A single amino acid change at Leu-188 in the reverse transcriptase of HIV-2 and SIV renders them sensitive to non-nucleoside reverse transcriptase inhibitors

Archives of Virology

Volumn 146, Issue 4, 2001, Pages 743-755

  Isaka, Y ^a   Miki, S ^a   Kawauchi, S ^a   Suyama, A ^a   Sugimoto, H ^a   Adachi, A ^b   Miura, T ^c   Hayami, M ^c   Yoshie, O ^d   Fujiwara, T ^a   Sato, A ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; AMINO ACID; CYSTEINE; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUCINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SENSITIVITY; SIMIAN IMMUNODEFICIENCY VIRUS; SITE DIRECTED MUTAGENESIS; TYROSINE; VIRUS MUTATION; VIRUS RESISTANCE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-HIV AGENTS; CELL LINE; DELAVIRDINE; DRUG RESISTANCE, MICROBIAL; HELA CELLS; HIV-2; HUMANS; LEUCINE; MOLECULAR SEQUENCE DATA; NEVIRAPINE; OXAZINES; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; SEQUENCE HOMOLOGY, AMINO ACID; SIMIAN IMMUNODEFICIENCY VIRUS; SPECIES SPECIFICITY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0035016048     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007050170143     Document Type: Article

References (26)

1. Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A, Martin MA (1986) Production of acquired immunodeficiency syndrome-associated retrovirus in human and non-human cells transfected with an infectious molecular clone. J Virol 59: 284-291
2. Bacolla A, Shih CK, Rose JM, Piras G, Warren TC, Grygon CA, Ingraham RH, Cousins RC, Greenwood DJ, Richmann D, Cheng YC, Griffin JA (1993) Amino acid substitution in HIV-1 reverse transcriptase with corresponding residues from HIV-2. J Biol Chem 268: 16571-16577
3. Debyser Z, De Vreese K, Pauwels R, Yamamoto N, Anne J, De Clercq E, Desmyter J (1992) Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus. J Gen Virol 73: 1799-1804
4. De Clercq E (1992) HIV inhibitors targeted at the reverse transcriptase. AIDS Res Hum Retroviruses 8: 119-134
5. De Clercq E (1998) The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection. Antiviral Res 38: 153-179
6. Emini EA, Graham DJ, Gotlib L, Condra JH, Byrnes VW, Schleif WA (1993) HIV and multidrug resistance. Science 364: 679
7. Fujiwara M, Kodama EN, Okamoto M, Tokuhisa K, Ide T, Hanasaki Y, Katsuura K, Takayama H, Aimi N, Mitsuya H, Shigeta S, Konno K, Yokota T, Baba M (1999) Characterization of human immunodeficiency virus type 1 strains resistant to the non-nucleoside reverse transcriptase inhibitor RD4-2217. Antiviral Chem Chemother 10: 315-320
8. Fujiwara T, Sato A, El-Farrash M, Miki S, Abe K, Isaka Y, Kodama M, Wu Y, Chen LB, Harada H, Sugimoto H, Hatanaka M, Hinuma Y (1998) S-1153 inhibits replication of known drug-resistant strains of human immunodeficiency virus type 1. Antimicrob Agents Chemother 42: 1340-1345
9. Jeffrey S, Baker D, Tritch R, Rizzo C, Logue K, Bacheler L (1988) A resistance and cross resistance profile for SUSTIVA (Efavirenz, DMP-266). 5th Conference on Retroviruses and Opportunistic Infections, Chicago, Illinois
10. Isaka Y, Sato A, Kawauchi S, Suyama A, Miki S, Hayami M, Fujiwara T (1998) Construction of the chimeric reverse transcriptase of simian immunodeficiency virus sensitive to nonnucleoside reverse transcriptase inhibitor. Microbiol Immunol 42: 195-202
11. Isaka Y, Sato A, Miki S, Kawauchi S, Sakaida H, Hori T, Uchiyama T, Adachi A, Hayami M, Fujiwara T, Yoshie O (1999) Small amino acid changes in the V3 Loop of human immunodeficiency virus type 2 determines the coreceptor usage for CXCR4 and CCR5. Virology 264: 237-243
12. Isaka Y, Miki S, Kawauchi S, Suyama A, Sugimoto H, Adachi A, Hayami M, Yoshie O, Fujiwara T, Sato A (2000) Isolation and characterization of simian immunodeficiency virus variants that are resistant to nonnucleoside reverse transcriptase inhibitors. Arch Virol 145: 2481-2492
13. Kawamura M, Shimano R, Ogasawara T, Inubushi R, Amano K, Akari H, Adachi A (1998) Mapping the genetic determinants of human immunodeficiency virus type 2 for cell tropism and replication efficiency. Arch Virol 143: 1-9
14. Kimpton J, Emerman M (1992) Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene. J Virol 66: 2232-2239
15. MAC. J Virol 62: 4691-4696
16. Peeters M, Piot P, Van der Groen G (1991) Variability among HIV and SIV strains of African origin. AIDS 5 [Suppl 1]: S29-S36
17. Sato A, Kodama M, Abe K, Miki S, Nishimura M, Suyama A, Ogata M, Toyoda T, Sugimoto H, Yoshie O, Fujiwara T (1995) A simple and rapid method for preliminary evaluation of in vivo efficacy of anti-HIV compounds in mice. Antiviral Res 27: 151-163
18. Sato A, Sugita K, Isaka Y, Miki S, Kawauchi S, Suyama A, Abe K, Sugimoto H, Fujiwara T. Resistance Profile of human immunodeficiency virus Type 1 non-nucleoside reverse transcriptase inhibitor AG1549/S-1153 (in preparation)
19. Schmit JC, Cogniaux J, Hermans P, Van Vaeck C, Sprecher S, Van Remoortel B, Witvrouw M, Barizarini J, Desmyter J, De Clercq E, Vandamme AM (1996) Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type a patient strain. J Infect Dis 174: 962-968
20. Shaharabany M, Hizi A (1992) The catalytic functions of chimeric reverse transcriptases of human immunodeficiency viruses type 1 and type 2. J Biol Chem 267: 3674-3678
21. AGM. J Virol 64: 742-747
22. Shibata R, Kawamura M, Sakai H, Hayami M, Ishimoto A, Adachi A (1991) Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. J Virol 65: 3514-3520
23. Shih CK, Rose JM, Hansen GL, Wu JC, Bacolla A, Griffin JA (1991) Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptase display reversed sensitivity to nonnucleoside analog inhibitors. Proc Natl Acad Sci USA 88: 9878-9882
24. Tachibana K, Nakajima T, Sato A, Igarashi K, Shida H, Iizawa H, Yoshida N, Yoshie O, Kishimoto T, Nagasawa T (1997) CXCR-4/fusin is not a species-specific barrier in murine cells for HIV-1 entry. J Exp Med 185: 1865-1870
25. Tisdale M, Kemp SD, Parry NR, Larder BA (1993) Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc Natl Acad Sci USA 90: 5653-5656
26. Young SD, Britcher SF, Tran LO, Payne LS, Lumma WC, Lyle TA, Huff JR, Anderson PS, Olsen DB, Carroll SS, Pettibone DJ, O'Brien JA, Ball RG, Balani SK, Lin JH, Chen IW, Schleif WA, Sardana VV, Long WJ, Byrnes VW, Emini EA (1995) L-743,726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 39: 2602-2605