Extracellular signal-regulated kinase and c-Src, but not Jun N-terminal kinase, are involved in basal and gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone α-subunit promoter

Endocrinology

Volumn 144, Issue 2, 2003, Pages 612-622

  Harris, Dagan ^a   Chuderland, Dana ^a   Bonfil, David ^a   Kraus, Sarah ^b   Seger, Rony ^b   Naor, Zvi ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCIUM ION; CALCIUM IONOPHORE; CHLORAMPHENICOL ACETYLTRANSFERASE; GLYCOPROTEIN; GONADORELIN; IONOMYCIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; SYNAPTOPHYSIN;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CELL LYSATE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HORMONE RELEASE; MOUSE; NONHUMAN; ONCOGENE SRC; PEPTIDE MAPPING; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSACTIVATION;

CARCINOGENS; CELL LINE; FERTILITY AGENTS, FEMALE; GENE DELETION; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; GONADOTROPIN-RELEASING HORMONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE KINASES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC;

EID: 0037318494     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-220690     Document Type: Article

References (53)

1. Pierce JG, Parsons TF 1981 Glycoprotein hormones: structure and function. Annu Rev Biochem 50:465-495
2. Gharib SD, Wierman ME, Shupnik MA, Chin WW 1990 Molecular biology of the pituitary gonadotropins. Endocr Rev 11:177-199
3. 2+ mobilizing hormones: the case of gonadotropin-releasing hormone. Endocr Rev 11:326-353
4. Stojilkovic SS, Reinhart J, Catt KJ 1994 Gonadotropin-releasing hormone receptors: structure and signal transduction pathways. Endocr Rev 15:462-499
5. Sealfon SC, Weinstein H, Millar RP 1997 Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor. Endocr Rev 18:180-205
6. Naor Z, Benard O, Seger R 2000 Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor. Trends Endocrinol Metab 11:91-99
7. Shacham S, Harris D, Ben Shlomo H, Cohen I, Bonfil D, Przedecki F, Lewy H, Ashkenazi IE, Seger R, Naor Z 2001 Mechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs. Vitam Horm 63:63-90
8. Kraus S, Naor Z, Seger R 2001 Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor. Arch Med Res 32:499-509
9. Brown P, McNeilly AS 1999 Transcriptional regulation of pituitary gonadotrophin subunit genes. Rev Reprod 4:117-124
10. Counis R 1999 Gonadotropin biosynthesis. In: Neill J, Knobil E, eds. Encyclopedia of reproduction, vol 2. New York: Academic Press; 507-520
11. Pearson G, Robinson F, Beers GT, Xu BE, Karandikar M, Berman K, Cobb MH 2001 Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22:153-183
12. Mitchell R, Sim PJ, Leslie T, Johnson MS, Thomson FJ 1994 Activation of MAP kinase associated with the priming effect of LHRH. J Endocrinol 140: R15-R18
13. Roberson MS, Misra-Press A, Laurance ME, Stork PJ, Maurer RA 1995 A role for mitogen-activated protein kinase in mediating activation of the glycoprotein hormone α-subunit promoter by gonadotropin-releasing hormone. Mol Cell Biol 15:3531-3539
14. Sundaresan S, Colin IM, Pestell RG, Jameson JL 1996 Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone: evidence for the involvement of protein kinase C. Endocrinology 137:304-311
15. Reiss N, Llevi LN, Shacham S, Harris D, Seger R, Naor Z 1997 Mechanism of mitogen-activated protein kinase activation by gonadotropin-releasing hormone in the pituitary αT3-1 cell line: differential roles of calcium and protein kinase C. Endocrinology 138:1673-1682
16. Levi NL, Hanoch T, Benard O, Rozenblat M, Harris D, Reiss N, Naor Z, Seger R 1998 Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary αT3-1 cell line is mediated by protein kinase C, c-Src, and CDC42. Mol Endocrinol 12:815-824
