Selective killing of human immunodeficiency virus-infected cells by targeted gene transfer and inducible gene expression using a recombinant human immunodeficiency virus vector

Human Gene Therapy

Volumn 12, Issue 3, 2001, Pages 227-233

  Miyake, K ^a   Iijima, O ^b   Suzuki, N ^a   Matsukura, M ^c   Shimada, T ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b Tsukuba Building Test Laboratory of CBL   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CELL KILLING; CONTROLLED STUDY; DRUG SENSITIVITY; GENE EXPRESSION; GENE INDUCTION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PROMOTER REGION; VIRION; VIRUS ENVELOPE; VIRUS INHIBITION; VIRUS RECOMBINANT;

ANIMALS; ANTIVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CELL DEATH; CELL LINE; COLORING AGENTS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; GANCICLOVIR; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HELA CELLS; HIV INFECTIONS; HIV-1; HUMANS; MODELS, GENETIC; PLASMIDS; RIBONUCLEASES; SIMPLEXVIRUS; TETRAZOLIUM SALTS; THIAZOLES; THYMIDINE KINASE; TIME FACTORS;

ANIMALIA; HERPES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SIMPLEXVIRUS;

EID: 0035835372     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340150218378     Document Type: Article

References (31)

1. Intracellular immunization
2. Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors
3. Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase
4. + cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected population
5. Protection of primary human T cells from HIV infection by Trey: A transdominant fusion gene
6. Inhibition of human immunodeficiency virus type-1 by retroviral vectors expressing antisense-TAR
7. Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice
8. + cells by transdominant negative Rev-expressing retrovirus yields partial anti-HIV protection of progeny macrophages
9. HIV-regulated diphtheria toxin A chain gene confers long-term protection against HIV type 1 infection in the human promonocytic cell line U937
10. A conditionally replicating HIV-1 vector interferes with wild-type HIV-1 replication and spread
11. High level inhibition of HIV replication with combination RNA decoys expressed from an HIV-Tat inducible vector
12. Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene
13. A phase I clinical trial to evaluate the safety and biological activity of HIV-IT (TAF) (HIV-1IIIBenv-transduced, autologous fibroblasts) in asymptomatic HIV-1 infected subjects
14. Gene therapy for infectious disease: The AIDS model
15. Two-step gene transfer using an adenoviral vector carrying the CD4 gene and human immunodeficiency viral vectors
16. Stable integration of HIV-based retroviral vectors into the chromosomes of non-dividing cells
17. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
18. Gene therapy for AIDS using retroviral mediated gene transfer to deliver HIV-1 antisense TAR and transdominant Rev protein genes to syngeneic lymphocytes in HIV-1 infected identical twins
19. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
20. In vivo gene delivery and stable transduction of nondividing cells by a lentivirus vector
21. Gene therapy for adult T cell leukemia using human immunodeficiency virus vector carrying the thymidine kinase gene of herpes simplex virus type 1
22. Defective HIV-1 provirus encoding a multitarget-ribozyme inhibits accumulation of spliced and unspliced HIV-1 mRNAs, reduces infectivity of viral progeny, and protects the cells from pathogenesis
23. Permanent cardiovascular protection from hypertension by the AT(1) receptor antisense gene therapy in hypertensive rat offspring
24. + cells by a recombinant human immunodeficiency virus retroviral vector
25. Transient protection of human T-cells from human immunodeficiency virus type I infection by transduction with adeno-associated viral vectors which express RNA decoys
26. Trans-acting transcriptional activation of the long terminal repeat of human T-lymphotropic viruses in infected cells
27. Hematopoietic stem cell-based gene therapy for acquired immunodeficiency syndrome: Efficient transduction and expression of RevM10 in myeloid cells in vivo and in vitro
28. Preclinical characterization of an anti-tat ribozyme for therapeutic application
29. Hybrid plasmid containing an active thymidine kinase gene of herpes simplex virus 1
30. A controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA
31. Progress towards gene therapy for HIV infections