Activation of human platelets by 2-arachidonoylglycerol is enhanced by serotonin

Thrombosis and Haemostasis

Volumn 89, Issue 2, 2003, Pages 340-347

  Maccarrone, Mauro ^a   Bari, Monica ^b   Del Principe, Domenico ^b   Finazzi Agrò, Alessandro ^b  

^a UNIVERSITY OF TERAMO   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Agonists; Cyclic AMP; Endocannabinoids; Inositol 1,4,5 triphosphate; Receptors; Transporters

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 1 RECEPTOR ANTAGONIST; CANNABINOID 2 RECEPTOR ANTAGONIST; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CYCLIC AMP; INOSITOL 1,4,5 TRISPHOSPHATE; KETANSERIN; RIMONABANT; SEROTONIN; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELL SURFACE; CONTROLLED STUDY; CYCLIC AMP BLOOD LEVEL; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MALE; MICHAELIS CONSTANT; PLASMA; PRIORITY JOURNAL; PROTEIN TRANSPORT; THROMBOCYTE; THROMBOCYTE ACTIVATION; VELOCITY;

EID: 0037324128     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613451     Document Type: Article

References (40)

1. Howlett AC, Mukhopadhyay S. Cellular signal transduction by anandamide and 2-arachidonoylglycerol. Chem Phys Lipids 2000; 108: 53-70.
2. Hanus L, Abu-Lafi S, Fride E, Breuer A, Vogel Z, Shalev DE, Kustanovich I, Mechoulam R. 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci USA 2001; 98: 3662-5.
3. Kunos G, Járai Z, Batkai S, Goparaju SK, Ishac EJ, Liu J, Wang L, Wagner JA. Endocannabinoids as cardiovascular modulators. Chem Phys Lipids 2000; 108: 159-68.
4. Maccarrone M, Bari M, Battista N, Finazzi-Agrò A. Endocannabinoid degradation, endotoxic shock and inflammation. Current Drug Targets - Inflammation & Allergy 2002; 2: 53-63.
5. Batkai S, Járai Z, Wagner JA, Goparaju SK, Varga K, Liu J, Wang L, Mirshahi F, Khanolkar AD, Makriyannis A, Urbaschek R, Garcia N Jr, Sanyal AJ, Kunos G. Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. Nature Med 2001; 7: 827-32.
6. Alberich-Jordà M, Verbakel SE, Valk PJ, Vankan-Berkhoudt YV, Maccarrone M, Finazzi-Agrò A, Löwenberg B, Delwel R. Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol. Blood. 2002; 99: 2786-93.
7. Maccarrone M, Del Principe D, Finazzi-Agrò A. Endocannabinoids: New physiological (co-)agonists of human platelets. Thromb Haemost 2002; 88: 165-6.
8. Fox JE. Cytoskeletal proteins and platelet signaling. Thromb Haemost 2001; 86: 198-213.
9. Furie B, Furie BC, Flaumenhaft R. A journey with platelet P-selectin: The molecular basis of granule secretion, signalling and cell adhesion. Thromb Haemost 2001; 86: 214-21.
10. Phillips DR, Nannizzi-Alaimo L, Prasad KS. Beta3 tyrosine phosphorylation in alphaIIb beta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling. Thromb Haemost 2001; 86: 246-58.
11. Maccarrone M, Bari M, Menichelli A, Giuliani E, Del Principe D, Finazzi-Agrò A. Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. Eur J Biochem 2001; 268: 819-25.
12. Dale GL, Friese P, Batar P, Hamilton SF, Reed GL, Jackson KW, Clemetson KJ, Alberio L. Stimulated platelets use serotonin to enhance their retention of procoagualant proteins on the cell surface. Nature 2002; 415: 175-9.
13. Pawlak D, Malczyk E, Darewicz J, Azzadin A, Buczko W. Platelet serotonergic mechanisms in patients with cancer of the urinary bladder. Thromb Res 2000; 98: 367-74.
14. Thomas EA, Carson MJ, Neal MJ, Sutcliffe JG. Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide. Proc Natl Acad Sci USA 1997; 94: 14115-19.
15. Hao S, Avraham Y, Mechoulam R, Berry EM. Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice. Eur J Pharmacol 2000; 392: 147-56.
