Genetic and structural heterogeneity of proteophosphoglycans in Leishmania

Molecular and Biochemical Parasitology

Volumn 121, Issue 1, 2002, Pages 75-85

  Montgomery, Jacqui ^a   Curtis, Joan ^a   Handman, Emanuela ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Glycosylphosphatidylinositol; Leishmania; Parasite; Proteophosphoglycan

Indexed keywords

GLYCAN DERIVATIVE; GLYCOSYLATED PROTEIN; POLYPEPTIDE;

ARTICLE; CHROMOSOME; CONTROLLED STUDY; GENE STRUCTURE; GENETIC HETEROGENEITY; GLYCOSYLATION; LEISHMANIA; MOLECULAR WEIGHT; MULTIGENE FAMILY; NONHUMAN; PARASITE ISOLATION; PARASITE LOCALIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; STANDARD; SURFACE PROPERTY;

ANIMALS; CELL MEMBRANE; CHROMOSOME MAPPING; ELECTROPHORESIS, AGAR GEL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LEISHMANIA; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEOGLYCANS; PROTOZOAN PROTEINS; VARIATION (GENETICS);

LEISHMANIA MAJOR;

EID: 0037197767     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00024-5     Document Type: Article

References (45)

1. Structure of the lipophosphoglycan from Leishmania major
2. Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids
3. An amphipathic sulphated glycoconjugate of Leishmania: Characterization with monoclonal antibodies
4. The generation of infective stage Leishmania major promastigotes is associated with the cell-surface expression and release of a developmentally regulated glycolipid
5. Purification and structural characterization of a filamentous, mucin-like proteophosphoglyean secreted by Leishmania parasites
6. Molecular cloning and characterization of a novel repeat-containing leishmania major gene, ppg1, that encodes a membrane-associated form of proteophosphoglycan with a putative glycosylphosphatidylinositol anchor
7. Molecular determinants of Leishmania virulence
8. Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania
9. Cell biology of Leishmania
10. Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major
11. Proteophosphoglycans of Leishmania
12. Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana
13. Stage-specific proteophosphoglycan from Leishmania mexicana amastigotes
14. The role of phosphoglycans in Leishmania-sand fly interactions
15. Filamentous proteophosphoglycan secreted by Leishmania promastigotes forms gel-like three-dimensional networks that obstruct the digestive tract of infected sandfly vectors
16. Purification, partial characterization and immunolocalizadon of a proteophosphoglycan secreted by Leishmania mexicana amastigotes
17. Identification and predicted structure of a leucine-rich repeat motif shared by Leishmania major proteophosphoglycan and parasite surface antigen 2
18. Proteophosphoglycans of Leishmania mexicana, Molecular cloning and characterization of the Leishmania mexicana ppg2 gene encoding the proteophosphoglycans appg and pppg2 that are secreted by amastigotes and promastigotes
19. Isolation and characterization of infective and non-infective clones of Leishmania tropica
20. Presentation of the Leishmania antigen LACK by infected macrophages is dependent upon the virulence of the phagocytosed parasites
21. Leishmania major and L. donovani: A method for rapid purification of amastigotes
22. Monoclonal antibodies to Leishmania mexicana promastigote antigens. I. Secreted acid phosphatase and other proteins share epitopes with lipophosphoglycan
23. Monoclonal antibodies directed against Leishmania secreted acid phosphatase and lipophosphoglycan. Partial characterization of private and public epitopes
24. Genomic organization, chromosomal location and transcription of dispersed and repeated tubulin genes in Leishmania major
25. Chromosome size polymorphisms and mapping of tubulin gene loci in Leishmania
26. The 63-kilobase circular amplicon of tunicamycin-resistant Leishmania amazonensis contains a functional N-acetylglucosamine-1-phosphate transferase gene that can be used as a dominant selectable marker in transfection
27. Episomal expression of specific sense and antisense mRNAs in Leishmania amazonensis: Modulation of gp63 level in promastigotes and their infection of macrophages in vitro
28. Multi-site DNA polymorphism analyses of Leishmania isolates define their genotypes predicting clinical epidemiology of leishmaniasis in a specific region
29. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
30. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
31. Methods for separation and deglycosylation of mucin subunits
32. High-efficiency blotting of proteins of diverse sizes following sodium dodecyl sulfate-polyacrylamide gel electrophoresis
33. The Complete Chromosomal Organization of the Reference Strain of the Leishmania Genome Project, L. major 'Friedlin'
34. The Leishmania genome comprises chromosomes conserved across widely divergent human pathogenic species
35. Leishmania major proteophosphoglycan is expressed by amastigotes and has an immunomodulatory effect on macrophage function
36. Mucin-like proteophosphoglycans from the protozoan parasite Leishmania
37. Ricin-resistant mutants of Leishmania major which express modified lipophosphoglycan remain infective for mice
38. Variants of a Leishmania surface antigen derived from a multigenic family
39. Ser/Thr-rich repetitive motifs as targets for phosphoglycan modifications in Leishmania mexicana secreted acid phosphatase
40. Proteophosphoglycans of Leishmania mexicana. Identification, purification, structural and ultra structural characterization of the secreted promastigote proteophosphoglycan pppg2, a stage-specific glycoisoform of amastigote appg
41. Characterization of polymer release from the flagellar pocket of Leishmania mexicana promastigotes
42. Passive transfer of Leishmania lipophosphoglycan confers parasite survival in macrophages
43. Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI): Protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins
44. Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glycoprotein 63 in promastigotes and amastigotes of Leishmania mexicana