Preferential in vivo incorporation of [3H]arachidonic acid from blood into rat brain synaptosomal fractions before and after cholinergic stimulation

Journal of Neurochemistry

Volumn 67, Issue 2, 1996, Pages 822-829

  Jones, Collins R ^a   Arai, Toshanari ^a   Bell, Jane M ^a   Rapoport, Stanley I ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Arachidonic acid; Brain; Cholinergic; Fatty acid model; Functional activity; Phospholipids; Synapse

Indexed keywords

5' NUCLEOTIDASE; ALKALINE PHOSPHATASE; AMINE OXIDASE (FLAVIN CONTAINING); ARACHIDONIC ACID; ARECOLINE; LACTATE DEHYDROGENASE; METHYLATROPINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; PHOSPHOLIPID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; SUCCINATE DEHYDROGENASE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CHOLINERGIC STIMULATION; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; SYNAPTOSOME;

ANIMALIA; TRITIUM;

EID: 0030016993     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67020822.x     Document Type: Article

References (45)

1. 2 and arachidonic acid release in signal transduction. Biochem. Soc. Trans. 18, 503-507.
2. 2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers. Trends Neurosci. 11, 117-123.
3. Bennett F. C., Mong S., Clarke M., Kruse L., and Crooke S. (1987a) Differential effects of manoalide on secreted and intracellular phospholipases. Biochem. Pharmacol. 36, 733-740.
4. Bennett F. C., Mong S., Wu H. L. W., Clark M., Wheeler L., and Crooke S. (1987b) Inhibition of phosphoinositide-specific phospholipase C by manoalide. Mol. Pharmacol. 32, 587-593.
5. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-257.
6. 2. Glia 7, 219-244.
7. Brunner G. and Murphy S. (1993b) Muscarinic acetylcholine receptor-expression in astrocytes in the cortex of young and aged rats. Glia 8, 42-50.
8. Corbin D. R. and Sun G. Y. (1978) Characterization of the enzyme transfer of arachidonyl groups to 1-acylphosphoglycerides in mouse synaptosome fractions. J. Neurochem. 30, 77-82.
9. Cotman C. W. and Matthews D. A. (1971) Synaptic plasma membranes from rat brain synaptosomes: isolation and partial characterization. Biochim. Biophys. Acta 249, 380-395.
10. DeGeorge J. J., Ousley A. H., McCarthy K. D., Lapetina E. G., and Morell P. (1987) Acetylcholine stimulates selective liberation and re-esterification of arachidonate and accumulation of inositol phosphates and glycerophospholipid in C62B glioma cells. J. Biol. Chem. 262, 8077-8083.
11. 14C]arachidonate to examine regional brain lipid metabolism in unanesthetized rats. J. Neurosci. Res. 24, 413-423.
12. DeGeorge J. J., Nariai T., Yamazaki S., Williams W. M., and Rapoport S. I. (1991) Arecoline-stimulated brain incorporation of intravenously administered fatty acids in unanesthetized rats. J. Neurochem. 56, 352-355.
13. Dennis E. A., Rhee S. G., Billah M. M., and Hannun Y. (1991) Role of phospholipases in generating lipid second messengers in signal transduction. FASEB J. 5, 2068-2077.
14. Eichberg J. and Hauser G. (1973) The subcellular distribution of polyphosphoinositides in myelinated and unmyelinated rat brain. Biochim. Biophys. Acta 326, 210-223.
15. Farooqui A. A., Hirashima Y., and Horrocks L. A. (1992) Brain phospholipases and their role in signal transduction, in Neurobiology of Essential Fatty Acids (Bazan N. G., Murphy M. G., and Toffano G., eds), pp. 11 -25. Plenum Press, New York.
16. Folch J., Lees M., and Sloane-Stanley G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissue. J. Biol. Chem. 226, 497-509.
17. Gordon-Weeks P. R. (1987) Isolation of synaptosomes, growth cones and their subcellular components, in Neurochemistry: A Practical Approach (Turner A. J. and Bachelard H. S., eds), pp. 5-6. IRL Press, Washington, D.C.
18. Graham J. M. (1993) The identification of subcellular fractions from mammalian cells, in Biomembrane Protocols: I. Isolation and Analysis (Graham J. M. and Higgins J., eds), pp. 1-18. Humana Press, Totowa, New Jersey.
19. Hall Z. W. (1992) An Introduction to Molecular Neurobiology, p. 193. Sinauer Associates, Sunderland, Massachusetts.