16. Franke L, Schewe HJ, Muller B, Campman V, Kitzrow W, Uebelhack R, Berghofer A, Muller-Oerlinghausen B. Serotonergic platelet variables in unmedicated patients suffering from major depression and healthy subjects: Relationship between 5-HT content and 5-HT uptake. Life Sci 2000; 67: 301-5.
17. 2A receptor densities in suicidal and non-suicidal depressives and control subjects. Psychiatry Res 2000; 94: 273-7.
18. Najib A, Pelliccioni P, Gil C, Aguilera J. Serotonin transporter phosphorylation modulated by tetanus toxin. FEBS Lett 2000; 486: 136-42.
19. Mortensen OV, Kristensen AS, Wiborg O. Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants. J Neurochem 2001; 79: 237-47.
20. 5a receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells. J Neurosci Res 2000; 61: 75-81.
21. 3H(N)] arachidonoyl-glycerol (2-AG), a putative endogenous cannabinoid receptor ligand. J Labelled Cpd Radiopharm 1999; 42: S787-9.
22. Del Principe D, Menichelli A, De Matteis W, Di Corpo ML, Di Giulio S, Finazzi-Agrò A. Hydrogen peroxide has a role in the aggregation of human platelets. FEBS Lett 1985; 185: 142-6.
23. Born GV. Uptake of adenosine and of adenosine diphosphate by human blood platelets. Nature 1965; 206: 1121-2.
24. Maccarrone M, Van Der Stelt M, Rossi A, Veldink GA, Vliegenthart JFG, Finazzi-Agrò A. Anandamide hydrolysis by human cells in culture and brain. J Biol Chem 1998; 273: 32332-9.
25. Beltramo M, Piomelli D. Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. Neuroreport 2000; 11: 1231-5.
26. Maccarrone M, Lorenzon T, Bari M, Melino G, Finnazi-Agrò A. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J Biol Chem 275; 2000: 31938-45.
27. 2A receptor binding kinetic assay. Life Sci 1999; 65: 2615-22.
28. Maccarrone M, Bari M, Lorenzon T, Bisogno T, Di Marzo V, Finazzi-Agrò A. Anandamide uptake by human endothelial cells and its regulation by nitric oxide. J Biol Chem 275; 2000: 13484-92.
29. Pertwee RG. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 1997; 74: 129-80.
30. Qi R, Ozaki Y, Satoh K, Kurota K, Asazuma N, Yatomi Y, Kume S. Quantitative measurement of various 5-HT receptor antagonists on platelet activation induced by serotonin. Thromb Res 1996; 81: 43-54.
31. Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 2002; 71: 533-54.
32. De Petrocellis L, Bisogno T, Maccarrone M, Davis JB, Finazzi-Agrò A, Di Marzo V. The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J Biol Chem 2001; 276: 12856-63.
33. Maccarrone M, Bari M, Menichelli A, Del Principe D, Finazzi-Agrò A. Anandamide activates human platelets through a pathway independent of the arachidonate cascade. FEBS Lett 1999; 447: 277-82.
34. 2A receptors in schizophrenic patients with and without neuroleptic treatment. Psychiatry Res 2000; 96: 41-50.
35. Daniel JL, Dangelmaier C, Jin J, Ashby B, Smith JB, Kunapuli SP. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J Biol Chem 1998; 273: 2024-9.
36. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, Coughlin SR. A dual thrombin receptor system for platelet activation. Nature 1998; 394: 690-4.
37. Pasquet JM, Noury M, Nurden AT. Evidence that the platelet integrin αIIbβ3 is regulated by the integrin-linked kinase, ILK, in a PI3-kinase dependent pathway. Thromb Haemost 2002; 88: 115-22.
38. 3A receptors: Probable involvement of an allosteric modulatory site. Br J Pharmacol 2002; 137: 589-96.
39. Giuffrida A, Piomelli D. The endocannabinoid system: A physiological perspective on its role in psychomotor control. Chem Phys Lipids 2000; 108: 151-8.
40. Ravary A, Muzerelle A, Darmon M, Murphy DL, Moessner R, Lesch KP, Gaspar P. Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. Eur J Neurosci 2001; 13: 1349-62.