Embryonic stem cells and potency to induce transplantation tolerance

Expert Opinion on Biological Therapy

Volumn 3, Issue 1, 2003, Pages 5-13

  Zavazava, Nicholas ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Embryonic stem cells; Haematopoietic cells; Mixed chimaerism; Rejection; Tolerance; Transplantation

Indexed keywords

ALLOGRAFT; ANIMAL CELL; BONE MARROW TRANSPLANTATION; CHIMERA; CLONAL ANERGY; EMBRYO CELL; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNE DEFICIENCY; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; ORGAN TRANSPLANTATION; REVIEW; RISK ASSESSMENT; STEM CELL TRANSPLANTATION; TRANSPLANTATION TOLERANCE;

ANIMALS; GRAFT REJECTION; HUMANS; ORGAN TRANSPLANTATION; STEM CELL TRANSPLANTATION; TRANSPLANTATION TOLERANCE;

ANIMALIA; RODENTIA;

EID: 0037322537     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.3.1.5     Document Type: Review

References (56)

1. BILLINGHAM R, BRENT L, MEDAWAR PB: 'Actively acquired tolerance' of foreign cells. Nature (1953) 172:603-606. Early report on donor-derived haematopoietic cells inducing graft tolerance.
2. MURRAY J, MERRILL J, HARRISSON JH: Renal homotransplantation in identical twins. Surg. Forum (1955) 6:432-436.
3. MURRAY J, MERRIL J, DAMMIN GJ et al.: Study of transplantation immunity after total body irradiation: clinical and experimental investigation. Surgery (1960) 48:272-284.
4. LARSEN C, ELWOOD E, ALEXANDER D et al.: Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature (1996) 381:434-438. Induction of skin and cardiac graft tolerance using blockage of costimulation. First in vivo evidence of the efficacy of costimulation blockade to prevent rejection.
5. SAITOVITCH D, BUSHELL A, MABBS D, MORRIS P, WOOD K: Kinetics of induction of transplantation tolerance with a nondepleting anticd4 monoclonal antibody and donor-specific transfusion before transplantation. Transplantation (1996) 61:1642-1647.
6. BEHRENS D, LANGE K, FRIED A et al.: Donor-derived soluble MHC antigens plus low-dose cyclosporin induce transplantation unresponsiveness independent of the thymus by downregulating T cell mediated alloresponses in a rat transplantation model. Transplantation (2001) 72:1974-1982.
7. SAITOVITCH D, MORRIS P, WOOD K: Recipient cells expressing single donor MHC locus products can substitute for donor-specific transfusion in the induction of transplantation tolerance when pretreatment is combined with antiCD4 monoclonal antibody. Transplantation (1996) 61:1532-1538.
8. DOUILLARD P, PANNETIER C, JOSIEN R et al.: Donor-specific blood transfusion-induced tolerance in adult rats with a dominant TCR-V beta rearrangement in heart allografts. J. Immunol. (2002) 157(3):1250-1260.
9. SYKES M: Mixed chimerism and transplant tolerance. Immunity. (2001) 14:417-424.
10. SAYEGH MH, TURKA LA: The role of T cell costimulatory activation pathways in transplant rejection. N. Engl. J. Med. (1998) 338:1813-1821. Role of mixed chimaerism in induction of specific graft tolerance.
11. ILDSTAD ST, SACHS DH: Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature (1984) 307:168-170.
12. MCSWEENEY PA, NIEDERWIESER D, SHIZURU JA et al.: Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing highdose cytotoxic therapy with graft-versustumour effects. Blood (2001) 97:3390-3400.
13. FEINSTEIN LYLE, SANDMAIER BREN, MALONEY DAVI et al.: Nonmyeloablative hematopoietic cell transplantation: replacing high-dose cytotoxic therapy by the graft-versus-tumour Effect. Ann. NY Acad. Sci. (2001) 938:328-339.
14. STORB R, SALE G, BARNETT T, YU C, ZELLMER E, LITTLE MT: Transient mixed hematopoietic chimerism in dogs given thymic irradiation before and pharmacologic immunosuppression after marrow transplantation. Blood (2001) 97:2915-2917. Induction of mixed chimaerism without the use of a toxic conditioning regimen.
15. MILLAN M, SHIZURU J, HOFFMANN P et al.: Mixed chimerism and immunosuppressive withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation. Transplantation (2002) 73:1386-1391. Preliminary report on an attempt to induce clinical tolerance after induction of haematopoietic mixed chimaerism without the use of a toxic conditioning regimen. Four patients who received living-related renal cardiac transplants were studied.
16. BILLINGHAM R, BRENT L, MEDAWAR P: Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance. Philos. Trans. R. Soc. Lond. (Biol.) (1956) 239:357-412.
17. WEISSMANN A: Essays upon hereditary and kindred biological problems. Poulton EB, Schonland S & Shipley AE (Eds.) (1889):25.
18. SPITZER TR, DELMONICO F, TOLKOFF-RUBIN N et al.: Combined histocompatibility leukocyte antigenmatched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation (1999) 68:480-484.
19. GILL R, COULOMBE M, LAFFERTY K: Pancreatic islet allograft immunity and tolerance: the two-signal hypothesis revisited. Immunol. Rev. (1996) 149:75-96.
20. LENSCHOW D, ZENG Y, HATHCOCK K et al.: Inhibition of transplant rejection following treatment with antiB7-2 and antiB7-1 antibodies. Transplantation (1997) 60:1171-1178.
21. BLUESTONE J: Is CTLA-4 a master switch for peripheral T cell tolerance. J. Immunol (1997) 158(5):1989-1993.
22. KNECHTLE SJ: Knowledge about transplantation tolerance gained in primates. Curr. Opin. Immunol (2000) 12:556.
23. KAWAI T, ANDREWS D, COLVIN R, SACHS D, COSIMI A: Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat. Med. (2000) 6:114.
24. YAMADA A, SAYEGH M: The CD154CD40 costimulatory pathway in transplantation. Transplantation (2002) 73(Suppl. 1):S36-S39.
25. GEARHART J: New potential for human embryonic stem cells. Science (1998) 282:1064.
26. FÄNDRICH F, LIN X, CHAI G et al.: Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning. Nat. Med. (2002) 8:171-178. Embryonic stem cells induce mixed lymphocyte tolerance without preconditioning and subsequently tolerance to donor-type cardiac allografts.
27. JAFFE LE, BIKOFF E: Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens. Proc. Natl. Acad. Sci. USA (1992) 89(13):5927-5931.
28. THOMSON J, ITSKOVITZ-ELDOR J, SHAPIRO S et al.: Embryonic stem cell lines derived from human blastocysts. Science (1998) 282:1147.
29. BJORKLUND M, SANCHEZPERNAUTE R, CHUNG S et al.: Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc. Natl. Acad. Sci. USA (2002) 99:2344-2349. Therapeutic application of embryonic stem cells to repair damaged neural tissue.
30. CIBELLI JB, GRANT KA, CHAPMAN KB et al.: Parthenogenetic stem cells in nonhuman primates. Science (2002) 295:819. Derivation of embryonic stem cells by parthenogenesis instead of the use of embryos.
31. KAUFMAN MH, ROBERTSON E, HANDYSIDE A, EVANS M: Establishment of pluripotential cell lines from haploid mouse embryos. J. Embrol. Exp. Morphol. (1983) 73:249-261.
32. ROBERTSON E, KAUFMANN M, BRADLEY A, EVANS M: In: Teratocarrinoma stem cells. Silver LM, Martin GR & Strickland S (Eds.), Cold Spring Harbor Laboratory, New York, USA (1983):647-663.
33. CAMPBELL KH, MCWHIR J, RITCHIE WA, WILMUT I: Sheep cloned by nuclear transfer from a cultured cell line. Nature (1996) 380:64-66.
34. WILMUT I: Cloning for medicine. Sci. Am. (1998) 279:58-63.
35. SHIELS PG, KIND AJ, CAMPBELL KH et al.: Analysis of telomere lengths in cloned sheep. Nature (1999) 399:316-317.
36. OGONUKI N, INOUE K, YAMAMOTO Y et al.: Early death of mice cloned from somatic cells. Nat. Genet. (2002) 30:253-254.
37. HUMPHERYS D, EGGAN K, AKUTSU H et al.: Epigenetic instability in ES cells and cloned mice. Science (2001) 293:95-97.
38. LANZA RP, CIBELLI JB, BLACKWELL C et al.: Extension of cell lifespan and telomere length in animals cloned from senescent somatic cells. Science (2000) 288:665-669.
39. SCHOLER HR, HATZOPOULOS AK, BALLING R, SUZUKI N, GRUSS P: A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J. (1989) 8:2543-2550.
40. SMITH AG, HEATH JK, DONALDSON DD et al.: Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature (1988) 336:688-690.
41. WILLIAMS RL, HILTON DJ, PEASE S et al.: Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature (1988) 336:684-687.
42. GOUGH NM, WILLIAMS RL, HILTON DJ et al.: LIF: a molecule with divergent actions on myeloid leukaemic cells and embryonic stem cells. Reprod. Fertil Dev. (1989) 1:281-288.
43. DRUKKER M, KATZ G, URBACH A et al.: Characterization of the expression of MHC proteins in human embryonic stem cells. Proc. Natl. Acad. Sci. USA (2002) 99:9864-9869.
44. THOMPSON J, ITSKOVITZ-ELDOR J, SHAPIRO SS et al.: Embryonic stem cell lines derived from human blastocysts. Science (1998) 282:1145-1147.
45. LILIE F: The theory of the free-martin. Science (1916) XLIII:611-613.
46. OWEN R: Immunogenetic consequences of vascular anastomoses between bovine twins. Science (1945) 102:400-401. Evidence of red blood cells from twin sibling in free-martin cattle.
47. WEKERLE T, KURTZ J, ITO H: Allogeneic bone marrow transplantation with costimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat. Med. (2000) 6:464-469. Induction of mixed chimaerism using a non-myeloablative approach.
48. FUCHIMOTO Y, HUANG CA, YAMADA K et al.: Mixed chimerism and tolerance without whole body irradiation in a large animal model. J. Clin. Invest. (2000) 105:1779-1789.
49. SYKES M: Immunobiology of transplantation. FASEB J. (1996) 10:721-730.
50. LEE L, GRITSCH H, SERGIO J et al.: Specific tolerance across a discordant xenogeneic transplantation barrier. Proc. Natl. Acad. Sci. USA (1994) 91:10864-10867.
51. GARDNER R, BEDDINGTON R: Multilineage 'stem' cells in the mammalian embryo. J. Cell Sci. (1988) 10(Suppl.):11-27.
52. GARDNER RL, BROOK FA: Reflections on the biology of embryonic stem (ES) cells. Int. J. Dev. Biol. (1997) 41:235-243.
53. EVANS M, KAUFMANN M: Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 292:154-156.
54. NICHOLS J, CHAMBERS I, TAGA T, SMITH A: Physiological rationale for responsiveness of mouse embryonic stem cells to gp 130 cytokines. Development (2001) 128:2333-2339.
55. ILDSTAD ST, SACHS DH: Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature (1984) 307:168-170.
56. SYKES M, SACHS D: Mixed allogeneic chimerism as an approach to transplantation tolerance. Immunology Today (1988) 9:23-27.