Unexpected protection of glomerular mesangial cells from oxidant- triggered apoptosis by bioflavonoid quercetin

American Journal of Physiology - Renal Physiology

Volumn 273, Issue 2 42-2, 1997, Pages

  Yokoo, Takashi ^a   Kitamura, Masanori ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

c Jun activator protein 1; Mesangial cell; Tyrosine kinase

Indexed keywords

ANTINEOPLASTIC AGENT; BIOFLAVONOID; ONCOPROTEIN; PROTEIN TYROSINE KINASE; QUERCETIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; EPITHELIUM CELL; FIBROBLAST CULTURE; GENE REPRESSION; GLOMERULUS; MESANGIUM CELL; NONHUMAN; ONCOGENE C JUN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0030770782     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1997.273.2.f206     Document Type: Article

References (37)

1. Abate, C., L. Patel, F. J. Rauscher III, and T. Curran. Redox regulation of Fos and Jun DNA-binding activity in vitro. Science 249: 1157-1161, 1990.
2. Arends, M. J., R. G. Morris, and A. H. Wyllie. Apoptosis: the role of the endonuclease. Am. J. Pathol. 136: 593-608, 1990.
3. Arias, J., A. S. Alberts, P. Brindle, F. X. Claret, T. Smeal, M. Karin, J. Feramisco, and M. Montminty. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370: 266-229, 1994.
4. Chomczynsky, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
5. Craig, E. A., J. S. Weissman, and A. L. Horwich. Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cells. Cell 78: 365-372, 1994.
6. Curran, T., and B. R. Franza, Jr. Fos and Jun: the AP-1 connection. Cell 55: 395-397, 1988.
7. Devary, Y., R. A. Gottlieb, T. Smeal, and M. Karin. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71: 1081-1091, 1992.
8. Devary, Y., R. A. Gottlieb, L. F. Lau, and M. Karin. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell. Biol. 11: 2804-2811, 1991.
9. Elia, G., and M. G. Santoro. Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells. Biochem. J. 300: 201-209, 1994.
10. Hansson, M., A. Asea, U. Ersson, S. Hermodsson, and K. Hellstrand. Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites. J. Immunol. 156: 42-47, 1996.
11. 2 and vanadate stimulate protein tyrosine phosphorylation in intact cells. J. Biol. Chem. 265: 2896-2902, 1990.
12. Hosokawa, N., K. Hirayoshi, A. Nakai, Y. Hosokawa, N. Marui, M. Yoshida, T. Sakai, H. Ninoshino, A. Aoike, K. Kawai, and K. Nagata. Flavonoids inhibit the expression of heat shock proteins. Cell Struct. Funct. 15: 393-401, 1990.
13. Ioannou, Y. A., and F. W. Chen. Quantitation of DNA fragmentation in apoptosis. Nucleic Acids Res. 24: 992-993, 1996.
14. Joshi-Barve, S. S., V. V. Rangnekar, S. F. Sells, and V. M. Rangnekar. Interleukin-1-inducible expression of groβ via NF-κB activation is dependent upon tyrosine kinase signaling. J. Biol. Chem. 268: 18018-18029, 1993.
15. Kitamura, M. Creation of a reversible on/off system for site-specific in vivo control of exogenous gene activity in the renal glomerulus. Proc. Natl. Acad. Sci. USA 93: 7387-7391, 1996.
16. Kitamura, M., S. Burton, J. English, H. Kawachi, and L. G. Fine. Transfer of a mutated gene encoding active transforming growth factor-β1 suppresses mitogenesis and IL-1 response in the glomerulus. Kidney Int. 48: 1747-1757, 1995.
17. Kitamura, M., T. Mitarai, N. Maruyama, R. Nagasawa, H. Yoshida, and O. Sakai. Mesangial cell behavior in a three-dimensional extracellular matrix. Kidney Int. 40: 653-661, 1991.
18. Kitamura, M., T. Sütö, T. Yokoo, F. Shimizu, and L. G. Fine. Transforming growth factor-β1 is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells. J. Immunol. 156: 2964-2971, 1996.
19. Kitamura, M., S. Taylor, R. Unwin, S. Burton, and L. G. Fine. Gene transfer into the rat renal glomerulus via a mesangial cell vector: site-specific delivery, in situ amplification, and sustained expression of an exogenous gene in vivo. J. Clin. Invest. 94: 497-505, 1994.
20. Kühnau, J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev. Nutr. Diet. 24: 117-191, 1976.
21. McDonnell, S. E., L. D. Kerr, and L. M. Matrisian. Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C. Mol. Cell. Biol. 10: 4284-4293, 1990.
22. Mehlen, P., K. Schulze-Osthoff, and A. P. Arrigo. Small stress proteins as novel regulators of apoptosis: heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death. J. Biol. Chem. 271: 16510-16514, 1996.
23. Middleton, E., and C. Kandaswami. Effects of flavonoids on immune and inflammatory cell functions. Biochem. Pharmacol. 43: 1167-1179, 1992.
24. Miller, C. C., P. Hale, and A. P. Pentland. Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation. J. Biol. Chem. 269: 3529-3533, 1994.
25. Mosser, D. D., and L. H. Martin. Induced thermotolerance to apoptosis in human T lymphocyte cell line. J. Cell. Physiol. 151: 561-570, 1992.
26. Pratt, C. B., M. V. Relling, W. H. Meyer, E. C. Douglass, S. J. Kellie, and L. Avery. Phase 1 study of flavone acetic acid (NSC 347512, LM957) in patients with pediatric malignant solid tumors. Am. J. Clin. Oncol. 14: 483-486, 1991.
27. Rovin, B. H., and L. C. Tan. Role of protein kinase pathways in IL-1-induced chemoattractant expression by human mesangial cells. Kidney Int. 46: 1059-1068, 1994.
28. Savill, J. S., A. H. Wyllie, J. E. Henson, M. J. Walport, P. M. Henson, and C. Haslett. Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J. Clin. Invest. 83: 865-875, 1989.
29. Sawai, H., T. Okazaki, H. Yamamoto, H. Okano, Y. Takeda, M. Tashima, H. Sawada, M. Okuma, H. Ishikura, H. Umehara, and N. Domae. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J. Biol. Chem. 270: 27326-27331, 1995.
30. Sellins, K. S., and J. J. Cohen. Gene induction by γ-irradiation leads to DNA fragmentation in lymphocytes. J. Immunol. 139: 3199-3206, 1987.
31. Uckun, F. M., K. G. Waddick, S. Mahajan, X. Jun, M. Tanaka, J. Bolen, and T. Kurosaki. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cell. Science 273: 1096-1100, 1996.
32. Walker, P. R., J. Kwast-Welfeld, H. Gourdeau, J. Leblanc, W. Neugebauer, and M. Sikorska. Relationship between apoptosis and the cell cycle in lymphocytes: roles of protein kinase C, tyrosine phosphorylation, and AP-1. Exp. Cell Res. 207: 142-151, 1993.
33. Wei, Y., X. Zhao, Y. Kariya, H. Fukata, K. Teshigawara, and A. Uchida. Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54: 4952-4957, 1994.
34. Yokoo, T., and M. Kitamura. c-Jun/AP-1, but not NF-κB, is a mediator for oxidant-initiated apoptosis in glomerular mesangial cells. J. Am. Soc. Nephrol. In press.
35. Yokoo, T., and M. Kitamura. Antioxidant PDTC induces stromelysin expression in mesangial cells via a tyrosine kinase-AP-1 pathway. Am. J. Physiol. 270 (Renal Fluid Electrolyte Physiol. 39): F806-F811, 1996.
36. Yokoo, T., and M. Kitamura. Dual regulation of IL-1β-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-κB and AP-1. Am. J. Physiol. 270 (Renal Fluid Electrolyte Physiol. 39): F123-F130, 1996.
37. Yokoo, T., and M. Kitamura. Opposite, binary regulatory pathways involved in IL-1-mediated stromelysin gene expression in rat mesangial cells. Kidney Int. 50: 894-901, 1996.