Leptin levels in obese children: Effects of gender, weight reduction and androgens

Physiological Research

Volumn 52, Issue 1, 2003, Pages 53-60

  Pilcová, Renata ^a   Sulcova J ^a   Hill, M ^a   Blaha P ^c   Lisa L ^b  

^a INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

^b UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Androgens; Children; Leptin; Obesity

Indexed keywords

ANDROGEN; CHOLESTEROL; LEPTIN; PRASTERONE; PRASTERONE SULFATE; TESTOSTERONE;

ADOLESCENT; ANDROGEN BLOOD LEVEL; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CHILD; CHOLESTEROL BLOOD LEVEL; FEMALE; GENDER; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; SEX DIFFERENCE; WEIGHT REDUCTION;

ADOLESCENT; ANDROGENS; BODY COMPOSITION; BODY MASS INDEX; CHILD; CHOLESTEROL; FEMALE; HUMANS; LEPTIN; MALE; OBESITY; SEX CHARACTERISTICS; WEIGHT LOSS;

EID: 0037231151     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. AHIMA RS, SAPER CB, FLIER JS, ELMQUIST JK: Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21: 263-307, 2000.
2. ARGENTE J, BARRIOS V, CHOWEN AJ, SINHA MK, CONSIDINE RV: Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa. J Pediatr 131: 833-838, 1997.
3. ARSLANIAN S, SUPRASONGSIN C: Testosterone treatment in adolescents with delayed puberty: changes in body composition, protein, fat, and glucose metabolism. J Clin Endocrinol Metab 82: 3213-3220, 1997.
4. BAO W, SRINIVASAN SR, WATTIGNEY WA, BERENSON GS: Persistence of multiple cardiovascular risk clustering related to syndrome X from childhood to young adulthood. The Bogalusa Heart Study. Arch Intern Med 154: 1842-1847, 1994.
5. BOSTON BA: Pro-opiomelanocortin and weight regulation: from mice to men. J Pediatr Endocrinol Metab 14 (Suppl 6): 1409-1416, 2001.
6. BRAY GA: Obesity and reproduction. Hum Reprod 12 (Suppl 1): 26-29, 1997.
7. BYRNES SE, BAUR LA, BERMINGHAM M, BROCK K, STEINBECK K: Leptin and total cholesterol are predictors of weight gain in pre-pubertal children. Int J Obes Relat Metab Disord 23: 146-150, 1999.
8. CONSIDINE RV, SINHA MK, HEIMAN ML, KRIAUCIUNAS A, STEPHENS TW, NYCE MR, OHANNESIAN JP, MARCO CC, MCKEE LJ, BAUER TL, CARO JF: Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295, 1996.
9. DE PERGOLA G: The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone. Int J Obes Relat Metab Disord 24 (Suppl 2): S59-S63, 2000.
10. DE PERGOLA G, ZAMBONI M, SCIARAFFIA M, TURCATO E, PANNACCIULLI N, ARMELLINI F, GIORGINO F, PERRINI S, BOSELLO O, GIORGINO R: Body fat accumulation is possibly responsible for lower dehydroepiandrosterone circulating levels in premenopausal obese women. Int J Obes Relat Metab Disord 20: 1105-1110, 1996.
11. FODOR M, DELEMARRE-VAN DE WAAL HA: Are POMC neurons targets for sex steroids in the arcuate nucleus of the rat? Neuroreport 12: 3989-3991, 2001.
12. GARCIA-MAYOR RV, ANRADE MA, RIOS M, LAGE M, DIEGUEZ C, CASANUEVA FF: Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metabol 82: 2839-2846, 1997.
13. HALUZÍK M, KÁBRT J, NEDVÍDKOVA J, SVOBODOVÁ J, KOTRLÍKOVÁ E, PAPEŽOVA H: The relationship of serum leptin levels and selected nutritional parameters in patients with protein-caloric malnutrition. Nutrition 15: 829-833, 1999a.
14. HALUZÍK M, SVOBODOVÁ J, NEDVÍDKOVÁ J, PAPEŽOVÁ H, KOTRLÍKOVÁ E, KÁBRT J: The relation of serum leptin levels and the degree of protein catabolism in patients with malnutrition. Physiol Res 48 (Suppl 1): S78, 1999b.
15. HALUZÍK M, PAPEŽOVÁ H, NEDVÍDKOVÁ J, KÁBRT J: Serum leptin levels in patients with anorexia nervosa before and after partial refeeding, relationships to serum lipids and biochemical nutritional parameters. Physiol Res 48: 197-202, 1999c.
16. th Symposium on the Analysis of Steroids. S GOROG (ed), 1993, pp 163-169.
17. HASSINK SG, SHESLOW DV, DE LANCEY E, PENATANOVA I, CONSIDINE RV, CARO JF: Serum leptin in children with obesity: relationship to gender and development. Pediatrics 98: 201-203, 1996.
18. HETHERINGTON AW, RANSON SW: Hypothalamic lesions and adiposity in the rat. Anat Rec 78: 149-172, 1940.
19. HUSZAR D, LYNCH CA, FAIRCHILD-HUNTRESS V, DUNMORE JH, FANG Q, BERKEMEIER LR, GU W, KESTERSON RA, BOSTON BA, CONE RD, SMITH FJ, CAMPFIELD LA, BURN P, LEE F: Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131-141, 1997.
