The Ascendancy of Amblyomma americanum as a Vector of Pathogens Affecting Humans in The United States

Annual Review of Entomology

Volumn 48, Issue , 2003, Pages 307-337

  Childs, James E ^a   Paddock, Christopher D ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Ehrlichioses; Emerging diseases; Epidemiology; Tick borne diseases; Zoonotic diseases

Indexed keywords

DISEASE TRANSMISSION; DISEASE VECTOR; EPIDEMIOLOGY; HEALTH RISK; TICK;

UNITED STATES;

ACARI; AMBLYOMMA; AMBLYOMMA AMERICANUM; BORRELIA; BORRELIA LONESTARI; EHRLICHIA; EHRLICHIA CHAFFEENSIS; EHRLICHIA EWINGII; IXODIDAE;

ANIMAL; BORRELIA; BORRELIA INFECTION; COXIELLA BURNETII; DEER; DISEASE CARRIER; DISEASE TRANSMISSION; DOMESTIC ANIMAL; EHRLICHIA; EHRLICHIOSIS; FRANCISELLA TULARENSIS; HUMAN; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOGENICITY; Q FEVER; REVIEW; TICK; TULAREMIA; UNITED STATES; WILD ANIMAL; ZOONOSIS;

ANIMALS; ANIMALS, DOMESTIC; ANIMALS, WILD; BORRELIA; BORRELIA INFECTIONS; COXIELLA BURNETII; DEER; DISEASE RESERVOIRS; EHRLICHIA; EHRLICHIOSIS; FRANCISELLA TULARENSIS; HUMANS; INSECT VECTORS; IXODIDAE; Q FEVER; TULAREMIA; UNITED STATES; ZOONOSES;

EID: 0037209284     PISSN: 00664170     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.ento.48.091801.112728     Document Type: Review

References (155)

1. Alekseev AN, Dubinina HV, Semenov AV, Bolshakov CV. 2001. Evidence of ehrlichiosis agents found in ticks (Acari: Ixodidae) collected from migratory birds. J. Med. Entomol. 38:471-74
2. Anderson BE, Dawson JE, Jones DC, Wilson KH. 1991. Ehrlichia chaffeensis, a new species associated with human ehrlichoisis. J. Clin. Microbiol. 29:2838-42
3. Anderson BE, Sims KG, Olson JG, Childs JE, Piesman JF, et al. 1993. Amblyomma americanum: apotential vector of human ehrlichiosis. Am. J. Trop. Med. Hyg. 49:239-44
4. Anigstein L, Anigstein D. 1975. A review of the evidence in retrospect for a rickettsial etiology in Bullis fever. Tex. Rep. Biol. Med. 33:201-11
5. Anigstein L, Bader MN. 1942. New epidemiological aspect of spotted fever in the gulf coast of Texas. Science 96:357-58
6. Anigstein L, Bader MN. 1943. Investigations on rickettsial diseases in Texas, part 4. Experimental study on Bullis fever. Tex. Rep. Biol. Med. 1:380-409
7. Antony SJ, Dummer JS, Hunter E. 1995. Human ehrlichiosis in a liver transplant recipient. Transplantation 60:879-81
8. Anziani OS, Ewing SA, Barker RW. 1990. Experimental transmission of a granulocytic form of the tribe Ehrlichieae by Dermacentor variabilis and Amblyomma americanum to dogs. Am. J. Vet. Res. 51:929-31
9. Armstrong PM, Brunet LR, Spielman A, Telford SR III. 2001. Risk of Lyme disease: perceptions of residents of a Lone Star tick-infested community. Bull. WHO 19:916-25
10. Baker RO, Timm RM. 1998. Management of conflicts between urban coyotes and humans in southern California. Proc. Vert. Pest Conf. 18:288-312
11. Bakken JS, Dumler JS, Chen SM, Eckman MR, Van Etta LL, Walker DH. 1994. Human granulocytic ehrlichiosis in the upper midwest United States. A new species emerging? JAMA 272:212-18
12. Barbour AG, Maupin GO, Teltow GJ, Carter CJ, Piesman J. 1996. Identification of an uncultivable Borrelia species in the hard tick Amblyomma americanum: possible agent of a Lyme disease-like illness. J. Infect Dis. 173:403-9
13. Bishopp FC, Trembley HL. 1945. Distribution and hosts of certain North American ticks. J. Parasitol. 31:1-54
14. Bloemer SR, Zimmerman RH. 1988. Ixodid ticks on the coyote and gray fox at Land Between the Lakes, Kentucky-Tennessee, and implications for tick dispersal. J. Med. Entomol. 25:5-8
