Genetics of obesity: More complicated than initially thought

Lipids

Volumn 38, Issue 2, 2003, Pages 97-101

  Shuldiner, Alan R ^a   Munir, Kashif M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENVIRONMENTAL IMPACT; HEALTH CARE; PHOSPHOLIPIDS;

OBESITY;

GENES;

BETA 3 ADRENERGIC RECEPTOR; CARBOXYPEPTIDASE H; LEPTIN; LEPTIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

BODY MASS; CALORIC INTAKE; CONFERENCE PAPER; DNA SEQUENCE; ENVIRONMENTAL FACTOR; ETHNIC DIFFERENCE; GENETIC RISK; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN GENOME; LIFESTYLE; MOLECULAR CLONING; MUTATION; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSICAL ACTIVITY; PREVALENCE;

ANIMALS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION; OBESITY; RECEPTORS, ADRENERGIC, BETA-3; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0037316383     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-003-1037-5     Document Type: Conference Paper

References (42)

1. O'Brien, P.E., and Dixon, J.B. (2002) The Extent of the Problem of Obesity, Am. J. Surg. 184, S4-S8.
2. National Center for Health Statistics, Prevalence of Overweight and Obesity Among Adults, National Center for Health Statistics, Centers for Disease Control and Prevention, Atlanta, available at: www.cdc.gov/nchs/products/pubs/pubd/hestats/obese/ obse99.htm (accessed February 13, 2003).
3. Adler, A. (2002) Obesity and Target Organ Damage: Diabetes, Int. J. Obes. Relat. Metab. Disord. 26, S11-S14.
4. Flegal, K.M., Carroll, M.D., Ogden, C.L., and Johnson, C.L. (2002) Prevalence and Trends in Obesity Among U.S. Adults, 1999-2000, JAMA 288, 1723-1727.
5. Pi-Sunyer, F.X. (2002) The Medical Risks of Obesity, Obes. Surg. 12, S6-S11.
6. Stunkard, A.J., Sorensen, T.I., Hanis, C., Teasdale, T.W., Chakraborty, R., Schull, W.J., and Schulsinger, F. (1986) An Adoption Study of Human Obesity, N. Engl. J. Med. 314, 193-198.
7. Allison, D.B., Kaprio, J., Korkeila, M., Koskenvuo, M., Neale, M.C., and Hayakawa, K. (1996) The Heritability of Body Mass Index Among an International Sample of Monozygotic Twins Reared Apart, Int. J. Obes. Relat. Metab. Disord. 20, 501-506.
8. Coady, S.A., Jaquish, C.E., Fabsitz, R.R., Larson, M.G., Cupples, L.A., and Myers, R.H. (2002) Genetic Variability of Adult Body Mass Index: A Longitudinal Assessment in Framingham Families, Obes. Res. 10, 675-681.
9. Rice, T., Perusse, L., Bouchard, C., and Rao, D.C. (1999) Familial Aggregation of Body Mass Index and Subcutaneous Fat Measures in the Longitudinal Québec Family Study, Genet. Epidemiol. 16, 316-334.
10. Comuzzie, A.G., Blangero, J., Mahaney, M.C., Haffner, S.M., Mitchell, B.D., Stern, M.P., and MacCluer, J.W. (1996) Genetic and Environmental Correlations Among Hormone Levels and Measures of Body Fat Accumulation and Topography, J. Clin. Endocrinol. Metab. 81, 597-600.
11. Neel, J.V. (1962) Diabetes Mellitus; A "Thrifty" Genotype Rendered Detrimental by Progress? Am. J. Hum. Genet. 14, 353-363.
12. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J.M. (1994) Positional Cloning of the Mouse Obese Gene and Its Human Homologue, Nature 372, 425-432.
