Differences in regional and subcellular localization of Gq/11 and RGS4 protein levels in Alzheimer's disease: Correlation with muscarinic M1 receptor binding parameters

Synapse

Volumn 47, Issue 1, 2003, Pages 58-65

  Muma, Nancy A ^a   Mariyappa, Ramesh ^a   Williams, Kyle ^a   Lee, John M ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; G protein; RGS protein

Indexed keywords

BRAIN PROTEIN; CARBACHOL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANYLYLIMIDODIPHOSPHATE; MUSCARINIC M1 RECEPTOR; PROTEIN SUBUNIT; RGS PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; BRAIN MEMBRANE; BRAIN REGION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CEREBELLUM; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSOL; DATA ANALYSIS; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; MOLECULAR MECHANICS; PARIETAL LOBE; PRIORITY JOURNAL; RECEPTOR BINDING;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AUTOPSY; BRAIN; BRAIN CHEMISTRY; CARBACHOL; CASE-CONTROL STUDIES; CELL MEMBRANE; CEREBELLUM; CHOLINERGIC AGONISTS; CYTOSOL; FRONTAL LOBE; GTP-BINDING PROTEINS; GUANYLYL IMIDODIPHOSPHATE; HUMANS; IMMUNOBLOTTING; NEURONS; PARIETAL LOBE; RECEPTOR, MUSCARINIC M1; RECEPTORS, MUSCARINIC; RGS PROTEINS;

EID: 0037211793     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10153     Document Type: Article

References (32)

1. i subfamily of G protein α subunits. Cell 86:445-452.
2. Braak H, Braak E. 1995. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16:271-278.
3. i3, is a member of a protein family with highly conserved core domain. Proc Natl Acad Sci USA 92:11916-11920.
4. Dietzel C, Kurjan J. 1987. Pheromonal regulation and sequence of the Saccharomyces cerevisiae SST2 gene: A model for desensitization to pheromone. Mol Cell Biol 7:4169-4177.
5. Dohlman HG, Apaniesk D, Chen Y, Song J, Nusskern D. 1995. Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae. Mol Cell Biol 15:3635-3643.
6. Dohlman HG, Song J, Ma D, Courchesne MW, Thorner J. 1996. Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: Expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein α subunit). Mol Cell Biol 16:5194-5209.
7. Druey KM, Blumer KJ, Kang VH, Kehrl JH. 1996. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature 379:742-746.
8. Gold SJ, Ni YG, Dohlman HG, Nestler EJ. 1997. Regulators of G-protein signaling (RGS) proteins: Region-specific expression of nine subtypes in rat brain. J Neurosci 17:8024-8037.
9. Hepler JR. 1999. Emerging roles for RGS proteins in cell signalling. Trends Pharmacol Sci 20:376-382.
10. qα. Proc Natl Acad Sci USA 94:428-432.
11. Huang CF, Hepler JR, Gilman AG, Mumby SM. 1997. Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells. Proc Natl Acad Sci USA 94:6159-6163.
12. Hunt TW, Fields TA, Casey PJ, Peralta EG. 1996. RGS10 is a selective activator of Gαi GTPase activity. Nature 383:175-177.
13. Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, Ross EM, Gilman AG, Worley PF. 1998. Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci 18:7178-7188.
14. Jope RS, Song L, Li X, Powers R. 1994. Impaired phosphoinositide hydrolysis in Alzheimer's disease brain. Neurobiol Aging 15:221- 226.
15. Koelle MR, Horvitz HR. 1996. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell 84:115-125.
16. Ladner CJ, Lee JM. 1998. Pharmacological drug treatment of Alzheimer disease: The cholinergic hypothesis revisited. J Neuropathol Exp Neurol 57:719-731.
17. Ladner CJ, Lee JM. 1999. Reduced high-affinity agonist binding at the M(1) muscarinic receptor in Alzheimer's disease brain: Differential sensitivity to agonists and divalent cations. Exp Neurol 158:451-458.
18. Ladner CJ, Celesia GG, Magnuson DJ, Lee JM. 1995. Regional alterations in M1 muscarinic receptor-G protein coupling in Alzheimer's disease. J Neuropathol Exp Neurol 54:783-789.
19. Mirnics K, Middleton FA, Stanwood GD, Lewis DA, Levitt P. 2001. Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry 6:293-301.
20. Muller DM, Mendla K, Farber SA, Nitsch RM. 1997. Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain. Life Sci 60:985-991.
21. Muller D, Wiegmann H, Langer U, Moltzen-Lenz S, Nitsch RM. 1998. Lu 25-109, a combined ml agonist and m2 antagonist, modulates regulated processing of the amyloid precursor protein of Alzheimer's disease. J Neural Transm 105:1029-1043.
22. Nitsch RM, Deng M, Growdon JH, Wurtman RJ. 1996. Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. J Biol Chem 271:4188-4194.
23. Nomoto S, Adachi K, Yang LX, Hirata Y, Muraguchi S, Kiuchi K. 1997. Distribution of RGS4 mRNA in mouse brain shown by in situ hybridization. Biochem Biophys Res Commun 241:281-287.
24. Popov S, Yu K, Kozasa T, Wilkie TM. 1997. The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPASE activating protein activity in vitro. Proc Natl Acad Sci USA 94:7216-7220.
25. Shuey DJ, Jones PG, Betty M, Khawaja XZ, Cockett MI. 1997. Attenuation of G-protein coupled receptor signaling by RGS proteins and their brain localization. Neurosci Abst 23.
26. Siderowski DP, Hessel A, Chung S, Mak TW, Tyers M. 1996. A new family of regulators of G-protein-coupled receptors? Curr Biol 6:211-212.
27. Tesmer JJ, Berman DM, Gilman AG, Sprang SR. 1997. Structure of RGS4 bound to AlF4-activated G(i alpha1): Stabilization of the transition state for GTP hydrolysis. Cell 89:251-261.
28. Tu YP, Woodson J, Ross EM. 2001. Binding of regulator of G protein signaling (RGS) proteins to phospholipid bilayers - Contribution of location and/or orientation to GTPase-activating protein activity. J Biol Chem 276:20160-20166.
29. Watson N, Linder ME, Druey KM, Kehrl JH, Blumer KJ. 1996. RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits. Nature 383:172-175.
30. Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR. 1993. Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. J Biol Chem 268:25001- 25008.
31. q-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesis. J Biol Chem 272:11924-11927.
32. Zhong HL, Neubig RR. 2001. Regulator of G protein signaling proteins: Novel multifunctional drug targets. J Pharmacol Exp Ther 297:837-845.