20. JANEČKOVÁ R: The role of leptin in human physiology and pathophysiology. Physiol Res 50: 443-459, 2001.
21. JOCKENHOVEL F, BLUM WF, VOGEL E, ENGLARO P, MULLER-WIELANDD, REINWEIN D: Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J Clin Endocrinol Metab 82: 2510-2513, 1997.
22. KIESS W, REICH A, MEYR K, GALSOW A, DEUTSCHER J, KLAMMT J, YANG Y, MULLER G, KRATZSCH J: A role for leptin in sexual maturation and puberty? Horm Res 51: 55-63, 1999.
23. KLEIN S, COPPACK SW, MOHAMED-ALI V, LANDT M, RASCHER W, KRONE W: Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45: 984-987, 1996.
24. LAHLOU N, LANDAIS P, DE BOISSIEU D, BOUGNERES PF: Circulating leptin in normal children and during the dynamic phase of juvenile obesity. Relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism. Diabetes 46: 989-993, 1997.
25. LUUKKAA V, PESONEN U, HUHTANIEMI I, LEHTONEN A, TILVIS R, TUOMILEHTO J, KOULUU M, HUUPPONEN R: Inverse correlation between serum testosterone and leptin in men. J Clin Endocrinol Metab 83: 3243-3246, 1998.
26. MARTIN R, SALLER K. Lehrbuch der Anthropologie. G. FISCHER (ed.), Stuttgart, 1957, p 456.
27. MARTIN LJ, MAHANEY MC, ALMASY L, MACCLUER JW, BLANGERO J, JAQUISH CE, COMMUZIE AG. Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone. Obes Res 10: 14-21, 2002.
28. MUST A, JACQUES PF, DALLAL GE, BAJEMA CJ, DIETZ WH: Long-term morbidity and mortality of overweight adolescents: A follow up of the Harvard Growth Study of 1922 to 1935. N Engl J Med 327: 1350-1355, 1992.
29. NEDVÍDKOVÁ J, HALUZÍK M, SCHREIBER V: The decrease in serum leptin levels in estrogen-treated male mice. Physiol Res 46: 291-294, 1997.
30. OSTLUND RE, YANG JW, KLEIN S, GINGERICH R: Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 81: 3909-3913, 1996.
31. PEIRIS AN, MUELLER RA, SRUVE MF, SMITH GA, KISSEBAH AH: Relationship of androgenic activity to splanchnic insulin metabolism and peripheral glucose utilization in premenopausal women. J Clin Endocrinol Metab 164: 162-169, 1987.
32. PORŠOVÁ-DUTOIT I, ŠULCOVÁ J, STÁRKA L: Do DHEA/DHEAS play a protective role in coronary heart disease? Physiol Res 49 (Suppl 1): S43-S56, 2000.
33. RAMIREZ ME, McMURRY NIP, WIEBKE GA, FELTEN KJ, REN K, MEIKLE W, IVERIUS PH: Evidence for sex steroid inhibition of lipoprotein lipase in men: comparison of abdominal and femoral adipose tissue. Metabolism 46: 179-185, 1997.
34. REITERER EE, SUDI KM, MAYER A, LIMBERT-ZINTERL S, STALZER-BRUNNER C, FUGER G, BORKENSTEIN MH: Changes in leptin, insulin and body composition in obese children during a weight reduction program. J Pediatr Endocrinol Metab 12: 853-862, 1999.
35. RAITAKARI TO, PORKKA KVK, RASANEN L, RONNEMAA T, VIIKARI JS: Clustering and six year clustertracking of serum total cholesterol, HDL-cholesterol and diastolic blood pressure in children and young adults. The cardiovascular risk in young Finns study. J Clin Epidemiol 47: 1085-1093, 1994.
36. ROEMMICH JN, ROGOL AD: Role of leptin during childhood growth and development. Endocrinol Metab Clin North Am 28: 749-764, 1999.
37. ROSENBAUM M, NICOLSON M, HIRSCH J, HEYMSFELD SB, GALLAGHER D, CHU F, LEIBEL RL: Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81: 3424-3427, 1996.
38. SINHA MK, OHANNESIAN JP, HEIMAN ML, KRIAUCIUNAS A, STEPHENS TW, MAGOSIN S, MARCO C, CARO JF: Nocturnal rise in leptin in lean, obese and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 97: 1344-1347, 1996.
39. ŠULCOVÁ J, HILL M, HAMPL R, STÁRKA L. Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects. J Endocrinol 154: 57-62, 1997.
40. VIGNEROVÁ J, BLÁHA P (eds): Investigation of the Growth of the Czech Children and Adolescent. SZÚ, Prague, 2001, p. 172.
41. WABITSCH M, HAUNER H, HEINZE E, BOCKAMNN A, BENZ R, MAYER H, TELLER W: Body fat distribution and steroid hormone concentrations in obese adolescent girls before and after weight reduction. J Clin Endocrinol Metab 80: 3469-3475, 1995.
42. WABITSCH M, BLUM WF, MUCHE R, BRAUN M, HUBE F, RASCHER W, HEINZE E, TELLER W, HAUNER H: Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 100: 808-813, 1997.
43. ZHANG Y, PROENCA R, MAFFEI M, BARONE M, LORI L, FRIEDMAN JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.