15. Bloemer SR, Zimmerman RH, Fairbanks K. 1988. Abundance, attachment sites, and density estimators of lone star ticks (Acari: Ixodidae) infesting white-tailed deer. J. Med. Entomol. 25:295-300
16. Bolte JR, Hair JA, Fletcher J. 1970. White-tailed deer mortality following tissue destruction induced by lone star ticks. J. Wildl. Manag. 34:546-52
17. Brennan JM. 1945. Field investigations pertinent to Bullis fever. The lone star tick, Amblyomma americanum (Linnaeus 1758). Notes and observations from Camp Bullis, Texas. Tex. Rep. Biol. Med. 3:204-26
18. Brillhart DB, Fox LB, Upton SJ. 1994. Ticks (Acari: Ixodidae) collected from small and medium-sized Kansas mammals. J. Med. Entomol. 31:500-4
19. Buller RS, Arens M, Hmiel SP, Paddock CD, Sumner JW, et al. 1999. Ehrlichia ewingii, a newly recognized agent of human ehrlichiosis. N. Engl. J. Med. 341:148-55
20. Burgdorfer W. 1975. A review of Rocky Mountain spotted fever (tick-borne typhus), its agent, and its tick vectors in the United States. J. Med. Entomol. 12:269-78
21. Burgdorfer W, Adkins TR Jr, Priester LE. 1975. Rocky Mountain spotted fever (tick-borne typhus) in South Carolina: an educational program and tick/rickettsial survey in 1973 and 1974. Am. J. Trop. Med. Hyg. 24:866-72
22. Burgdorfer W, Hayes SF, Thomas LA, Lancaster JL Jr. 1981. A new spotted fever group rickettsia from the lone star tick, Amblyomma americanum. In Rickettsiae and Rickettsial Diseases, ed. W Burgdorfer, RL Anacker, pp. 595-602. New York: Academic
23. Calhoun EL, Alford HI. 1955. Incidence of tularemia and Rocky Mountain spotted fever among common ticks of Arkansas. Am. J. Trop. Med. Hyg. 4:310-17
24. Carpenter CF, Gandhi TK, Kong LK, Corey GR, Chen SM, et al. 1999. The incidence of ehrlichial and rickettsial infection in patients with unexplained fever and recent history of tick bite in central North Carolina. J. Infect. Dis. 180:900-3
25. Centers for Disease Control and Prevention. 2000. HIV/AIDS Surveillance Rep. 12(2)1-44, CDC, Atlanta, GA
26. Centers for Disease Control and Prevention. 2001. Summary of notifiable diseases, United States 1999. MMWR Morb. Mortal. Wkly. Rep. 48:1-104
27. Childs JE, McQuiston JH, Sumner JW, Nicholson WL, Comer JA, et al. 1999. Human monocytic ehrlichiosis due to Ehrlichia chaffeensis: how do we count the cases? In Rickettsiae and Rickettsial Diseases at the Turn of the Third Millenium, ed. D Raoult, P Brouqui, pp. 287-93. Paris: Elsevier
28. Childs JE, Sumner JW, Nicholson WL, Massung RF, Standaert SM, Paddock CD. 1999. Outcome of diagnostic tests using samples from patients with culture-proven human monocytic ehrlichiosis: implications for surveillance. J. Clin. Microbiol. 37:2997-3000
29. Cohn SE, Klein JD, Mohr JE, van der Horst CM, Weber DJ. 1994. The geography of AIDS: patterns of urban and rural migration. South. Med. J. 87:599-606
30. Comer JA, Nicholson WL, Paddock CD, Sumner JW, Childs JE. 2000. Detection of antibodies reactive with Ehrlichia chaffeensis in the raccoon. J. Wildl. Dis. 36:705-12
31. Cooley RA, Kohls GM. 1944. The genus Amblyomma (Ixodidae) in the U.S. J. Parasitol. 30:77-111
32. Cox HR. 1940. Rickettsia diaporica and American Q fever. Am. J. Trop. Med. Hyg. 20:463-69
33. Dasch GA, Kelly DJ, Richards AL, Sanchez JL, Rives CC. 1993. Western blotting analysis of sera from military personnel exhibiting serological reactivity to spotted fever group rickettsiae. Am. Soc. Trop. Med. Hyg. 49(Suppl. 3):220
