Alteration of the Cytokine Phenotype in an Experimental Lung Granuloma Model by Inhibiting Nitric Oxide

Journal of Immunology

Volumn 159, Issue 11, 1997, Pages 5585-5593

  Hogaboam, Cory M ^a   Chensue, Stephen W ^a,b   Steinhauser, Matthew L ^a   Huffnagle, Gary B ^a   Lukacs, Nicholas W ^a   Strieter, Robert M ^a   Kunkel, Steven L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; TUBERCULIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BIOSYNTHESIS; CBA MOUSE; DRUG ANTAGONISM; ENZYMOLOGY; EOSINOPHIL; FEMALE; IMMUNOLOGY; LUNG; LUNG DISEASE; LUNG GRANULOMA; METABOLISM; MOUSE; NEUTROPHIL; PHYSIOLOGY; TH1 CELL;

ANIMALS; CYTOKINES; EOSINOPHILS; FEMALE; GRANULOMA, RESPIRATORY TRACT; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; LUNG; LUNG DISEASES; MICE; MICE, INBRED CBA; NEUTROPHILS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; TH1 CELLS; TUBERCULIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031297365     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051.
2. Moncada, S. 1992. The L-arginine:nitric oxide pathway. Acta Physiol. Scand. 145:201.
3. Nathan, C., and J. B. Hibbs. 1991. Role of nitric oxide in macrophage antimicrobial activity. Curr. Opin. Immunol. 3:65.
4. Goldman, D., Y. Cho, M.-L. Zhao, A. Casadevall, and S. C. Lee. 1996. Expression of inducible nitric oxide synthase in rat pulmonary Cryptococcus neoformans granulomas. Am. J. Pathol. 148:1275.
5. Tsuji, M., V. B. Dimov, and T. Yoshida. 1995. In vivo expression of monokine and inducible nitric oxide synthase in experimentally induced pulmonary granulomatous inflammation: evidence for sequential production of interleukin-1, inducible nitric oxide synthase, and tumor necrosis factor. Am. J. Pathol. 147:1001.
6. Gutierrez, H. H., B. R. Pitt, M. Schwarz, S. C. Watkins, C. Lowenstein, I. Caniggia, P. Chumley, and B. A. Freeman. 1995. Pulmonary alveolar epithelial inducible NO synthase gene expression: regulation by inflammatory mediators. Am. J. Physiol. 268:L501.
7. Punjabi, C., J. Laskin, K. Pendino, N. Goller, S. Durham, and D. Laskin. 1994. Production of nitric oxide by rat type II pneumocytes: increased expression of inducible nitric oxide synthase following inhalation of a pulmonary irritant. Am. J. Respir. Cell Mol. Biol. 11:165.
8. Mulligan, M. S., J. M. Hevel, M. A. Marletta, and P. A. Ward. 1991. Tissue injury caused by deposition of immune complexes is L-arginine-dependent. Proc. Natl. Acad. Sci. USA 88:6338.
9. Meyer, J., L. D. Traber, S. Nelson, C. W. Lentz, H. Nakazada, D. N. Herndon, H. Noda, and D. L. Traber. 1992. Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of nitric oxide synthesis. J. Appl. Physiol. 73:324.
10. Habib, A., C. Bernard, M. Lebret, C. Creminon, B. Esposito, A. Tedgui, and J. Maclouf. 1997. Regulation of the expression of cyclooxygenase-2 by nitric oxide in rat peritoneal macrophages. J. Immunol. 158:3845.
11. Roisant, R., K. J. Falke, F. Lopez, K. Slama, U. Pison, and W. M. Zapol. 1993. Inhaled nitric oxide for the adult respiratory distress syndrome. N. Engl. J. Med. 328:399.
12. Boros, D. L. 1978. Granulomatous inflammations. Prog. Allergy 24:183.
13. Kunkel, S. L., N. W. Lukacs, R. M. Strieter, and S. W. Chensue. 1996. Th1 and Th2 responses regulate experimental lung granuloma development. Sarcoidosis Vasculitis Diffuse Lung Dis. 13:120.
14. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
15. Chensue, S. W., K. Warmington, J. Ruth, P. Lincoln, M.-C. Kuo, and S. L. Kunkel. 1994. Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation: production of Th1 and Th2 cytokines and relative contribution of tumor necrosis factor. Am. J. Pathol. 145: 1105.
16. Chensue, S. W., J. H. Ruth, K. Warmington, P. Lincoln, and S. L. Kunkel. 1995. In vivo regulation of macrophage IL-12 production during Type 1 and Type 2 cytokine-mediated granuloma formation. J. Immunol. 155:3546.
17. Lukacs, N. W., C. Addison, J. Gauldie, F. Graham, K. Simpson, R. M. Strieter, K. Warmington, S. W. Chensue, and S. L. Kunkel. 1997. Transgene-induced production of IL-4 alters the development and collagen expression of Th1-type pulmonary granulomas. J. Immunol. 158:4478.
18. Chensue, S. W., K. S. Warmington, J. H. Ruth, P. S. Sanghi, P. Lincoln, and S. L. Kunkel. 1996. Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation. J. Immunol. 157:4602.
19. Lukacs, N. W., S. L. Kunkel, R. M. Strieter, K. Warmington, and S. W. Chensue. 1993. The role of macrophage inflammatory protein 1 α in Schistosoma mansoni egg induced granulomatous inflammation. J. Exp. Med. 177:1551.
20. Chan, J., K. Tanaka, D. Carroll, J. Flynn, and B. R. Bloom. 1995. Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect. Immun. 63:736.
21. Rees, D. D., R. M. J. Palmer, R. Shulz, H. F. Hodson, and S. Moncada. 1990. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101:746.
22. G-monomethyl-L-arginine. J. Immunol. 146:1294.
23. Hogaboam, C. M., K. J. Jacobson, S. M. Collins, and M. G. Blennerhassett. 1995. The selective beneficial effects of nitric oxide inhibition in experimental colitis. Am. J. Physiol. 268:G673.
24. Zador, I. Z., G. D. Deshmukh, R. Kunkel, K. Johnson, and N. S. Radin. 1993. A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus. J. Clin. Invest. 91:797.
25. Standiford, T. J., M. R. Rolfe, S. L. Kunkel, J. P. I. Lynch, F. S. Becker, M. B. Orringer, S. Phan, and R. M. Strieter. 1993. Altered production and regulation of monocyte chemoattractant protein-1 from pulmonary fibroblasts isolated from patients with idiopathic pulmonary fibrosis. Chest 103:121S.
26. Lukacs, N. W., S. W. Chensue, R. E. Smith, R. M. Strieter, K. Warmington, C. Wilke, and S. L. Kunkel. 1994. Production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 α by inflammatory granuloma fibroblasts. Am. J. Pathol. 144:711.
27. Su, W. Y., B. J. Day, B. H. Kang, J. D. Crapo, Y. C. Huang, and L. Y. Chang. 1996. Lung epithelial cell-released nitric oxide protects against PMN-mediated cell injury. Am. J. Physiol. 271:L581.
28. Kubes, P., M. Suzuki, and D. N. Granger. 1991. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA 88:4651.
29. De Caterina, R., P. Libby, H. B. Peng, V. J. Thannickal, T. B. Rajavashisth, M. A. J. Gimbrone, W. S. Shin, and J. K. Liao. 1995. Nitric oxide decreases cytokine-induced endothelial cell activation: nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J. Clin. Invest. 96:60.
30. Cayatte, A. J., F. Magner, and R. A. Cohen. 1997. VCAM-1 induction by TNF in human umbilical vein endothelial cells: a regulatory mechanism sensitive to intracellular generation of reactive oxygen species and exogenous nitric oxide. FASEB J. 11:2647.
31. Lukacs, N. W., S. W. Chensue, R. M. Strieter, K. Warmington, and S. L. Kunkel. 1994. Inflammatory granuloma formation is mediated by TNF-α-inducible adhesion molecule-1. J. Immunol. 152:5883.
32. Beckman, J. S., T. W. Beckman, J. Chen, P. A. Marshall, and B. A. Freeman. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87:1620.
