Unaltered control of extracellular GABA-concentration through GAT-1 in the hippocampus of rats after pilocarpine-induced status epilepticus

Epilepsy Research

Volumn 52, Issue 3, 2003, Pages 243-252

  Frahm, Christiane ^a,b   Stief, Frank ^a   Zuschratter, Werner ^c   Draguhn, Andreas ^a  

^a Johannes Muller Inst fur P der C   (Germany)

^b Forschungszentrum Experimentelle N   (Germany)

^c BL Institut für Neurobiologie   (Germany)

Author keywords

Epilepsy; Epilepticus; GABA uptake; Gat; Hippocampus; Pilocarpine induced status

Indexed keywords

4 AMINOBUTYRIC ACID; PILOCARPINE; TIAGABINE;

4 AMINOBUTYRIC ACID UPTAKE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CHRONIC DISEASE; CONTROLLED STUDY; DENTATE GYRUS; DISEASE MODEL; DRUG EFFECT; DRUG INDUCED DISEASE; EPILEPTIC STATE; EXTRACELLULAR SPACE; GRANULE CELL; HIPPOCAMPUS; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

ANIMALS; DISEASE MODELS, ANIMAL; EXTRACELLULAR SPACE; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; MALE; MUSCARINIC AGONISTS; NIPECOTIC ACIDS; PILOCARPINE; RATS; RATS, WISTAR; STATUS EPILEPTICUS;

EID: 0037236009     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(02)00233-4     Document Type: Article

References (61)

