Dimerization of the Polycomb-group protein Mel-18 is regulated by PKC phosphorylation

Biochemical and Biophysical Research Communications

Volumn 300, Issue 1, 2003, Pages 135-140

  Fujisaki, Seiji ^a   Ninomiya, Yuichi ^a   Ishihara, Hiroto ^a   Miyazaki, Masaki ^a   Kanno, Rieko ^a   Asahara, Toshimasa ^a   Kanno, Masamoto ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Mel 18; Phosphorylation; Polycomb; Protein protein interactions

Indexed keywords

M PROTEIN; METHIONINE; PHOSPHOPROTEIN PHOSPHATASE; POLYCOMB PROTEIN; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL CELL; ARTICLE; ASSAY; CELL LINE; CONTROLLED STUDY; DEPHOSPHORYLATION; DIMERIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; STOICHIOMETRY;

AMINO ACID MOTIFS; ANIMALS; COS CELLS; DIMERIZATION; DNA-BINDING PROTEINS; MICE; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; ZINC FINGERS;

HOMO;

EID: 0037225966     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02791-2     Document Type: Article

References (40)

1. P.N. Adler, E.C. Martin, J. Charlton, K. Jones, Phenotypic consequences and genetic interactions of a null mutation in the Drosophila posterior sex combs gene, Dev. Genet. 12 (1991) 349-361.
2. M.J. Alkema, M. Bronk, E. Verhoeven, A. Otte, L.J. van't Veer, A. Berns, M. van Lohuizen, Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex, Genes Dev. 11 (1997) 226-240.
3. M. Bienz, J. Muller, Transcriptional silencing of homeotic genes in Drosophila, Bioessays 17 (1995) 775-784.
4. A. Breiling, B.M. Turner, M.E. Bianchi, V. Orlando, General transcription factors bind promoters repressed by Polycomb group proteins, Nature 412 (2001) 651-655.
5. G. Cavalli, R. Paro, Chromo-domain proteins: Linking chromatin structure to epigenetic regulation, Curr. Opin. Cell Biol. 10 (1998) 354-360.
6. N.N. Cheng, D.A. Sinclair, R.B. Campbell, H.W. Brock, Interactions of Polyhomeotic with Polycomb group genes of Drosophila melanogaster, Genetics 138 (1994) 1151-1162.
7. M.J. Gunster, D.P. Satijn, K.M. Hamer, J.L. den Blaauwen, D. de Bruijn, M.J. Alkema, M. van Lohuizen, R. van Driel, A.P. Otte, Identification and characterization of interactions between the vertebrate Polycomb-group protein BMI1 and human homologs of Polyhomeotic, Mol. Cell. Biol. 17 (1997) 2326-2335.
8. M. Hasegawa, O. Tetsu, R. Kanno, H. Inoue, H. Ishihara, M. Kamiyasu, M. Taniguchi, M. Kanno, Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking, Mol. Immunol. 35 (1998) 559-563.
9. N. Hashimoto, H.W. Brock, M. Nomura, M. Kyba, J. Hodgson, Y. Fujita, Y. Takihara, K. Shimada, T. Higashinakagawa, RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes, Biochem. Biophys. Res. Commun. 245 (1998) 356-365.
10. C.S. Hemenway, B.W. Halligan, L.S. Levy, The Bmi-1 oncoprotein interacts with dinG and MPh2, the role of RING finger domains, Oncogene 16 (1998) 2541-2547.
11. A. Ishida, H. Asano, M. Hasegawa, H. Koseki, T. Ono, M.C. Yoshida, M. Taniguchi, M. Kanno, Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif, Gene 129 (1993) 249-255.
12. J.J. Jacobs, P. Keblusek, E. Robanus-Maandag, P. Kristel, M. Lingbeek, P.M. Nederlof, T. van Welsem, M.J. van de Vijver, E.Y. Koh, G.Q. Daley, M. van Lohuizen, Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers, Nat. Genet. 26 (2000) 291-299.
13. J.J. Jacobs, B. Scheijen, J.W. Voncken, K. Kieboom, A. Berns, M. van Lohuizen, Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF, Genes Dev. 13 (1999) 2678-2690.
14. J.J. Jacobs, M. van Lohuizen, Cellular memory of transcriptional states by Polycomb-group proteins, Semin. Cell Dev. Biol. 10 (1999) 227-235.
15. C.A. Jones, J. Ng, A.J. Peterson, K. Morgan, J. Simon, R.S. Jones, The Drosophila esc and E(z) proteins are direct partners in Polycomb group-mediated repression, Mol. Cell. Biol. 18 (1998) 2825-2834.
16. M. Kanno, M. Hasegawa, A. Ishida, K. Isono, M. Taniguchi, Mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity, EMBO J. 14 (1995) 5672-5678.
17. J.A. Kennison, The Polycomb and trithorax group proteins of Drosophila: Trans-regulators of homeotic gene function, Annu. Rev. Genet. 29 (1995) 289-303.
18. M. Kyba, H.W. Brock, The Drosophila Polycomb group protein Psc contacts ph and Pc through specific conserved domains, Mol. Cell. Biol. 18 (1998) 2712-2720.
19. M. Kyba, H.W. Brock, The SAM domain of Polyhomeotic, RAE28, and scm mediates specific interactions through conserved residues, Dev. Genet. 22 (1998) 74-84.
20. J. Lessard, A. Schumacher, U. Thorsteinsdottir, M. van Lohuizen, T. Magnuson, G. Sauvageau, Functional antagonism of the Polycomb-group genes eed and Bmi1 in hemopoietic cell proliferation, Genes Dev. 13 (1999) 2691-2703.
21. J. Ng, C.M. Hart, K. Morgan, J.A. Simon, A Drosophila ESC-E(Z) protein complex is distinct from other Polycomb group complexes and contains covalently modified ESC, Mol. Cell. Biol. 20 (2000) 3069-3078.
22. K. Noguchi, R. Shiurba, T. Higashinakagawa, Nuclear translocation of mouse Polycomb m33 protein in regenerating liver, Biochem. Biophys. Res. Commun. 291 (2002) 508-515.
23. H. Ogawa, K. Ishiguro, S. Gaubatz, D.M. Livingston, Y. Nakatani, A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells, Science 296 (2002) 1132-1136.
24. V. Pirrotta, Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression, Trends Genet. 13 (1997) 314-318.
25. V. Pirrotta, PcG complexes and chromatin silencing, Curr. Opin. Genet. Dev. 7 (1997) 249-258.
26. V. Pirrotta, Polycombing the genome: PcG, trxG, and chromatin silencing, Cell 93 (1998) 333-336.
27. M.J. Reijnen, K.M. Hamer, J.L. den Blaauwen, C. Lambrechts, I. Schoneveld, R. van Driel, A.P. Otte, Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other, Mech. Dev. 53 (1995) 35-46.
28. J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
29. D.P. Satijn, M.J. Gunster, J. van der Vlag, K.M. Hamer, W. Schul, M.J. Alkema, A.J. Saurin, P.S. Freemont, R. van Driel, A.P. Otte, RING1 is associated with the Polycomb group protein complex and acts as a transcriptional repressor, Mol. Cell. Biol. 17 (1997) 4105-4113.
30. D.P. Satijn, K.M. Hamer, J. den Blaauwen, A.P. Otte, The Polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos, Mol. Cell. Biol. 21 (2001) 1360-1369.
31. D.P. Satijn, A.P. Otte, Polycomb group protein complexes: Do different complexes regulate distinct target genes?, Biochim. Biophys. Acta 1447 (1999) 1-16.
32. D.P. Satijn, A.P. Otte, RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity, Mol. Cell. Biol. 19 (1999) 57-68.
33. A.J. Saurin, Z. Shao, H. Erdjument-Bromage, P. Tempst, R.E. Kingston, A Drosophila Polycomb group complex includes Zeste and dTAFII proteins, Nature 412 (2001) 655-660.
34. R.G. Sewalt, J. van der Vlag, M.J. Gunster, K.M. Hamer, J.L. den Blaauwen, D.P. Satijn, T. Hendrix, R. van Driel, A.P. Otte, Characterization of interactions between the mammalian Polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian Polycomb-group protein complexes, Mol. Cell. Biol. 18 (1998) 3586-3595.
35. J. Simon, Locking in stable states of gene expression: Transcriptional control during Drosophila development, Curr. Opin. Cell Biol. 7 (1995) 376-385.
36. M. Tagawa, T. Sakamoto, K. Shigemoto, H. Matsubara, Y. Tamura, T. Ito, I. Nakamura, A. Okitsu, K. Imai, M. Taniguchi, Expression of novel DNA-binding protein with zinc finger structure in various tumor cells, J. Biol. Chem. 265 (1990) 20021-20026.
37. O. Tetsu, H. Ishihara, R. Kanno, M. Kamiyasu, H. Inoue, T. Tokuhisa, M. Taniguchi, M. Kanno, Mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25, Immunity 9 (1998) 439-448.
38. M. van Lohuizen, M. Tijms, J.W. Voncken, A. Schumacher, T. Magnuson, E. Wientjens, Interaction of mouse Polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: Indication for separate Pc-G complexes, Mol. Cell. Biol. 18 (1998) 3572-3579.
39. M. van Lohuizen, S. Verbeek, B. Scheijen, E. Wientjens, H. van der Gulden, A. Berns, Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging, Cell 65 (1991) 737-752.
40. J.W. Voncken, D. Schweizer, L. Aagaard, L. Sattler, M.F. Jantsch, M. van Lohuizen, Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status, J. Cell Sci. 112 (1999) 4627-4639.