Equilibrium and transition between single- and double-headed binding of kinesin as revealed by single-molecule mechanics

Biophysical Journal

Volumn 84, Issue 2 I, 2003, Pages 1103-1113

  Kawaguchi, Kenji ^a   Uemura, Sotaro ^a   Ishiwata, Shin'Ichi ^a  

^a WASEDA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; KINESIN;

ARTICLE; BINDING AFFINITY; HISTOGRAM; MATHEMATICAL ANALYSIS; MICROTUBULE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; YOUNG MODULUS;

EID: 0037306229     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(03)74926-1     Document Type: Article

References (34)

1. Block, S. M., L. S. B. Goldstein, and B. J. Schnapp. 1990. Bead movement by single kinesin molecules studied with optical tweezers. Nature. 348:348-352.
2. Coppin, C. M., D. W. Pierce, L. Hsu, and R. D. Vale. 1997. The load dependence of kinesin's mechanical cycle. Proc. Natl. Acad. Sci. USA. 94:8539-8544.
3. Coy, D. L., M. Wagenbach, and J. Howard. 1999. Kinesin takes one 8-nm step for each ATP that it hydrolyzes. J. Biol. Chem. 276:3667- 3671.
4. Crevel, I. M., A. Lockhart, and R. A. Cross. 1996. Weak and strong states of kinesin and NCD. J. Mol. Biol. 257:66-76.
5. Cross, R. A. 1995. On the hand over hand footsteps of kinesin heads. J. Muscle Res. Cell Motil. 16:91-94.
6. Gittes, F., E. Meyhöfer, S. Baek, and J. Howard. 1996. Directional loading of the kinesin motor molecule as it buckles a microtubule. Biophys. J. 70:418-429.
7. Hackney, D. D. 1994. Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis. Proc. Natl. Acad. Sci. USA. 91:6865-6869.
8. Hancock, W. O., and J. Howard. 1999. Kinesin's processivity results from mechanical and chemical coordination between the ATP hydrolysis cycles of the two motor domains. Proc. Natl. Acad. Sci. USA. 96: 13147-13152.
9. Higuchi, H., E. Muto, Y. Inoue, and T. Yanagida. 1997. Kinetics of force generation by single kinesin molecules activated by laser photolysis of caged ATP. Proc. Natl. Acad. Sci. USA. 94:4395-4400.
10. Hirokawa, N. 1998. Kinesin and dynein superfamily proteins and mechanism of organelle transport. Science. 279:519-526.
11. Hirose, K., A. Lockhart, R. A. Cross. and L. A. Amos. 1995. Nucleotide-dependent angular change in kinesin motor domain bound to tubulin. Nature. 376:277-279.
12. Hoenger, A., M. Thormahlen, R. Diaz-Avalos, M. Doerhoefer, K. N. Goldie, J. Muller, and E. Mandelkow. 2000. A new look at the microtubule binding patterns of dimeric kinesins. J. Mol. Biol. 297: 1087-1103.
13. Howard, J. 1996. The movement of kinesin along microtubules. Annu. Rev. Physiol. 58:703-729.
14. Hua, W., E. C. Young, M. L. Fleming, and J. Gelles. 1997. Coupling of kinesin steps to ATP hydrolysis. Nature. 388:390-393.
15. Hyman, A. A. 1991. Preparation of marked microtubules for the assay of the polarity of microtubule-based motors by fluorescence. J. Cell Sci. 14:125-127.
16. Kawaguchi, K., and S. Ishiwata. 2000. Temperature dependence of force, velocity and processivity of single kinesin molecules. Biochem. Biophys. Res. Commun. 272:895-899.
17. Kawaguchi, K., and S. Ishiwata. 2001a. Nucleotide-dependent single- to double-headed binding of kinesin. Science. 291:667-669.
18. Kawaguchi, K., and S. Ishiwata. 2001b. Thermal activation of single kinesin molecules with temperature pulse microscopy. Cell Motil. Cytoskeleton. 49:41-47.
19. Kojima, H., E. Muto, H. Higuchi, and T. Yanagida. 1997. Mechanics of single kinesin molecules measurement by optical trapping nanometry. Biophys. J. 73:2012-2022.
20. Mandelkow, E., and K. A. Johnson, 1998. The structural and mechanochemical cycle of kinesin. TIBS. 23:429-433.
21. Merkel, R., P. Nassoy, A. Leung, K. Ritchie, and E. Evans. 1999. Energy landscapes of receptor-ligand explored with dynamic force spectroscopy. Nature. 397:50-53.
22. Nishizaka, T., T. Miyata, H. Yoshikawa, S. Ishiwata, and K. Kinosita, Jr. 1995. Unbinding force of a single motor molecule of muscle measured using optical tweezers. Nature. 377:251-254.
23. Nishizaka, T., R. Seo, H. Tadakuma, K. Kinosita, Jr., and S. Ishiwata. 2000. Characterization of single actomyosin rigor bonds - load-dependence of lifetime and mechanical properties. Biophys. J. 79:962-974.
24. Rice, S., A. W. Lin, D. Safer, C. L. Hart, N. Naber, B. O. Carragher, S. M. Cain, E. Pechatnikova, E. M. Wilson-Kubalek, M. Whittaker, E. Pate, R. Cooke, E. W. Taylor, R. A. Milligan, and R. D. Vale. 1999. A structural change in the kinesin motor protein that drives motility. Nature. 402:778-784.
25. Schnitzer, M. J., and S. M. Block. 1997. Kinesin hydrolyses one ATP per 8-nm step. Nature. 388:386-390.
26. Strunz, T., K. Oroszlan, I. Schumakovitch, H.-J. Güntherodt, and M. Hegner. 2000. Model energy landscapes and the force-induced dissociation of ligand-receptor bonds. Biophys. J. 79:1206-1212.
27. Svoboda, K., C. F. Schmidt, B. J. Schnapp, and S. M. Block. 1993. Direct observation of kinesin stepping by optical trapping interferometry. Nature. 365:721-727.
28. Svoboda, K., and S. M. Block. 1994. Force and velocity measured for single kinesin molecules. Cell. 77:773-784.
29. Uemura, S., K. Kawaguchi, J. Yajima, M. Edamatsu, Y. Y. Toyoshima, and S. Ishiwata. 2002. Kinesin-microtubule binding is dependent on both nucleotide state and loading direction. Proc. Natl. Acad. Sci. USA. 99: 5977-5981.
30. Vale, R. D., T. Funatsu, D. W. Pierce, L. Romberg, Y. Harada, and T. Yanagida, 1996. Direct observation of single kinesin molecules moving along microtubules. Nature. 380:451-453.
31. Vale, R. D. 1999. Guidebook to the Cytoskeletal and Motor Proteins, 2nd ed. T. E. Kreis, editor. Oxford University Press, Oxford, England. 398-402.
32. Vale, R. D., and R. A. Milligan. 2000. The way things move: looking under the hood of molecular motor proteins. Science. 288: 88-95.
33. Woehlke, G., A. K. Ruby, C. L. Hart, B. Ly, N. Hom-Booher, and R. D. Vale. 1997. Microtubule interaction site of the kinesin motor. Cell. 90: 207-216.
34. Wong, S. S., E. Joselevich, A. T. Woolley, C. L. Cheung, and C. M. Lieber. 1998. Covalently functionalized nanotubes as nanometer-sized probes in chemistry and biology. Nature. 394:52-55. 1114-11231