34. Daszak P, Cunningham AA, Hyatt AD. 2000. Emerging infectious diseases of wildlife - threats to biodiversity and human health. Science 287:443-49
35. Davidson WR, Lockhart JM, Stallknecht DE, Howerth EW. 1999. Susceptibility of red and gray foxes to infection by Ehrlichia chaffeensis. J. Wildl. Dis. 35: 696-702
36. Davidson WR, Siefken DA, Creekmore LH. 1994. Seasonal and annual abundance of Amblyomma americanum (Acari: Ixodidae) in central Georgia. J. Med. Entomol. 31:67-71
37. Dawson JE, Anderson BE, Fishbein DB, Sanchez JL, Goldsmith CS, et al. 1991. Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis. J. Clin. Microbiol. 29:2741-45
38. Dawson JE, Biggie KL, Warner CK, Cookson K, Jenkins S, et al. 1996. Polymerase chain reaction evidence of Ehrlichia chaffeensis, etiologic agent of human ehrlichiosis, in dogs from southeast Virginia. Am. J. Vet. Res. 57:1175-79
39. Dawson JE, Childs JE, Biggie KL, Moore C, Stallknecht D, et al. 1994. White-tailed deer as a potential reservoir of Ehrlichia spp. J. Wildl. Dis. 30:162-68
40. Dawson JE, Stallknecht DE, Howerth EW, Warner C, Biggie K, et al. 1994. Susceptibility of white-tailed deer (Odocoileus virginianus) to infection with Ehrlichia chaffeensis, the etiologic agent of human ehrlichiosis. J. Clin. Microbiol. 32:2725-28
41. Dawson JE, Warner CK, Baker V, Ewing SA, Stallknecht DE, et al. 1996. Ehrlichia-like 16S rDNA sequence from wild white-tailed deer (Odocoileus virginianus). J. Parasitol. 82:52-58
42. Demaree HA Jr. 1986. Ticks of Indiana. Pittman-Robertson Bull. 16:1-178
43. Dobson A, Foufopoulos J. 2001. Emerging infectious pathogens of wildlife. Philos. Trans. R. Soc. London Ser. B. 356: 1001-12
44. Dugan VG, Little SE, Stallknecht DE, Beall AD. 2000. Natural infection of domestic goats with Ehrlichia chaffeensis. J. Clin. Microbiol. 38:448-49
45. Dumler JS, Barbet AF, Bekker CP, Dasch GA, Palmer GH, et al. 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the-order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51:2145-65
46. Durden LA, Oliver JH Jr, Kinsey AA. 2001. Ticks (Acari: Ixodidae) and spirochetes (Spirochaetaceae: Spirochaetales) recovered from birds on a Georgia Barrier Island. J. Med. Entomol. 38:231-36
47. Eng TR, Harkess JR, Fishbein DB, Dawson JE, et al. 1990. Epidemiologic, clinical, and laboratory findings of human ehrlichiosis in the United States, 1988. JAMA 264:2251-58
48. Everett ED, Evans KA, Henry RB, McDonald G. 1994. Human ehrlichiosis in adults after tick exposure; diagnosis using polymerase chain reaction. Ann. Intern. Med. 120:730-35
49. Ewing SA, Dawson JE, Kocan AA, Barker RW, Warner CK, et al. 1995. Experimental transmission of Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) among white-tailed deer by Amblyomma americanum (Acari: Ixodidae). J. Med. Entomol. 32:368-74
50. Ewing SA, Roberson WR, Buckner RG, Hayat CS. 1971. A new strain of Ehrlichia canis. J. Am. Vet. Med. Assoc. 159:1771-74
51. Felz MW, Durden LA. 1999. Attachment sites of four tick species (Acari: Ixodidae) parasitizing humans in Georgia and South Carolina. J. Med. Entomol. 36:361-64
52. Felz MW, Durden LA, Oliver JH. 1996. Ticks parasitizing humans in Georgia and South Carolina. J. Parasitol. 82:505-8
53. Fishbein DB, Dawson JE, Robinson LE. 1994. Human ehrlichiosis in the United States, 1985 to 1990. Ann. Intern. Med. 120:736-43
54. Fishbein DB, Kemp A, Dawson JE, Greene NR, Redus MA, Fields DH. 1989. Human ehrlichiosis: prospective active surveillance in febrile hospitalized patients. J. Infect. Dis. 160:803-9