20. Hardy J. A., Dodd P. R., Oakley A. E., Perry R. H., Edwardson J. A., and Kidd A. M. (1983) Metabolically active synaptosomes can be prepared from frozen rat and human brain. J. Neurochem. 40, 608-614.
21. Heymann D., Reddington M., and Kreutzberg G. W. (1984) Subcellular localization of 5′-nucleotidase in rat brain. J. Neurochem. 43, 971-978.
22. Horrocks L. A. (1989) Sources for brain arachidonic acid uptake and turnover in glycerophospholipids. Ann. NY Acad. Sci. 559, 17-24.
23. Johnston P. A., Cameron P. L., Stukenbrok H., Jahn R., De Camilli P., and Sudhof T. C. (1989) Synaptophysin is targeted to similar microvesicles in CHO and PC12 cells. EMBO J. 8, 2863-2872.
24. 3H-arachidonic acid into rat brain subcellular fractions. (Abstr.) Trans. Am. Soc. Neurochem. 25, 244.
25. Kimelberg H. K. (1988) Glial Cell Receptors. Raven Press. New York.
26. Kramer R. E., DuBois R. E., Simpson E. R., Anderson C. M., Kashiwagi K., Lambeth J. D., Jefcoate C. R., and Waterman M. R. (1982) Cell free synthesis of precursor forms of mitochondrial steroid hydroxylase enzymes of the bovine adrenal cortex. Arch. Biochem. Biophys. 215, 478-485.
27. Lai J. C. K. and Clark J. B. (1979) Preparation of synaptic and nonsynaptic mitochondria from mammalian brain. Methods Enzymol. 55, 51-60.
28. Lin Tai-An, Zhang J. P., and Sun G. Y. (1993) The cholinergic receptor-linked phosphoinositide metabolism in mouse cerebrum and cerebellum in vivo. Brain Res. 622, 169-176.
29. 2(s); comparison of arachidonyl-selective and -nonselective enzymes. FASEB J. 7, 339-348.
30. 2+-dependent protein kinase. Science 224, 622-625.
31. Qian Z., Reddy P. V., and Drewes L. R. (1990) Guanine nucleotide-binding protein regulation of microsomal phospholipase D activity of canine cerebral cortex. J. Neurochem. 54, 1632-1638.
32. Robinson P. J., Noronha J., DeGeorge J. J., Freed L. M., Nariai T., and Rapoport S. I. (1992) A quantitative method for measuring regional in vivo fatty acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res. Rev. 17, 187-214.
33. Stahl W. L. and Swanson P. D. (1975) Effects of freezing and storage on subcellular fractions of guinea pig and human brain. J. Neurobiol. 5, 393-400.
34. Storrie B. and Madden E. A. (1990) Isolation of subcellular organelles. Methods Enzmol. 182, 203-225.
35. Sumida C., Graber R., and Nunez E. (1993) Role of fatty acids in signal transduction: modulators and messengers. Prostaglandins Leukot. Essent. Fatty Acids 48, 117-122.
36. Sun G. Y. (1977) Metabolism of arachidonate and stearate injected simultaneously into the mouse brain. Lipids 12, 661-665.
37. Sun G. Y. and MacQuarrie R. A. (1989) Deacylation-reacylation of arachidonyl groups in cerebral phospholipids. Ann. NY Acad. Sci. 559, 37-55.
38. 14C]arachidonic acid into lipids in subcellular fractions of mouse brain. J. Neurochem. 27, 87-92.
39. Sun G. Y., Huang H.-M., Kelleher J. A., Stubbs E. B. Jr., and Sun A. Y. (1988) Marker enzymes, phospholipids and acyl group composition of a somal plasma membrane fraction isolated from rat cerebral cortex: a comparison with microsomes and synaptic plasma membranes. Neurochem. Int. 12, 69-77.
40. Thompson G. A. (1992) Phospholipids, in The Regulation of Membrane Lipid Metabolism, pp. 81-118. CRC Press, Boca Raton, Florida.
41. Towbin H., Staehelin T., and Gordon J. (1979) Electrophoretic transfer of proteins to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
42. Wakelam M. J. O., Pettit T. R., Kaur P., Briscoe C. P., Stewart A., Paul A., Paterson A., Cross M. J., Gardner S. D., Currie S., MacNulty E. E., Plevin R., and Cook S. J. (1993) Phosphatidylcholine hydrolysis: a multiple messenger generating system. Adv. Second Messenger Phosphoprotein Res. 28, 73-80.
43. 3H] arachidonate in the anesthetized rat. J. Neurochem. 63, 727-736.
44. Whittaker V. P. (1959) The isolation and characterization of acetylcholine-containing particles from brain. Biochem. J. 72, 694-706.
45. Yamazaki S., DeGeorge J. J., Bell J. M., and Rapoport S. I. (1994) Effects of pentobarbital on incorporation of plasma palmitate into rat brain. Anesthesiology 80, 151-158.