33. Fehsel, K., K. D. Kroncke, K. L. Meyer, H. Huber, H. Wahn, and V. Kolb-Bachofen. 1995. Nitric oxide induces apoptosis in mouse thymocytes. J. Immunol. 155:2858.
34. Lu, L., C. A. Bonham, F. G. Chambers, S. C. Watkins, R. A. Hoffman, R. L. Simmons, and A. W. Thomson. 1996. Induction of nitric oxide in mouse dendritic cells by IFN-γ, endotoxin, and interaction with allogenic T cells: nitric oxide production is associated with dendritic cell apoptosis. J. Immunol. 157: 3577.
35. Peng, H. B., P. Libby, and J. K. Liao. 1995. Induction and stabilization of IκBα by nitric oxide mediates inhibition of NFκB. J. Biol. Chem. 270:14214.
36. Peng, H. B., T. B. Rajavashisth, P. Libby, and J. K. Liao. 1995. Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells. J. Biol. Chem. 270:17050.
37. Liew, F. Y. 1995. Regulation of lymphocyte functions by nitric oxide. Curr. Opin. Immunol. 7:396.
38. Hogaboam, C. M., E. Y. Bissonnette, A. D. Befus, and J. L. Wallace. 1993. Modulation of mast cell reactivity by interleukin 1-β: divergent effects on nitric oxide and platelet activating factor. J. Immunol. 151:3767.
39. Galli, S. J., J. R. Gordon, and B. K. Wershal. 1991. Cytokine production by mast cells and basophils. Curr. Opin. Immunol. 3:865.
40. Fiorentino, D. F., A. Zlotnik, P. Vieira, T. R. Mosmann, M. Howard, K. Moore, and A. O'Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146:3444.
41. Uyemura, K., L. L. Dremer, S. C. Castle, D. Jullien, J. A. Berliner, M. K. Gately, R. R. Warrier, N. Pham, A. M. Fogelman, and R. L. Modlin. 1996. Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J. Clin. Invest. 97:2130.
42. Kunkel, S. L., N. W. Lukacs, and R. W. Strieter. 1995. Chemokines and their role in human disease. Agents Actions 46:11.
43. Taub, D. D., S. M. Turcovski, M. L. Key, D. L. Longo, and W. J. Murphy. 1996. Chemokines and T lymphocyte activation. I. β chemokines costimulate human T lymphocyte activation in vitro. J. Immunol. 156:2095.
44. Karpus, W. J., N. W. Lukacs, K. J. Kennedy, W. S. Smith, S. D. Hurst, and T. A. Barrett. 1997. Differential CC chemokine-induced enhancement of T helper cell cytokine production. J. Immunol. 158:4129.
45. Lukacs, N., S. W. Chensue, R. M. Strieter, and S. L. Kunkel. 1997. C-C chemokines differently alter IL-4 production by lymphocytes. Am. J. Pathol. 150: 1861.
46. Karpus, W. J., and N. W. Lukacs. 1996. The role of chemokines in oral tolerance: abrogation of nonresponsiveness by treatment with antimonocyte chemotactic protein-1. Ann. NY Acad. Sci. 778:133.
47. Lukacs, N. W., R. M. Strieter, S. W. Chensue, and S. L. Kunkel. 1996. Activation and regulation of chemokines in allergic airway inflammation. J. Leukocyte Biol. 59:13.
48. Orlofsky, A., E. Y. Lin, and M. B. Prystowsky. 1994. Selective induction of the β-chemokine C10 by IL-4 in mouse macrophages. J. Immunol. 152:5084.
49. Huang, P. L., T. M. Dawson, D. S. Bredt, S. H. Snyder, and M. C. Fishman. 1993. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75:1273.
50. MacMicking, J. D., C. Nathan, G. Horn, N. Chartrain, D. S. Fletcher, M. Trumbauer, K. Stevens, Q. W. Xie, K. Sokol, and N. Hutchinson. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641.
51. Shesely, E. G., N. Maeda, H. S. Kim, K. M. Desai, J. H. Krege, V. E. Laubach, P. A. Sherman, W. C. Sessa, and O. Smithies. 1996. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 93: 13176.