Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1

Molecular Genetics and Genomics

Volumn 268, Issue 5, 2003, Pages 585-597

  Asp, E ^a   Sunnerhagen, P ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Fission yeast; Green fluorescent protein (GFP); Meiosis; Mitosis; Protein phosphorylation

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; NITROGEN; PROTEIN; PROTEIN STY1; UNCLASSIFIED DRUG;

ARTICLE; FUNGAL CELL; IMMUNOPRECIPITATION; IN VIVO STUDY; MEIOSIS; MOLECULAR BIOLOGY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY; WILD TYPE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 0037292952     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-002-0786-y     Document Type: Article

References (45)

1. Bilsland-Marchesan E, Ariño J, Saito H, Sunnerhagen P, Posas F (2000) Rck2 kinase is a substrate for the osmotic-stress activated MAP kinase Hog1. Mol Cell Biol 20:3887-3895
2. Bähler J, Wu JQ, Longtine MS, Shah NG, McKenzie A, 3rd et al. (1998) Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14:943-951
3. Brewster JL, de Valoir T, Dwyer ND, Winter E, Gustin MC (1993) An osmosensing signal transduction pathway in yeast. Science 259:1760-1763
4. Chang L, Karin M (2001) Mammalian MAP kinase signalling cascades. Nature 410:37-40
5. Dahlkvist A, Sunnerhagen P (1994) Two novel deduced serine/ threonine protein kinases from Saccharomyces cerevisiae. Gene 139:27-33
6. Dahlkvist A, Kanter-Smoler G, Sunnerhagen P (1995) The RCK1 and RCK2 protein kinase genes from Saccharomyces cerevisiae suppress cell cycle checkpoint mutations in Schizosaccharomyces pombe. Mol Gen Genet 246:316-326
7. Degols G, Russell P (1997) Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe. Mol Cell Biol 17:3356-63
8. Degols G, Shiozaki K, Russell P (1996) Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Mol Cell Biol 16:2870-2877
9. Gachet Y, Tournier S, Millar JB, Hyams JS (2001) A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast. Nature 412:352-355
10. Gutz H, Heslot H, Leupold U, Loprieno N. 1974. Schizosaccharomyces pombe. In King RC (ed) Handbook of genetics, Vol. 1: Bacteria, bacteriophages, and fungi. Plenum, New York, pp. 395-446.
11. Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415:180-183
12. Hunter T (1991) Protein kinase classification. Meth Enzymol 200:3-37
13. Kato T Jr, Okazaki K, Murakami H, Stettler S, Fantes PA, Okayama H (1996) Stress signal, mediated by a Hogl-like MAP kinase, controls sexual development in fission yeast. FEBS Lett 378:207-12
14. Kimura M, Takahata N (1983) Selective constraint in protein polymorphism: study of the effectively neutral mutation model by using an improved pseudosampling method. Proc Natl Acad Sci U S A 80:1048-52
15. Kon N, Schroeder SC, Krawchuk MD, Wahls WP (1998) Regulation of the Mts1-Mts2-dependent ade6-M26 meiotic recombination hot spot and developmental decisions by the Spc1 mitogen-activated protein kinase of fission yeast. Mol Cell Biol 18:7575-7583
16. Kotlyarov A, Neininger A, Schubert C, Eckert R, Birchmeier C et al. (1999) MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat Cell Biol 1:94-97
17. + controls the onset of sexual development via a pathway independent of the cAMP cascade. Curr Genet 28:32-38
18. +- gene, which encodes a pivotal transcription factor for sexual development. Mol Biol Cell 11:3205-3217
19. Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869
20. Li P, McLeod M (1996) Molecular mimicry in development: identification of stell+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1 + kinase. Cell 87:869-880
21. Melcher ML, Thorner J (1996) Identification and characterization of the CLK1 gene product, a novel CaM kinase-like protein kinase from the yeast Saccharomyces cerevisiae. J Biol Chem 271:29958-29968
22. Millar JB (1999) Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts. Biochem Soc Symp 64:49-62
23. Millar JB, Buck V, Wilkinson MG (1995) Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast. Genes Dev 9:2117-2130
24. Moreno S, Klar A, Nurse P (1991) Molecular genetic analysis of the fission yeast Schizosaccharomyces pombe. Meth Enzymol 194:795-823
25. + encoding syntaxin-like protein. Mol Biol Cell 12:3955-72
26. Neiman AM, Stevenson BJ, Xu HP, Sprague GF, Jr., Herskowitz I et al. (1993) Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Mol Biol Cell 4:107-120
27. Neufeld B, Grosse-Wilde A, Hoffmeyer A, Jordan BW, Chen P, Dinev D, Ludwig S, Rapp UR (2000) Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. J Biol Chem 275:20239-20242
28. Ramne A, Bilsland-Marchesan E, Erickson S, Sunnerhagen P (2000) The protein kinases Rck1 and Rck2 inhibit meiosis in budding yeast. Mol Gen Genet 263:253-261
29. Rasmussen CD (2000) Cloning of a calmodulin kinase I homologue from Schizoxaccharomycex pombe. J Biol Chem 275:685-690
30. Roberts CJ, Nelson B, Marton MJ, Stoughton R, Meyer MR et al. (2000) Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287:873-880
31. Sanchez-Piris M, Posas F, Alemany V, Winge I, Hidalgo E et al. (2002) The serine/threonine kinase Cmk2 is required for oxidative stress response in fission yeast. J Biol Chem 277:17722-17727
32. Shiozaki K, Russell P (1995a) Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature 378:739-743
33. Shiozaki K, Russell P (1995b) Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast. EMBO J 14:49-502
34. Shiozaki K, Russell P (1996) Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast. Genes Dev 10:2276-2288
35. Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (1999) Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J Biol Chem 274:2893-2898
36. Smith JA, Poteet-Smith CE, Lannigan DA, Freed TA, Zoltoski AJ, Sturgill TW (2000) Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function. J Biol Chem 275:31588-31593
37. Stettler S, Warbrick E, Prochnik S, Mackie S, Fantes P (1996) The wis1 signal transduction pathway is required for expression of cAMP- repressed genes in fission yeast. J Cell Sci 109:1927-35
38. + encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Genes Dev 5:1990-1999
39. + encodes a transcription factor required for sexual development and entry into stationary phase. EMBO J 14:6193-6208
40. Tanoue T, Adachi M, Moriguchi T, Nishida E (2000) A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat Cell Biol 2:110-116
41. Teige M, Scheikl E, Reiser V, Ruis H, Ammerer G (2001) Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast. Proc Natl Acad Sci USA 98:5625-5630
42. Toone WM, Kuge S, Samuels M, Morgan BA, Toda T, Jones N (1998) Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/ Spc1. Genes Dev 12:1453-63
43. Uetz P, Giot L, Cagney G, Mansfield TA, Judson RS et al. (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403:623-627
44. Wilkinson MG, Samuels M, Takeda T, Toone WM, Shieh JC et al. (1996) The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast. Genes Dev 10:2289-2301
45. RSK/MAPKAPK1 via ERK and JNK pathways. J Biol Chem 276:14572-14580