Analysis of targeting sequences demonstrates that trafficking to the Toxoplasma gondii plastid branches off the secretory system

Journal of Cell Science

Volumn 113, Issue 22, 2000, Pages 3969-3977

  DeRocher, A ^a   Hagen, C B ^a   Froehlich, J E ^a   Feagin, J E ^a   Parsons, M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Apicoplast; Chloroplast; Mitochondrion; Protein targeting; Toxoplasma gondii

Indexed keywords

AMINO ACID; PROTEIN; RIBOSOME PROTEIN; SIGNAL PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL NUCLEUS; CHLOROPLAST; GENE DELETION; GENE FUSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRION; MODEL; NONHUMAN; PLASTID; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN TARGETING; PROTEIN TRANSPORT; SECRETION; TOXOPLASMA GONDII;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL NUCLEUS; CHLOROPLASTS; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; ORGANELLES; PLASTIDS; PROTEIN BIOSYNTHESIS; PROTOZOAN PROTEINS; RIBOSOMAL PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TOXOPLASMA; TRANSCRIPTION, GENETIC; TRANSFECTION;

PROTOZOA; TOXOPLASMA GONDII;

EID: 0034474466     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
2. Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics
3. Targeting proteins to diatom plastids involves transport through an endoplasmic reticulum
4. In vitro import of protein into chloroplasts
5. Thermolysin is a suitable protease for probing the surface of intact pea chloroplasts
6. Simultaneous targeting of pea glutathione reductase and of a bacterial fusion protein to chloroplasts and mitochondria in transgenic tobacco
7. Distinct domains of a nucleolar protein mediate protein kinase binding, interaction with nucleic acids and nucleolar localization
8. ChloroP, a neural network-based method for predicting chloroplast transit peptides and their cleavage sites
9. Mitochondrial genome diversity in parasites
10. A plastid organelle as a drug target in apicomplexan parasites
11. Chloroplast transit peptides from the green alga Chlamydomonas reinhardtii share features with both mitochondrial and higher plant chloroplast preseqeunces
12. A yeast mitochondrial leader peptide functions in vivo as a dual targeting signal for both chloroplasts and mitochondria
13. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalerial drugs
14. Protein import and routing systems of chloroplasts
15. The presequence of Euglena LHCPII, a cytoplasmically synthesized chloroplast protein, contains a functional endoplasmic reticulum-targeting domain
16. A plastid of probable green algal origin in apicomplexan parasites
17. Protein import into 'complex' diatom plastids utilizes two different targeting signals
18. Toxoplasmosis: From clinics to basic science
19. Something borrowed, something green: Lateral transfer of chloroplasts by secondary endosymbiosis
20. The single mitochondrion of tachyzoites of Toxoplasma gondii
21. A single gene of chloroplast origin codes for mitochondrial and chloroplastic methionyl-tRNA synthetase in Arabidopsis thaliana
22. A knowledge base for predicting protein localization sites in eukaryotic cells
23. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
24. Stage-dependent localization of LHCP II apoprotein in the Golgi of synchronized cells of Euglena gracilis by immunogold electron microscopy
25. Second-hand chloroplasts and the case of the disappearing nucleus
26. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii
27. Amphiphilicity is essential for mitochondrial presequence function
28. Protein import into cyanelles and complex chloroplasts
29. Toxoplasma gondii: A paraformaldehyde-insensitive diaphorase activity acts as a specific histochemical marker for the single mitochondrion
30. Two distinct forms of the peridinin-chlorophyll a-protein from Amphidinum carterae
31. Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: A high affinity interaction
32. Expression, secretion, and organellar targeting of the green fluorescent protein in Toxoplasma gondii
33. The polyprotein precursor to the Euglena light-harvesting chlorophyl a/b-binding protein is transported to the Golgi apparatus prior to chloroplast import and polyprotein processing
34. Molecular cloning, organellar targeting, and developmental expression of mitochondrial chaperone HSP60 in Toxoplasma gondii
35. Domain structure of mitochondrial and chloroplast targeting peptides
36. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
37. Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway
38. Isolation and characterization of a substractive library enriched for developmentally regulated transcripts expressed during encystation of Toxoplasma gondii