1. Akbar M.T., Rattray M., Williams R.J., Chong N.W., Meldrum B.S. Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat. Neuroscience. 85:1998;1235-1251.
2. Andre V., Marescaux C., Nehlig A., Fritschy J.M. Alterations of hippocampal GABAergic system contribute to devfelopment of spontaneous recurrent seizures in the rat lithium-pilocarpine model of temporal lobe epilepsy. Hippocampus. 11:2001;452-468.
3. Arida R.M., Scorza F.A., Peres C.A., Cavalheiro E.A. The course of untreated seizures in the pilocarpine model of epilepsy. Epilepsy Res. 34:1999;99-107.
4. Balslev T., Uldall P., Buchholt J. Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients. Eur. J. Paediatr. Neurol. 4:2000;169-170.
5. Banks M.I., Pearce R.A. Kinetic differences between synaptic and extrasynaptic GABA(A) receptors in CA1 pyramidal cells. J. Neurosci. 20:2000;937-948.
6. Belhage B., Hansen G.H., Schousboe A. Depolarization by K+ and glutamate activates different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA. Neuroscience. 54:(4):1993;1019-1034.
7. Borden L.A., Murali Dhar T.G., Smith K.E., Weinshank R.L., Branchek T.A., Gluchowski C. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur. J. Pharmacol. 269:(2):1994;219-224.
8. Borden L.A., Smith K.E., Vaysse P.J., Gustafson E.L., Weinshank R.L., Branchek T.A. Re-evaluation of GABA transport in neuronal and glial cell cultures: correlation of pharmacology and mRNA localization. Recept. Channels. 2:1995;129-146.
9. Bouilleret V., Loup F., Kiener T., Marescaux C., Fritschy J.M. Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in a mouse model of mesial temporal lobe epilepsy. Hippocampus. 10:(3):2000;305-324.
10. Brickley S.G., Revilla V., Cull Candy S.G., Wisden W., Farrant M. Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature. 409:2001;88-92.
11. Brooks-Kayal A.R., Shumate M.D., Jin H., Rikhter T.Y., Coulter D.A. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat. Med. 4:(10):1998;1166-1172.
12. Buhl E.H., Otis T.S., Mody I. Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science. 271:(5247):1996;369-373.
13. Dingledine R., Korn S.J. Gamma-aminobutyric acid uptake and the termination of inhibitory synaptic potentials in the rat hippocampal slice. J. Physiol. (Lond). 366:1985;387-409.
14. Draguhn A., Heinemann U. Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells. J. Neurophysiol. 76:1996;3983-3993.
15. During M.J., Ryder K.M., Spencer D.D. Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature. 376:1995;174-177.
16. Engel D., Schmitz D., Gloveli T., Frahm C., Heinemann U., Draguhn A. Laminar difference in GABA uptake and GAT-1 expression in rat CA1. J. Physiol. 512:1998;643-649.
17. Faingold C.L., Randall M.E., Anderson C.A. Blockade of GABA uptake with tiagabine inhibits audiogenic seizures and reduces neuronal firing in the inferior colliculus of the genetically epilepsy-prone rat. Exp. Neurol. 126:(2):1994;225-232.
18. Frahm C., Engel D., Piechotta A., Heinemann U., Draguhn A. Presence of gamma-aminobutyric acid transporter mRNA in interneurons and principal cells of rat hippocampus. Neurosci. Lett. 288:(3):2000;175-178.
19. Frahm C., Engel D., Draguhn A. Efficacy of background GABA uptake in rat hippocampal slices. Neuroreport. 12:2001;1593-1596.
20. Gaspary H.L., Wang W., Richerson G.B. Carrier-mediated GABA release activates GABA receptors on hippocampal neurons. J. Neurophysiol. 80:1998;270-281.
21. Gibbs J.W., Shumate M.D., Coulter D.A. Differential epilepsy-associated alterations in postsynaptic GABA (A) receptor function in dentate granule and CA1 neurons. J. Neurophysiol. 77:1997;1924-1938.
22. Halonen T., Nissinen J., Jansen J.A., Pitkanen A. Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus. Eur. J. Pharmacol. 299:(1-3):1996;69-81.
23. Hirao T., Morimoto K., Yamamoto Y., Watanabe T., Sato H., Sato K., Sato S., Yamada N., Tanaka K., Suwaki H. Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats. Brain Res. Mol. Brain Res. 54:(1):1998;49-55.
24. Holtkamp M., Pfeiffer M., Buchheim K., Meierkord H. Tiagabin und nonkonvulsiver Status epilepticus. Nervenarzt. 70:(12):1999;1104-1106.
25. Isaacson J.S., Solis J.M., Nicoll R.A. Local and diffuse synaptic actions of GABA in the hippocampus. Neuron. 10:(2):1993;165-175.
26. Jackson M.F., Esplin B., Capek R. Activity-dependent enhancement of hyperpolarizing and depolarizing gamma-aminobutyric acid (GABA) synaptic responses following inhibition of GABA uptake by tiagabine. Epilepsy Res. 37:(1):1999;25-36.
27. Janjua N.A., Mori A., Hiramatsu M. Gamma-aminobutyric acid uptayke is decreased in the hippocampus in a genetic model of human temporal lobe epilepsy. Epilepsy Res. 8:1991;71-74.
28. Jefferys J.G.R., Mitchell P., O'Hara L., Tiley C., Hardy J., Jordan S.J., Lynch M., Wadsworth J. Ex vivo release of GABA from tetanus toxin-induced chronic epileptic foci decreased during the active seizure phase. Neurochem. Int. 18:1991;373-379.
29. A receptor subunit mRNAs in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis: an in situ hybridization study. Brain Res. Mol. Brain Res. 31:1995;33-47.
30. Kang T.C., Kim H.S., Seo M.O., Park S.K., Kwon H.Y., Kang J.H., Won M.H. The changes in the expressions of gamma-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure. Neurosci. Lett. 310:(1):2001;29-32.
31. Loup F., Wieser H.G., Yonekawa Y., Aguzzi A., Fritschy J.M. Selective alterations in GABAA receptor subtypes in human temporal lobe epilepsy. J. Neurosci. 20:(14):2000;5401-5419.
