Transactivation of human cdc2 promoter by adenovirus E1A

Current Topics in Microbiology and Immunology

Volumn 272, Issue , 2003, Pages 365-397

  Padmanabhan, R ^a   Tanimoto, A ^b   Sasaguri, Y ^c  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b TORANOMON HOSPITAL   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT BINDING FACTOR; CELL CYCLE PROTEIN; DNA; NUCLEAR FACTOR Y; ONCOPROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS; BINDING AFFINITY; BINDING SITE; CELL CYCLE; CELL PROLIFERATION; DEREGULATION; DNA BINDING; DNA SYNTHESIS; DNA TUMOR VIRUS; EUKARYOTIC CELL; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; IMMUNOPRECIPITATION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REVIEW; SERUM; TATA BOX; TRANSACTIVATION; VIRUS REPLICATION;

ADENOVIRIDAE; EUKARYOTA; TUMOR VIRUS;

EID: 0037262803     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-662-05597-7_12     Document Type: Review

References (176)

1. AGOFF SN and WU B (1994) CBF mediates adenovirus E1a trans-activation by interaction at the C-terminal promoter targeting domain of conserved region 3. Oncogene 9:3707-11
2. ALONSO CR, PESCE CG and KORNBLIHTT AR (1996) The CCAAT-binding proteins CP1 and NF-I cooperate with ATF-2 in the transcription of the fibronectin gene. J Biol Chem 271:22271-9
3. AVANTAGGIATI ML, OGRYZKO V, GARDNER K, GIORDANO A, LEVINE AS and KELLY K (1997) Recruitment of p300/CBP in p53-dependent signal pathways. Cell 89:1175-84
4. BAGCHI S, RAYCHAUDHURI P and NEVINS JR (1990) Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. Cell 62:659-69
5. BANDARA LR and LA THANGUE NB (1991) Adenovirus E1A prevents the retinoblastoma gene product from complexing with a cellular transcription factor. Nature 351:494-7
6. BARBER GN (2001) Host defense, viruses and apoptosis. Cell Death Differ 8:113-26.
7. BEACH D, DURKACZ B and NURSE P (1982) Functionally homologous cell cycle control genes in budding and fission yeast. Nature 300:706-9
8. BECK GRJ, ZERLER B and MORAN E (1998) Introduction to DNA tumor viruses: Adenovirus, Simian Virus 40, Polyomavirus. In: Human Tumor Viruses (DJ McCance, ed), pp 51-86. American Society for Microbiology Press, Washington DC
9. Bi W, WU L, COUSTRY F, DE CROMBRUGGHE B and MAITY SN (1997) DNA binding specificity of the CCAAT-binding factor CBF/NF-Y. J Biol Chem 272:26562-72
10. BRAITHWAITE AW, CHEETHAM BF, LI P, PARISH CR, WALDRON-STEVENS LK and BELLETT AJ (1983) Adenovirus-induced alterations of the cell growth cycle: a requirement for expression of E1A but not of E1B. J Virol 45:192-9
11. BUCHKOVICH K, DUFFY LA and HARLOW E (1989) The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097-105
12. CHANG ZF and LIU CJ (1994) Human thymidine kinase CCAAT-binding protein is NF-Y, whose A subunit expression is serum-dependent in human IMR-90 diploid fibroblasts. J Biol Chem 269:17893-8
13. CHELLAPPAN S, KRAUS VB, KROGER B, MUNGER K, HOWLEY PM, PHELPS WC and NEVINS JR (1992) Adenovirus E1A, simian virus 40 tumor antigen and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci USA 89:4549-53
14. CHEN H, CAMPISI J and PADMANABHAN R (1996) SV40 large T antigen transactivates the human cdc2 promoter by inducing a CCAAT box binding factor. J Biol Chem 271:13959-67
15. CHEN PL, SCULLY P, SHEW JY, WANG JY and LEE WH (1989) Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58:1193-8
