Lentivirus-mediated expression of angiostatin efficiently inhibits neovascularization in a murine proliferative retinopathy model

Gene Therapy

Volumn 10, Issue 3, 2003, Pages 219-226

  Igarashi, Tsutomu ^a,b   Miyake, Koichi ^a   Kato, Ko ^a,b   Watanabe, Atsushi ^a   Ishizaki, Masamichi ^b   Ohara, Kunitoshi ^b   Shimada, Takashi ^a  

^a Division of Cellular Signaling   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Angiostatin; Diabetic retinopathy; Gene therapy; Lentivirus vector; Retinal neovascularization; Retinopathy of prematurity

Indexed keywords

ANGIOSTATIN; BUFFER; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; OXYGEN; PHOSPHATE; SODIUM CHLORIDE; VASCULOTROPIN; VIRUS VECTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL NUCLEUS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; FEMALE; GENE EXPRESSION; GENETIC CODE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROLIFERATIVE RETINOPATHY; QUANTITATIVE ANALYSIS; RETINA NEOVASCULARIZATION; REVIEW; TISSUE SECTION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANGIOSTATINS; ANIMALS; ARTHRITIS, RHEUMATOID; DIABETIC RETINOPATHY; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HIV-1; HUMANS; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; PEPTIDE FRAGMENTS; PLASMINOGEN; RETINA; RETINAL NEOVASCULARIZATION; TRANSDUCTION, GENETIC;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; LENTIVIRUS; MURINAE;

EID: 0037318972     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301878     Document Type: Review

References (45)

1. Klein R, klein B. Vision disorders in diabetes. In: National Diabetes Data Group (ed). Diabetes in America. 2nd edn., National Institutes of Health: Washington, DC, 1995; pp. 305-321.
2. The Diabetic Retinopathy Study Research Group. Preliminary report on effects of photocoagulation therapy Am J Ophthalmol 1976; 81(4): 383-396.
3. Early Treatment Diabetic Retinopathy Study Group. Ophthalmology 1991; 98: 741-840.
4. O'Reilly MS et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994; 79: 315-328.
5. Tanaka T, Cao Y, Folkman J, Fine HA. Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA. Cancer Res 1998; 58: 3362-3369.
6. Gyorffy S, Palmer K, Gauldie J. Adenoviral vector expressing murine angiostatin inhibits a model of breast cancer metastatic growth in the lungs of mice. Am J Pathol 2001; 159: 1137-1147.
7. Indraccolo S et al. Effects of angiostatin gene transfer on functional properties and in vivo growth of Kaposi's sarcoma cells. Cancer Res 2001; 61: 5441-5446.
8. Mori K et al. AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci 2002; 43: 1994-2000.
9. Lai CC et al. Suppression of choroidal neovascularization by adeno-associated virus vector expressing angiostatin. Invest Ophthalmol Vis Sci 2001; 42: 2401-2407.
10. Bainbridge JW et al. Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1. Gene Ther 2002; 9: 320-326.
11. Lai YK et al. Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy. Gene Ther 2002; 9: 804-813.
12. Mori K et al. Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin. Am J Pathol 2001; 159: 313-320.
13. Smith LE et al. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 1994; 35: 101-111.
14. Gao G et al. Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5. J Biol Chem 2002; 277: 9492-9497.
15. McDonald HR, Schatz H. Macular edema following panretinal photocoagulation. Retina 1985; 5: 5-10.
16. Lucas R et al. Multiple forms of angiostatin induce apoptosis in endothelial cells. Blood 1998; 92: 4730-4741.
17. Troyanovsky B et al. Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation. J Cell Biol 2001; 152: 1247-1254.
18. Tanaka K et al. Inhibition of infiltration and angiogenesis by thrombospondin-1 in papillary thyroid carcinoma. Clin Cancer Res 2002; 8: 1125-1131.
19. Aiello LP et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331: 1480-1487.
20. Lopez PF et al. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest Ophthalmol Vis Sci 1996; 37: 855-868.
21. Pierce EA et al. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci USA 1995; 92: 905-909.
22. Dawson DW et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999; 285: 245-248.
23. Tombran-Tink J, Johnson LV. Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells. Invest Ophthalmol Vis Sci 1989; 30: 1700-1707.
24. Gao G et al. Unbalanced expression of VEGF and PEGF in ischemia-induced retinal neovascularization. FEBS Lett 2001; 489: 270-276.
25. Spranger J et al. Release of the angiogenesis inhibitor angiostatin in patients with proliferative diabetic retinopathy: association with retinal photocoagulation. Diabetologia 2000; 43: 1404-1407.
26. O'Reilly MS et al. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 1996; 2: 689-692.
27. Berger AS et al. Intravitreal sustained release corticosteroid-5-fluoruracil conjugate in the treatment of experimental proliferative vitreoretinopathy Invest Ophthalmol Vis Sci 1996; 37: 2318-2325.
28. Yang CS et al. An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy. Arch Ophthalmol 1998; 116: 69-77.
29. Li T et al. In vivo transfer of a reporter gene to the retina mediated by an adenoviral vector. Invest Ophthalmol Vis Sci 1994; 35: 2543-2549.
30. Murata T et al. Retrovirus-mediated gene transfer targeted to retinal photocoagulation sites. Diabetologia 1998; 41: 500-506.
31. Ferrari FK et al. Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol 1996; 70: 3227-3234.
32. Igarashi T et al. New strategy for in vivo transgene expression in corneal epithelial progenitor cells, submitted for publication. Current Eye Research 2002; 24: 46-50.
33. + cells by a recombinant human immunodeficiency virus retroviral vector. J Clin Invest 1991; 88: 1043-1047.
34. Emi N, Friedmann T, Yee JK. Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus. J Virol 1991; 65: 1202-1207.
35. Uchida N et al. HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells. Proc Natl Acad Sci USA 1998; 95: 11 939-11 944.
36. Zufferey R et al. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 1997; 15: 871-875.
37. Miyoshi H et al. Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci USA 1997; 94: 10 319-10 323.
38. Takahashi M et al. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol 1999; 73: 7812-7816.
39. Cao Y. Endogenous angiogenesis inhibitors and their therapeutic implications. Int J Biochem Cell Biol 2001; 33: 357-369.
40. Orimo H et al. Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability. J Hum Genet 2000; 45: 228-230.
41. Miyoshi H et al. Development of a self-inactivating lentivirus vector. J Virol 1998; 72: 8150-8157.
42. Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991; 108: 193-199.
43. Naldini L et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-267.
44. Miyake K et al. Selective killing of human immunodeficiency virus-infected cells by targeted gene transfer and inducible gene expression using a recombinant human immunodeficiency virus vector. Hum Gene Ther 2001; 12: 227-233.
45. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold spring Harbor Laboratory Press: Cold Spring Harbor NY, 1989, pp. 1860-1875.