32. Ma Y., Hu J.H., Zhao W.J., Fei J., Yu Y., Zhou X.G., Mei Z.T., Guo L.H. Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice. Cell Res. 11:(1):2001;61-67.
33. Mathern G.W., Mendoza D., Lozada A., Pretorius J.K., Dehnes Y., Danbolt N.C., Nelson N., Leite J.P., Chimelli L., Born D.E., Sakamoto A.C., Assirati J.A., Fried I., Peacock W.J., Ojemann G.A., Adelson P.D. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. Neurology. 52:(3):1999;453-472.
34. A receptors responsible for tonic and phasic conductances. Neurochem. Res. 26:2001;907-913.
35. Orozco-Suarez S., Brunson K.L., Feria-Velasco A., Ribak C.E. Increased expression of gamma-aminobutyric acid transporter-1 in the forebrain of infant rats with corticotropin-releasing hormone-induced seizures but not in those with hyperthermia-induced seizures. Epilepsy Res. 42:2000;141-157.
36. Patrylo P.R., Spencer D.D., Williamson A. GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis. J. Neurophysiol. 85:2001;1533-1542.
37. Perkins K.L., Wong R.K. The depolarizing GABA response. Can. J. Physiol. Pharmacol. 75:(5):1997;516-519.
38. Pfeiffer M., Draguhn A., Meierkord H., Heinemann U. Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro. J. Pharmacol. 119:1996;569-577.
39. Pietrini G., Suh Y.J., Edelmann L., Rudnick G., Caplan M.J. The axonal gamma-aminobutyric acid transporter GAT-1 is sorted to the apical membranes of polarized epithelial cells. J. Biol. Chem. 269:(6):1994;4668-4674.
40. Radian R., Ottersen O.P., Storm Mathisen J., Castel M., Kanner B.I. Immunocytochemical localization of the GABA transporter in rat brain. J. Neurosci. 10:(4):1990;1319-1330.
41. Ribak C.E., Tong W., Brecha N.C. The GABA plasma membrane transporters, GAT-1 and GAT-3, display different distributions in the rat hippocampus. J. Comp. Neurol. 367:1996;595-606.
42. Roepstorff A., Lambert J.D. Factors contributing to the decay of the stimulus-evoked IPSC in rat hippocampal CA1 neurons. J. Neurophysiol. 72:1994;2911-2926.
43. Sabau A., Frahm C., Pfeiffer M., Breustedt J., Piechotta A., Numberger M., Engel D., Heinemann U., Draguhn A. Age-dependence of the anticonvulsant effects of the GABA uptake inhibitor tiagabine in vitro. Eur. J. Pharmacol. 383:(3):1999;259-266.
44. Schmidt D., Gram L., Brodie M., Kramer G., Perucca E., Kalviainen R., Elger C.E. Tiagabine in the treatment of epilepsy - a clinical review with a guide for the prescribing physician. Epilepsy Res. 41:2000;245-251.
45. Schousboe A., Larsson O.M., Wood J.D., Krogsgaard-Larsen P. Transport and metabolism of γ-aminobutyric acid in neurons and glia: implications for epilepsy. Epilepsia. 24:1983;531-538.
46. Schwartz E.A. Depolarization without calcium can release gamma-aminobutyric acid from a retinal neuron. Science. 238:(4825):1987;350-355.
47. Schwarzer C., Tsunashima K., Wanzenbock C., Fuchs K., Sieghart W., Sperk G. GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy. Neuroscience. 80:1997;1001-1017.
48. Sperk G., Schwarzer C., Tsunashima K., Kandlhofer S. Expression of GABA(A) receptor subunits in the hippocampus of the rat after kainic acid-induced seizures. Epilepsy Res. 32:(1-2):1998;129-139.
49. Shumate M.D., Lin D.D., Gibbs J.W., Holloway K.L., Coulter D.A. GABA(A) receptor function in epileptic human dentate granule cells: comparison to epileptic and control rat. Epilepsy Res. 32:(1-2):1998;114-128.
50. Staley K.J., Soldo B.L., Proctor W.R. Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science. 269:(5226):1995;977-981.
51. Stasheff S.F., Hines M., Wilson W.A. Axon terminal hyperexcitability associated with epileptogenesis in vitro. I. Origin of ectopic spikes. J. Neurophysiol. 70:(3):1993;961-975.
52. Sutch R.J., Davies C.C., Bowery N.G. GABA release and uptake measured in crude synaptosomes from Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Neurochem. Int. 34:1999;415-425.
53. Suzdak P.D. Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment. Epilepsy Res. 19:(3):1994;205-213.
54. Taira T., Lamsa K., Kaila K. Posttetanic excitation mediated by GABA(A) receptors in rat CA1 pyramidal neurons. J. Neurophysiol. 77:1997;2213-2218.
55. Trinka E., Moroder T., Nagler M., Staffen W., Loscher W., Ladurner G. Clinical and EEG findings in complex partial status epilepticus with tiagabine. Seizure. 8:(1):1999;41-44.
56. Ueda Y., Willmore L.J. Hippocampal gamma-aminobutyric acid transporter alterations following focal epileptogenesis induced in rat amygdala. Brain Res. Bull. 52:(5):2000;357-361.
57. Ueda Y., Willmore L.J. Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis. Exp. Brain Res. 133:(3):2000;334-339.
58. Walton N.Y., Gunawan S., Treiman D.M. Treatment of experimental status epilepticus with the GABA uptake inhibitor, tiagabine. Epilepsy Res. 19:(3):1994;237-244.
59. Williamson A., Telfeian A.E., Spencer D.D. Prolonged GABA responses in dentate granule cells in slices isolated from patients with temporal lobe sclerosis. J. Neurophysiol. 74:(1):1995;378-387.
60. Wolf H.K., Spanle M., Muller M.B., Elger C.E., Schramm J., Wiestler O.D. Hippocampal loss of the GABAA receptor alpha 1 subunit in patients with chronic pharmacoresistant epilepsies. Acta Neuropathol. (Berl). 88:(4):1994;313-319.
61. Yan X.X., Cariaga W.A., Ribak C.E. Immunoreactivity for GABA plasma membrane transporter, GAT-1, in the developing rat cerebral cortex: transient presence in the somata of neocortical and hippocampal neurons. Brain Res. Dev. Brain Res. 99:(1):1997;1-19.