Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes

American Journal of Pathology

Volumn 162, Issue 1, 2003, Pages 161-170

  Chaturvedi, Vijaya ^a   Cesnjaj, Mirjana ^a   Bacon, Patricia ^a   Panella, Jeffery ^a   Choubey, Divaker ^a   Diaz, Manuel O ^a   Nickoloff, Brian J ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; METHYLCELLULOSE; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL ESTER; PROTEIN; PROTEIN P12; PROTEIN P14; PROTEIN P16; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; KERATINOCYTE; MITOGENESIS; MOLECULAR BIOLOGY; ONCOGENE; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PSORIASIS; SENESCENCE; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 0037223452     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63807-2     Document Type: Article

References (46)

1. Campisi J: The role of cellular senescence in skin aging. J Invest Dermatol 1998, 3:1-5
2. Krtolica A, Parrinell S, Lockett S, Desprez P-Y, Campisi J: Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci USA 2001, 98:12072-12077
3. Yaar M, Gilchrest BA: Aging versus photoaging: Postulated mechanisms and effectors. J Invest Dermatol 1998, 3:47-51
4. Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ: Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998, 396: 84-88
5. Rheinwaid JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricala C, O'Toole KM: A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol 2002, 22:5157-5172
6. Loughran O, Malliri A, Owens D, Gallimore PH, Stanley MA, Ozanne B, Frame MC, Parkinson EK: Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: Relationship of dysfunction to immortality and neoplasia. Oncogene 1996, 13:561-568
7. El-Naggar AK, Lai S, Clayman G, Lee JK, Luna MA, Goepfert H, Batsakis JG: Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma. Am J Pathol 1997, 151;1767-1774
8. Dickson MA, Hahn WC, Ino Y, Ronfard V, Wu JY, Weinberg RA, Louis DN, Li FP, Rheinwald JG: Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 2000, 20:1436-1447
9. Robertson KD, Jones PA: Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. Oncogene 1999, 18: 3810-3820
10. Sherr CJ: The INK4a/ARF network in tumor suppression. Mol Cell Biol 2001, 2:731-737
11. Ramirez RD, Morales CP, Herbert BS, Rohde JM, Passons C, Shay JW, Wright WE: Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev 2001, 15:398-403
12. Alani RM, Hasskarl J, Grace M, Hernandez MC, Israel MA, Munger K: Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1. Proc Natl Acad Sci USA 1999, 96:9637-9641
13. Nickoloff BJ, Chaturvedi V, Bacon P, Qin JZ, Denning MF, Diaz MO: Id-1 delays senescence but does not immortalize keratinocytes. J Biol Chem 2000, 275:27501-27504
14. Chaturvedi V, Qin JZ, Denning MF, Choubey D, Diaz MO, Nickoloff BJ: Apoptosis in proliferating, senescent, and immortalized keratinocytes. J Biol Chem 1999, 274:23358-23367
15. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p161NK4a. Cell 1997, 88:593-602
16. Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F: Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF Cell 2000, 103:321-330
17. Tremain R, Marko M, Kinnimulki V, Ueno H, Bottinger E, Glick A: Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras. Oncogene 2000, 19:1698-1709
18. Zhang HS, Postigo AA, Dean DC: Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p161NK4a, TGFbeta, and contact inhibition. Cell 1999, 97:53-61
19. Lo RS, Wotton D, Massague J: Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J 2001, 20:128-136
20. Van Seuningen I: Transcriptional regulation of the 11P15 mucin genes, towards new biological tools in human therapy in inflammatory diseases and cancer. Front Biosci 2001, 6:D1216-D1234
21. Nickoloff BJ: Creation of psoriatic plaques: The ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease Viewpoint. J Cutan Pathol 2001, 28:57-64
22. Nickoloff BJ: The cytokine network in psoriasis. Arch Dermatol 1991, 127:871-884
23. Rasmussen HH, Celis JE: Evidence for an altered protein kinase C (PKC) signaling pathway in psoriasis. J Invest Dermatol 1993, 101: 560-566
24. Huang RP, Fan Y, de Belle I, Niemeyer C, Gottardis MM, Mercola D, Adamson ED: Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation. Int J Cancer 1997, 72:102-109
25. Qin JZ, Chaturvedi V, Denning MF, Choubey D, Diaz MO, Nickoloff BJ: Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes. J Biol Chem 1999, 274:37957-37964
26. Qin JZ, Chaturvedi V, Denning MF, Bacon P, Panella J, Choubey D, Nickoloff BJ: Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes. Oncogene 2002, 21:2991-3002
27. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995, 92:9363-9367
28. Dlugosz AA, Cheng C, Williams EK, Dharia AG, Denning MF, Yuspa SH: Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha. Cancer Res 1994, 54:6413-6420
29. Eckert RL, Crish JF, Robinson NA: The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev 1997, 77:397-424
30. Dajee M, Tarutani M, Deng H, Cai T, Khavari PA: Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene 2002, 21:1527-1538
31. Wei S, Sedivy JM: Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts. Cancer Res 1999, 59:1539-1543
32. Zhu J, Woods D, McMahon M, Bishop JM: Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 1998, 12:2997-3007
33. Zeigler ME, Chi Y, Schmidt T, Varani J: Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes. J Cell Physiol 1999, 180:271-284
34. Peus D, Vasa RA, Beyerle A, Meves A, Krautmacher C, Pittelkow MR: UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J Invest Dermatol 1999, 112: 751-756
35. Shimizu H, Banno Y, Sumi N, Naganawa T, Kitajima Y, Nozawa Y: Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells. J Invest Dermatol 1999, 112:769-774
36. Jost M, Huggett TM, Karl C, Boise LH, Rodeck U: Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway. J Biol Chem 2001, 276:6320-6326
37. Kim SH, Kaminker P, Campisi J: Telomeres, aging and cancer: In search of a happy ending. Oncogene 2002, 21:503-511
38. Stewart SA, Weinberg RA: Senescence: Does it all happen at the ends? Oncogene 2002, 21:627-630
39. Dimri GP, Itahana K, Acosta M, Campisi J: Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol 2000, 20:273-285
40. Padgett RA, Mount SM, Steitz JA, Sharp PA: Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleo-protein. Cell 1983, 35:101-107
41. Nambiar MP, Enyedy EJ, Warke VG, Krishnan S, Dennis G, Wong HK, Kammer GM, Tsokos GC: T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA. Arthritis Rheum 2001, 44:1336-1350
42. Haase I, Hobbs RM, Romero MR, Broad S, Watt FM: A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis. J Clin Invest 2001, 108:527-536
43. Wee S, Lin Q, Tao S, Fan H, Khavari PA: Profiling genomic expression in disorders of epidermal proliferation identifies Egr-1 as a potent regulator of epidermal growth. J Invest Dermatol 2001, 117:477
44. Sukhatme VP: Early transcriptional events in cell growth: The Egr family. J Am Soc Nephrol 1990, 1:859-866
45. Amendt C, Mann A, Schirmacher P, Blessing M: Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds. J Cell Sci 2002, 115:2189-2198
46. Riggs PK, Rho O, DiGiovanni J: Alteration of Egr-1 mRNA during multistage carcinogenesis in mouse skin. Mol Carcinog 2000, 27:247-251