HCMV glycoprotein US6 mediated inhibition of TAP does not affect HLA-E dependent protection of K-562 cells from NK cell lysis

Human Immunology

Volumn 64, Issue 2, 2003, Pages 231-237

  Ulbrecht, Matthias ^a   Hofmeister, Valeska ^a   Yüksekdag, Gülnihål ^a   Ellwart, Joachim W ^b   Hengel, Hartmut ^a   Momburg, Frank ^c   Martinozzi, Silvia ^d   Reboul, Murielle ^d   Pla, Marika ^d   Weiss, Elisabeth H ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d SAINT LOUIS HOSPITAL   (France)

Author keywords

HLA E; Human cytomegalovirus; Killer inhibitory receptor; MHC class I; NK cell

Indexed keywords

CARRIER PROTEIN; CD94 ANTIGEN; EPITOPE; HLA E ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN US6; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

EID: 0037316287     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(02)00788-7     Document Type: Article

References (26)

1. Ploegh HL: Viral strategies of immune evasion. Science 280:248, 1998.
2. Biron CA, Byron KS, Sullivan JL: Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med 320:1731, 1989.
3. Ciccone E, Pende D, Vitale M, Nanni L, Di Donato C, Bottino C, Morelli L, Viale O, Amoroso A, Moretta A, Moretta L: Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells. Eur J Immunol 24:1003, 1994.
4. Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML: A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 7:273, 1997.
5. Leong CC, Chapman TL, Bjorkman PJ, Formankova D, Mocarski ES, Phillips JH, Lanier LL: Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: the role of endogenous class I major histocompatibility complex and a viral class I homolog. J Exp Med 187:1681, 1998.
6. Schust DJ, Tortorella D, Seebach J, Phan C, Ploegh HL: Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. J Exp Med 188:497, 1998.
7. Huard B, Früh K: A role for MHC class I down-regulation in NK cell lysis of herpes virus-infected cells. Eur J Immunol 30:509, 2000.
8. Jun Y, Kim E, Jin M, Sung HC, Han H, Geraghty DE, Ahn K: Human cytomegalovirus gene products US3 and US6 down-regulate trophoblast class I MHC molecules J Immunol 164:805, 2000.
9. Tomasec P, Braud VM, Rickards C, Powell MB, McSharry BP, Gadola S, Cerundolo V, Borysiewicz LK, McMichael AJ, Wilkinson GW: Surface expression of HLA-E a? inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science 287:1031, 2000.
10. Ulbrecht M, Martinozzi S, Grezeschik M, Hengel H, Ellwart JW, Pla M, Weiss EH: Cutting edge: the humar cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis. J Immunol 164:5019, 2000.
11. Borrego F, Ulbrecht M, Weiss EH, Coligan JE, Brooks AG: Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J Exp Med 187:813, 1998.
12. Braud VM, Allan DS, O'Callaghan CA, Soderstrom K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 391:795, 1998.
13. Lee N, Llano M, Carretero M, Ishitani A, Navarro F, Lopez-Botet M, Geraghty DE: HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci USA 95:5199, 1998.
14. Braud VM, Allan DS, Wilson D, McMichael AJ: TAP-and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. Curr Biol 8:1, 1998.
15. Lee N, Goodlett DR, Ishitani A, Marquardt H, Geraghty DE: HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences. J Immunol 160:4951, 1998.
16. Pacasova R, Martinozzi S, Boulouis HJ, Szpak Y, Ulbrecht M, Sigaux F, Weiss EH, Pla M: Cell surface detection of HLA-E gene products with a specific monoclonal antibody. J Reprod Immunol 43:195, 1999.
17. Hengel H, Koopmann JO, Flohr T, Muranyi W, Goulmy E, Hämmerling GJ, Koszinowski UH, Momburg F: A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter. Immunity 6:623, 1997.
18. Martinozzi S, Pacasova R, Boulouis HJ, Ulbrecht M, Weiss EH, Sigaux F, Pla M: Cutting edge: requirement of class I signal sequence-derived peptides for HLA-E recognition by a mouse cytotoxic T cell clone. J Immunol 162:5662, 1999.
19. Ohe Y, Zhao D, Saijo N, Podack ER: Construction of a novel bovine papillomavirus vector without detectable transforming activity suitable for gene transfer. Hum Gene Ther 6:325, 1995.
20. Crisa L, McMaster MT, Ishii JK, Fisher SJ, Salomon DR: Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts. J Exp Med 186:289, 1997.
21. 2-microglobulin and allelic differences. Eur J Immunol 29:537, 1999.
22. Koopmann JO, Post M, Neefjes JJ, Hämmerling GJ, Momburg F: Translocation of long peptides by transporters associated with antigen processing (TAP). Eur J Immunol 26:1720, 1996.
23. Momburg F, Roelse J, Hämmerling GJ, Neefjes JJ: Peptide size selection by the major histocompatibility complex-encoded peptide transporter. J Exp Med 179:1613, 1994.
24. Lemberg MK, Bland FA, Weihofen A, Braud VM, Martoglio B: Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes. J Immunol 167:6441, 2001.
25. Bai A, Aldrich CJ, Forman J: Factors controlling the trafficking and processing of a leader-derived peptide presented by Qa-1. J Immunol 165:7025, 2000.
26. Zhu H, Cong JP, Mamtora G, Gingeras T, Shenk T: Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc Natl Acad Sci USA 95:14470, 1998.