcker, Hans ^a   Wagner, Hermann ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

CpG DNA; Il 12 p40; IL 4; RNA stability

Indexed keywords

BACTERIAL DNA; INTERLEUKIN 12; INTERLEUKIN 4; MESSENGER RNA; PROTEIN P40;

ANIMAL CELL; CELL POLARITY; CONTROLLED STUDY; CPG ISLAND; GENETIC TRANSFECTION; MACROPHAGE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; RNA DEGRADATION; RNA STABILITY; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

ANIMALS; CELL LINE; CPG ISLANDS; DACTINOMYCIN; GENES, REPORTER; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-4; LUCIFERASES; MACROPHAGES; MICE; NUCLEIC ACID SYNTHESIS INHIBITORS; PROMOTER REGIONS (GENETICS); PROTEIN SUBUNITS; RECOMBINANT FUSION PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TRANSFECTION;

EID: 0037331966     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/immu.200310017     Document Type: Review

References (26)

1. Gately, M. K., Renzetti, L. M., Magram, J., Stern, A. S., Adorini, L., Gubler, U. and Presky, D. H., The interleukin-12/ interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 1998. 16: 495-521.
2. Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J. and Paul, W. E., The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 1999. 17: 701-738.
3. Reiner, S. L. and Locksley, R. M., The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 1995. 13: 151-177.
4. Park, A. Y., Hondowicz, B. D. and Scott, P., IL-12 is required to maintain a Th1 response during Leishmania major infection. J. Immunol. 2000. 165: 896-902.
5. Kopf, M., Brombacher, F., Kohler, G., Kienzie, G., Widmann, K. H., Lefrang, K., Humborg, C., Ledermann, B. and Solbach, W., IL-4-deficient Balb/c mice resist infection with Leishmania major. J. Exp. Med. 1996. 184: 1127-1136.
6. Neurath, M. F., Fuss, I., Kelsall, B. L., Stuber, E. and Strober, W., Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 1995. 182: 1281-1290.
7. Trembleau, S., Penna, G., Gregori, S., Gately, M. K. and Adorini, L., Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes. Eur. J. Immunol. 1997. 27: 2330-2339.
8. Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
9. Gubler, U., Chua, A. O., Schoenhaut, D. S. et al., Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 1991. 88: 4143-4147.
10. Wolf, S. F., Temple, P. A., Kobayashi, M. at al., Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 1991. 146: 3074-3081.
11. Ling, P., Gately, M. K., Gubler, U., Stern, A. S., Lin, R, Hollfelder, K., Su, C., Pan, Y. C. and Hakimi, J., Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J. Immunol. 1995. 154: 116-127.
12. Biedermann, T., Zimmermann, S., Himmelreich, H., Gumy, A., Egeter, O., Sakrauski, A. K., Seegmuller, I., Voigt, H., Launois, P., Levine, A. D., Wagner, H., Heeg, K., Louis, J. A. and Rocken, M., IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat. Immunol. 2001. 2: 1054-1060.
13. Hochrein, H., O'Keeffe, M., Luft, T., Vandenabeele, S., Grumont, R. J., Maraskovsky, E. and Shortman, K., Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J. Exp. Med. 2000. 192: 823-833.
14. Na, S. Y., Kang, B. Y., Chung, S. W., Han, S. J., Ma, X., Trinchieri, G., Im, S. Y., Lee, J. W. and Kim, T. S., Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFκB. J. Biol. Chem. 1999. 274: 7674-7680.
15. Lu, H. T., Yang, D. D., Wysk, M., Gatti, E., Mellman, I., Davis, R. J. and Flavell, R. A., Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 1999. 18: 1845-1857.
16. Hacker, H., Mischak, H., Hacker, G., Eser, S., Prenzel, N., Ullrich, A. and Wagner, H., Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells. EMBO J. 1999. 18: 6973-6982.
17. Sparwasser, T., Koch, E. S., Vabulas, R. M., Heeg, K., Lipford, G. B., Ellwart, J. W. and Wagner, H., Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 1998. 28: 2045-2054.
18. Hacker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R., Sparwasser, T., Heeg, K., Lipford, G. and Wagner, H., CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 1998. 17: 6230-6240.
19. Niiro, H., Otsuka, T., Ogami, E., Yamaoka, K., Nagano, S., Akahoshi, M., Nakashima, H., Arinobu, Y., Izuhara, K. and Niho, Y., MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes. Biochem. Biophys. Res. Commun. 1998. 250: 200-205.
20. Manna, S. K. and Aggarwal, B. B., Interleukin-4 down-regulates both forms of tumor necrosis factor receptor and receptor-mediated apoptosis, NF-κB, AP-1, and c-Jun N-terminal kinase. Comparison with interleukin-13. J. Biol. Chem. 1998. 273: 33333-33341.
21. Bennett, B. L., Cruz, R., Lacson, R. G. and Manning, A. M., Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-κB. J. Biol. Chem. 1997. 272: 10212-10219.
22. Murphy, T. L., Cleveland, M. G., Kulesza, P., Magram, J. and Murphy, K. M., Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 1995. 15: 5258-5267.
23. Kontoyiannis, D., Pasparakis, M., Pizarro, T. T., Cominelli, F. and Kollias, G., Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999. 10: 387-398.
24. Dumitru, C. D., Ceci, J. D., Tsatsanis, C., Kontoyiannis, D., Stamatakis, K., Lin, J. H., Patriotis, C., Jenkins, N. A., Copeland, N. G., Kollias, G. and Tsichlis, P. N., TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 2000. 103: 1071-1083.
25. Chen, C. Y. and Shyu, A. B., AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 1995. 20: 465-470.
26. Rolfe, F. G. and Sewell, W. A., Analysis of human interleukin-5 gene transcription by a novel nuclear run on method based on the polymerase chain reaction. J. Immunol. Methods 1997. 202: 143-151.