55. Gardner LI, Brundage JF, Burke DS, McNeil JG, Visintine R, Miller RN. 1989. Evidence for spread of the human immunodeficiency virus epidemic into low prevalence areas of the United States. J. Acquir. Immune Defic. Syndr. 2:521-32
56. Ginsberg HS, Ewing CP, O'Connell AF, Bosler EM, Daley JG, Sayre MW. 1991. Increased population densities of Amblyomma americanum (Acari: Ixodidae) on Long Island, New York. J. Parasitol. 77:493-95
57. Goddard J. 1987. A review of the diseases harbored and transmitted by the lone star tick, Amblyomma americanum (L.). South. Entomol. 12:158-71
58. Goddard J. 1988. Was Bullis fever actually ehrlichiosis? JAMA 260:3006-7
59. Goddard J, Norment BR. 1986. Spotted fever group rickettsiae in the lone star tick, Amblyomma americanum (Acari: Ixodidae). J. Med. Entomol. 23:465-72
60. Gubler DJ, Reiter P, Ebi KL, Yap W, Nasci R, Patz JA. 2001. Climate variability and change in the United States: potential impacts on vector- and rodentborne diseases. Environ. Health Perspect. 109(Suppl. 2):223-33
61. Haile DG. 1989. Computer simulation of the effects of changes in weather patterns on vector-borne disease transmission. Rep. U.S. Environ. Prot. Agency 230-05-89-057, Appendix G, U.S. Environ. Prot. Agency, Washington, DC
62. Hair JA, Howell DE. 1970. Lone star ticks. Their biology and control in Ozark recreation areas. Rep. Bull. B-679, Oklahoma State Univ., Agric. Exp. Sta., Okla
63. Heppner DG, Wongsrichanalai C, Walsh DS, McDaniel P, Eamsila C, et al. 1997. Human ehrlichiosis in Thailand. Lancet 350:785-86
64. Hooker WA, Bishopp FC, Wood HP. 1912. The life history and bionomics of some North American ticks. Rep. Bureau Entomol.-Bull. No. 106. U.S. Dep. Agric., Washington, DC
65. Hopla CE. 1953. Experimental studies on tick transmission of tularemia organisms. Am. J. Hyg. 58:101-8
66. Hopla CE, Downs CM. 1953. The isolation of Bacterium tularense from the tick Amblyomma americanum. J. Kans. Entomol. Soc. 26:71-72
67. Ijdo JW, Wu C, Magnarelli LA, Stafford KC, Anderson JF, Fikrig E. 2000. Detection of Ehrlichia chaffeensis DNA in Amblyomma americanum ticks in Connecticut and Rhode Island. J. Clin. Microbiol. 38:4655-56
68. Irving RP, Pinger RR, Vann CN, Olesen JB, Steiner FE. 2000. Distribution of Ehrlichia chaffeensis (Rickettsiales: Rickettsiaeceae) in Amblyomma americanum in southern Indiana and prevalence of E. chaffeensis-reactive antibodies in white-tailed deer in Indiana and Ohio in 1998. J. Med. Entomol. 37:595-600
69. Jackson RT, Jackson JW. 1997. Ehrlichiosis with systemic sepsis syndrome. Tenn. Med. 90:185-86
70. James AM, Livens D, Wormser GP, Schwarte I, Montecalvo MA, Johnson BJ. 2001. Borrelia lonestari infection after a bite by an Amblyomma americanum tick. J. Infect. Dis. 183:1810-14
71. Keirans JE, Lacombe EH. 1998. First records of Amblyomma americanum, Ixodes (Ixodes) dentatus, and Ixodes (Ceratixodes) uriae (Acari : Ixodidae) from Maine. J. Parasitol. 84:629-31
72. Kennamer JE, Kennamer M, Brenneman R. 1992. History. In The Wild Turkey: Biology and Management, ed. JG Dickson, pp. 6-17. Mechanicsburg, PA: Stackpole Books
73. Kirkland KB, Klimko TB, Meriwether RA, Schriefer M, Levin M, et al. 1997. Erythema migrans-like rash illness at a camp in North Carolina: a new tick-borne disease? Arch. Intern. Med. 157:2635-41
74. Knox WM. 1997. Historical changes in the abundance and distribution of deer in Virginia. See Ref. 93a, pp. 27-36
75. Kocan A, Levesque GC, Whitworth LC, Murphy GL, Ewing SA, Barker RW. 2000. Naturally occurring Ehrlichia chaffeensis infection in coyotes from Oklahoma. Energy Infect. Dis. 6:477-80