16. CHODOSH LA, OLESEN J, HAHN S, BALDWIN AS, GUARENTE L and SHARP PA (1988). A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Cell 53:25-35
17. COBRINIK D (1996) Regulatory interactions among E2Fs and cell cycle control proteins. Curr Top Microbiol Immunol 208:31-61
18. COLE C (1996) Polyomavirinae. In: 'Fundamental Virology' (Fields B, Knipe D and Howley P, eds), pp 917-946. Lippencott-Raven, Philadelphia
19. CORBEIL HB and BRANTON PE (1997) Characterization of an E2F-p130 complex formed during growth arrest. Oncogene 15:657-68
20. CRESS WD and NEVINS JR (1996) Use of the E2F transcription factor by DNA tumor virus regulatory proteins. Curr Top Microbiol Immunol 208:63-78
21. CROOK T, TIDY JA and VOUSDEN KH (1991) Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell 67:547-56
22. DAGNINO L, FRY CJ, BARTLEY SM, FARNHAM P, GALLIE BL and PHILLIPS RA (1997) Expression patterns of the E2F family of transcription factors during murine epithelial development. Cell Growth Differ 8:553-63
23. DALTON S (1992) Cell cycle regulation of the human cdc2 gene. EMBO J 11:1797-1804
24. DEAN DC, BLAKELEY MS, NEWBY RF, GHAZAL P, HENNIGHAUSEN L and BOURGEOIS S (1989) Forskolin inducibility and tissue-specific expression of the fibronectin promoter. Mol Cell Biol 9:1498-506
25. DEAN DC, MCQUILLAN JJ and WEINTRAUB S (1990) Serum stimulation of fibronectin gene expression appears to result from rapid serum-induced binding of nuclear proteins to a cAMP response element. J Biol Chem 265:3522-7
26. DEAN DC, NEWBY RF and BOURGEOIS S (1988) Regulation of fibronectin biosynthesis by dexamethasone, transforming growth factor beta and cAMP in human cell lines. J Cell Biol 106:2159-70
27. DECAPRIO JA, LUDLOW JW, FIGGE J, SHEW JY, HUANG CM, LEE WH, MARSILIO E, PAUCHA E and LIVINGSTON DM (1988) SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275-83
28. DECAPRIO JA, LUDLOW JW, LYNCH D, FURUKAWA Y, GRIFFIN J, PIWNICA-WORMS H, HUANG CM and LIVINGSTON DM (1989) The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58:1085-95
29. DOERFLER W (1968) The fate of the DNA of adenovirus type 12 in baby hamster kidney cells. Proc Natl Acad Sci USA 60:636-43
30. DOERFLER W (1975) Integration of viral DNA into the host genome. Curr Top Microbiol Immunol 71:1-78
31. DOOLEY KA, MILLINDER S and OSBORNE TF (1998) Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y. J Biol Chem 273:1349-56
32. DORN A, BOLLEKENS J, STAUB A, BENOIST C and MATHIS D (1987) A multiplicity of CCAAT box-binding proteins. Cell 50:863-72
33. DRAETTA G (1990) Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends in Biochemical Sciences 15:378-383
34. DRAETTA G and BEACH D (1988) Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54:17-26
35. DRAETTA G, BEACH D and MORAN E (1988) Synthesis of p34, the mammalian homolog of the yeast cdc2+/CDC28 protein kinase, is stimulated during adenovirus-induced proliferation of primary baby rat kidney cells. Oncogene 2:553-7
36. DRAETTA G, BRIZUELA L, POTASHKIN J and BEACH D (1987) Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell 50:319-25
37. D'URSO G, MARRACCINO RL, MARSHAK DR and ROBERTS JM (1990) Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase. Science 250:786-91
38. DYSON N, BERNARDS R, FRIEND SH, GOODING LR, HASSELL JA, MAJOR EO, PIPAS JM, VANDYKE T and HARLOW E (1990) Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol 64:1353-6
39. DYSON N and HARLOW E (1992) Adenovirus E1A targets key regulators of cell proliferation. Cancer Surv 12:161-95
40. EGAN C, JELSMA TN, HOWE JA, BAYLEY ST, FERGUSON B and BRANTON PE (1988) Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5. Mol Cell Biol 8:3955-9
41. EWEN ME, XING YG, LAWRENCE JB and LIVINGSTON DM (1991) Molecular cloning, chromosomal mapping and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell 66:1155-64
42. FAGAN R, FLINT KJ and JONES N (1994) Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein. Cell 78:799-811
43. FANG F and NEWPORT JW (1991) Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell 66:731-42
44. FECHTELER K, TATZELT J, HUPPERTZ S, WILGENBUS P and DOERFLER W (1995) The mechanism of adenovirus DNA integration: studies in a cell-free system. Curr Top Microbiol Immunol 199:109-37
45. FERGUSON B, KRIPPL B, ANDRISANI O, JONES N, WESTPHAL H and ROSENBERG M (1985) E1A 13 S and 12 S mRNA products made in Escherichia coli both function as nucleus-localized transcription activators but do not directly bind DNA. Mol Cell Biol 5:2653-61
46. FLINT J and SHENK T (1989) Adenovirus E1A protein paradigm viral transactivator. Annu Rev Genet 23:141-61
47. FURUKAWA Y, PIWNICA WORMS H, ERNST TJ, KANAKURA Y and GRIFFIN JD (1990) cdc2 gene expression at the G1 to S transition in human T lymphocytes. Science 250: 805-8
48. GALLIMORE PH (1974) Viral DNA in transformed cells. II. A study of the sequences of adenovirus 2 dna in nine lines of transformed rat cells using specific fragments of the viral genome. J Mol Biol 89:49-72
49. GIRLING R, BANDARA LR, ZAMANIAN M, SORENSEN TS, XU FH and LA THANGUE NB (1993) DRTFI/E2F transcription factor: an integrator of cell-cycle events with the transcriptional apparatus. Biochem Soc Trans 21:939-42
50. GOOD L, CHEN J and CHEN KY (1995) Analysis of sequence-specific binding activity of cis-elements in human thymidine kinase gene promoter during G1/S phase transition. J Cell Physiol 163:636-44
51. GOPALAKRISHNAN S, DOUGLAS JL and QUINLAN MP (1997) Immortalization of primary epithelial cells by E1A 12 S requires late, second exon-encoded functions in addition to complex formation with pRB and p300. Cell Growth Differ 8: 541-51
52. GOTTLIEB TM and OREN M (1996) p53 in growth control and neoplasia. Biochim Biophys Acta 1287:77-102
53. GRAHAM FL, SMILEY J, RUSSELL WC and NAIRN R (1977) Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 36:59-74
54. GRAHAM FL, VAN DER EB AJ and HEIJNEKER HL (1974). Size and location of the transforming region in human adenovirus type 5 DNA. Nature 251:687-91
55. GRANA X and REDDY EP (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11:211-9
56. GU W, SHI X-L and ROEDER RG (1997) Synergistic activation of transcription by CBP and p53. Nature (Lond) 387:823-827
57. HABENER JF (1990) Cyclic AMP response element binding proteins: a cornucopia of transcription factors. Mol Endocrinol 4:1087-94
58. HANNON GJ, DEMETRICK D and BEACH D (1993) Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev 7:2378-91
59. HARLOW E, WHYTE P, FRANZA BR, Jr and SCHLEY C (1986) Association of adenovirus early-region 1 A proteins with cellular polypeptides. Mol Cell Biol 6:1579-89
60. HATAMOCHI A, GOLUMBEK PT, VAN SCHAFTINGEN E and DE CROMBRUGGHE B (1988) A CCAAT DNA binding factor consisting of two different components that are both required for DNA binding. J Biol Chem 263:5940-7
61. HOOFT VAN HUIJSDUIJNEN RA, BOLLEKENS J, DORN A, BENOIST C and MATHIS D (1987) Properties of a CCAAT box-binding protein. Nucleic Acids Res 15:7265-82
62. HOROWITZ JM, PARK SH, BOGENMANN E, CHENG JC, YANDELL DW, KAYE FJ, MINNA JD, DRYJA TP and WEINBERG RA (1990) Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci USA 87:2775-9
63. HOUWELING A, VAN DEN ELSEN PJ and VAN DER EB AJ (1980) Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA. Virology 105:537-50
64. HOWE JA, MYMRYK JS, EGAN C, BRANTON PE and BAYLEY ST (1990) Retinoblastoma growth suppressor and a 300 kDa protein appear to regulate cellular DNA synthesis. Proc Natl Acad Sci USA 87:5883-7
65. IMBRIANO C, BOLOGNESE F, GURTNER A, PIAGGIO G and MANTOVANI R (2001) HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes. J Biol Chem 276:26332-9
66. INNOCENTE SA, ABRAHAMSON JL, COGSWELL JP and LEE JM (1999) p53 regulates a G2 checkpoint through cyclin B1. Proc Natl Acad Sci USA 96:2147-52
67. JONES KA, KADONAGA JT, ROSENFELD PJ, KELLY TJ and TJIAN R (1987) A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Cell 48:79-89
68. KAO CY, TANIMOTO A, ARIMA N, SASAGURI Y and PADMANABHAN R (1999) Transactivation of the human cdc2 promoter by adenovirus E1A: E1A induces the expression and assembly of a heteromeric complex consisting of the CCAAT box binding factor, CBF/NF-Y and a 110 kDa DNA binding protein. J Biol Chem 274:23043-23051
69. KNUDSON AG (1996) Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol 122:135-40
70. KO LJ and PRIVES C (1996) p53: puzzle and paradigm. Genes Dev 10:1054-72
71. KRAMER A, CARSTENS CP, WASSERMAN WW and FAHL WE (1997) CBP/cycA, a CCAAT-binding Protein Necessary for Adhesion-dependent Cyclin A Transcription, Consists of NF-Y and a Novel Mr 115,000 Subunit. Cancer Res 57:5117-5121
72. KREK W and NIGG EA (1989) Structure and developmental expression of the chicken CDC2 kinase. EMBO J 8:3071-3078
73. KU DH, WEN SC, ENGELHARD A, NICOLAIDES NC, LIPSON KE, MARINO TA and CALABRETTA B (1993) c-myb transactivates cdc2 expression via Myb binding sites in the 5′-flanking region of the human cdc2 gene [published erratum appears in J Biol Chem 1993 Jun 15; 268(17):13010]. J Biol Chem 268:2255-9
74. LA THANGUE NB (1996) E2F and the molecular mechanisms of early cell-cycle control. Biochem Soc Trans 24:54-9
75. LANE DP and CRAWFORD LV (1979) T antigen is bound to a host protein in SV40-transformed cells. Nature 278:261-3
76. LEE EY, To H, SHEW JY, BOOKSTEIN R, SCULLY P and LEE WH (1988a) Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science 241: 218-21
77. LEE MG, NORBURY CJ, SPURR NK and NURSE P (1988b) Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein. Nature 333: 676-9
78. LEE MG and NURSE P (1987) Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature 327:31-5
79. LEVINE AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-31
80. LI Y, GRAHAM C, LACY S, DUNCAN AM and WHYTE P (1993) The adenovirus E1A-associated 130 kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev 7:2366-77
81. LILL NL, GROSSMAN SR, GINSBERG D, DECAPRIO J and LIVINGSTON DM (1997) Binding and modulation of p53 by p300/CBP coactivators. Nature 387:823-7
82. LILLIE JW, GREEN M and GREEN MR (1986) An adenovirus E1A protein region required for transformation and transcriptional repression. Cell 46:1043-51
83. LILLIE JW and GREEN MR (1989) Transcription activation by the adenovirus E1A protein. Nature 338:39-44
84. LINZER DI and LEVINE AJ (1979) Characterization of a 54 K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17:43-52
85. LIU F and GREEN MR (1990) A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1A protein. Cell 61:1217-24
86. LUCIBELLO FC, TRUSS M, ZWICKER J, EHLERT F, BEATO M and MULLER R (1995) Periodic cdc25 C transcription is mediated by a novel cell cycle-regulated repressor element (CDE). EMBO J 14:132-42
87. LUDLOW JW (1993) Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53. Faseb J 7:866-71
88. LUDLOW JW, SHON J, PIPAS JM, LIVINGSTON DM and DECAPRIO JA (1990). The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 60:387-96
89. LUKAS J, PETERSEN BO, HOLM K, BARTEK J and HELIN K (1996) Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol Cell Biol 16:1047-57
90. LUM LS, HSU S, VAEWHONGS M and WU B (1992) The hsp70 gene CCAAT-binding factor mediates transcriptional activation by the adenovirus E1A protein. Mol Cell Biol 12:2599-605
91. LUM LS, SULTZMAN LA, KAUFMAN RJ, LINZER DI and WU BJ (1990) A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. Mol Cell Biol 10:6709-17
92. MAITY SN, GOLUMBEK PT, KARSENTY G and DE CROMBRUGGHE B (1988). Selective activation of transcription by a novel CCAAT binding factor. Science 241:582-5
93. MANTOVANI R (1998) A survey of 178 NF-Y binding CCAAT boxes. Nucleic Acids Res 26:1135-43
94. MANTOVANI R, LI XY, PESSARA U, HOOFT VAN HUISJDUIJNEN R, BENOIST C and MATHIS D (1994) Dominant negative analogs of NF-YA. J Biol Chem 269:20340-6
95. MAYOL X, GRANA X, BALDI A, SANG N, HU Q and GIORDANO A (1993) Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene 8:2561-6
96. MIHARA K, CAO XR, YEN A, CHANDLER S, DRISCOLL B, MURPHREE AL, T'ANG A and FUNG YK (1989) Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science 246:1300-3
97. MILARSKI KL and MORIMOTO RI (1986) Expression of human HSP70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci USA 83:9517-21
98. MILOS PM and ZARET KS (1992) A ubiquitous factor is required for C/EBP-related proteins to form stable transcription complexes on an albumin promoter segment in vitro. Genes Dev 6:991-1004
99. MONTELL C, FISHER EF, CARUTHERS MH and BERK AJ (1982) Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site. Nature 295:380-4
100. MORAN B and ZERLER B (1988). Interactions between cell growth- regulating domains in the products of the adenovirus E1A oncogene. Mol Cell Biol 8:1756-64
101. MORAN E (1993) Interaction of adenoviral proteins with pRB and p53. Faseb J 7:880-5
102. MORGAN DO (1995) Principles of CDK regulation. Nature 374:131-4
103. MULLER H, MORONI MC, VIGO E, PETERSEN BO, BARTEK J and HELIN K (1997) Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol Cell Biol 17:5508-20
104. MURRAY AW (1992) Creative blocks: cell-cycle checkpoints and feedback controls. Nature 359:599-604
105. MURRAY AW (1995) The genetics of cell cycle checkpoints. Curr Opin Genet Dev 5:5-11
106. MYMRYK JS and BAYLEY ST (1994) Multiple pathways for activation of E2 A expression in human KB cells bythe 243R E1A protein of adenovirus type 5. Virus Res 33:89-97
107. NEVINS JR (1992) E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-9
108. NEVINS JR (1993) Disruption of cell-cycle control by viral oncoproteins. Biochem Soc Trans 21:935-8
109. NURSE P (1990) Universal control mechanism regulating onset of M-phase. Nature 344:503-8
110. NURSE P and BISSETT Y (1981) Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature 292:558-60
111. OSHIMA J, STEINMANN KE, CAMPISI J and SCHLEGEL R (1993) Modulation of cell growth, p34cdc2 and cyclin A levels by SV-40 large T antigen. Oncogene 8:2987-93
112. PAGANO M, PEPPERKOK R, LUKAS J, BALDIN V, ANSORGE W, BARTEK J and DRAETTA G (1993) Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol 121:101-11
113. PESCE CG, NOGUES G, ALONSO CR, BARALLE FE and KORNBLIHTT AR (1999). Interaction between the (-170) CRE and the (-150) CCAAT box is necessary for efficient activation of the fibronectin gene promoter by cAMP and ATF-2. FEBS Lett 457: 445-51
114. PINES J (1995) Cyclins, CDKs and cancer. Semin Cancer Biol 6:63-72
115. PIPAS JM and LEVINE AJ (2001) Role of T antigen interactions with p53 in tumorigenesis. Semin Cancer Biol 11:23-30
116. PISE-MASISON CA, DITTMER J, CLEMENS KE and BRADY JN (1997) Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y. Mol Cell Biol 17:1236-43
117. QUINLAN MP (1994) Enhanced proliferation, growth factor induction and immortalization by adenovirus E1A 12 S in the absence of E1B. Oncogene 9:2639-47
118. QUINLAN MP, WHYTE P and GRODZICKER T (1988) Growth factor induction by the adenovirus type 5 E1A 12 S protein is required for immortalization of primary epithelial cells. Mol Cell Biol 8:3191-203
119. RAMACHANDRA M, NAKANO R, MOHAN PM, RAWITCH AB and PADMANABHAN R (1993) Adenovirus DNA polymerase is a phosphoprotein. J Biol Chem 268:442-8
120. RAMACHANDRA M and PADMANABHAN R (1993) Adenovirus DNA polymerase is phosphorylated by a stably associated histone H1 kinase. J Biol Chem 268:17448-56
121. RAMACHANDRA M and PADMANABHAN R (1995) Expression, nuclear transport and phosphorylation of adenovirus DNA replication proteins. Curr Top Microbiol Immunol 199:50-88
122. RAO L, DEBBAS M, SABBATINI P, HOCKENBERY D, KORSMEYER S and WHITE E (1992) The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19 kDa and Bcl-2 proteins. Proc Natl Acad Sci USA 89:7742-6
123. RAYCHAUDHURI P, BAGCHI S, DEVOTO SH, KRAUS VB, MORAN E and NEVINS JR (1991) Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. Genes Dev 5: 1200-11
124. REED SI, HADWIGER JA and LORINCZ AT (1985) Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28. Proc Natl Acad Sci USA 82:4055-9
125. RIABOWOL K, DRAETTA G, BRIZUELA L, VANDRE D and BEACH D (1989) The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57: 393-401
126. RULEY HE (1983) Adenovirus early region 1 A enables viral and cellular transforming genes to transform primary cells in culture. Nature 304:602-6
127. SARNOW P, HO YS, WILLIAMS J and LEVINE AJ (1982) Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell 28:387-94
128. SCOLNICK DM, CHEHAB NH, STAVRIDI ES, LIEN MC, CARUSO L, MORAN E, BERGER SL and Halazonetis TD (1997) CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Res 57:3693-6
129. SHARP PA, PETTERSSON U and SAMBROOK J (1974) Viral DNA in transformed cells. I. A study of the sequences of adenovirus 2 DNA in a line of transformed rat cells using specific fragments of the viral genome. J Mol Biol 86:709-26
130. SHENK T and FLINT J (1991) Transcriptional and transforming activities of the adenovirus E1A proteins. Adv Cancer Res 57:47-85
131. SIMANIS V and NURSE P (1986) The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation. Cell 45:261-8