13. Chen, H., Charlat, O., Tartaglia, L.A., Woolf, E.A., Weng, X., Ellis, S.J., Lakey, N.D., Culpepper, J., Moore, K.J., Breitbart, R.E., et al. (1996) Evidence That the Diabetes Gene Encodes the Leptin'Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice, Cell 84, 491-495.
14. Naggert, J.K., Fricker, L.D., Varlamov, O., Nishina, P.M., Rouille, Y., Steiner, D.F., Carroll, R.J., Paigen, B.J., and Leiter, E.H. (1995) Hyperproinsulinaemia in Obese Fat/Fat Mice Associated with a Carboxypeptidase E Mutation Which Reduces Enzyme Activity, Nat. Genet. 10, 135-142.
15. Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J., and Cone, R.D. (1997) Role of Melanocortinergic Neurons in Feeding and the Agouti Obesity Syndrome, Nature 385, 165-168.
16. Kleyn, P.W., Fan, W., Kovats, S.G., Lee, J.J., Pulido, J.C., Wu, Y., Berkemeier, L.R., Misumi, D.J., Holmgren, L., Charlat, O., et al. (1996) Identification and Characterization of the Mouse Obesity Gene Tubby: A Member of a Novel Gene Family, Cell 85, 281-290.
17. Nagle, D.L., McGrail, S.H., Vitale, J., Woolf, E.A., Dussault, B.J., Jr., DiRocco, L., Holmgren, L., Montagno, J., Bork, P., Huszar, D., et al. (1999) The Mahogany Protein Is a Receptor Involved in Suppression of Obesity, Nature 398, 148-152.
18. Clement, K., Vaisse, C., Lahlou, N., Cabrol, S. Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.M., et al. (1998) A Mutation in the Human Leptin Receptor Gene Causes Obesity and Pituitary Dysfunction, Nature 392, 398-401.
19. Montague, C.T., Farooqi, I.S., Whitehead, J.P., Soos, M.A., Rau, H., Wareham, N.J., Sewter, C.P., Digby, J.E., Mohammed, S.N., Hurst, J.A., et al. (1997) Congenital Leptin Deficiency Is Associated with Severe Early-Onset Obesity in Humans, Nature 387, 903-908.
20. Jackson, R.S., Creemers, J.W., Ohagi, S., Raffin-Sanson, M.L., Sanders, L., Montague, C.T., Hutton, J.C., and O'Rahilly, S. (1997) Obesity and Impaired Prohormone Processing Associated with Mutations in the Human Prohormone Convertase 1 Gene, Nat. Genet. 16, 303-306.
21. Farooqi, I.S., Yeo, G.S., Keogh, J.M., Aminian, S., Jebb, S.A., Butler, G., Cheetham, T., and O'Rahilly, S. (2000) Dominant and Recessive Inheritance of Morbid Obesity Associated with Melanocortin 4 Receptor Deficiency, J. Clin. Invest. 106, 271-279.
22. Rankinen, T., Perusse, L., Weisnagel, S.J., Snyder, E.E., Chagnon, Y.C., and Bouchard, C. (2002) The Human Obesity Gene Map: The 2001 Update, Obes. Res. 10, 196-243.
23. 3-Adrenergic-Receptor Gene, N. Engl. J. Med. 333, 343-347.
24. 3-Adrenergic-Receptor Gene with Features of the Insulin Resistance Syndrome in Finns, N. Engl. J. Med. 333, 348-351.
25. 3-Adrenergic-Receptor and Increased Capacity to Gain Weight in Patients with Morbid Obesity, N. Engl. J. Med. 333, 352-354.
26. Yen, C.J., Beamer, B.A., Negri, C., Silver, K., Brown, K.A., Yarnall, D.P., Burns, D.K., Roth, J., and Shuldiner, A.R. (1997) Molecular Scanning of the Human Peroxisome Proliferator Activated Receptor γ (HPPAR γ) Gene in Diabetic Caucasians: Identification of a Pro12A1a PPARγ2 Missense Mutation, Biochem. Biophys. Res. Commun. 241, 270-274.