76. Koch HG, Dunn JE. 1980. Ticks collected from small and medium-sized wildlife hosts in Leflore County, Oklahoma. South. Nat. 5:214-21
77. Kollars TM. 1993. Ticks (Acari: Ixodidae) infesting medium-sized wild mammals in southwestern Tennessee. J. Med. Entomol. 30:896-900
78. Kordick SK, Breitschwerdt EB, Hegarty BC, Southwick KL, Colitz CM, et al. 1999. Coinfection with multiple tick-borne pathogens in a Walker Hound kennel in North Carolina. J. Clin. Microbiol. 37:2631-38
79. Lane RS, Piesman J, Burgdorfer W. 1991. Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and Europe. Annu. Rev. Entomol. 36:587-609
80. Levine JF, Sonenshine DE, Nicholson WL, Turner RT. 1991. Borrelia burgdorferi in ticks (Acari: Ixodidae) from coastal Virginia. J. Med. Entomol. 28:668-74
81. Little SE, Stallknecht DE, Lockhart JM, Dawson JE, Davidson WR. 1998. Natural coinfection of a white-tailed deer (Odocoileus virginianus) population with three Ehrlichia spp. J. Parasitol. 84:897-901
82. Lockhart JM, Davidson WR, Dawson JE, Stallknecht DE. 1995. Temporal association of Amblyomma americanum with the presence of Ehrlichia chaffeensis reactive antibodies in white-tailed deer. J. Wildl. Dis. 31:119-24
83. Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE. 1996. Site-specific geographic association between Amblyomma americanum (Acari: Ixodidae) infestations and Ehrlichia chaffeensis-reactive (Rickettsiales: Ehrlichieae) antibodies in white-tailed deer. J. Med. Entomol. 33:153-58
84. Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE. 1998. Lack of seroreactivity to Ehrlichia chaffeensis among rodent populations. J. Wildl. Dis. 34:392-96
85. Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE, Howerth EW. 1997. Isolation of Ehrlichia chaffeensis from wild white-tailed deer (Odocoileus virginianus) confirms their role as natural reservoir hosts. J. Clin. Microbiol. 35:1681-86
86. Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE, Little SE. 1997. Natural history of Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) in the piedmont physiographic province of Georgia. J. Parasitol. 83:887-94
87. Long L, DeAre D. 1982. Repopulating the countryside: a 1980 census trend. Science 217:1111-16
88. Maeda K, Markowitz N, Hawley RC, Ristic M, Cox D, McDade JE. 1987. Human infection with Ehrlichia canis, a leukocytic rickettsia. N. Engl. J. Med. 316:853-56
89. Magnarelli LA, Anderson JF, Stafford KC, Dumler JS. 1997. Antibodies to multiple tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in white-footed mice. J. Wildl. Dis. 33:466-73
90. Marty AM, Dumler JS, Imes G, Brusman HP, Smrkovski LL, Frisman DM. 1995. Ehrlichiosis mimicking thrombotic thrombocytopenic purpura. Case report and pathological correlation. Hum. Pathol. 26:920-25
91. Masters EJ, Donnell HD, Fobbs M. 1994. Missouri Lyme disease: 1989 through 1992. J. Spir. Tick-Borne Dis. 1:12-17
92. McCabe TR, McCabe RE. 1997. Recounting whitetails past. See Ref. 93a, pp. 11-26
93. McCall CL, Curns AT, Singleton JS, Comer JA, Olson JG, et al. 2001. Fort Chaffee revisited; the epidemiology of tickborne diseases at a persistent focus. Vect. Borne Zoonot. Dis. 2:119-27
94. McDade JE. 1990. Ehrlichiosis - a disease of animals and humans. J. Infect. Dis. 161:609-17
95. McQuiston JH, Paddock CD, Holman RC, Childs JE. 1999. The human ehrlichioses in the United States. Emerg. Infect. Dis. 5:635-42
96. McShea WJ, Underwood HB, Rappole JH, eds. 1997. The Science of Over Abundance: Deer Ecology and Population Management. Washington, DC: Smithson. Inst. Press. 432 pp.
97. Means RG, White DJ. 1997. New distribution records of Amblyomma americanum (L.) (Acari: Ixodidae) in New York State. J. Vector Ecol. 22:133-45
98. Merten HA, Durden LA. 2000. A state-by-state survey of ticks recorded from humans in the United States. J. Vector Ecol. 25:102-13
99. Mock DE, Applegate RD, Fox LB. 2001. Preliminary survey of ticks (Acari: Ixodidae) parasitizing wild turkeys (Aves: Phasianidae) in eastern Kansas. J. Med. Entomol. 38:118-21
100. Moore GC, Parker GR. 1992. Colonization by the eastern coyote (Canis latrans). In Ecology and Management of the Eastern Coyote, ed. AH Boer, pp. 21-37. Fredericton, N.B.: Wildl. Res. Unit, Univ. New Brunswick
101. Morris JG Jr, Potter M. 1997. Emergence of new pathogens as a function of changes in host susceptibility. Emerg. Infect. Dis. 3:435-41
102. Mount GA, Haile DG, Barnard DR, Daniels E. 1993. New version of LST-SIM for computer simulation of Amblyomma americanum (Acari: Ixodidae) population dynamics. J. Med. Entomol. 30:843-57
103. Mueller-Anneling L, Gilchrist MJ, Thorne PS. 2000. Ehrlichia chaffeensis antibodies in white-tailed deer, Iowa, 1994 and 1996. Emerg. Infect. Dis. 6:397-400
104. Murphy GL, Ewing SA, Whitworth LC, Fox JC, Kocan AA. 1998. A molecular and serologic survey of Ehrlichia canis, E. chaffeensis, and E. ewingii in dogs and ticks from Oklahoma. Vet. Parasitol. 79:325-39
105. Nuti M, Serafini DA, Bassetti D, Ghionni A, Russino F, et al. 1998. Ehrlichia infection in Italy. Emerg. Infect. Dis. 4:663-65
106. Olano JP, Masters E, Cullman L, Hogrefe W, Yu XJ, Walker DH. 1999. Human monocytotropic ehrlichiosis (HME): epidemiological, clinical and laboratory diagnosis of a newly emergent infection in the United States. In Rickettsiae and Rickettsial Diseases at the Turn of the Third Millenium, ed. D Raoult, P Brouqui, pp. 262-68. Paris: Elsevier
107. Oliver JH Jr, Chandler FW Jr, James AM, Sanders FH Jr, Hutcheson HJ, et al. 1995. Natural occurrence and characterization of the Lyme disease spirochete, Borrelia burgdorferi, in cotton rats (Sigmodon hispidus) from Georgia and Florida. J. Parasitol. 81:30-36
108. Oliver JH Jr, Chandler FW Jr, Luttrell MP, James AM, Stallknecht DE, et al. 1993. Isolation and transmission of the Lyme disease spirochete from the southeastern United States. Proc. Natl. Acad. Sci. USA 90:7371-75
109. Ostfeld RS, Keesing F. 2000. Biodiversity and disease risk: the case of Lyme disease. Conserv. Biol. 14:722-28
110. Ouellette J, Apperson CS, Howard P, Evans TL, Levine JF. 1997. Tick-raccoon associations and the potential for Lyme disease spirochete transmission in the coastal plain of North Carolina. J. Wildl. Dis. 33:28-39
111. Paddock CD, Folk SM, Shore GM, Machado LJ, Huycke MM, et al. 2001. Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with HIV. Clin. Infect. Dis. 33:1586-94
112. Paddock CD, Sumner JW, Shore GM, Bartley DC, Elie RC, et al. 1997. Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis. J. Clin. Microbiol. 35:2496-502
113. Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, et al. 1998. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators. N. Engl. J. Med. 338:853-60
114. Parker RR, Kohls GM. 1943. American Q fever: the occurrence of Rickettsia diaporica in Amblyomma americanum from eastern Texas. Pub. Health Rep. 58:1510-11
115. Parker RR, Kohls GM, Cox GW, Davis GE. 1939. Observations on an infectious agent from Amblyomma maculatum. Pub. Health Rep. 54:1482-84
