Open channel structure of MscL and the gating mechanism of mechanosensitive channels

Nature

Volumn 418, Issue 6901, 2002, Pages 942-948

  Perozo, Eduardo ^a   Cortes, D Marien ^a   Sompornpisut, Pornthep ^a,b   Kloda, Anna ^c   Martinac, Boris ^c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUDITION; ELECTRON SPIN RESONANCE SPECTROSCOPY; LIPIDS; MORPHOLOGY;

OPEN CHANNEL STRUCTURES;

ELECTRIC SWITCHES;

BIOLOGY;

CHANNEL GATING; ELECTRON SPIN RESONANCE; HEARING; LIPID BILAYER; MEMBRANE CHANNEL; MOLECULAR DYNAMICS; OSMOREGULATION; PRIORITY JOURNAL; REVIEW; TOUCH;

COMPUTER SIMULATION; CYSTEINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI PROTEINS; ION CHANNEL GATING; ION CHANNELS; LIPID BILAYERS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROTEIN STRUCTURE, QUATERNARY; SOLVENTS; SPIN LABELS; THERMODYNAMICS;

PROKARYOTA;

EID: 0037194760     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00992     Document Type: Article

References (38)

1. Mechanosensitive channels of Escherichia coli: The MscL gene, protein, and activities
2. Osmosensing by bacteria: Signals and membrane-based sensors
3. Molecular basis of mechanotransduction in living cells
4. Mechanosensitive ion channels of E. Coli activated by amphipaths
5. A large-conductance mechanosensitive channel in E. Coli encoded by mscL alone
6. A mammalian two pore domain mechano-gated S-like K + channel
7. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: Identification of genes required for MscS ativity
8. Structure of the MscL homolog from Mycobacterium tuberculosis: A gated mechanosensitive ion channel
9. One face of a transmembrane helix is crucial in mechanosensitive channel gating
10. Hydrophilicity of a single residue residue within MscL correlates with increased channel mechanosensitivity
11. Chemically charging the pore constriction opens the mechanosensitive channel MscL
12. Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli
13. Feeling the pressure: Structural insights into a gated mechanosensitive channel
14. Channel gate: Tension, leak and disclosure
15. The gating mechanism of the large mechanosensitive channel MscL
16. Structural models of the MscL gating mechanism
17. Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating
18. + channels TREK-1 and TRAAK
19. Recent advances in site-directed spin labeling of proteins
20. Identifying conformational changes with site-directed spin labeling
21. Site-directed spin-labeling analysis of reconstituted Mscl in the closed state
22. Calculation of rigid-body conformational changes using restraint-driven Cartesian transformations
23. Structure of the KcsA channel intracellular gate in the open state
24. The interpretation of protein structures: Estimation of static accessibility
25. Pressure-sensitive ion channel in Escherichia coli
26. Mechanosensitive channels in prokaryotes
27. Structural determinants of MscL gating studied by molecular dynamics simulations
28. HOLE a program for the analysis of the pore dimensions of ion channel structural models
29. Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL
30. + channel studied by EPR spectroscopy
31. Molecular architecture of full-length KcsA: Role of cytoplasmic domains in ion permeation and activation gating
32. Transmembrane protein structure: Spin labeling ofbacteriorhodopsin mutants
33. Spectroscopically-determined solvent accessibilities as constraints for global fold discrimination in proteins
34. AQUA PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR
35. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons