The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease

Experimental Neurology

Volumn 175, Issue 1, 2002, Pages 98-111

  Armstrong, Richard J E ^a   Hurelbrink, Carrie B ^a   Tyers, Pam ^a   Ratcliffe, Emma L ^a   Richards, Andrew ^b   Dunnett, Stephen B ^c   Rosser, Anne E ^c   Barker, Roger A ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Imutran Ltd (A Novartis Pharma AG Company)   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Cell therapy; EGF; FGF 2; Neural stem cell; Tyrosine hydroxylase; Xenotransplantation

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; DOPAMINERGIC NERVE CELL; EMBRYO; NERVE TRANSPLANTATION; NEUROCHEMISTRY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SWINE; XENOGRAFT; XENOTRANSPLANTATION;

EID: 0036251017     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.7889     Document Type: Article

References (80)

1. Estimation of nuclear population from microtome sections
2. Fetal mesencephalic neurons survive and extend long axons across peripheral nervous system grafts inserted into the adult rat striatum
3. Porcine neural xenografts in the immunocompetent rat: Immune response following grafting of expanded neural precursor cells
4. Neural stem cell transplantation as an approach to brain repair
5. Neural stem cell technology as a novel treatment for Parkinson's disease
6. The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum
7. A role for complement in the rejection of porcine ventral mesencephalic xenografts in a rat model of Parkinson's disease
8. Reformation of the nigrostriatal pathway by fetal dopaminergic micrografts into the substantia nigra is critically dependent on the age of the host
9. Cell replacement therapies for central nervous system disorders
10. Intracerebral grafting of neuronal cell suspensions. II. Survival and growth of nigral cell suspensions implanted in different brain sites
11. Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro
12. Functional and anatomical reconstruction of the 6-hydroxydopamine lesioned nigrostriatal system of the adult rat
13. Functional effects of mesencephalic dopamine neurons and adrenal chromaffin cells grafted to the rodent striatum
14. Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats
15. Heparin, but not other proteoglycans potentiates the mitogenic effects of FGF-2 on mesencephalic precursor cells
16. Co-expression of glial fibrillary acidic protein and vimentin in reactive astrocytes following brain injury in rats
17. Activin co-operates with fibroblast growth factor 2 to regulate tyrosine hydroxylase expression in the basal forebrain ventricular zone progenitors
18. Generation of tyrosine hydroxylase-producing neurons from precursors of the embryonic and adult forebrain
19. Pig fetal septal neurons implanted into the hippocampus of aged or cholinergic deafferented rats grow axons and form cross-species synapses in appropriate target regions
20. Cytoarchitectonic development, axon-glia relationships, and long distance axon growth of porcine striatal xenografts in rats
21. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
22. Cell therapy in Parkinson's disease - Stop or go?
23. Intracerebral grafting of neuronal cell suspensions. IV. Behavioural recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different forebrain sites
24. Mechanisms of function of neural grafts in the adult mammalian brain
25. Topographic factors affecting the functional viability of dopamine-rich grafts in the neostriatum
26. Nigrostriatal reconstruction after 6-OHDA lesions in rats: Combination of dopamine-rich nigral grafts and nigrostriatal "bridge" grafts
27. Astrocytic and neuronal factors affecting axon regeneration in the damaged central nervous system
28. Transplantation of embryonic dopamine neurons for severe Parkinson's disease
29. Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain
30. Cell therapy
31. Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex
32. α-Gal is widely expressed in embryonic porcine stem cells and neural tissue
33. Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat
34. Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres
35. A primate model of Huntington's disease: Cross-species implantation of striatal precursor cells to the excitotoxically lesioned baboon caudate-putamen
36. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system
37. Neuroepithelial stem cells from the embryonic spinal cord: Isolation, characterization, and clonal analysis
38. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
39. CNS stem cells express a new class of intermediate filament protein
40. Clinical observations after neural transplantation in Parkinson's disease
41. Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines
42. Analysis of neural stem cells by flow cytometry: Cellular differentiation modifies patterns of MHC expression
43. NeuN, a neuronal specific nuclear protein in vertebrates
44. Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation
45. Neural xenotransplantation: Reconstruction of neuronal circuitry across species barriers
46. Prevention of mouse-rat brain xenograft rejection by a combination therapy of cyclosporin A, prednisolone and azathioprine
47. Xenotransplantation
48. Triple immunosuppression protects murine intracerebral, hippocampal xenografts in adult rat hosts: Effects on cellular infiltration, major histocompatibility complex antigen induction and bloodbrain barrier leakage
49. Glial-restricted precursors are derived from multipotent neuroepithelial stem cells
50. Proliferation, differentiation, and long-term culture of primary hippocampal neurons
51. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
52. The morphological development of neurons derived from EGF- and FGF-2-driven human CNS precursors depends on their site of integration in the neonatal rat brain
53. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain
54. Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene
55. Immunocytochemical demonstration of vimentin in astrocytes and ependymal cells of developing and adult mouse nervous system
56. Dopamine cells in nigral grafts differentiate prior to implantation
57. Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
58. Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonion rats
59. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
60. Neural stem cells in the developing central nervous system: Implications for cell therapy through transplantation
61. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease
62. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system
63. Restricted growth potential of rat neural precursors as compared to mouse
64. A new method for the rapid and long term growth of human neural precursor cells
65. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures
66. Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina
67. Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system
68. Differential neurite growth on astrocyte substrates: Interspecies facilitation in green fluorescent protein-transfected rat and human neurons
69. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation
70. Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes
71. Is there a neural stem cell in the mammalian forebrain?
72. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
73. Axon outgrowth from grafts of human embryonic spinal cord in the lesioned adult rat spinal cord
74. Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts
75. Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats
76. The Lund transplant program for Parkinson's disease and patients with MPTP-induced Parkinsonism
77. A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra
78. Transplantation in the rat model of Parkinson's disease: Ectopic versus homotopic graft placement
79. Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors