Brain lipid metabolism in the cPLA2 knockout mouse

Journal of Lipid Research

Volumn 44, Issue 1, 2003, Pages 109-117

  Rosenberger, Thad A ^a   Villacreses, Nelly E ^a   Contreras, Miguel A ^a   Bonventre, Joseph V ^b   Rapoport, Stanley I ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Arachidonate; Docosahexaenoate; Kinetics; Phospholipase A2; Phospholipid; Turnover

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; LINOLEIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE A2; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; ENCEPHALITIS; ESTERIFICATION; KNOCKOUT MOUSE; LIPID BLOOD LEVEL; LIPID BRAIN LEVEL; LIPID METABOLISM; MEMBRANE FLUIDITY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ARACHIDONIC ACID; BRAIN; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; GENE DELETION; KINETICS; LIPID METABOLISM; LIPIDS; MICE; MICE, KNOCKOUT; PHOSPHOLIPASES A; TRITIUM;

EID: 0037237777     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M200298-JLR200     Document Type: Article

References (75)

1. 2+- dependent translocation domain with homology to PKC and GAP. Cell. 65: 1043-1051.
2. 2 enzymes: classification and characterization. Biochim. Biophys. Acta. 1488: 1-19.
3. 2. Adv. Second Messenger Phosphoprotein Res. 28: 81-89.
4. 2 and its role in brain tissue. J. Neurochem. 69: 889-901.
5. Molloy, G. Y., M. Rattray, and R. J. Williams. 1998. Genes encoding multiple forms of phospholipase A2 are expressed in rat brain. Neurosci. Lett. 258: 139-142.
6. DeGeorge, J. J., T. Nariai, S. Yamazaki, W. M. Williams, and S. I. Rapoport. 1991. Arecoline-stimulated brain incorporation of intravenously administered fatty acids in unanesthetized rats. J. Neurochem. 56: 352-355.
7. Garcia, M. C., and H. Y. Kim. 1997. Mobilization of arachidonate and docosahexaenoate by stimulation of the 5-HT2A receptor in rat C6 glioma cells. Brain Res. 768: 43-48.
8. 3H]arachidonic acid from blood in rat brain synaptosomal fractions before and after cholinergic stimulation. J. Neurochem. 67: 822-829.
9. Kim, H. Y., L. Edsall, M. Garcia, and H. Zhang. 1999. The release of polyunsaturated fatty acids and their lipoxygenation in the brain. Adv. Exp. Med. Biol. 447: 75-85.
10. Bazan, N. G. 1998. The neuromessenger platelet-activating factor in plasticity and neurodegeneration. Prog. Brain Res. 118: 281-291.
11. 2 and G proteins. Trends Neurosci. 18: 64-65.
12. 2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism. Biochem. J. 323: 281-287.
13. Brooks, R. C., K. D. McCarthy, E. G. Lapetina, and P. Morell. 1989. Receptor-stimulated phospholipase A2 activation is coupled to influx of external calcium and not to mobilization of intracellular calcium in C62B glioma cells. J. Biol. Chem. 264: 20147-20153.
14. 2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis. Proc. Natl. Acad. Sci. USA. 87: 2187-2191.
15. 2. J. Neurochem. 64: 2765-2772.
16. Brusa, R. 1999. Genetically modified mice in neuropharmacology. Pharmacol. Res. 39: 405-419.
17. 2 in ischemic and toxic brain injury. Neurochem. Res. 25: 745-753.
18. 2. Nature. 390: 622-625.
19. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J. Biol. Chem. 268: 1960-1964.
20. 2 activity. Neurochem. Res. 23: 887-892.
21. 2 is a target for chronic lithium in rat brain. Neuroreport. 10: 3887-3890.
22. Sapirstein, A., and J. V. Bonventre. 2000. Specific physiological roles of cytosolic phospholipase A2 as defined by gene knockouts. Biochim. Biophys. Acta. 1488: 139-148.
23. 2 are resistant to MPTP neurotoxicity. J. Neurochem. 71: 2634-2637.
24. Shimizu, T., and L. S. Wolfe. 1990. Arachidonic acid cascade and signal transduction. J. Neurochem. 55: 1-15.
25. Fitzpatrick, F. A., and R. Soberman. 2001. Regulated formation of eicosanoids. J. Clin. Invest. 107: 1347-1351.
26. 3H]arachidonate in the anesthetized rat. J. Neurochem. 63: 727-736.
27. 2 gene in inbred mouse strains. J. Biol. Chem. 270: 22378-22385.
28. Radin, N. S. 1981. Extraction of tissue lipids with a solvent of low toxicity. Methods Enzymol. 72: 5-7.
29. Jolly, C. A., T. Hubbell, W. D. Behnke, and F. Schroeder. 1997. Fatty acid binding protein: stimulation of microsomal phosphatidic acid formation. Arch. Biochem. Biophys. 341: 112-121.
30. Murphy, E. J., R. Stephens, M. Jurkowitz-Alexander, and L. A. Horrocks. 1993. Acidic hydrolysis of plasmalogens followed by high-performance liquid chromatography. Lipids. 28: 565-568.
31. Rouser, G., A. N. Siakotos, and S. Fleischer. 1969. Quantitative analysis of phospholipids by thin-layer chromatography and phosphorus analysis of spots. Lipids. 1: 85-86.
32. Deutsch, J., E. Grange, S. I. Rapoport, and A. D. Purdon. 1994. Isolation and quantitation of long-chain acyl-coenzyme A esters in brain tissue by solid-phase extraction. Anal. Biochem. 220: 321-323.
33. Folch, J., M. Lees, and G. H. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissue. J. Biol. Chem. 226: 497-509.
34. Breckenridge, W. C., and A. Kuksis. 1968. Specific distribution of short-chain fatty acids in molecular distillates of bovine milk fat. Lipid Res. 9: 388-393.
35. Wood, R., and T. Lee. 1983. High-performance liquid chromatography of fatty acids: quantitative analysis of saturated, monoenoic, polyenoic and geometrical isomers. J. Chromatogr. 254: 237-246.
36. Chen, H., and R. E. Anderson. 1992. Quantitation of phenacyl esters of retinal fatty acids by high-performance liquid chromatography. J. Chromatogr 578: 124-129.
37. Grange, E., J. Deutsch, Q. R. Smith, M. Chang, S. I. Rapoport, and A. D. Purdon. 1995. Specific activity of brain palmitoyl-CoA pool provides rates of incorporation of palmitate in brain phospholipids in awake rats. J. Neurochem. 65: 2290-2298.
38. Rapoport, S. I. 2001. In vivo fatty acid incorporation into brain phospholipids in relation to plasma availability, signal transduction and membrane remodeling. J. Mol. Neurosci. 16: 243-261.
39. Robinson, P. J., J. Noronha, J. J. DeGeorge, L. M. Freed, T. Nariai, and S. I. Rapoport. 1992. A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res. Brain Res. Rev. 17: 187-214.
40. Rapoport, S. I., M. C. Chang, and A. A. Spector. 2001. Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. J. Lipid Res. 42: 678-685.
41. 2. J. Biol. Chem. 272: 16709-16712.
42. 2. J. Biol. Chem. 273: 14411-14423.
43. 2-mediated oleic acid mobilization in lipopolysaccharide-stimulated P388D (1) macrophages. J. Biol. Chem. 275: 4783-4786.
44. 2. J. Biol. Chem. 269: 13057-13060.
45. Rebecchi, M. J., R. Eberhardt, T. Delaney, S. Ali, and R. Bittman. 1993. Hydrolysis of short acyl chain inositol lipids by phospholipase C-delta 1. J. Biol. Chem. 268: 1735-1741.
46. Rebecchi, M. J., and O. M. Rosen. 1987. Purification of a phosphoinositide-specific phospholipase C from bovine brain. J. Biol. Chem. 262: 12526-12532.
47. Exton, J. H. 1994. Phosphatidylcholine breakdown and signal transduction. Biochim. Biophys. Acta. 1212: 26-42.
48. Matsumoto, K., I. Morita, H. Hibino, and S. Murota. 1993. Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. Prostaglandins Leukot. Essent. Fatty Acids. 49: 861-866.
49. Kulmacz, R. J., R. B. Pendleton, and W. E. Lands. 1994. Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase. Interpretation of reaction kinetics. J. Biol. Chem. 269: 5527-5536.
50. Holman, R. T. 1986. Nutritional and biochemical evidences of acyl interaction with respect to essential polyunsaturated fatty acids. Prog. Lipid Res. 25: 29-39.
51. Parker-Barnes, J. M., T. Das, E. Bobik, A. E. Leonard, J. M. Thurmond, L. T. Chaung, Y. S. Huang, and P. Mukerji. 2000. Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids. Proc. Natl. Acad. Sci. USA. 97: 8284-8289.
52. Sprecher, H. 2000. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim. Biophys. Acta. 1486: 219-231.
53. Contreras, M. A., M. C. Chang, T. A. Rosenberger, R. S. Greiner, C. S. Myers, N. Salem, Jr., and S. I. Rapoport. 2001. Chronic nutritional deprivation of n-3 alpha-linolenic acid does not affect n-6 arachidonic acid recycling within brain phospholipids of awake rats. J. Neurochem. 79: 1090-1099.
54. Chang, M. C., E. Grange, O. Rabin, J. M. Bell, D. D. Allen, and S. I. Rapoport. 1996. Lithium decreases turnover of arachidonate in several brain phospholipids. Neurosci. Lett. 220: 171-174.
55. Chang, M. C., J. M. Bell, A. D. Purdon, E. G. Chikhale, and E. Grange. 1999. Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment. Neurochem. Res. 24: 399-406.
56. 2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells. Proc. Natl. Acad. Sci. USA. 96: 4803-4807.
57. Ikemoto, A., M. Ohishi, N. Hata, Y. Misawa, Y. Fujii, and H. Okuyama. 2000. Effect of n-3 fatty acid deficiency on fatty acid composition and metabolism of aminophospholipids in rat brain synaptosomes. Lipids. 35: 1107-1115.
58. Kang, M. J., T. Fujino, H. Sasano, H. Minekura, N. Yabuki, H. Nagura, H. Iijima, and T. T. Yamamoto. 1997. A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis. Proc. Natl. Acad. Sci. USA. 94: 2880-2884.
59. Laposata, M., E. L. Reich, and P. W. Majerus. 1985. Arachidonoyl-CoA synthetase. Separation from nonspecific acyl-CoA synthetase and distribution in various cells and tissues. J. Biol. Chem. 260: 11016-11020.
60. Salem, N., Jr., and C. D. Niebylski. 1995. The nervous system has an absolute molecular species requirement for proper function. Mol. Membr. Biol. 12: 131-134.
61. Abe, K., K. Kogure, H. Yamamoto, M. Imazawa, and K. Miyamoto. 1987. Mechanism of arachidonic acid liberation during ischemia in gerbil cerebral cortex. J. Neurochem. 48: 503-509.
62. Bazan, N. G., and E. B. Rodriguez de Turco. 1980. Membrane lipids in the pathogenesis of brain edema: phospholipids and arachidonic acid, the earliest membrane components changed at the onset of ischemia. Adv. Neurol. 28: 197-205.
63. Rabin, O., M. C. Chang, E. Grange, J. Bell, S. I. Rapoport, J. Deutsch, and A. D. Purdon. 1998. Selective acceleration of arachidonic acid reincorporation into brain membrane phospholipid following transient ischemia in awake gerbil. J. Neurochem. 70: 325-334.
64. Nonaka, S., and D. M. Chuang. 1998. Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats. Neuroreport. 9: 2081-2084.
65. Stubbs, C. D., and A. D. Smith. 1984. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim. Biophys. Acta. 779: 89-137.
66. Hattori, T., T. Andoh, N. Sakai, H. Yamada, Y. Kameyama, K. Ohki, and Y. Nozawa. 1987. Membrane phospholipid composition and membrane fluidity of human brain tumour: a spin label study. Neurol. Res. 9: 38-43.
67. 2alpha deficiency is crucial for 'on-time' embryo implantation that directs subsequent development. Development. 129: 2879-2889.
68. Ansell, G. B. 1973. Phospholipids and the Nervous System. In Form and Function of Phospholipids. G. B. Ansell, J. N. Hawthorne, R. M. C. Dawson, editors. Elsevier, New York. 377-422.
69. Chang, M. C., M. A. Contreras, T. A. Rosenberger, J. J. Rintala, J. M. Bell, and S. I. Rapoport. 2001. Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brain phospholipids: a possible common effect of mood stabilizers. J. Neurochem. 77: 796-803.
70. Porcellati, G., G. Goracci, and G. Arienti. 1983. Lipid turnover. In Handbook of Neurochemistry. A. Lajtha, editor. Plenum Press, New York. 277-210.
71. Sun, G. Y., and K. L. Su. 1979. Metabolism of arachidonoyl phosphoglycerides in mouse brain subcellular fractions. J. Neurochem. 32: 1053-1059.
72. 14C)arachidonic acid in the neutral glycerides and phosphoglycerides of mouse brain. J. Neurochem. 23: 99-104.
73. 2 to liberate arachidonic acid. Biochim. Biophys. Acta. 1349: 43-54.
74. 2. J. Biol. Chem. 274: 11494-11504.
75. Miller, S. L., J. A. Benjamins, and P. Morell. 1977. Metabolism of glycerophospholipids of myelin and microsomes in rat brain. Reutilization of precursors. J. Biol. Chem. 252: 4025-4037.