The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin

Molecular Microbiology

Volumn 47, Issue 2, 2003, Pages 495-506

  Camougrand, Nadine ^a   Grelaud Coq, Angela ^a   Marza, Esther ^a   Priault, Muriel ^a   Bessoule, Jean Jacques ^a   Manon, Stéphen ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; LIPID; PROTEIN BAX; RAPAMYCIN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL MEMBRANE; CONTROLLED STUDY; FERMENTATION; FUNGAL GENE; GENE UTH1; MAMMAL CELL; MITOCHONDRION; MUTATION; NONHUMAN; OUTER MEMBRANE; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; YEAST;

ANTIBIOTICS, ANTIFUNGAL; APOPTOSIS; AUTOPHAGY; BCL-2-ASSOCIATED X PROTEIN; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HEAT-SHOCK PROTEINS; LIPID METABOLISM; MITOCHONDRIA; MUTATION; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SACCHAROMYCES CEREVISIAE PROTEINS; SIROLIMUS; YEASTS;

MAMMALIA;

EID: 0037238512     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2003.03311.x     Document Type: Article

References (51)

1. Abeliovich, H., and Klionsky, D.J. (2001) Autophagy in yeast: mechanistic insights and physiological function. Microbiol Mol Biol Rev 65: 463-479.
2. Abudugupur, A., Mitsui, K., Yokota, S., and Tsurugi, K. (2002) An ARL1 mutation affected autophagic cell death in yeast, causing a defect in central vacuole formation. Cell Death Diff 9: 158-168.
3. Arico, S., Petiot, A., Bauvy, C., Dubbelhuis, P.F., Meijer, A.J., Codogno, P., and Ogier-Denis, E. (2001) The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 276: 35243-35246.
4. Arico, S., Pattingre, S., Bauvy, C., Gane, P., Barbat, A., Codogno, P., and Ogier-Denis, E. (2002) Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer cell line HT-29. J Biol Chem 277: 27613-27621.
5. Arnoult, D., Akarid, K., Grodet, A., Petit, P.X., Estaquier, J., and Ameisen, J.C. (2002) On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization. Cell Death Diff 9: 65-81.
6. Austriaco, N.R. (1996) Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. Yeast 12: 623-630.
7. Bandara, P.D., Flattery-O'Brien, J.A., Grant, C.M., and Dawes, I.W. (1998) Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative-stress response. Curr Genet 34: 259-268.
8. Beck, T., and Hall, M.N. (1999) The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402: 689-692.
9. Bursch, W. (2001) The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Diff 8: 569-581.
10. Camougrand, N., and Rigoulet, M. (2001) Studies of some genes involved both in aging and in response to oxidative stress. Respir Physiol 128: 393-401.
11. Camougrand, N., Mouassite, M., Velours, G., and Guérin, M. (2000) The 'SUN' family: UTH1, an ageing gene, is also involved in the regulation of mitochondria biogenesis in Saccharomyces cerevisiae. Arch Biochem Biophys 375: 154-160.
12. Campbell, C.L., and Thorsness, P.E. (1998) Escape of mitochondrial DNA to the nucleus in yme1 yeast is mediated by vacuolar-dependent turnover of abnormal mitochondrial compartments. J Cell Sci 111: 2455-2464.
13. De Jong, A.J., Yakimova, E.T., Kapchina, V.M., and Woltering, E.J. (2002) A critical role for ethylene in hydrogen peroxide release during programmed cell death in tomato suspension cells. Planta 214: 537-545.
14. George, M.D., Baba, M., Scott, S.V., Mizushima, N., Garrisson, B.S., Ohsumi, Y., and Klionsky, D.J. (2000) Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways. Mol Biol Cell 11: 969-982.
15. Greenhalf, W., Stephan, C., and Chaudhuri, B. (1996) Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae. FEBS Lett 380: 169-175.
16. Hammond, E.M., Brunet, C.L., Johnson, G.D., Parkhill, J., Milner, A.E., Brady, G.,et al. (1998) Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast. FEBS Lett 425: 391-395.
17. Heitman, J., Movva, N.R., and Hall, M.N. (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253: 905-909.
18. Kametaka, S., Matsuura, A., Wada, Y., and Ohsumi, Y. (1996) Structural and functional analyses of APG5, a gene involved in autophagy in yeast. Gene 178: 139-143.
19. Kennedy, B.K., Austriaco, N.R., Zhang, J., and Guarente, L. (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80: 485-496.
20. Klionsky, D.J., and Emr, S.D. (2000) Autophagy as a regulated pathway of cellular degradation. Science 290: 1717-1721.
21. Laun, P., Pichova, A., Madeo, F., Fuchs, J., Ellinger, A., Kohlwein, S.,et al. (2001) Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol Microbiol 39: 1166-1173.
22. Law, R.H.P., Manon, S., Devenish, R.J., and Nagley, P. (1995) ATP synthase from Saccharomyces cerevisiae. Methods Enzymol 260: 133-163.
23. Lemasters, J.J., Nieminen, A.L., Qian, T., Trost, L.C., Elmore, S.P., Nishimura, Y.,et al. (1998) The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1366: 177-196.
24. Liang, X.H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., and Levine, B. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676.