116. Parker RR, Kohls GM, Steinhaus EA. 1943. Rocky Mountain spotted fever: spontaneous infection in Amblyomma americanum. Pub. Health Rep. 58:721-29
117. Pawelec G, Solana R, Remarque E, Mariani E. 1998. Impact of aging on innate immunity. J. Leukoc. Biol. 64:703-12
118. Philip CB, White JS. 1955. Disease agents recovered incidental to a tick survey of the Mississippi Gulf Coast. J. Econ. Entomol. 48:396-99
119. Pung OJ, Durden LA, Banks CW, Jones DN. 1994. Ectoparasites of opossums and raccoons in southeastern Georgia. J. Med. Entomol. 31:915-19
120. Rawlings J. 1996. Human ehrlichiosis in Texas. J. Spir. Tick-Borne Dis. 3:94-97
121. Rehacek J. 1989. Ecological relationships between ticks and rickettsiae. Eur. J. Epidemiol. 5:407-13
122. Riley SPD, Hadidian J, Manski DA. 1998. Population density, survival, and rabies in raccoons in an urban national park. Can. J. Zool. 76:1153-64
123. Ripoll CM, Remondegui CE, Ordonez G, Arazamendi R, Fusaro H, et al. 1999. Evidence of rickettsial spotted fever and ehrlichial infections in a subtropical territory of Jujuy, Argentina. Am. J. Trop. Med. Hyg. 61:350-54
124. Rue LL. 1978. The Deer of North America. New York: Crown Publ.
125. Rumley RL, Shappley NC, Waivers LE, Esinhart JD. 1991. AIDS in rural eastern North Carolina - patient migration: a rural AIDS burden. AIDS 5:1373-78
126. Rutberg AT. 1997. The science of deer management; an animal welfare perspective. See Ref. 93a, pp. 37-54
127. Sadikot R, Shaver MJ, Reeves WB. 1999. Ehrlichia chaffeensis in a renal transplant recipient. Am. J. Nephrol. 19:674-76
128. Schultze TL, Bosler EM. 1996. Another look at the potential role of Amblyomma americanum in the transmission of tickborne disease. J. Spir. Tick-Borne Dis. 3:113-15
129. Sexton DJ, Corey GR, Carpenter C, Kong LQ, Gandhi T, et al. 1998. Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report. Emerg. Infect. Dis. 4:311-16
130. Shibata S, Kawahara M, Rikihisa Y, Fujita H, Watanabe Y, et al. 2000. New Ehrlichia species closely related to Ehrlichia chaffeensis isolated from Ixodes ovatus ticks in Japan. J.Clin. Microbiol. 38:1331-38
131. Sonenshine DE, Stout IJ. 1971. Ticks infesting medium-sized wild mammals in two forest localities in Virginia (Acarina: Ixodidae). J. Med. Entomol. 8:217-27
132. Standaert SM, Dawson JE, Schaffner W, Childs JE, Biggie KL, et al. 1995. Ehrlichiosis in a golf-oriented retirement community. N. Engl. J. Med. 333:420-25
133. Standaert SM, Yu T, Scott MA, Childs JE, Paddock CD, et al. 2000. Primary isolation of Ehrlichia chaffeensis from patients with febrile illnesses: clinical and molecular characteristics. J. Infect. Dis. 181:1082-88
134. Steiner FE, Pinger RR, Vann CN. 1999. Infection rates of Amblyomma americanum (Acari: Ixodidae) by Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) and prevalence of E. chaffeensis-reactive antibodies in white-tailed deer in southern Indiana, 1997. J. Med. Entomol. 36:715-19
135. Stromdahl EY, Evans SR, O'Brien JJ, Gutierrez AG. 2001. Prevalence of infection in ticks submitted to the human tick test kit program of the U.S. Army Center for Health Promotion and Preventive Medicine. J. Med. Entomol. 38:67-74
136. Stromdahl EY, Randolph MP, O'Brien JJ, Gutierrez AG. 2000. Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) infection in Amblyomma americanum (Acari: Ixodidae) at Aberdeen Proving Ground, Maryland. J. Med. Entomol. 37:349-56
137. Sumner JW, McKechnie D, Janowski D, Paddock CD. 2000. American Society for Rickettsiology. Presented at 15th Meet., Captiva Flor. 51 (Abstr.)