27. Beamer, B.A., Yen, C.J., Andersen, R.E., Muller, D., Elahi, D., Cheskin, L.J., Andres, R., Roth, J., and Shuldiner, A.R. (1998) Association of the Pro12A1a Variant in the Peroxisome Proliferator-Activated Receptor-γ2 Gene with Obesity in Two Caucasian Populations, Diabetes 47, 1806-1808.
28. 3-Adrenoceptor Gene Forms a Well-Conserved Haplotype That Is Associated with Moderate Obesity and Altered Receptor Function, Diabetes 48, 203-205.
29. 3-Adrenoceptor Gene Variant, Diabetes 49, 1709-1713.
30. 3-Adrenergic Receptor Is Associated with Visceral Obesity but Decreased Serum Triglyceride, Diabetologia 40, 469-472.
31. 3-Adrenergic-Receptor Polymorphism: A Genetic Marker for Visceral Fat Obesity and the Insulin Resistance Syndrome, Diabetologia 40, 200-204.
32. 3-Adrenoceptor: When Does a Candidate Gene Become a Disease Susceptibility Gene? Obes. Res. 9, 806-809.
33. 2b-Adrenoceptor Gene Polymorphisms on Fat Mass in Caucasian Women, Diabetes 50, 91-95.
34. Hsueh, W.C., Cole, S.A., Shuldiner, A.R., Beamer, BA., Blangero, J., Hixson, J.E., MacCluer, J.W., and Mitchell, B.D. (2001) Interactions Between Variants in the β3-Adrenergic Receptor and Peroxisome Proliferator-Activated Receptor-γ2 Genes and Obesity, Diabetes 24, 672-677.
35. 3-Adrenergic Receptor, Diabetes 51, 880-883.
36. Deeb, S.S., Fajas, L., Nemoto, M., Pihlajamaki, J., Mykkanen, L., Kuusisto, J., Laakso, M., Fujimoto, W., and Auwerx, J. (1998) Pro12A1a Substitution in PPARγ2 Associated with Decreased Receptor Activity, Lower BMI and Improved Insulin Sensitivity, Nat. Genet. 20, 284-287.
37. Celi, F.S., and Shuldiner, A.R. (2002) The Role of Peroxisome Proliferator-Activated Receptor Gamma in Diabetes and Obesity, in Current Diabetes Reports (Elbein, S., ed.), pp. 179-185, Current Sciences, Philadelphia.
38. Stumvoll, M., and Haring, H. (2002) The Peroxisome Proliferator-Activated Receptor-γ2 Pro12A1a Polymorphism, Diabetes 51, 2341-2347.
39. Altshuler, D., Hirschhorn, J.N., Klannemark, M., Lindgren, C.M., Vohl, M.C., Nemesh, J., Lane, C.R., Schaffner, S.F., Bolk, S., Brewer, C., et al. (2000) The Common PPARγ Pro12A1a Polymorphism Is Associated with Decreased Risk of Type 2 Diabetes, Nat. Genet. 26, 76-80.
40. Cole, S.A., Mitchell, B.D., Hsueh, W.C., Pineda, P., Beamer, B.A., Shuldiner, A.R., Comuzzie, A.G., Blangero, J., and Hixson, J.E. (2000) The Pro12A1a Variant of Peroxisome Proliferator-Activated Receptor-γ2 (PPAR-γ2) Is Associated with Measures of Obesity in Mexican Americans, Int. J. Obes. Relat. Metab. Disord. 24, 522-524.
41. Nicklas, B.J., vanRossum, E.F.C., Berman, D.M., Ryan, A.S., Dennis, K.E., and Shuldiner, A.R. (2001) Genetic Variation in the Peroxisome Proliferator-Activated Receptor-γ2 Gene (Pro12A1a) Affects Metabolic Responses to Weight Loss and Subsequent Weight Gain, Diabetes 50, 2172-2176.
42. Luan, J., Browne, P.O., Harding, A.H., Halsall, D.J., O'Rahilly, S., Chatterjee, V.K., and Wareham, N.J. (2001) Evidence for Gene-Nutrient Interaction at the PPARγ Locus, Diabetes 50, 686-689.