132. SIMON MC, KITCHENER K, KAO HT, HICKEY E, WEBER L, VOELLMY R, HEINTZ N and NEVINS JR (1987) Selective induction of human heat shock gene transcription by the adenovirus E1A gene products, including the 12 S E1A product. Mol Cell Biol 7:2884-90
133. SINHA S, MAITY SN, LU J and DE CROMBRUGGHE B (1995) Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc Natl Acad Sci USA 92:1624-8
134. SLANSKY JE and FARNHAM PJ (1996) Transcriptional regulation of the dihydrofolate reductase gene. Bioessays 18:55-62
135. STILLMAN B (1996) Cell cycle control of DNA replication. Science 274:1659-64
136. SUBRAMANIAN T, BOYD JM and CHINNADURAI G (1995) Functional substitution identifies a cell survival promoting domain common to adenovirus E1B 19 kDa and Bcl-2 proteins. Oncogene 11:2403-9
137. SUBRAMANIAN T and CHINNADURAI G (2001) Interaction of cellular apoptosis regulating proteins with adenovirus anti-apoptosis protein E1B-19 K. Methods Mol Biol 177:211-8
138. SUBRAMANIAN T, KUPPUSWAMY M, NASR RJ and CHINNADURAI G (1988) An N-terminal region of adenovirus E1A essential for cell transformation and induction of an epithelial cell growth factor. Oncogene 2:105-12
139. SUGARMAN JL, SCHONTHAL AH and GLASS CK (1995) Identification of a cell-type-specific and E2F-independent mechanism for repression of cdc2 transcription. Mol Cell Biol 15:3282-90
140. SUGRUE MM, SHIN DY, LEE SW and AARONSON SA (1997) Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc Natl Acad Sci USA 94:9648-53
141. SUNDSETH R, MACDONALD G, TING J and KING AC (1997) DNA elements recognizing NF-Y and Sp1 regulate the human multidrug-resistance gene promoter. Mol Pharmacol 51:963-71
142. TANIMOTO A, CHEN H, KAO CY, MORAN E, SASAGURI Y and PADMANBHAN R (1998a) Transactivation of the human cdc2 promoter by adenovirus E1A in cycling cells is mediated by induction of a 110 kDa CCAAT-box-binding factor. Oncogene 17: 3103-3114
143. TANIMOTO A, KAO CY, CHANG CC, SASAGURI Y and PADMANABHAN R (1998b) Deregulation of cdc2 gene expression correlates with overexpression of a 110 kDa CCAAT box binding factor in transformed cells. Carcinogenesis 19:1735-41
144. TAO Y, KASSATLY RF, CRESS WD and HOROWITZ JM (1997) Subunit composition determines E2F DNA-binding site specificity. Mol Cell Biol 17:6994-7007
145. TAYLOR WR, SCHONTHAL AH, GALANTE J and STARK GR (2001) p130/E2F4 binds to and represses the cdc2 promoter in response to p53. J Biol Chem 276:1998-2006
146. TAYLOR WR and STARK GR (2001) Regulation of the G2/M transition by p53. Oncogene 20:1803-15
147. TEMPLETON D and ECKHART W (1982) Mutation causing premature termination of the polyoma virus medium T antigen blocks cell transformation. J Virol 41:1014-24
148. TOMMASI S and PFEIFER GP (1995) In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol Cell Biol 15:6901-13
149. TREISMAN R, NOVAK U, FAVALORO J and KAMEN R (1981) Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein. Nature 292:595-600
150. TRENTIN JJ, VAN HOOSIER GL, Jr and SAMPER L (1968) The oncogenicity of human adenoviruses in hamsters. Proc Soc Exp Biol Med 127:683-9
151. TSAI L.-H, HARLOW E and MEYERSON M (1991) Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature 353: 174-177
152. WANG HG, DRAETTA G and MORAN E (1991) E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products. Mol Cell Biol 11:4253-65
153. WANG HG, MORAN E and YACIUK P (1995) E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity. J Virol 69:7917-24
154. WANG HG, RIKITAKE Y, CARTER MC, YACIUK P, ABRAHAM SE, ZERLER B and MORAN E (1993) Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth. J Virol 67:476-88
155. WEINBERG RA (1985) The action of oncogenes in the cytoplasm and nucleus. Science 230:770-6
156. WEINTRAUB SJ, CHOW KN, LUO RX, ZHANG SH, HE S and DEAN DC (1995). Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-5
157. WEINTRAUB SJ and DEAN DC (1992) Interaction of a common factor with ATF, Sp1, or TATAA promoter elements is required for these sequences to mediate transactivation by the adenoviral oncogene E1A. Mol Cell Biol 12:512-7
158. WEINTRAUB SJ, PRATER CA and DEAN DC (1992) Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358:259-61
159. WERNESS BA, LEVINE AJ and HOWLEY PM (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-9
160. WHITE E (1993) Regulation of apoptosis by the transforming genes of the DNA tumor virus adenovirus. Proc Soc Exp Biol Med 204:30-9
161. WHITE E (1996) Life, death and the pursuit of apoptosis. Genes Dev 10:1-15
162. WHYTE P, BUCHKOVICH KJ, HOROWITZ JM, FRIEND SH, RAYBUCK M, WEINBERG RA and HARLOW E (1988) Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334: 124-9
163. WHYTE P, WILLIAMSON NM and HARLOW E (1989) Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75
164. WILLIAMS GT, MCCLANAHAN TK and MORIMOTO RI (1989) E1A transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Mol Cell Biol 9:2574-87
165. WINBERG G and SHENK T (1984) Dissection of overlapping functions within the adenovirus type 5 E1A gene. EMBO J 3:1907-12
166. WU BJ, KINGSTON RE and MORIMOTO RI (1986) Human HSP70 promoter contains at least two distinct regulatory domains. Proc Natl Acad Sci USA 83:629-33
167. WU BJ and MORIMOTO RI (1985) Transcription of the human hsp70 gene is induced by serum stimulation. Proc Natl Acad Sci USA 82:6070-4
168. YAMAMOTO KK, GONZALEZ GA, MENZEL P, RIVIER J and MONTMINY MR (1990) Characterization of a bipartite activator domain in transcription factor CREB. Cell 60:611-7
169. YU L, WU Q, YANG CP and HORWITZ SB (1995) Coordination of transcription factors, NF-Y and C/EBP beta, in the regulation of the mdr1b promoter. Cell Growth Differ 6:1505-12
170. YUN J, CHAE HD, CHOY HE, CHUNG, J, YOO HS, HAN MH and SHIN DY (1999) p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor. J Biol Chem 274:29677-82
171. ZERFASS K, SPITKOVSKY D, SCHULZE A, JOSWIG S, HENGLEIN B and JANSEN-DURR P (1996) Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107. J Virol 70:2637-42
172. ZERLER B, MORAN B, MARUYAMA K, MOOMAW J, GRODZICKER T and RULEY HE (1986) Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells. Mol Cell Biol 6:887-99
173. ZERLER B, ROBERTS RJ, MATHEWS MB and MORAN E (1987) Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products. Mol Cell Biol 7:821-9
174. ZWICKER J, GROSS C, LUCIBELLO FC, TRUSS M, EHLERT F, ENGELAND K and MULLER R (1995a) Cell cycle regulation of cdc25 C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1. Nucleic Acids Res 23: 3822-30
175. ZWICKER J, LUCIBELLO FC, WOLFRAIM LA, GROSS C, TRUSS M, ENGELAND K and MULLER R (1995b) Cell cycle regulation of the cyclin A, cdc25 C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J 14:4514-22
176. ZWICKER J and MULLER R (1997) Cell-cycle regulation of gene expression by transcriptional repression. Trends Genet 13:3-6