138. Sumner JW, Storch GA, Buller RS, Liddell AM, Stockham SL, et al. 2000. PCR amplification and phylogenetic analysis of groESL operon sequences from Ehrlichia ewingii and Ehrlichia muris. J. Clin. Microbiol. 38:2746-49
139. Tabor GM, Ostfeld RS, Poss M, Dobson AP, Aguirre AA. 2001. Conservation biology and the health sciences: defining the research priorities of conservation medicine. In Conservation Biology, ed. ME Soulé, GH Orians, pp. 155-73. Washington, DC: Island
140. Taylor JP, Istre GR, McChesney TC, Satalowich FT, Parker RL, McFarland LM. 1991. Epidemiologic characteristics of human tularemia in the southwest-central states, 1981-1987. Am. J. Epidemiol. 133:1032-38
141. Thompson C, Spielman A, Krause PJ. 2001. Coinfecting deer-associated zoonoses: lyme disease, babesiosis, and ehrlichiosis. Clin. Infect. Dis. 33:676-85
142. Topping NH. 1947. The epidemiology of Rocky Mountain spotted fever. N. Y. State J. Med. 1585-87
143. Tugwell P, Lancaster JL Jr. 1962. Results of a tick-host study in northwest Arkansas. J. Kans. Entomol. Soc. 35:202-11
144. U.S. Census Bureau. 1999. Statistical Abstract of the United States. Washington, DC: U.S. Census Bureau. pp. 1-1005
145. U.S. Census Bureau. 2001. Current population reports, series P23-205, population profile of the United States, 1999. Washington, DC: U.S. Gov Print. Off.
146. Uhaa IJ, MacLean JD, Green CR, Fishbein DB. 1992. A case of human ehrlichiosis acquired in Mali: clinical and laboratory findings. Am. J. Trop. Med. Hyg. 46:161-64
147. Walker DH. 2000. Diagnosing human ehrlichioses: current status and recommendations. ASM News 66:287-89
148. Walker DH, Barbour AG, Oliver JH, Lane RS, Dumler JS, et al. 1996. Emerging bacterial zoonotic and vector-borne diseases. Ecological and epidemiological factors. JAMA 275:463-69
149. Washburn AM, Tuohy JH. 1949. The changing picture of tularemia transmission in Arkansas. South. Med. J. 42:60-62
150. Weller SJ, Baldridge GD, Munderloh UG, Noda H, Simser J, Kurtti TJ. 1998. Phylogenetic placement of rickettsiae from the ticks Amblyomma americanum and Ixodes scapularis. J.Clin. Microbiol. 36:1305-17
151. Whitlock JE, Fang QQ, Durden LA, Oliver JH Jr. 2000. Prevalence of Ehrlichia chaffeensis (Rickettsiales: Rickettsiaceae) in Amblyomma americanum (Acari: Ixodidae) from the Georgia coast and Barrier Islands. J. Med. Entomol. 37:276-80
152. Woodland JC, McDowell MM, Richards JT. 1943. Bullis fever (Lone Star tick fever-tick fever). JAMA 122:1156-60
153. Wolf L, McPherson T, Harrison B, Engber B, Anderson A, Whitt P. 2000. Prevalence of Ehrlichia ewingii in Amblyomma americanum in North Carolina. J. Clin. Microbiol. 38:2795
154. Yabsley MJ, Varela AS, Tate CM, Dugan VG, Stallknecht DE, et al. 2002. Ehrlichia ewingii infection in white-tailed deer (Odocoileus virginianus). Emerg. Infect. Dis. 8:668-71
155. Zimmerman RH, McWherter GR, Bloemer SR. 1988. Medium-sized mammal hosts of Amblyomma americanum and Dermacentor variabilis (Acari: Ixodidae) at Land Between the Lakes, Tennessee, and effects of integrated tick management on host infestations. J. Med. Entomol. 25:461-66