Specific effects of polyunsaturated fatty acids on gene expression

Current Opinion in Lipidology

Volumn 7, Issue 1, 1996, Pages 53-55

  Baillie, Rebecca A ^a   Jump, Donald B ^b   Clarke, Steven D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIVER ENZYME; PEROXISOME PROLIFERATOR; POLYUNSATURATED FATTY ACID; PROTEIN; TRANSCRIPTION FACTOR;

DNA TRANSCRIPTION; GENE EXPRESSION; HUMAN; LIPOGENESIS; PRIORITY JOURNAL; SHORT SURVEY; TRANSCRIPTION REGULATION;

ANIMALS; DIETARY FATS, UNSATURATED; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0029875558     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199602000-00012     Document Type: Short Survey

References (16)

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2. Clarke SD, Jump DB: Dietary polyunsaturated fatty acid regulation of gene transcription. Ann Rev Nutr 1994, 14:83-98. An excellent review of all the work done in the field of polyunsaturated fatty acids and gene expression up to 1993.
3. Clarke SD, Armstrong MK, Jump DB: Dietary polyunsaturated fats uniquely suppress rat liver fatty acid synthase and S14 mRNA content J Nutr 1990, 120:225-232.
4. Girard J, Perdereau D, Foufelle F, Prip-Buus C, Ferrre P: Regulation of lipogenic enzyme gene expression by nutrients and hormones. FASEB J 1994, 8:36-42.
5. Clarke BA, Clarke SD: Suppression of rat liver fatty acid synthesis by elcosa-5,8,11,14-tetraynoic acid without a reduction in lipogenic enzymes. J Nutr 1982, 112:1212-1219.
6. Jump DB, Clarke SD, Thelen A, Liimatta M: Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res 1994, 35:1076-1084. This study emphasizes the regulation of multiple genes by PUFAs using both animals and isolated hepatocytes to show transcriptional regulation.
7. Liimatta M, Towle HC, Clarke SD, Jump DB: Dietary polyunsaturated fatty acids interfere with the insulin/glucose activation of L-type pyruvate kinase gene transcription. Mol Endo 1994, 8:1147-01153. Polyunsaturated fatty acids regulate transcription of the pyruvate kinase gene. Mutational analysis is used to isolate and characterize the PUFA response site.
8. Jump DB, Clarke SD, MacDougald OA, Thelen A: Polyunsaturated fatty acids inhibit S14 gene transcription in rat liver and cultured hepatocytes. Proc Natl Acad Sci USA 1993, 90:8454-8458.
9. Landschulz KT, Jump DB, MacDougald OA, Lane MD: Transcriptional control of the stearoyl-CoA desaturase-1 gene by polyunsaturated fatty acids. Biochem Biophys Res Comm 1994, 200:763-768. This study gives direct evidence that PUFAs regulate stearoyl-CoA desaturase-1 transcription coordinately with other lipogenic genes.
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13. Green S, Wahli W: Peroxisomal proliferator-activated receptors: finding the orphan a home. Mol Cell Endocrinol 1994, 100:149-153.
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15. Iritani N, Hosomi H, Fukuda H, Ikeda H: Polyunsaturated fatty acid regulation of lipogenic enzyme gene expression in liver of genetically obese rat. Biochim Biophys Acts 1995, 1255:1-8.
16. Jump DB, Ren B, Clarke SD, Thelen A: Effects of fatty acids on hepatic gene transcription. Prostaglandins Leukot and Essent Fatty Acids 1995, 52:107-111. In gel motility shift assays using binding of purified PPAR and RXR, the PUFA response region of the S14 gene did not compete with an acyl-CoA oxidase PPAR response element.