Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins

Journal of Medicinal Chemistry

Volumn 43, Issue 22, 2000, Pages 4160-4168

  Sun, Z Y ^a   Botros, E ^a   Su, A D ^a   Kim, Y ^a   Wang, E ^a   Baturay, N Z ^a   Kwon, C H ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [BIS(2 CHLOROETHYL)AMINO] 4 [[4 [BIS(2 CHLOROETHYL)AMINO]PHENYL]SULFINYL]BENZENE; 2 [BIS(2 CHLOROETHYL)AMINO]DIBENZOTHIOPHEN 5 ONE; 2,8 BIS[BIS(2 CHLOROETHYL)AMINO]DIBENZOTHIOPHEN 5 ONE; 4 [[4 (ACRIDIN 9 YLAMINO)PHENYL]SULFINYL] 1 [BIS(2 CHLOROETHYL)AMINO]BENZENE HYDROCHLORIDE; 4 [[4 [BIS(2 CHLOROETHYL)AMINO]PHENYL]SULFINYL] 1 NITROBENZENE; 4 [[4 [BIS(2 CHLOROETHYL)AMINO]PHENYL]SULFINYL]PHENYLAMINE; 4 [BIS(2 CHLOROETHYL)AMINO] 1 (METHYLSULFINYL)BENZENE; 4 [BIS(2 CHLOROETHYL)AMINO] 1 (PHENYLSULFINYL)BENZENE; 4 [BIS(2 CHLOROETHYL)AMINO] 1 (PROPYLSULFINYL)BENZENE; ACETALDEHYDE; BENZALDEHYDE; CHLORMETHINE; CYTOTOXIN; MENADIONE; PYRIMIDINE DERIVATIVE; SULFOXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG SYNTHESIS; HYPOXIA; NONHUMAN; REDUCTION;

AEROBIOSIS; ANAEROBIOSIS; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL HYPOXIA; CELL LINE, TRANSFORMED; CHO CELLS; CRICETINAE; MECHLORETHAMINE; OXIDATION-REDUCTION; PRODRUGS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOXIDES; TUMOR STEM CELL ASSAY;

EID: 0034597583     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9904957     Document Type: Article

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