Lithium decreases turnover of arachidonate in several brain phospholipids

Neuroscience Letters

Volumn 220, Issue 3, 1996, Pages 171-174

  Chang, Michael C J ^a   Grange, Eric ^a   Rabin, Olivier ^a   Bell, Jane M ^a   Allen, David D ^a   Rapoport, Stanley I ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Acyl CoA; Arachidonate; Brain; Fatty acids; In vivo incorporation; Lithium; Palmitate; Phosholipase A2; Phospholipids; Rat; Signal transduction; Turnover

Indexed keywords

ARACHIDONIC ACID; LITHIUM; LITHIUM CHLORIDE; PALMITIC ACID; PHOSPHOLIPASE A2; PHOSPHOLIPID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ARACHIDONIC ACID; BRAIN CHEMISTRY; DEPRESSION, CHEMICAL; FATTY ACIDS, NONESTERIFIED; KINETICS; LITHIUM; MALE; PALMITIC ACID; PALMITOYL COENZYME A; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPIDS; RATS; RATS, INBRED F344; SIGNAL TRANSDUCTION;

EID: 0030596052     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13264-X     Document Type: Article

References (20)

1. [1] Avissar, S., Schreiber, G., Danon, A. and Belmaker, R.H., Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex, Nature, 331 (1988) 440-442.
2. 2 and arachidonic release in signal transduction, Biochem. Soc. Trans., 18 (1990) 503-507.
3. [3] Berridge, M.J., Downes, C.P. and Hanley, M.R., Neural and developmental actions of lithium: a unifying hypothesis, Cell, 59 (1989) 411-419.
4. [4] Brami, B., Leli, U. and Hauser, G., Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG 108-15 cells, J. Neurochem., 60 (1993) 1137-1142.
5. 2+ exchanger in neuronal cells, Mol. Pharmacol., 43 (1993) 976-981.
6. [6] Farooqui, A.A., Hirashima, Y. and Horrocks, L.A., Brain phospholipases and their role in signal transduction. In N.G. Bazan, M.G. Murphy and G. Toffano (Eds.), Neurobiology of Essential Fatty Acids, Plenum Press, New York, 1992, pp. 11-25.
7. [7] Gao, X.-M., Fukamauchi, F. and Chuang, D.-M., Long-term biphasic effects of lithium treatment on phospholipase C-coupled M3-muscarinic acetylcholine receptors in cultured cerebellar granule cells, Neurochem. Int., 22 (1993) 395-403.
8. 3H]palmitate in plasma and brain palmitoyl-CoA pool, J. Neurochem., 65 (1995) 2290-2298.
9. [9] Hallcher, L.M. and Sherman, W.R., The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain, J. Biol. Chem., 255 (1980) 10896-10901.
10. [10] Horrobin, D.F., Lithium as a regulator of prostaglandin synthesis. Relevance of manic depressive illness. In F.N. Johnson and S. Johnson (Eds.), Lithium in Medical Practice, University Park Press, Baltimore, MD, 1978, pp. 243-246.
11. 3H]arachidonic acid from blood into rat brain synaptosomal fractions before and after cholinergic stimulation, J. Neurochem., (1996) in press.
12. [12] Joseph, N.E., Renshaw, P.F. and Leigh, Jr., J.S., Systemic lithium administration alters rat cerebral cortex phospholipids, Biol. Psychiatry, 22 (1987) 540-544.
13. [13] Lenox, R.H. and Watson, D.G., Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness, Clin. Chem., 40 (1994) 309-314.
14. [14] Manji, H.K., Etcheberrigaray, R., Chen, G. and Olds, J.L., Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the a isozyme, J. Neurochem., 61 (1993) 2303-2309.
15. [15] Mork, A. and Geisler, A., Effects of GTP on hormone-stimulated adenylate cyclase activity in cerebral cortex, striatum, and hippocampus from rats treated chronically with lithium, Biol. Psychiatry, 26 (1989) 279-288.
16. 2, Prostaglandins, 14 (1977) 273-281.
17. [17] Purdon, A.D., Arai, T. and Rapoport, S.I., Insignificant contribution of plasma esterified palmitate to palmitate flux into brain phospholipid, J. Neurochem., 64 (1996) S101D.
18. [18] Robinson, P.J., Noronha, J.G., DeGeorge, J.J., Freed, L.M., Nariai, T. and Rapoport, S.I., A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis, Brain Res. Rev., 17 (1992) 187-214.
19. [19] Sherman, W.R., Leavitt, A.L., Honchar, M.P., Hallcher, L.M. and Phillips, B.E., Evidence that lithium alters phosphoinositide metabolism: chronic administration elevates primarily D-myo-inositol-1-phosphate in cerebral cortex of the rat, J. Neurochem., 36 (1981) 1947-1951.
20. [20] Washizaki, K., Smith, Q.R., Rapoport, S.I. and Purdon, A.D., In vivo cerebral incorporation of radiolabeled fatty acids after acute unilateral orbital enucleation in adult hooded Long-Evans rats, J. Cerebral Blood Flow Metab., 14 (1994) 312-323.