17. Roberson MS, Zhang T, Li HL, Mulvaney JM 1999 Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone. Endocrinology 140:1310-1318
18. Grosse R, Schmid A, Schoneberg T, Herrlich A, Muhn P, Schultz G, Gudermann T 2000 Gonadotropin-releasing hormone receptor initiates multiple signaling pathways by exclusively coupling to G(q/11) proteins. J Biol Chem 275:9193-9200
19. Mulvaney JM, Zhang T, Fewtrell C, Roberson MS 1999 Calcium influx through L-type channels is required for selective activation of extracellular signal-regulated kinase by gonadotropin-releasing hormone. J Biol Chem 274:29796-29804
20. Mulvaney JM, Roberson MS 2000 Divergent signaling pathways requiring discrete calcium signals mediate concurrent activation of two mitogen-activated protein kinases by gonadotropin-releasing hormone. J Biol Chem 275:14182-14189
21. Yokoi T, Ohmichi M, Tasaka K, Kimura A, Kanda Y, Hayakawa J, Tahara M, Hisamoto K, Kurachi H, Murata Y 2000 Activation of the luteinizing hormone β promoter by gonadotropin-releasing hormone requires c-Jun NH2-terminal protein kinase. J Biol Chem 275:21639-21647
22. Benard O, Naor Z, Seger R, 2001 Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone. J Biol Chem 276:4554-4563
23. Deleted in proof
24. Weck J, Fallest PC, Pitt LK, Shupnik MA 1998 Differential gonadotropin-releasing hormone stimulation of rat luteinizing hormone subunit gene transcription by calcium influx and mitogen-activated protein kinase-signaling pathways. Mol Endocrinol 12:451-457
25. Call GB, Wolfe MW 1999 Gonadotropin-releasing hormone activates the equine luteinizing hormone β promoter through a protein kinase C/mitogen-activated protein kinase pathway. Biol Reprod 61:715-723
26. Harris D, Bonfil D, Chuderland D, Kraus S, Seger R, Naor Z 2002 Activation of MAPK cascades by GnRH: ERK and Jun N-terminal kinase are involved in basal and GnRH-stimutated activity of the glycoprotein hormone LHβ-subunit promoter. Endocrinology 143:1018-1025
27. Heckert LL, Schultz K, Nilson JH 1996 The cAMP response elements of the α subunit gene bind similar proteins in trophoblasts and gonadotropes but have distinct functional sequence requirements. J Biol Chem 271:31650-31656
28. Kikkawa U, Ogita K, Shearman MS, Ase K, Sekiguchi K, Naor Z, Ido M, Nishizuka Y, Saito N, Tanaka C 1988 The heterogeneity and differential expression of protein kinase C in nervous tissues. Philos Trans R Soc Lond B Biol Sci 320:313-324
29. Harris D, Reiss N, Naor Z 1997 Differential activation of protein kinase C delta and epsilon gene expression by gonadotropin-releasing hormone in αT3-1 cells. Autoregulation by protein kinase C. J Biol Chem 272:13534-13540
30. Kay TW, Jameson JL 1992 Identification of a gonadotropin-releasing hormone-responsive region in the glycoprotein hormone α-subunit promoter. Mol Endocrinol 6:1767-1773
31. Heckert LL, Schultz K, Nilson JH 1995 Different composite regulatory elements direct expression of the human α subunit gene to pituitary and placenta. J Biol Chem 270:26497-26504
32. Schoderbek WE, Roberson MS, Maurer RA 1993 Two different DNA elements mediate gonadotropin releasing hormone effects on expression of the glycoprotein hormone α-subunit gene. J Biol Chem 268:3903-3910
33. Horn F, Windle JJ, Barnhart KM, Mellon PL 1992 Tissue-specific gene expression in the pituitary: the glycoprotein hormone α-subunit gene is regulated by a gonadotrope-specific protein. Mol Cell Biol 12:2143-2153
34. Jameson JL, Powers AC, Gallagher GD, Habener JF 1989 Enhancer and promoter element interactions dictate cyclic adenosine monophosphate mediated and cell-specific expression of the glycoprotein hormone α-gene. Mol Endocrinol 3:763-772
35. Steger DJ, Altschmied J, Buscher M, Mellon PL 1991 Evolution of placenta-specific gene expression: comparison of the equine and human gonadotropin α-subunit genes. Mol Endocrinol 5:243-255
36. Delegeane AM, Ferland LH, Mellon PL 1987 Tissue-specific enhancer of the human glycoprotein hormone α-subunit gene: dependence on cyclic AMP-inducible elements. Mol Cell Biol 7:3994-4002
37. Jameson JL, Deutsch PJ, Gallagher GD, Jaffe RC, Habener JF 1987 Trans-acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin α gene. Mol Cell Biol 7:3032-3040
38. Pierce KL, Lefkowitz RJ 2001 Classical and new roles of β-arrestins in the regulation of G-protein-coupled receptors. Nat Rev Neurosci 2:727-733
39. Grosse R, Roelle S, Herrlich A, Hohn J, Gudermann T 2000 Epidermal growth factor receptor tyrosine kinase mediates Ras activation by gonadotropin releasing hormone J Biol Chem 275:12251-12260
40. Haisenleder DJ, Cox ME, Parsons SJ, Marshall JC 1998 Gonadotropin-releasing hormone pulses are required to maintain activation of mitogen-activated protein kinase: role in stimulation of gonadotrope gene expression. Endocrinology 139:3104-3111
41. Ben Menahem D, Shraga Z, Lewy H, Limor R, Hammel I, Stein R, Naor Z 1992 Dissociation between release and gene expression of gonadotropin α-subunit in gonadotropin-releasing hormone-stimulated α T3-1 cell line. Biochemistry 31:12893-12898
42. Saunders BD, Sabbagh E, Chin WW, Kaiser UB 1998 Differential use of signal transduction pathways in the gonadotropin-releasing hormone-mediated regulation of gonadotropin subunit gene expression. Endocrinology 139:1835-1843
43. Liu F, Austin DA, Mellon PL, Olefsky JM, Webster NJ 2002 GnRH activates ERK1/2 leading to the induction of c-fos and LHβ protein expression in LβT2 cells. Mol Endocrinol 16:419-434
44. Chedrese PJ, Kay TW, Jameson JL 1994 Gonadotropin-releasing hormone stimulates glycoprotein hormone α-subunit messenger ribonucleic acid (mRNA) levels in α T3 cells by increasing transcription and mRNA stability. Endocrinology 134:2475-2481
45. 2+ and protein kinase C. Biochemistry 33:3698-3704
46. 2+ and protein kinase C. Biochem J 309:325-329
47. Schoderbek WE, Kim KE, Ridgway EC, Mellon PL, Maurer RA 1992 Analysis of DNA sequences required for pituitary-specific expression of the glycoprotein hormone α-subunit gene. Mol Endocrinol 6:893-903
48. Bach I, Rhodes SJ, Pearse RV, Heinzel T, Gloss B, Scully KM, Sawchenko PE, Rosenfeld MG 1995 P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc Natl Acad Sci USA 92:2720-2724
49. Roberson MS, Schoderbek WE, Tremml G, Maurer RA 1994 Activation of the glycoprotein hormone α-subunit promoter by a LIM-homeodomain transcription factor. Mol Cell Biol 14:2985-2993
50. Strahl BD, Huang HJ, Sebastian J, Ghosh BR, Miller WL 1998 Transcriptional activation of the ovine follicle-stimulating hormone β-subunit gene by gonadotropin-releasing hormone: involvement of two activating protein-1-binding sites and protein kinase C. Endocrinology 139:4455-4465
51. Holdstock JG, Aylwin SJ, Burrin JM 1996 Calcium and glycoprotein hormone α-subunit gene expression and secretion in α T3-1 gonadotropes. Mol Endocrinol 10:1308-1317
52. Kaiser UB, Sabbagh E, Katzenellenbogen RA, Conn PM, Chin WW 1995 A mechanism for the differential regulation of gonadotropin subtmit gene expression by gonadotropin-releasing hormone. Proc Natl Acad Sci USA 92: 12280-12284
53. Gur G, Bonfil D, Safarian H, Naor Z, Yaron Z 2002 GnRH signaling pathways regulate differentially the tilapia gonadotropin subunit genes Mol Cell Endocrinol 189:125-134