25. Ligr, M., Madeo, F., Fröhlich, E., Hilt, W., Fröhlich, K.U., and Wolf, D.H. (1998) Mammalian Bax triggers apoptotic changes in yeast. FEBS Lett 438: 61-65.
26. Ludovico, P., Rodrigues, F., Almeida, A., Silva, M.T., Barrientos, A., and Corte-Real, M. (2002) Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Mol Biol Cell 13: 2598-2606.
27. Madeo, F., Fröhlich, E., and Fröhlich, K.U. (1997) A yeast mutant showing diagnostic markers of early and late apoptosis. J Cell Biol 139: 729-734.
28. Madeo, F., Fröhlich, E., Ligr, M., Grey, M., Sigrist, S.J., Wolf, D.H., and Fröhlich, K.U. (1999) Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol 145: 757-767.
29. Madeo, F., Herker, E., Maldener, C., Wissing, S., Lachelt, S., Herlan, M.,et al. (2002) A caspase-related protease regulates apoptosis in yeast. Mol Cell 9: 911-917.
30. Manon, S., Chaudhuri, B., and Guérin, M. (1997) Release of cytochrome c and decrease of cytochrome c oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-xL. FEBS Lett 415: 29-32.
31. Manon, S., Priault, M., and Camougrand, N. (2001) Mito-chondrial AAA-type protease Yme1p is involved in Bax effects on cytochrome c oxidase. Biochem Biophys Res Commun 289: 1314-1319.
32. Marchetti, P., Castedo, M., Susin, S.A., Zamzami, N., Hirsch, T., Macho, A.,et al. (1996) Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 184: 1155-1160.
33. Marza, E., Camougrand, N., and Manon, S. (2002) Bax expression protects yeast plasma membrane against ethanol-induced permeabilization. FEBS Lett 521: 47-52.
34. Masters, S.C., and Fu, H. (2001) 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem 276: 45193-45200.
35. Mignotte, B., and Vayssière, J.L. (1998) Mitochondria and apoptosis. Eur J Biochem 252: 1-15.
36. Mouassite, M., Guérin, M., and Camougrand, N. (2000a) The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity. FEMS Microbiol Lett 182: 137-141.
37. Mouassite, M., Camougrand, N., Schwob, E., Demaison, G., Laclau, M., and Guérin, M. (2000b) The 'SUN' family: yeast SUN4/SCW3 is involved in cell septation. Yeast 16: 905-919.
38. Oliver, L., Priault, M., Tremblais, K., Le Cabellec, M.T., Meflah, K., Manon, S., and Vallette, F.M. (2000) The substitution of the C-terminus of bax by that of bcl-xL does not affect its subcellular localization but abrogates its pro-apoptotic properties. FEBS Lett 487: 161-165.
39. Pavlov, E.V., Priault, M., Pietkiewicz, D., Cheng, E.H., Antonsson, B., Manon, S.,et al. (2001) A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast. J Cell Biol 155: 725-731.
40. Petiot, A., Ogier-Denis, E., Blommaart, F., Meijer, A.J., and Codogno, P. (2000) Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 275: 992-998.
41. Priault, M., Chaudhuri, B., Clow, A., Camougrand, N., and Manon, S. (1999a) Investigation of bax-induced release of cytochrome c from yeast mitochondria permeability of mitochondrial membranes, role of VDAC and ATP requirement. Eur J Biochem 260: 684-691.
42. Priault, M., Camougrand, N., Chaudhuri, B., and Manon, S. (1999b) Role of the C-terminal domain of Bax and Bcl-XL in their localization and function in yeast cells. FEBS Lett 443: 225-228.
43. Priault, M., Camougrand, N., Chaudhuri, B., Schaeffer, J., and Manon, S. (1999c) Comparison of the effects of bax-expression in yeast under fermentative and respiratory conditions. investigation of the role of adenine nucleotides carrier and cytochrome c. FEBS Lett 456: 232-238.
44. Priault, M., Bessoule, J.J., Grelaud-Coq, A., Camougrand, N., and Manon, S. (2002) Bax-induced cell death depends on mitochondrial lipid oxidation Eur J Biochem 269: 5440-5450.
45. Roucou, X., Prescott, M., Devenish, R.J., and Nagley, P. (2000) A cytochrome c-GFP fusion is not released from mitochondria into the cytoplasm upon expression of Bax in yeast cells. FEBS Lett 471: 235-239.
46. Shafer, K.S., Hanekamp, T., White, K.H., and Thorsness, P.E. (1999) Mechanisms of mitochondrial DNA escape to the nucleus in the yeast Saccharomyces cerevisiae. Curr Genet 36: 183-194.
47. Subramanian, R.R., Masters, S.C., Zhang, H., and Fu, H. (2001) Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis. Exp Cell Res 271: 142-151.
48. Takeshige, K., Baba, M., Tsuboi, S., Noda, T., and Ohsumi, Y. (1992) Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J Cell Biol 119: 301-311.
49. Velours, G., Boucheron, C., Manon, S., and Camougrand, N. (2002) Dual cell wall/mitochondria localization of the 'SUN' family proteins. FEMS Microbiol Lett 207: 165-172.
50. Xue, L., Fletcher, G.C., and Tolkovsky, A.M. (1999) Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution. Mol Cell Neurosci 14: 180-198.
51. Zhou, X.M., Liu, Y., Payne, G., Lutz, R.J., and Chittenden, T. (2000) Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155. J Biol Chem 275: 25046-25051.