Endocannabinoids: New physiological (Co-)agonists of human platelets

Thrombosis and Haemostasis

Volumn 88, Issue 1, 2002, Pages 165-166

  Maccarrone, Mauro ^a   Del Principe, Domenico ^a   Finazzi Agrò, Alessandro ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ADENOSINE DIPHOSPHATE; ANANDAMIDE; CALCIUM; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID DERIVATIVE; CYCLIC AMP; ENDOCANNABINOID DERIVATIVE; INOSITOL 1,4,5 TRISPHOSPHATE; LIPOPOLYSACCHARIDE; THROMBIN; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG; ENDOCANNABINOID; UNSATURATED FATTY ACID;

CARDIOVASCULAR SYSTEM; CELL LEVEL; CONCENTRATION (PARAMETERS); DRUG EFFECT; DRUG HYDROLYSIS; DRUG RECEPTOR BINDING; HUMAN; HYPOTENSION; LETTER; LIVER CIRRHOSIS; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE RICH PLASMA; CHEMISTRY; METABOLISM; NOTE; PHYSIOLOGY; THROMBOCYTE;

BLOOD PLATELETS; ENDOCANNABINOIDS; FATTY ACIDS, UNSATURATED; HUMANS; PLATELET ACTIVATION;

EID: 0036301791     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613175     Document Type: Letter

References (15)

1. Cytoskeletal proteins and platelet signaling
2. A journey with platelet P-selectin: The molecular basis of granule secretion, signalling and cell adhesion
3. Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling
4. Cellular signal transduction by anandamide and 2-arachidonoylglycerol
5. 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
6. Endocanabinoids as cardiovascular modulators
7. Endocannabinoid degradation, endotoxic shock and inflammation
8. Endocannabinoids acting at vascular CB1 receptors mediate the vasolidated state in advanced liver cirrhosis
9. Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor
10. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets
11. A dual thrombin receptor system for platelet activation
12. Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid
13. Platelet activation: A new vascular activity of anandamide
14. Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes
15. Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells