Mechanism of enhanced lipid peroxidation in the liver of Long-Evans cinnamon (LEC) rats

Archives of Toxicology

Volumn 73, Issue 8-9, 1999, Pages 457-464

  Yamamoto, Hideki ^a,b   Hirose, Kyogo ^a   Hayasaki, Yayoi ^a   Masuda, Makihiko ^a   Kazusaka, Akio ^a   Fujita, Shoichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Copper; Hepatitis; Hydroxyl radical; Lipid peroxidation; Long Evans cinnamon (LEC) rats

Indexed keywords

BUTYLCRESOL; CATALASE; COPPER; EDETIC ACID; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; S 9;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; LIPID PEROXIDATION; LIVER METABOLISM; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; WILSON DISEASE;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; BLOTTING, WESTERN; CATALASE; COPPER; EDETIC ACID; ELECTRON SPIN RESONANCE SPECTROSCOPY; FEMALE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LIPID PEROXIDATION; LIVER; RATS; RATS, INBRED LEC; SUBCELLULAR FRACTIONS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0033428679     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050635     Document Type: Article

References (51)

1. Aust SD, Morehouse LA, Thomas CE (1985) Role of metals in oxygen radicals reactions. Free Radic Biol Med 1: 3-25
2. Bacon BR, O'Neill R, Britton RS (1993) Hepatic mitochondrial energy production in rats with chronic iron overload. Gastroenterology 105: 1134-1140
3. Beers RF Jr, Sizer IW (1952) A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195: 133-140
4. Britton RS (1996) Metal-induced hepatotoxicity. Semin Liver Dis 16: 3-12
5. Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52: 302-310
6. Burkitt MJ, Mason RP (1991) Direct evidence for in vivo hydroxyl-radical generation in experimental iron overload: an ESR spin-trapping investigation. Proc Natl Acad Sci USA 88: 8440-8444
7. Burkitt MJ, Gilbert BC (1990) Model studies of the iron-catalyzed Haber-Weiss cycle and the ascorbate-driven Fenton reaction. Free Radic Res Commun 10: 265-280
8. Carney JM, Floyd RA (1991) Protection against oxidative damage to CNS by alpha-phenyl-tert-butylnitrone (PBN) and other spin-trapping agents: a novel series of nonlipid free radical scavengers. J Mol Neurosci 3: 47-57
9. Clerch LB, Iqbal J, Massaro D (1991) Perinatal rat lung catalase gene expression: influence of corticosteroid and hyperoxia. Am J Physiol 260: L428-L433
10. Halliwell B (1991) Reactive 1:oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 91(Suppl 3C): 14S-22S
11. Halliwell B, Gutteridge JMC (1984) Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219: 1-5
12. Halliwell B, Gutteridge JMC, Cross E (1992) Free radicals, anti-oxidants and human disease: where are we now? J Lab Clin Med 119: 598-620
13. Hildebrandt AG, Roots I, Tjoe M, Heinemeyer G (1978) Hydrogen peroxide in hepatic microsomes. Methods Enzymol 52: 342-350
14. Imai I, Ito A, Sato R (1966) Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J Biochem 60: 417-428
15. Kachur AV, Koch CJ, Biaglow JE (1998) Mechanism of copper-catalyzed oxidation of glutathione. Free Radic Res 28: 259-269
16. Kadiiska MB, Hannan PM, Hernandez L, Mason RP (1992) In vivo evidence of hydroxyl radical formation after acute copper and ascorbic acid intake: electron spin resonance spin-trapping investigation. Mol Pharmacol 42: 723-729
17. Ko IY, Park SS, Song BJ, Patten C, Tan Y, Hah Y, Yang CS, Gelboin HV (1987) Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitro-soamines. Cancer Res 47: 3101-3109
18. Koizumi M, Fujii K, Suzuki K, Inoue T, Gutteridge JMC, Taniguchi N (1998) A marked increase in free copper levels in the plasma and liver of LEC rats: an animal model for Wilson's disease and liver cancer. Free Radic Res 28: 441-450
19. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
20. Li Y, Togashi Y, Sato S, Emoto T, Kang JH, Takeichi N, Kobayashi H, Kojima Y, Une Y, Uchino J (1991) Spontaneous hepatic copper accumulation in Long-Evans cinnamon rats with hereditary hepatitis: a model of Wilson's disease. J Clin Invest 87: 1858-1861
21. Lowry OH, Rosebrough NJ, Far AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275
22. Ma Y, Zhang D, Kawabata T, Kiriu T, Toyokuni S, Uchida K, Okada S (1997) Copper and iron-induced oxidative damage in non-tumor bearing LEC rats. Pathol Int 47: 203-208
23. Masters BSS, Williams CH Jr, Kamin H (1967) The preparation and properties of microsomal TPNH-cytochrome c reductase from pig liver. Methods Enzymol 10: 565-573
24. Minkel DT, Poulsen K, Weilgus S, Shaw CF, Petering DH (1980) On the sensitivity of metallothioneins to oxidation during isolation. Biochem J 191: 475-485
25. Muramatsu Y, Yamada T, Miura M, Sakai T, Suzuki Y, Serikawa T, Tanji RE, Matsumoto K (1994) Wilson' s disease gene is homologous to hts causing abnormal copper transport in Long-Evans cinnamon rats. Gastroenterology 107: 1189-1192
26. Nappi AJ, Vass E (1997) Comparative studies of enhanced iron-mediated production of hydroxyl radical by glutathione, cysteine, ascorbic acid, and selected catechols. Biochim Biophys Acta 1336: 295-301
27. Ogihara H, Ogihara T, Miki M, Yasuda H, Mino M (1995) Plasma copper and antioxidant status in Wilson's disease. Pediatr Res 37: 219-226
28. Omura T, Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. J Biol Chem 239: 2370-2378
29. Ossola JO, Groppa MD, Tomaro ML (1997) Relationship between oxidative stress and heme oxygenase induction by copper sulfate. Arch Biochem Biophys 337: 332-337
30. Paglia DE, Valentine WN (1967) Studies on the quantitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158-169
31. Prasad R, Kaur G, Nath R, Walia BN (1996) Molecular basis of pathophysiology of Indian childhood cirrhosis: role of nuclear copper accumulation in liver. Mol Cell Biochem 156: 25-30
32. Rui M, Suzuki KT (1997) Copper in plasma reflects its status and subsequent toxicity in the liver of LEC rats. Res Commun M Pharmacol 98: 335-346
33. Rohrdanz E, Kahl R (1998) Alterations of antioxidant enzyme expression in response to hydrogen peroxide. Free Radic Biol Med 24: 27-38
34. Sakurai H, Nakajima K, Kamada H, Satoh H, Otaki N, Kimura M, Kawano K, Hagino T (1993) Copper-metallothionein distribution in the liver of Long-Evans cinnamon rats: studies on immunohistochemical staining, metal determination, gel nitration and electron spin resonance spectroscopy. Biochem Biophys Res Commun 192: 893-898
35. Sakurai H, Satoh H, Hatanaka A, Sawada T, Kawano K, Nagino T, Nakajima K (1994) Unusual generation of hydroxyl radicals in hepatic copper-metallothionein of LEC (Long-Evans Cinnamon) rats in the presence of hydrogen peroxide. Biochem Biophys Res Commun 199: 313-318
36. Sen S, Goldman H, Morehead M, Murphy S, Philips JW (1994) alpha-Phenyl-tert-butyl-nitrone inhibits free radical release in brain concussion. Free Radic Biol Med 16: 685-691
37. Sevanian A, Nordenbrand K, Kim E, Ernster L, Hochstein P (1990) Microsomal lipid peroxidation: the role of NADPH-cytochrome reductase and cytochrome P450. Free Radic Biol Med 8: 145-152
38. Sokol RJ, Devereaux MW, Mierau GW, Hambidge KM, Shikes RH (1990) Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload: modification by vitamin E deficiency. Gastroenterology 99: 1061-1071
39. Sokol RJ, Devereaux MW, O'Brien K, Khandwala RA (1993) Abnormal hepatic mitochondrial respiration and cytochrome C oxidase activity in rats with long-term copper overload. Gastroenterology 105: 178-187
40. Sokol RJ, Twedt D, Mckim JM Jr, Devereaux MW, Karrer FM, Kam I, Von Steigman G, Narkewicz MR, Bacon BR, Britton RS, Neushwander-Tetri BA (1994) Oxidant injury to hepatic mitochondria in patients with Wilson' s disease and Bedlington terriers with Cu toxicosis. Gastroenterology 107: 1788-1798
41. Sone H, Maeda M, Gotoh M, Wakabayashi K, Ono T, Yoshida MC, Takeichi N, Mori M, Hirohashi S, Sugiyama T, Nagao M (1992) Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats. Mol Carcinogenesis 5: 199-204
42. Suemizu H, Yoshimura S, Takeichi N, Moriuchi T (1994) Decreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma. Hepatology 19: 694-700
43. Suzuki K, Miyazawa N, Nakata T, Seo HG, Sugiyama T, Taniguchi N (1993a) High copper and iron levels and expression of Mn-superoxide disumutase in mutant rats displaying hereditary hepatitis and hepatoma (LEC rats). Carcinogenesis 14: 1881-1884
44. Suzuki KT, Yamamoto K, Kanno S, Aoki Y, Takeichi N (1993b) Selective removal of copper bound to metallothionein in the liver of LEC rats by tetrathiomolybdate. Toxicology 83: 149-158
45. Suzuki KT, Rui M, Ueda J, Ozawa T (1996) Production of hydroxyl radicals by copper-containing metallothionein: roles as prooxidant. Toxicol Appl Pharmacol 141: 231-237
46. Thomas CE, Reed DJ (1989) Current status of calcium in hepatocellular injury. Hepatology 10: 375-384
47. Wu D, Cederbaum AI (1994) Characterization of pyrazole and 4-methylpyrazole induction of cytochrome P4502E1 in rat kidney. J Pharmacol Exp Ther 270: 407-413
48. Wu J, Forbes JR, Chen HS, Cox DW (1994) The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nat Genet 7: 541-545
49. Yamada T, Sogawa K, Suzuki Y, Izumi K, Agui T, Matsumoto K (1992) Elevation of the level of lipid peroxidation associated with hepatic injury in LEC mutant rats. Res Commun Chem Pathol Pharmacol 77: 121-124
50. Yamashita T, Ohshima H, Asanuma T, Inukai N, Miyoshi I, Kasai N, Kon Y, Watanabe T, Sato F, Kuwabara M (1996) The effects of alpha-phenyl-tert-butyl nitrone (PBN) on copper induced rat fulminant hepatitis with jaundice. Free Radic Biol Med 21: 755-761
51. Yoshida MC, Masuda R, Sasaki M, Takeichi N, Kobayashi H, Dempo K, Mori M (1987) New mutation causing hereditary hepatitis in the laboratory rats. J Hered 78: 361-365